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ShareScore release 0.9.0
Dataset results
897 results for “Therapeutic targets”
Genomic Landscape and Therapeutic Targets of Adenosquamous Carcinoma of the Pancreas [CGH Microarray]
GEO Series GSE143256. Homo sapiens. 19 samples. Type: Genome variation profiling by genome tiling array.
The FOXP3+ pro-inflammatory T cell: A Potential Therapeutic Target in Crohn’s Disease
GEO Series GSE209832. Homo sapiens. 11 samples. Type: Expression profiling by high throughput sequencing.
Small molecule RNA therapeutics to target prostate cancer [Ribo-seq]
GEO Series GSE283445. Homo sapiens. 12 samples. Type: Other.
Dual-hit strategy for therapeutic targeting of pancreatic cancer in patient-derived xenograft tumors
GEO Series GSE159334. Homo sapiens. 6 samples. Type: Expression profiling by high throughput sequencing.
Transcriptomic Analysis Identifies B-Lymphocyte Kinase as a Therapeutic Target for Desmoplastic Small Round Cell Tumor Cancer Stem Cell-Like Cells [scRNA-seq]
GEO Series GSE248856. Homo sapiens. 2 samples. Type: Expression profiling by high throughput sequencing.
In vivo CRISPR Screening Identifying Therapeutic Target to Sensitize Anti-PD-1 Immunotherapy in Non-small Cell Lung Cancer
GEO Series GSE301822. Mus musculus. 72 samples. Type: Other.
Therapeutic Targeting Ewing Sarcoma through Inhibition of the FACT Complex (RNA-Seq I)
GEO Series GSE195803. Homo sapiens. 4 samples. Type: Expression profiling by high throughput sequencing.
FBXO44 Regulates Rac1 Spatiotemporal Dynamics: An Exploitable Therapeutic Vulnerability for Actin Cytoskeleton-Targeted Treatment in Gastric Cancer
GEO Series GSE292280. Homo sapiens. 6 samples. Type: Expression profiling by high throughput sequencing.
PDX models of relapsed pediatric AML preserve global gene expression patterns and reveal therapeutic targets
GEO Series GSE252945. Homo sapiens. 47 samples. Type: Expression profiling by high throughput sequencing.
MicroRNA expression profile of primary prostate cancer stem cells as a source of biomarkers and therapeutic targets
GEO Series GSE59156. Homo sapiens. 42 samples. Type: Non-coding RNA profiling by array.
EZH2 is a potential therapeutic target for H3K27M mutant paediatric gliomas [ChIP-Seq human cell lines]
GEO Series GSE85387. Homo sapiens. 8 samples. Type: Genome binding/occupancy profiling by high throughput sequencing.
Comprehensive molecular profiling of FH-deficient renal cell carcinoma identifies molecular subtypes and novel therapeutic targets
GEO Series GSE291073. Homo sapiens. 92 samples. Type: Methylation profiling by array.
Androgen receptor, although not a specific marker for, is a novel target to suppress glioma stem cells as a therapeutic strategy for glioblastoma
GEO Series GSE174295. Homo sapiens. 8 samples. Type: Expression profiling by high throughput sequencing.
Transcriptome sequencing reveals two subtypes of cortisol-secreting adrenocortical tumors in dogs and identifies CYP26B1 as a potential new therapeutic target
GEO Series GSE196108. Canis lupus familiaris. 59 samples. Type: Expression profiling by high throughput sequencing.
Protein neddylation as a therapeutic target in pulomonary and extrapulonary small cell carcinomas
GEO Series GSE171262. Homo sapiens. 29 samples. Type: Expression profiling by high throughput sequencing.
Targeting AEBP1 to mitigate pro-tumor activity of cancer-associated fibroblasts and increase therapeutic efficacy to anti-PD-1
GEO Series GSE301078. Mus musculus. 12 samples. Type: Expression profiling by high throughput sequencing.
Therapeutically Applicable Research to Generate Effective Treatments (TARGET)
The Therapeutically Applicable Research to Generate Effective Treatments (TARGET) program applies a comprehensive genomic approach to determine molecular changes that drive childhood cancers. The goal of the program is to use data to guide the development of effective, less toxic therapies. TARGET is organized into a collaborative network of disease-specific project teams.
