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6,818 results for “inhibition”
Figure 6 from: Laksmiani NPL, Widiantara IWA, Pawarrangan ABS (2022) Potency of moringa (Moringa oleifera L.) leaves extract containing quercetin as a depigmentation agent inhibiting the tyrosinase enzyme using in-silico and in-vitro assay. Pharmacia 69(1): 85-92. https://doi.org/10.3897/pharmacia.69.e73132
Figure 6 The regression curve of the relationship between AUC and series concentration of quercetin standard.
Figure 6 from: Todorova N, Rangelov M, Dincheva I, Badjakov I, Enchev V, Markova N (2022) Potential of hydroxybenzoic acids from Graptopetalum paraguayense for inhibiting of herpes simplex virus DNA polymerase – metabolome profiling, molecular docking and quantum-chemical analysis. Pharmacia 69(1): 113-123. https://doi.org/10.3897/pharmacia.69.e79467
Figure 6 Structures of amino acids from GP phenolic fraction "C", optimized at B3LYP/6-31+G(d,p) level.
Figure 3 from: Todorova N, Rangelov M, Dincheva I, Badjakov I, Enchev V, Markova N (2022) Potential of hydroxybenzoic acids from Graptopetalum paraguayense for inhibiting of herpes simplex virus DNA polymerase – metabolome profiling, molecular docking and quantum-chemical analysis. Pharmacia 69(1): 113-123. https://doi.org/10.3897/pharmacia.69.e79467
Figure 3 Acyclovir triphosphate and its vicinity in the DNA polymerase pocket after docking procedure: a) 3D plane of view and b) 2D plane of view. The interactions of the ligand in the active site cavity are represented as follows: the proximity contour is depicted with a black dotted line; solvent accessibility, as blue clouds around atoms or blue shadows around amino acid residues; polar amino acids are displayed with pink, while the lipophilic ones are in green. Basic amino acids are outlined with blue and the acidic – with red. Hydrogen bond interactions are depicted with dotted arrows, while the ionic ones are depicted with dotted lines.
Figure 2 from: Todorova N, Rangelov M, Dincheva I, Badjakov I, Enchev V, Markova N (2022) Potential of hydroxybenzoic acids from Graptopetalum paraguayense for inhibiting of herpes simplex virus DNA polymerase – metabolome profiling, molecular docking and quantum-chemical analysis. Pharmacia 69(1): 113-123. https://doi.org/10.3897/pharmacia.69.e79467
Figure 2 Phenolic (trans-ferulic) acid and its vicinity after docking procedure. The amino acid residues of HSV-1 DNA polymerase active site, mostly involved in interaction with ligands, are represented as follows: Lis928 is basic amino acid right from the ligand, Glu 927 is above it, basic amino acid on the left is Lis 939 and Asp 886 is in its right.
Supplementary material 1 from: Todorova N, Rangelov M, Dincheva I, Badjakov I, Enchev V, Markova N (2022) Potential of hydroxybenzoic acids from Graptopetalum paraguayense for inhibiting of herpes simplex virus DNA polymerase – metabolome profiling, molecular docking and quantum-chemical analysis. Pharmacia 69(1): 113-123. https://doi.org/10.3897/pharmacia.69.e79467
Tables S1–S3 and Figures S1–S4
Figure 8 from: Todorova N, Rangelov M, Dincheva I, Badjakov I, Enchev V, Markova N (2022) Potential of hydroxybenzoic acids from Graptopetalum paraguayense for inhibiting of herpes simplex virus DNA polymerase – metabolome profiling, molecular docking and quantum-chemical analysis. Pharmacia 69(1): 113-123. https://doi.org/10.3897/pharmacia.69.e79467
Figure 8 Complex of acyclovir triphosphate and amino acids from DNA polymerase active site, optimized at B3LYP/6-31+G(d,p) level.
Figure 7 from: Todorova N, Rangelov M, Dincheva I, Badjakov I, Enchev V, Markova N (2022) Potential of hydroxybenzoic acids from Graptopetalum paraguayense for inhibiting of herpes simplex virus DNA polymerase – metabolome profiling, molecular docking and quantum-chemical analysis. Pharmacia 69(1): 113-123. https://doi.org/10.3897/pharmacia.69.e79467
Figure 7 Complexes of phenolic acids from GP phenolic fraction "C" and amino acids from DNA polymerase active site, optimized at B3LYP/6-31+G(d,p) level.
Figure 5 from: Todorova N, Rangelov M, Dincheva I, Badjakov I, Enchev V, Markova N (2022) Potential of hydroxybenzoic acids from Graptopetalum paraguayense for inhibiting of herpes simplex virus DNA polymerase – metabolome profiling, molecular docking and quantum-chemical analysis. Pharmacia 69(1): 113-123. https://doi.org/10.3897/pharmacia.69.e79467
Figure 5 Structures of hydroxybenzoic acids from GP phenolic fraction "C", optimized at B3LYP/6-31+G(d,p) level.
