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1,200 results for “Meta analysis”
Adjunctive intraarterial thrombolysis in endovascular thrombectomy: a systematic review and meta-analysis
<p><b>Objective</b> To evaluate the safety and efficacy of intra-arterial thrombolysis (IAT) as an adjunct to endovascular thrombectomy (EVT) in ischemic stroke, we performed a systematic review and meta-analysis of the literature.</p> <p><b>Methods</b> Searches were performed using Medline, Embase, and Cochrane databases for studies that compared EVT to EVT with adjunctive IAT (EVT+IAT). Safety outcomes included symptomatic intracerebral hemorrhage (sICH) and mortality at three months. Efficacy outcomes included successful reperfusion (Thrombolysis in Cerebral Infarction score of 2b to 3), and functional independence, defined as a modified Rankin Scale score of 0 to 2 at three months.</p> <p><b>Results</b> Five studies were identified that compared combined EVT+IAT with alteplase <span><span>or urokinase to</span></span> EVT-only, and were included in the random effects meta-analysis. There were 1693 EVT patients, including 269 patients treated with combined EVT+IAT and 1424 patients receiving EVT-only. Pooled analysis did not demonstrate any differences between EVT+IAT and EVT-only in rates of sICH (OR: 0.61, 95% CI: 0.20-1.85; P=0.78), mortality (OR: 0.77, 95% CI: 0.54-1.10; P=0.15), or successful reperfusion (OR: 1.05, 95% CI: 0.52-2.15; P=0.89). There was a higher rate of functional independence in patients treated with EVT+IAT, although this was not statistically significant (OR: 1.34, 95% CI: 1.00-1.80; P=0.053).</p> <p><b>Conclusions</b> Adjunctive IAT appears to be safe. In specific situations, neurointerventionists may be justified in administering small doses of intraarterial alteplase or urokinase as rescue therapy during EVT.</p>
Western Juniper Woodlands climate relations meta analysis
<p>These data are based on tree-ring data from the internation tree ring data base and PRISM climate data.</p>
Duration of canine retraction with fixed appliances: A systematic review and meta-analysis
<p>Dataset for all analyses</p>
Data from: Widespread misperception about a major East Asian biogeographic boundary exposed through bibliographic survey and biogeographic meta-analysis
<p><strong>Aim</strong></p> <p>The Watase line, a major biogeographic boundary between Palearctic and Oriental realms in East Asia, is generally drawn between Akuseki and Kodakara Islands of the Northern Ryukyu archipelago, Japan. However, no evidence can be found to support the positioning of the boundary between these two tiny volcanic islands. This study aimed to confirm whether and where the biogeographical boundary should be drawn.</p> <p><strong>Location</strong></p> <p>East Asia</p> <p><strong>Taxon </strong></p> <p>Land snail, ant, dragonfly, butterfly, amphibian, reptile, bird, plant</p> <p><strong>Methods</strong></p> <p>A bibliographic survey was carried out to revisit an original definition of the Watase line and its usage. Biogeographic and meta-analyses were also performed using a Simpson dissimilarity index calculated from published distribution data to test whether and where any biogeographic boundary exists. To ensure the validity of the study design, similar surveys and analyses were conducted in another region of Southern Ryukyu, where a reliable biogeographic boundary has been proposed as a positive control.</p> <p><strong>Results</strong></p> <p>The bibliographic survey showed that the Watase line had been described without specifying the precise position. No revised definition has been proposed for the boundary to date. Biogeographic analyses do not support the existence of a boundary between Akuseki and Kodakara Islands. Meanwhile, the presence of a boundary in Southern Ryukyu was endorsed by both the bibliographic survey and biogeographic analyses, supporting the validity of this study's design.</p> <p><strong>Main conclusions</strong></p> <p>This study revealed that the major biogeographic boundary is widely used with deviations from the original definition. Presumably, ideas based on inappropriate evidence, such as the distribution of a symbolic species and unpublished data, have been referred to without being questioned and led to the current widespread misunderstanding. Misunderstandings like these could occur at any biogeographic boundaries around the world, and thus, systematic reviews of all boundaries are needed for an appropriate understanding of biodiversity. </p>
Supplementary material 1 from: Vyshedskiy A, Mahapatra S, Dunn R (2017) Linguistically deprived children: meta-analysis of published research underlines the importance of early syntactic language use for normal brain development. Research Ideas and Outcomes 3: e20696. https://doi.org/10.3897/rio.3.e20696
Linguistic isolates performance in verbal and nonverbal tests
Figure 5 from: Vyshedskiy A, Mahapatra S, Dunn R (2017) Linguistically deprived children: meta-analysis of published research underlines the importance of early syntactic language use for normal brain development. Research Ideas and Outcomes 3: e20696. https://doi.org/10.3897/rio.3.e20696
