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ShareScore release 0.9.0
Dataset results
814 results for “pancreatic adenocarcinoma”
Integrin alpha-V drives pancreatic adenocarcinoma progression due to activation of TGF-β
GEO Series GSE153702. Homo sapiens. 12 samples. Type: Expression profiling by array.
Mapping global miR-29a targets in pancreatic cancer adenocarcinoma (PDAC) cells using Next Generation Sequencing approach
GEO Series GSE128663. Homo sapiens. 12 samples. Type: Expression profiling by high throughput sequencing.
Med12 ablation promotes anti-tumor function by enhancing tumor intrinsic immunogenicity in Pancreatic ductal adenocarcinoma
GEO Series GSE242098. Homo sapiens; Mus musculus. 114 samples. Type: Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing.
Expression data from intermediate stage of murine pancreatic ductal adenocarcinoma (PDAC) and control pancreas
GEO Series GSE127891. Mus musculus. 13 samples. Type: Expression profiling by array.
Clostridium butyricum and its metabolite butyrate promote ferroptosis susceptibility in pancreatic ductal adenocarcinoma.
GEO Series GSE227418. Mus musculus. 6 samples. Type: Expression profiling by high throughput sequencing.
Med12 ablation promotes anti-tumor function by enhancing tumor intrinsic immunogenicity in Pancreatic ductal adenocarcinoma [CUT&Tag]
GEO Series GSE242097. Mus musculus. 45 samples. Type: Genome binding/occupancy profiling by high throughput sequencing.
Acute and chronic treatment of trametinib plus lapatinib in patient-derived xenografts (PDX) of pancreatic adenocarcinoma (PDAC)
GEO Series GSE98399. Homo sapiens. 43 samples. Type: Expression profiling by array.
Effect of Neoadjuvant Chemoradiation on Pancreatic Adenocarcinoma
GEO Series GSE60646. Homo sapiens. 26 samples. Type: Expression profiling by array.
Expression data from human pancreatic tissue from healthy subjects and pancreatic ductal adenocarcinoma patients
GEO Series GSE46234. Homo sapiens. 8 samples. Type: Expression profiling by array.
Dataset related to article "Early Recurrence after Upfront Surgery for Pancreatic Ductal Adenocarcinoma "
<p>This record contains raw data related to article "Early Recurrence after Upfront Surgery for Pancreatic Ductal Adenocarcinoma"</p><p><strong>Background: </strong>Survival after surgery for pancreatic ductal adenocarcinoma (PDAC) remains poor, due to early recurrence (ER) of the disease. A global definition of ER is lacking and different cut-off values (6, 8, and 12 months) have been adopted. The aims of this study were to define the optimal cut-off for the definition of ER and predictive factors for ER.</p><p><strong>Methods: </strong>Recurrence was recorded for all consecutive patients undergoing upfront surgery for PDAC at our institute between 2010 and 2017. Receiver operating characteristic (ROC) curves were utilized, to estimate the optimal cut-off for the definition of ER as a predictive factor for poor post-progression survival (PPS). To identify predictive factors of ER, univariable and multivariable logistic regression models were used.</p><p><strong>Results: </strong>Three hundred and fifty one cases were retrospectively evaluated. The recurrence rate was 76.9%. ER rates were 29.0%, 37.6%, and 47.6%, when adopting 6, 8, and 12 months as cut-offs, respectively. A significant difference in median PPS was only shown between ER and late recurrence using 12 months as cut-off (<i>p</i> = 0.005). In the multivariate analysis, a pre-operative value of CA 19-9 > 70.5 UI/L (OR 3.10 (1.41-6.81); <i>p</i> = 0.005) and the omission of adjuvant treatment (OR 0.18 (0.08-0.41); <i>p</i> < 0.001) were significant predictive factors of ER.</p><p><strong>Conclusions: </strong>A twelve-months cut-off should be adopted for the definition of ER. Almost 50% of upfront-resected patients presented ER, and it significantly affected the prognosis. A high preoperative value of CA 19-9 and the omission of adjuvant treatment were the only predictive factors for ER.</p>
Morphological and expression features of ductal pancreatic adenocarcinoma.
<p>Pancreatic cancer is one of the most unfavorable malignancies. Approximately 20 % of patients with pancreatic<br> cancer have resectable disease at the time of diagnosis, however the prognosis of the disease in these patients<br> remains poor, and the overall 5-year survival rate is only 5 %. The evaluation of morphological features, as well<br> as features of the expression of markers that determine the invasive potential of such neoplasms, can serve<br> in the future as a fundamental basis in solving problems concerning prognostic factors in pancreatic cancer.<br> the purpose of the study was to evaluate morphological and immunohistochemical features of pancreatic<br> ductal adenocarcinoma. Material and methods. The study included 84 patients with stage T1–4N0–2M0–1<br> pancreatic cancer. The age range was from 37 to 83 years. Surgery was the main treatment option. Morphological examination of surgical specimens showed that the tumor histotype corresponded to pancreatic ductal<br> adenocarcinoma. The preparation of histological specimens and immunohistochemical staining were carried out<br> according to standard procedures. results and conclusion. This study allowed us to determine the features of<br> tumor morphology, as well as the features of expression of markers associated with more pronounced invasive<br> properties of the tumor. The results of this study may be of interest in terms of their further comparison with the<br> parameters of various forms of progression in pancreatic cancer.</p>
Med12 ablation promotes anti-tumor function by enhancing tumor intrinsic immunogenicity in Pancreatic ductal adenocarcinoma [ATAC-seq]
GEO Series GSE242080. Mus musculus. 6 samples. Type: Genome binding/occupancy profiling by high throughput sequencing.
mRNA stability factor HuR promotes immune evasion in pancreatic ductal adenocarcinoma [RIP-seq]
GEO Series GSE287349. Mus musculus. 6 samples. Type: Other.
Histone demethylase JMJD3 disrupts spectrin-dependent cytoskeleton via activation of HKDC1 to suppress Pancreatic Ductal Adenocarcinoma
GEO Series GSE85933. Homo sapiens. 3 samples. Type: Expression profiling by array.
ScienceDex guides
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These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.