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857
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ShareScore release 0.9.0
Dataset results
857 results for “alternative splicing;”
EAPP is essential for tri-snRNP biogenesis and controls cell fate and tumor growth via the alternative splicing of MDM4
GEO Series GSE276681. Homo sapiens. 6 samples. Type: Expression profiling by high throughput sequencing.
A whole genome map of alternative splicing events in precancerous lung dysplasia and adenocarcinomas of c-Raf mice
GEO Series GSE38948. Mus musculus. 17 samples. Type: Expression profiling by array.
A novel Lysyl oxidase like 2 alternative splicing LOXL2 △e13 in esophageal squamous carcinoma cells
GEO Series GSE53676. Homo sapiens. 3 samples. Type: Expression profiling by array.
Gene expression and alternative splicing in human gastric cancer
GEO Series GSE13195. Homo sapiens. 100 samples. Type: Expression profiling by array.
Link to dataset related to article "Not only cancer: the long non-coding RNA MALAT1 affects the repertoire of alternatively spliced transcripts and circular RNAs in multiple sclerosis."
<p>Long non-coding RNAs (lncRNAs) are post-transcriptional and epigenetic regulators, whose implication in neurodegenerative and autoimmune diseases remains poorly understood. We analyzed publicly available microarray data sets to identify dysregulated lncRNAs in multiple sclerosis (MS), a neuroinflammatory autoimmune disease. We found a consistent upregulation in MS of the lncRNA MALAT1 (2.7-fold increase; meta-analysis, P = 1.3 × 10-8; 190 cases, 182 controls), known to regulate alternative splicing (AS). We confirmed MALAT1 upregulation in two independent MS cohorts (1.5-fold increase; P < 0.01; 59 cases, 50 controls). We hence performed MALAT1 overexpression/knockdown in cell lines, demonstrating that its modulation impacts on endogenous expression of splicing factors (HNRNPF and HNRNPH1) and on AS of MS-associated genes (IL7R and SP140). Minigene-based splicing assays upon MALAT1 modulation recapitulated IL7R and SP140 isoform unbalances observed in patients. RNA-sequencing of MALAT1-knockdown Jurkat cells further highlighted MALAT1 role in splicing (approximately 1100 significantly-modulated AS events) and revealed its contribution to backsplicing (approximately 50 differentially expressed circular RNAs). Our study proposes a possible novel role for MALAT1 dysregulation and the consequent AS alteration in MS pathogenesis, based on anomalous splicing/backsplicing profiles of MS-relevant genes.</p>
Alternatively-spliced isoforms of the cardiac Nav1.5 sodium channel modify channel activation by distinct structural mechanisms - Molecular dynamics results
<p>Output files associated with molecular dynamics simulations of the alternative splice variant of Nav1.5</p>
pICln, an spliceosome assembly chaperone, controls alternative splicing, flowering time and stress responses in Arabidopsis
GEO Series GSE130463. Arabidopsis thaliana. 12 samples. Type: Expression profiling by high throughput sequencing.
Alternative splicing changes in A. fumigatus sensitized mice
GEO Series GSE28258. Mus musculus. 16 samples. Type: Expression profiling by array.
SKIP regulates ABA-mediated alternative splicing and its signaling in Arabidopsis
GEO Series GSE144823. Arabidopsis thaliana. 8 samples. Type: Expression profiling by high throughput sequencing.
SRSF1-mediated alternative splicing is required for spermatogonial stem cell differentiation and mitotic-to-meiotic transition [RNA-Seq]
GEO Series GSE226550. Mus musculus. 6 samples. Type: Expression profiling by high throughput sequencing.
Hyperactive Alternative RNA Splicing Facilitates Immune Escape in Small Cell Lung Cancer [scRNA-Seq]
GEO Series GSE296664. Mus musculus. 4 samples. Type: Expression profiling by high throughput sequencing.
A primate-specific alternative splicing of CCNE1 (pCCNE1) is an activator for evolutionally-gained enhancers [GRO-seq]
GEO Series GSE128438. Homo sapiens. 3 samples. Type: Expression profiling by high throughput sequencing.
Transriptome analysis of alternative splicing under heat stress condition in atcyp18-2 mutant compared to Wild type (Col-0) of Arabidopsis
GEO Series GSE166755. Arabidopsis thaliana. 12 samples. Type: Expression profiling by high throughput sequencing.
Persistent large-scale changes in alternative splicing in prefrontal cortical neuron types following psychedelic exposure
GEO Series GSE286904. Mus musculus. 118 samples. Type: Expression profiling by high throughput sequencing.
SRSF1-mediated alternative splicing is required for spermatogonial stem cell differentiation and mitotic-to-meiotic transition [LACE-seq]
GEO Series GSE226551. Mus musculus. 4 samples. Type: Other.
ZMAT2 condensates regulate the alternative splicing of TRIM28 to promote the proliferation of hepatocellular carcinoma cells
GEO Series GSE263805. Homo sapiens. 2 samples. Type: Other.
SRp20 regulates Genome-wide Alternative RNA splicing events in MEF3T3 cells
GEO Series GSE60147. Mus musculus. 6 samples. Type: Expression profiling by array.
ScienceDex guides
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These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.