Protocols for the Isolation of Lactic Acid Bacteria and Determination of the Inhibition Diameter
<p>Video demonstrating the protocols for the isolation of lactic acid bacteria and the determination of the inhibition diameter using the spot-of-the-lawn agar test. Training video elaborated within the ArtiSaneFood project.</p>
Data for Native mycorrhizal fungi improve milkweed growth, latex, and establishment while some commercial fungi may inhibit them
<p>Arbuscular mycorrhizal (AM) fungi are root symbionts that can facilitate plant growth and influence plant communities by altering plant interactions with herbivores. Therefore, AM fungi could be critical for the conservation of certain rare plants and herbivores. For example, North American milkweed species are crucial hosts for monarch butterflies (<i>Danaus plexippus</i>). Understanding how mycorrhizal composition affects milkweeds will have direct impacts on the conservation and restoration of both increasingly threatened guilds.</p> <p>We present data from three studies on the effect of AM fungal composition on milkweed growth, latex production and establishment. First, we grew 7 milkweed species with and without a mixture of native mycorrhizal fungi. We assessed how important fungal composition is to milkweed growth and latex production by growing 4 milkweed species with 7 fungal compositions, as single species inoculations with 4 native fungi, a mixture of native fungi, a single commercial fungus of presumably non-native origin and non-inoculated controls. Finally, we assessed field establishment of two milkweed species with and without native mycorrhizal inoculation.</p> <p>Milkweed species grew 98% larger and produced 82% more latex after inoculation with native mycorrhizae. Milkweeds were strongly affected by fungal composition; milkweeds were inhibited by commercial fungi (average -14% growth) and showed variable but positive responses to native fungal species (average of +3% to +38% biomass). Finally, we found that restoration establishment was dependent on inoculation with native fungi and milkweed species. Overall, our findings indicate that some milkweed species (i.e. A. <i>syriaca</i> and <i>A. incarnata</i>) are not responsive to mycorrhizal fungal presence or sensitive to mycorrhizal composition while others are, including endangered species (<i>A. meadii</i>) and species of high conservation value (<i>A. tuberosa</i>). We conclude that reintroduction of native AM fungi could improve the establishment of desirable milkweed species and should be considered within strategies for plantings for monarch conservation.</p>
Figure 5 from: Santoso I, Fadhilah QG, Safitri SD, Handayani S, Maryanto AE, Yasman Y (2022) Inhibition of the phytopathogenic fungi Curvularia lunata BM and Ganoderma sp. TB4 by antifungal compounds produced by Bacillus siamensis LDR grown on hanjeli (Coix lacryma-jobi L.) starch. Pharmacia 69(1): 203-210. https://doi.org/10.3897/pharmacia.69.e80180
Figure 5 The chromatogram profile of the crude extract of Bacillus siamensis LDR : A. C14 iturin A; B. C14 bacillomycin F; C. C15 bacillomycin F; D. C16 bacillomycin F; E. C12 surfactin; F. C13 surfactin.
Figure 4 from: Santoso I, Fadhilah QG, Safitri SD, Handayani S, Maryanto AE, Yasman Y (2022) Inhibition of the phytopathogenic fungi Curvularia lunata BM and Ganoderma sp. TB4 by antifungal compounds produced by Bacillus siamensis LDR grown on hanjeli (Coix lacryma-jobi L.) starch. Pharmacia 69(1): 203-210. https://doi.org/10.3897/pharmacia.69.e80180
Figure 4 Thin layer chromatography of crude extract Bacillus siamensis LDR : A. lipid moiety; B. protein moiety.
Figure 6 from: Santoso I, Fadhilah QG, Safitri SD, Handayani S, Maryanto AE, Yasman Y (2022) Inhibition of the phytopathogenic fungi Curvularia lunata BM and Ganoderma sp. TB4 by antifungal compounds produced by Bacillus siamensis LDR grown on hanjeli (Coix lacryma-jobi L.) starch. Pharmacia 69(1): 203-210. https://doi.org/10.3897/pharmacia.69.e80180
Figure 6 The results of mass spectrometry analysis: A. C14 iturin A (m/z 1043.5526); B. C14 iturin A (m/z 1044.5375); C. C14 bacillomycin F (m/z 1057.5688); D. C15 bacillomycin F (m/z 1071.5848); E. C16 bacillomycin F (m/z 1085.6011); F. C12 surfactin (m/z 994.6440); and G. C13 surfactin (m/z 1008.6606)
Figure 2 from: Santoso I, Fadhilah QG, Safitri SD, Handayani S, Maryanto AE, Yasman Y (2022) Inhibition of the phytopathogenic fungi Curvularia lunata BM and Ganoderma sp. TB4 by antifungal compounds produced by Bacillus siamensis LDR grown on hanjeli (Coix lacryma-jobi L.) starch. Pharmacia 69(1): 203-210. https://doi.org/10.3897/pharmacia.69.e80180
Figure 2 Growth inhibition of Ganoderma sp. TB4 on potato dextrose agar (PDA)-filtrate medium: A. control, B. 12 days, C. 14 days, D. 16 days.
