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818
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ShareScore release 0.9.0
Dataset results
818 results for “atrophy”
Elevated levels of S100A8 and S100A9 exacerbate muscle mitochondrial fragmentation in sepsis-induced muscle atrophy
GEO Series GSE285318. Mus musculus. 12 samples. Type: Expression profiling by high throughput sequencing.
Transcriptomic insights into Multiple System Atrophy from a PLP-α-Synuclein transgenic mouse model
GEO Series GSE247259. Mus musculus. 15 samples. Type: Expression profiling by high throughput sequencing.
EAP of Apitegromab for Patients With Spinal Muscular Atrophy
ClinicalTrials.gov study NCT06877689. IPD Sharing: Not stated. Countries: 0. Publications: 0.
Rat muscle atrophy
GEO Series GSE97740. Rattus norvegicus. 8 samples. Type: Expression profiling by array.
CSF1R-mediated myeloid cell depletion prolongs lifespan but aggravates distinct motor symptoms in a model of multiple system atrophy
GEO Series GSE197153. Mus musculus. 36 samples. Type: Expression profiling by high throughput sequencing.
Gene Expression Analysis of spinal cord obtained from a mouse model of severe Spinal Muscular Atrophy (SMA)
GEO Series GSE19674. Mus musculus. 12 samples. Type: Expression profiling by array.
Effect of electroacupuncture on the skeletal muscle atrophy induced by hindlimb suspension in mice
GEO Series GSE38874. Mus musculus. 6 samples. Type: Expression profiling by array.
Excessive fatty acid oxidation induces muscle atrophy in cancer cachexia
GEO Series GSE80142. Mus musculus; Homo sapiens. 12 samples. Type: Expression profiling by array.
Frontal Atrophy and CSF Tau Levels With Neuropsychiatric Symptoms in Patients With Cognitive Impairment
<p>This database includes the raw data linked with the paper “ Frontal Atrophy and CSF Tau Levels With Neuropsychiatric Symptoms in Patients With Cognitive Impairment: A Memory Clinic Experience. ” published on “ Frontiers in Aging Neuroscience 5, March, 2021”.</p> <p>Behavioral and psychological symptoms of dementia (BPSD) are a distressful condition. We aimed to investigate the BPSD distribution in subjects with cognitive impairment, and the potential correlations between BPSD and neurodegeneration in terms of cerebrospinal fluid (CSF) tau and brain atrophy.</p> <p>One-hundred patients with mild cognitive impairment (MCI) or dementia (Alzheimer’s disease; Lewy-body disease, LBD; frontotemporal dementia; vascular dementia) underwent a complete diagnostic workup, including 3T-MRI and/or CT and CSF.</p> <p>Cortical atrophy was assessed with MTA, PA and GCA-F scales. BPSD were rated using Neuropsychiatric Inventory (NPI), and BPSD clusters were defined according to the European Alzheimer Disease Consortium.</p> <p>Delusions, hallucinations and psychosis cluster were differently distributed among the diagnostic groups (p<0.05, p<0.001, and p<0.05), with LBD patients showing higher scores for hallucinations (vs MCI, p<0.001, and AD, p<0.05) and psychosis cluster (vs MCI, p<0.05). In primary dementias, we found a negative trend between NPI total score and tau levels (p=0.08), while a positive relationship was observed in MCI (p=0.60). Higher GCA-F scores were associated to delusions and apathy (p<0.05, on both hemispheres) and to hallucinations (left: p<0.01, right: p<0.05). GCA-F scores were positively correlated with delusions and psychosis cluster (right: p<0.05), and agitation/aggression (left: p<0.05). Conversely, nighttime disturbances were positively correlated with both GCA-F and MTA scores (left: p<0.01; right: p<0.05).</p> <table align="left"> <tbody> <tr> <td> <p> </p> </td> </tr> </tbody> </table>
Diagnostic and prognostic value of external anal sphincter EMG patterns in Multiple System Atrophy
<p>This database includes the raw data linked with the paper “Diagnostic and prognostic value of external anal sphincter EMG patterns in multiple system atrophy”.</p> <p>We collected clinical data and external anal sphincter (EAS) EMG findings in 72 patients with multiple system atrophy (MSA) and 21 with Parkinson’s disease (PD). We ascertained the survival times of 49 MSA patients who died during follow-up. We aimed to assess the diagnostic and prognostic value and clinical correlations of a novel classification of EAS electromyography patterns in MSA. We identified four EAS electromyography patterns, ranging from normal findings (pattern I) to mild, moderate or severe neurogenic damage (patterns II, III and IV, respectively).</p> <p>Pattern I was frequently observed in PD patients, while it was associated with prolonged survival when identified in a few MSA patients. Patterns II, III and IV were predominant in MSA. Subjects with MSA and EAS abnormalities often showed fecal incontinence and urogenital symptoms, which were frequently present at disease onset in patients with patterns III and IV. Abnormal EAS patterns correlated with MSA diagnosis. In particular, pattern IV was associated with the highest likelihood of MSA diagnosis and with the worst prognosis in the MSA cohort.</p>
