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1,760 results for “small RNA”
Data from: Small RNA sequencing reveals a novel tsRNA-26576 mediating tumorigenesis of breast cancer
Purpose: As a malignancy that develops from breast tissue, breast cancer has been widely regarded as the most common type of cancer threatening the health of women worldwide. Emerging evidence has demonstrated that tsRNAs might play a vital part in the tumorigenesis and progression of several types of cancers. However, the functions of tsRNAs in breast cancer remain largely unknown. Here, we investigated the functions of tsRNA-26576 in tumorigenesis of breast cancer. Patients and methods: In this study, the tsRNA deregulation states in breast cancer patients (four cancer tissues and four adjacent normal tissues) were evaluated using small RNA sequencing. And then, RT-PCR was used to detected the tsRNA-26576 expression level in breast cancer patients. Results: A total of 263 tsRNAs were identified as significantly differentially expressed, of which 75 were upregulated, and 188 were downregulated. The functional classification through KEGG pathway database illustrated that the most significant pathway enriched by the targets of differentially expressed tsRNAs was the pathway in cancer. Among these differently expressed tsRNAs, we found that tsRNA-26576 was remarkably upregulated in cancer tissue in comparison with adjacent normal tissue. Meanwhile, RT-PCR results verified that tsRNA-26576 expression level was highly upregulated in 10 paired samples from breast cancer patients. Besides, tsRNA-26576 was found to motivate cellular multiplication and migration while suppressing cellular apoptosis in MDA-MB-231 cells. Moreover, mRNA sequencing results showed that several tumor suppressor genes, including FAT4 and SPEN, were upregulated after delivering tsRNA-26576 inhibitor in MDA-MB-231 cells. Conclusion: We found tsRNA-26576 was upregulated in breast cancer tissue, and it could promote the cell growth while inhibite cell apoptosis. Therefore, tsRNA-26576 might serve as a potential clinical therapy target and a predictive marker for breast cancer.
Small BAM files for practising RNA-seq and WES visualization (human)
<p>Two sets of BAM files for teaching RNA-seq and whole exome sequence (WES) visualization. </p> <p>All data was processed from open access SRA datasets. </p> <table> <tbody> <tr> <td>NAME</td> <td>RNA-EMT</td> <td>WES-LUNG</td> </tr> <tr> <td>SOURCE</td> <td>Yang et al. https://doi.org/10.1128/mcb.00019-16, SRA: PRJNA304419</td> <td>Ju et al. https://doi.org/10.1101/gr.133645.111; SRA: ERP001071)</td> </tr> <tr> <td>DESCRIPTION</td> <td>Human RNA-seq BAM files </td> <td>Human WES BAM files: Lung cancer</td> </tr> <tr> <td>SEQUENCING TYPE</td> <td>Illumina paired-end, stranded</td> <td>Illumina paired-end</td> </tr> <tr> <td>METHODS</td> <td>Original data are from cell lines subjected to epthithelium-mesenchymal transition. We took replicates corresponding to Day 0 (uninduced cells) and Day 7 (7 days after induction). Reads were aligned with STAR. BAM files are restricted to chromosome 18. Gene of interest: CDH2, up in mesenchymal state.</td> <td>WES were obtained from tumor and blood tissues from a non small cell lung cancer patient. Reads were aligned with BWA. A fraction of sequences corresponding to a panel of genes were retained. Genes of interest: DUSP27, KRAS</td> </tr> <tr> <td>MAPPED_TO</td> <td>HG19</td> <td>HG19</td> </tr> <tr> <td>SAMPLING RATE</td> <td>0.50%</td> <td>0.10%</td> </tr> <tr> <td>FILE SIZE</td> <td>2*40Mb</td> <td>2*7Mb</td> </tr> </tbody> </table> <div> </div>
Small RNA Pathways in Mammalian Gametogenesis
ClinicalTrials.gov study NCT02864329. IPD Sharing: NO. Countries: 1. Publications: 0.
Small RNA Profiling in EBC in Athletes
ClinicalTrials.gov study NCT07324252. IPD Sharing: YES. Countries: 1. Publications: 0.
The Effects of Diet on Small Non-coding RNA I Sperm Cells and the Possible Effects on Reproductive Success: Diet Intervention Effects on Sperm
ClinicalTrials.gov study NCT06831292. IPD Sharing: NO. Countries: 1. Publications: 0.
Small Circulating RNA as Molecular Markers of Lung Disease in Cystic Fibrosis
ClinicalTrials.gov study NCT02992080. IPD Sharing: NO. Countries: 1. Publications: 0.
Circulating Extracellular Exosomal Small RNA as Potential Biomarker for Human Pancreatic Cancer
ClinicalTrials.gov study NCT04636788. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Safety and Efficacy Study of Small Interfering Ribonucleic Acid (RNA) Molecule (Cand5) to Treat Wet Age-Related Macular Degeneration
ClinicalTrials.gov study NCT00259753. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Study of TD101, a Small Interfering RNA (siRNA) Designed for Treatment of Pachyonychia Congenita
ClinicalTrials.gov study NCT00716014. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Safety and Efficacy Study of Small Interfering RNA Molecule (Cand5) to Treat Diabetic Macular Edema
ClinicalTrials.gov study NCT00306904. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Diagnostic Performance of Small RNA Blood Test in Patients Undergoing Follow-up Imaging After Positive Low Dose CT Screening for Cancer of the Lung
ClinicalTrials.gov study NCT05987189. IPD Sharing: NO. Countries: 1. Publications: 0.
mRNA and small RNA associated with Crohn's disease behavior [RNA-Seq]
GEO Series GSE66207. Homo sapiens. 33 samples. Type: Expression profiling by high throughput sequencing.
Effects of SarsCov2 on small RNA transcriptome in human lung cells
GEO Series GSE276241. Homo sapiens. 12 samples. Type: Non-coding RNA profiling by high throughput sequencing.
Identification of potential miRNAs and their targets in Vriesea carinata (Poales, Bromeliaceae) [small RNA-seq]
GEO Series GSE38249. Vriesea carinata. 1 samples. Type: Non-coding RNA profiling by high throughput sequencing.
Altered small non-coding RNA expression profiles of extracellular vesicles in prostatic fluid of patients with chronic pelvic pain syndrome
GEO Series GSE195766. Homo sapiens. 6 samples. Type: Non-coding RNA profiling by high throughput sequencing.
small RNA-seq from esophagus squamous epithelium (ENCSR262TBN)
GEO Series GSE88146. Homo sapiens. 1 samples. Type: Non-coding RNA profiling by high throughput sequencing.
Reprogramming of DNA methylation in pollen guides epigenetic inheritance via small RNA.
GEO Series GSE40501. Arabidopsis thaliana. 3 samples. Type: Methylation profiling by high throughput sequencing.
Investigation of small RNA and RNA-seq transcripts from soybean (Glycine max) DCL1 mutants
GEO Series GSE76036. Glycine max. 14 samples. Type: Expression profiling by high throughput sequencing; Non-coding RNA profiling by high throughput sequencing.
Small RNA sequencing of melanoma samples to deduce microRNA expression profiles
GEO Series GSE36236. Homo sapiens. 31 samples. Type: Non-coding RNA profiling by high throughput sequencing.
Different RNA profiles in plasma derived small and large extracellular vesicles of Neurodegenerative diseases patients.
GEO Series GSE155700. Homo sapiens. 144 samples. Type: Expression profiling by high throughput sequencing; Non-coding RNA profiling by high throughput sequencing.
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Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
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DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.