Full transcriptome analysis reveals key regulatory networks and potential therapeutic targets of dorsal root ganglion in rats with painful diabetic peripheral neuropathy
GEO Series GSE305770. Rattus norvegicus. 10 samples. Type: Expression profiling by high throughput sequencing.
Characterization of the interaction between SARS-CoV-2 Membrane Protein and Proliferating Cell Nuclear Antigen (PCNA) as a Potential Therapeutic Target
<p>In this dataset, we have validated and explored the interaction between the SARS-CoV-2 M protein and the cellular protein PCNA, an interaction that was previously described by another proteomics study (Gordon et al., 2020). PCNA is an important nuclear protein involved in DNA replication and repair in the cell. The M-protein-PCNA interaction characterized here impacted the cell physiology, including increased localization of PCNA in the cytoplasm and associated DNA damage markers. These phenomena may have consequences for the fate of cells infected with SARS-CoV-2 and for the outcomes of COVID-19, such as persistent DNA damage after the infection. Finally, we show that inhibitors of PCNA and cell nuclear transport present effects in SARS-CoV-2 replication in vitro. Similar results have been presented by other RNA viruses in the literature. In sum, this study sheds light on novel molecular mechanisms of SARS-CoV-2 replication.</p>
Link to dataset related to article "Multimodal single-cell profiling of intrahepatic cholangiocarcinoma defines hyperactivated Tregs as a potential therapeutic target "
<p>This record contains raw data related to article “Multimodal single-cell profiling of intrahepatic cholangiocarcinoma defines hyperactivated Tregs as a potential therapeutic target"</p> <p>Abstract:</p> <p><strong>Background & aims: </strong> The landscape and function of the immune infiltrate of intrahepatic cholangiocarcinoma (iCCA), a rare, yet aggressive tumor of the biliary tract, remains poorly characterized, limiting development of successful immunotherapies. Herein, we aimed to define the molecular characteristics of tumor-infiltrating leukocytes with a special focus on CD4+ regulatory T cells (Tregs).</p> <p><strong>Methods: </strong> We used high-dimensional single-cell technologies to characterize the T-cell and myeloid compartments of iCCA tissues, comparing these with their tumor-free peritumoral and circulating counterparts. We further used genomics and cellular assays to define the iCCA-specific role of a novel transcription factor, mesenchyme homeobox 1 (MEOX1), in Treg biology.</p> <p><strong>Results: </strong> We found poor infiltration of putative tumor-specific CD39+ CD8+ T cells accompanied by abundant infiltration of hyperactivated CD4+ Tregs. Single-cell RNA-sequencing identified an altered network of transcription factors in iCCA-infiltrating compared to peritumoral T cells, suggesting reduced effector functions by tumor-infiltrating CD8+ T cells and enhanced immunosuppression by CD4+ Tregs. Specifically, we found that expression of MEOX1 was highly enriched in tumor-infiltrating Tregs, and demonstrated that MEOX1 overexpression is sufficient to reprogram circulating Tregs to acquire the transcriptional and epigenetic landscape of tumor-infiltrating Tregs. Accordingly, enrichment of the MEOX1-dependent gene program in Tregs was strongly associated with poor prognosis in a large cohort of patients with iCCA.</p> <p><strong>Conclusions: </strong> We observed abundant infiltration of hyperactivated CD4+ Tregs in iCCA tumors along with reduced CD8+ T-cell effector functions. Interfering with hyperactivated Tregs should be explored as an approach to enhance antitumor immunity in iCCA.</p> <p><strong>Lay summary: </strong> Immune cells have the potential to slow or halt the progression of tumors. However, some tumors, such as intrahepatic cholangiocarcinoma, are associated with very limited immune responses (and infiltration of cancer-targeting immune cells). Herein, we show that a specific population of regulatory T cells (a type of immune cell that actually suppresses the immune response) are hyperactivated in intrahepatic cholangiocarcinoma. Targeting these cells could enable cancer-targeting immune cells to act more effectively and should be looked at as a potential therapeutic approach to this aggressive cancer type.</p>
ScienceDex guides
Understand access before you commit
These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.