Vascular lesions and brain atrophy in Alzheimer's, vascular and mixed dementia: an optimized 3T MRI protocol reveals distinctive radiological profiles
<p><strong>Background</strong></p> <p>Behavioral and psychological symptoms of dementia (BPSD) are a distressful condition. We aimed to investigate the</p> <p>BPSD distribution in subjects with cognitive impairment, and the potential correlations between BPSD and neurodegeneration in</p> <p>terms of cerebrospinal fluid (CSF) tau and brain atrophy.</p> <p><strong>Methods</strong></p> <p>Seventy-six subjects received a diagnosis of Alzheimer’s (AD=32), vascular (VD=26) or mixed (MD=18) dementia according to Hachinski scale and NINCDS-ADRDA criteria. Three independent raters assessed the brain images acquired according to a high resolution 3T MRI protocol (including 3D FLAIR, T1, SWI and 2D coronal T2 sequences) with semiquantitative scales for vascular lesions (periventricular and deep white matter lesions, PVL and DWML, deep grey matter lesions, DGML, enlarged perivascular spaces, PVS, and microbleeds, MB) and brain atrophy (medial temporal atrophy, MTA, posterior atrophy, PA, global cortical atrophy-frontal, GCA-F, and Evans’ index). The inter-rater agreement was assessed with the intraclass correlation coefficient (ICC).</p> <p><strong>Results</strong></p> <p>Raters reached a good-to-excellent agreement for all scales (ICC ranging 0.78-0.96). A greater number of PVL (p<0.001), DWML (p<0.001), DGML (p=0.010) and PVS (p=0.001) was observed in VD compared to AD, while MD showed a significant greater number of PVL (p=0.001), DWML (p=0.002), DGML (p=0.018) and deep and juxtacortical MB (p=0.006 and p<0.001, respectively). No significant difference was observed in scores of cortical atrophy scales and Evans’ index among the three groups.</p> <p><strong>Conclusion</strong></p> <p>The use of a high-resolution 3T MRI protocol, including SWI, allowed a reliable and time-saving assessment of vascular lesions and atrophy using dedicated visual scales. Our findings confirm that white and grey matter lesions are the predominant abnormalities in both vascular and mixed dementia, whereas juxtacortical microbleeds predominate in mixed dementia, suggesting that cerebral amyloid angiopathy could be the main underlying pathology.</p>
Evaluation of body composition as a potential biomarker in spinal muscular atrophy
<p><strong>Introduction: </strong>We aimed to investigate the correlation between body composition (BC) and spinal muscular atrophy (SMA)-specific motor function assessments.</p> <p><strong>Methods: </strong>Patients with SMA types I or II, aged 1 to 10 years, were recruited in this cross-sectional study. The protocol included anthropometric measurements, and dual-energy X-ray absoprtiometry to assess fat mass (FM), lean mass (LM), fat-free mass (FFM), FM and FFM indexes (FMI, FFMI), and motor function assessments (Children's Hospital of Philadelphia Infant Test of Neuromuscular Disorders scale for SMAI, and Hammersmith Functional Motor Scale-Expanded for SMAII).</p> <p><strong>Results: </strong>Eighty-eight children were included. All had a higher FM percentage than reference values. Motor function was moderately correlated with body mass index (BMI), FFMI, and LMI in SMAI, and weakly correlated with FFMI, LMI, and LM:FM ratio in SMAII.</p> <p><strong>Discussion: </strong>BC shows promise as a potential biomarker for SMA, but further studies are needed.</p> <p> </p>
dataset relate to article "Adults with spinal muscular atrophy a large-scale natural history study shows gender effect on disease"
<p>Dataset contains clinical anonymized data of patients involved in study mentioned at title</p>
Psychosocial stress-induced brain atrophy and its suppression via theanine intake
GEO Series GSE120546. Mus musculus. 8 samples. Type: Expression profiling by array.