Figure 3 from: Santoso I, Fadhilah QG, Safitri SD, Handayani S, Maryanto AE, Yasman Y (2022) Inhibition of the phytopathogenic fungi Curvularia lunata BM and Ganoderma sp. TB4 by antifungal compounds produced by Bacillus siamensis LDR grown on hanjeli (Coix lacryma-jobi L.) starch. Pharmacia 69(1): 203-210. https://doi.org/10.3897/pharmacia.69.e80180
Figure 3 Growth inhibition of Curvularia lunata BM: A. control, B. treatment; Ganoderma sp. TB4 : C. control; D. treatment caused by the crude extract of Bacillus siamensis LDR.
Figure 1 from: Santoso I, Fadhilah QG, Safitri SD, Handayani S, Maryanto AE, Yasman Y (2022) Inhibition of the phytopathogenic fungi Curvularia lunata BM and Ganoderma sp. TB4 by antifungal compounds produced by Bacillus siamensis LDR grown on hanjeli (Coix lacryma-jobi L.) starch. Pharmacia 69(1): 203-210. https://doi.org/10.3897/pharmacia.69.e80180
Figure 1 Growth inhibition of Curvularia lunata BM on potato dextrose agar (PDA)-filtrate medium: A. control, B. 12 days, C. 14 days, D. 16 days.
Exposure to lysed bacteria can promote or inhibit growth of neighboring live bacteria depending on local abiotic conditions
Abstract Microbial death is extremely common in nature, yet the ecological role of dead bacteria is unclear. Dead cells are assumed to provide nutrients to surrounding microbes, but may also affect them in other ways. We found that adding lysate prepared from dead bacteria to cultures of Escherichia coli in nutrient-rich conditions suppressed their final population density. This is in stark contrast with the notion that the primary role of dead cells is nutritional, although we also observed this type of effect when we added dead bacteria to cultures that were not supplied with other nutrients. We only observed the growth-suppressive effect of our dead-bacteria treatment after they had undergone significant lysis, suggesting a key role for cellular contents released during lysis. Transcriptomic analysis indicated changes in gene expression in response to dead cells in growing populations, particularly in genes involved in motility. This was supported by experiments with genetic knockouts and copy-number manipulation. Because lysis is commonplace in natural and clinical settings, the growth-suppressive effect of dead cells we describe here may be a widespread and previously unrecognized constraint on bacterial population growth.
Live imaging data of XBP1 mRNA under ER stress and IRE1a inhibition
<p>Live microscopy data of XBP1 mRNA transcript in TM and 4u8C.</p>
Supplementary material 1 from: Yaseen Y, Kubba A, Shihab W, Tahtamouni L (2022) Synthesis, docking study, and structure-activity relationship of novel niflumic acid derivatives acting as anticancer agents by inhibiting VEGFR or EGFR tyrosine kinase activities. Pharmacia 69(3): 595-614. https://doi.org/10.3897/pharmacia.69.e86504
Figures S1, S2, Tables S1, S2
m6A modification inhibits miRNA intracellular function favouring their extracellular export and the cell-to-cell communication
<p>Epitranscriptomics represents a new layer of gene expression regulation. Specifically, N6-methyladenosine (m6A) regulates RNA maturation, stability, degradation, and translation. Regarding miRNAs, while it has been reported that m6A impact their biogenesis, no evidence is yet provided on their function. Here we show that m6A modification on specific miRNAs weakens their coupling to AGO2, impairs their function on target mRNAs, determines their delivery into extracellular vesicles (EVs) and provides functional information to receiving cells. Mechanistically, the intracellular functional impairment is caused by m6A-mediated inhibition of AGO2/miRNA interaction, the EV-loading is favoured by m6A-mediated recognition by the RBP hnRNPA2B1, the EV-miRNAs function in the receiving cell requires their FTO-mediated demethylation. Consequently, cells express specific miRNAs that do not impact endogenous transcripts but provide regulatory information for cell-to-cell communication. This highlights that a further level of complexity should be considered when relating cellular dynamics to specific miRNAs.</p>
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