Figure 5 - Flexible syntax, prepositions, adjectives, verb tenses, and other common elements of grammar, all facilitate the human ability to communicate an infinite number of novel images with the use of a finite number of words. The graph shows the number of distinct images that can be transmitted with high fidelity in a communication system with 1,000 nouns as a function of the number of spatial prepositions. In a communication system with no spatial prepositions and other recursive elements, 1000 nouns can communicate 1000 images to a listener. Adding just one spatial preposition allows for the formation of three-word phrases (such as: 'a bowl behind a cup' or 'a cup behind a bowl') and increases the number of distinct images that can be communicated to a listener from 1000 to one million (1000x1x1000). Adding a second spatial preposition and allowing for five-word sentences of the form object-preposition-object-preposition-object (such as: a bowl on a cup behind a plate) increases the number of distinct images that can be communicated to four billion (1000x2x1000x2x1000). The addition of a third spatial preposition increases the number of distinct images to 27 trillion (1000x3x1000x3x1000x3x1000), and so on. In general, the number of distinct images communicated by three-word sentences of the structure object-preposition-object equals the number of object-words times the number of prepositions times the number of object-words. A typical language with 1000 nouns and 100 spatial prepositions can theoretically communicate 1000101 x 100100 distinct images. This number is significantly greater than the total number of atoms in the universe. For all practical purposes, an infinite number of distinct images can be communicated by a syntactic communication system with just 1000 words and a few prepositions. Prepositions, adjectives, and verb tenses dramatically facilitate the capacity of a syntactic communication system with a finite number of words to communicate an infinite number of distinct images. Linguists refer to this property of human languages as recursion. The "infiniteness" of human language has been explicitly recognized by "Galileo, Descartes, and the 17th-century 'philosophical grammarians' and their successors, notably von Humboldt" (Hauser et al. 2002). The infiniteness of all human languages stand in stark contrast to finite homesign communication systems that are lacking spatial prepositions, syntax, and other recursive elements of a formal sign language.
Figure 4 from: Vyshedskiy A, Mahapatra S, Dunn R (2017) Linguistically deprived children: meta-analysis of published research underlines the importance of early syntactic language use for normal brain development. Research Ideas and Outcomes 3: e20696. https://doi.org/10.3897/rio.3.e20696
Figure 4 - Synchronicity has to be understood in terms of synchronicity of the arrival of action potentials to a target neuron rather than absolute equality of action potential conduction times over different paths. Consider the following example: suppose neuron A is receiving excitatory input from neurons B and C via two different pathways (neuron A is the target neuron for both neurons B and C). Suppose that the action potential conduction time is 2ms from neuron B to neuron A and 22ms from neuron C to neuron A (i.e., the axonal pathway B-A has a significantly shorter conduction time than the axonal pathway C-A). Does it mean that the connections B-A and C-A are always asynchronous? No. The answer depends on the predominant neural activity rhythm in this network. At the firing rate of 50Hz (inter-spike interval of 20ms that correspond to Gamma rhythm), neurons B and C can actually be considered synchronous in relationship to neuron A: consider a train of action potentials synchronously fired by neurons B and C. The first action potential from neuron B will reach neuron A in 2ms and the first action potential from neuron C will reach neuron A in 22ms. Obviously, there would be no coincidence in the arrival times of the 1st action potentials from neurons B and C. However the second action potential from neuron B will arrive to neuron A in 22ms, concurrently with the 1st action potential from neuron C. Thus, starting with the second action potential, neuron A will receive synchronous activation from neurons B and C. The synchronous activation has a significantly greater probability of enhancing synaptic connections between neurons A and B, and A and C (Hebbian learning: 'neurons that fire together, wire together' (Hebb 1949). Thus, synchronicity does not need to imply absolute equality in the conduction time over different pathways. Rather synchronicity implies near-zero phase-shift between the two firing trains of action potentials at the postsynaptic cells. This phase-shift depends on conduction times over each pathway and also on the dominant firing frequency in the neural network.