Selective ablation of dehydrodolichyl diphosphate synthase in murine retinal pigment epithelium (RPE) causes RPE atrophy and retinal degeneration.
<p>Supplementary files for manuscript.</p>
Data Set from Renna LV, Bosè F, Brigonzi E, Fossati B, Meola G, Cardani R. Aberrant insulin receptor expression is associated with insulin resistance and skeletal muscle atrophy in myotonic dystrophies. PLoS One. 2019 Mar 22;14(3):e0214254. doi: 10.1371/journal.pone.0214254. PMID: 30901379; PMCID: PMC6430513.
<p>Data Set from Renna LV, Bosè F, Brigonzi E, Fossati B, Meola G, Cardani R. Aberrant insulin receptor expression is associated with insulin resistance and skeletal muscle atrophy in myotonic dystrophies. PLoS One. 2019 Mar 22;14(3):e0214254. doi: 10.1371/journal.pone.0214254. PMID: 30901379; PMCID: PMC6430513.</p> <p> </p> <p>This is the abstact:</p> <p>Myotonic dystrophy type 1 (DM1) and type 2 (DM2) are autosomal dominant multisystemic disorders linked to two different genetic loci and characterized by several features including myotonia, muscle atrophy and insulin resistance. The aberrant alternative splicing of insulin receptor (IR) gene and post-receptor signalling abnormalities have been associated with insulin resistance, however the precise molecular defects that cause metabolic dysfunctions are still unknown. Thus, the aims of this study were to investigate in DM skeletal muscle biopsies if beyond INSR missplicing, altered IR protein expression could play a role in insulin resistance and to verify if the lack of insulin pathway activation could contribute to skeletal muscle wasting. Our analysis showed that DM skeletal muscle exhibits a lower expression of the insulin receptor in type 1 fibers which can contribute to the defective activation of the insulin pathway. Moreover, the aberrant insulin signalling activation leads to a lower activation of mTOR and to an increase in MuRF1 and Atrogin-1/MAFbx expression, possible explaining DM skeletal muscle fiber atrophy. Taken together our data indicate that the defective insulin signalling activation can contribute to skeletal muscle features in DM patients and are probably linked to an aberrant specific-fiber type expression of the insulin receptor.</p>
DATASET RELATED TO ARTICLE "The Alpha-Synuclein RT-QuIC Products Generated by the Olfactory Mucosa of Patients with Parkinson's Disease and Multiple System Atrophy Induce Inflammatory Responses in SH-SY5Y Cells"
<p>RAW DATA RELATED TO ARTICLE AT TITLE</p>
Spplemtental Data of "Resistance exercise with anti-inflammatory foods attenuate skeletal muscle atrophy induced by chronic inflammation"
<p>Spplemtental Data of "Resistance exercise with anti-inflammatory foods attenuate skeletal muscle atrophy induced by chronic inflammation"</p>
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Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.