Figure 2 from: Vyshedskiy A, Mahapatra S, Dunn R (2017) Linguistically deprived children: meta-analysis of published research underlines the importance of early syntactic language use for normal brain development. Research Ideas and Outcomes 3: e20696. https://doi.org/10.3897/rio.3.e20696
Figure 2 - A typical question testing subject's ability to mentally rotate an object is shown here as a 2x2 matrix with six answer choices displayed below the problem. The top row of the matrix indicates the rule: "the object in the right column is the result of 45° clockwise rotation." Applying this rule to the bottom row, we arrive at the correct answer depicted on the right.
Figure 1 from: Vyshedskiy A, Mahapatra S, Dunn R (2017) Linguistically deprived children: meta-analysis of published research underlines the importance of early syntactic language use for normal brain development. Research Ideas and Outcomes 3: e20696. https://doi.org/10.3897/rio.3.e20696
Figure 1 - Visual information processing in the cortex. From the primary visual cortex (V1, shown in yellow), the visual information is passed in two streams. The neurons along the ventral stream also known as the ventral visual cortex (shown in purple) are primarily concerned with what the object is. The ventral visual stream runs into the inferior temporal lobe. The neurons along the dorsal stream also known the dorsal visual cortex (shown in green) are primarily concerned with where the object is. The dorsal visual stream runs into the parietal lobe.
Figure 3 from: Vyshedskiy A, Mahapatra S, Dunn R (2017) Linguistically deprived children: meta-analysis of published research underlines the importance of early syntactic language use for normal brain development. Research Ideas and Outcomes 3: e20696. https://doi.org/10.3897/rio.3.e20696
Figure 3 - Linguistic isolates performance in verbal and nonverbal tests. This Figure is also available as a Power Point slide in Suppl. material 1.
Flow chart for article '' Digital Health Intervention in Patients Undergoing Cardiac Rehabilitation: Systematic Review and Meta-Analysis''
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Data set for article''Digital health intervention in patients undergoing cardiac rehabilitation: systematic review and meta-analysis''
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Dynamics of the gut resistome and mobilome in early life: a meta-analysis
<p>The identified marker families from CARD database (v.3.2.7) and MobileOG database (v.1.6)</p>
The supplementary files for the paper"systematic review and meta–analysis of the global prevalence and infection risk factors of Trichomonas vaginalis"
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Effect of orthodontic treatment on the subgingival microbiota: a systematic review and meta-analysis
<p>Datasets for the analysis in the published paper</p>
Supplementary material 2 from: Cole MW (2018) Effectiveness of peer-mediated learning for English language learners: A meta-analysis. Research Ideas and Outcomes 4: e29375. https://doi.org/10.3897/rio.4.e29375
These are studies that were potentially-relevant to the meta-anlayses, but that were ultimately excluded during inclusion coding. Future researchers might find this list especially valuable.
Spontaneous space closure after extraction of permanent first molars in children and adolescents: a systematic review and meta-analysis
<p>Dataset for all analyses</p>
Enhance physical activity by designing school based active transport interventions. A systematic review with meta-analysis.
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Replication package for: "Nudging for Tax Compliance: A Meta-Analysis"
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Comparative Efficacy of various Procedures of eccentric exercises for Midportion Achilles Tendinopathy: A Systematic Review and Network Meta-analysis
<p>supplementary materials<span><span> </span><span> 补充材料</span></span></p>
ScienceDex guides
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These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.