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1,195
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ShareScore release 0.9.0
Dataset results
1,195 results for “Cancer Genomics”
Genome-wide CRISPR screens decode cancer cell pathways that trigger gamma-delta T cell detection and killing
GEO Series GSE226931. Homo sapiens. 4 samples. Type: Genome binding/occupancy profiling by high throughput sequencing.
Genome wide expression profile in cervical cancer patients (staged, locally advanced)
GEO Series GSE56303. Homo sapiens. 89 samples. Type: Expression profiling by array.
Childhood Cancer Data Initiative (CCDI): Genomic Analysis in Pediatric Malignancies
Pediatric solid tumors are highly heterogeneous, encompassing a large number of histotypes. The genomic landscape of these diseases is characterized by few single-nucleotide variants (SNVs) compared to adult cancers. In contrast, many exhibit a high prevalence of structural or epigenetic changes that alter gene expression, underlining the need for comprehensive genomic approaches such as whole-genome sequencing (WGS). Several studies have specifically addressed the clinical utility of genomic analysis in the pediatric and AYA cancer setting. Review of these studies point to key challenges that must be addressed in order to advance the routine use of genomics in this population.
Childhood Cancer Data Initiative (CCDI): Whole Genome Landscapes of Patient Derived Osteosarcoma Xenograft Models
Osteosarcoma is the most common primary bone malignancy in children and young adults and has few treatment options. As a result, there has been little improvement in survival outcomes over the past few decades. The need for models to test novel therapies is especially great for this disease because it is both rare and unresponsive to most therapies. To address this need, an NCI-funded consortium has characterized and utilized a panel of patient-derived xenograft models of osteosarcoma for drug testing. The exomes, transcriptomes, and copy number landscapes of these models have been described previously. This study adds whole-genome sequencing (WGS) and reverse-phase protein array profiling data, which can be correlated with drug testing results. In addition, four new osteosarcoma models are described for use by the research community.
Pediatric Cancer Genome Project
In 2010, St. Jude Children's Research Hospital and Washington University School of Medicine launched a $65 million, three-year project to define the genomic landscape of pediatric cancer, including some of the least understood and most challenging cancers. The project goal was to sequence the complete normal and cancer genomes of 600 pediatric cancer patients. The St. Jude-Washington University Pediatric Cancer Genome Project became an ambitious effort to discover the origins of pediatric cancer and seek new treatments. The project ultimately sequenced the complete and normal genomes of about 800 pediatric cancer patients. It included whole exome and whole transcriptome sequencing of an additional 1,200 patients, which included more than 20 different cancers.
A genome-wide CRISPR activation screen identifies PRRX2 as a regulator of enzalutamide resistance in prostate cancer [ATAC-seq]
GEO Series GSE199537. Homo sapiens. 4 samples. Type: Genome binding/occupancy profiling by high throughput sequencing.
Genome-wide analysis of gene expression patterns in human prostate cancer (PCa)
GEO Series GSE69223. Homo sapiens. 30 samples. Type: Expression profiling by array.
Hi-C for genome-wide detection of enhancer-hijacking rearrangements in routine clinical biopsies of lymphoid cancers
GEO Series GSE289531. Homo sapiens. 45 samples. Type: Other.
Selectivity of ORC binding sites in the human genome and the relation to replication timing, fragile sites, and recurrent deletions in cancers
GEO Series GSE70165. Homo sapiens. 3 samples. Type: Genome binding/occupancy profiling by high throughput sequencing.
Genome-scale CRISPR-Cas9 screen of Wnt/β-catenin signalling identifies therapeutic targets for Colorectal Cancer
GEO Series GSE156083. Homo sapiens. 20 samples. Type: Genome binding/occupancy profiling by high throughput sequencing; Expression profiling by high throughput sequencing.
Performance Comparison of the Affymetrix SNP6.0 and Cytogenetic 2.7M Whole-genome Microarrays in Complex Cancer Samples
GEO Series GSE37979. Homo sapiens. 18 samples. Type: Genome variation profiling by SNP array.
Genome-wide analysis in human colorectal cancer cells reveals ischemia-mediated expression of motility genes via DNA hypomethylation (expression)
GEO Series GSE58049. Homo sapiens. 9 samples. Type: Expression profiling by array.
Genome-wide RNA-expression analysis after p53 activation in colorectal cancer cells.
GEO Series GSE67109. Homo sapiens. 2 samples. Type: Expression profiling by high throughput sequencing.
Genome-wide synthetic lethal screen identifies SRM as a target that enhances erdafitinib efficacy in FGFR-mutant bladder cancer
GEO Series GSE276232. Homo sapiens. 4 samples. Type: Expression profiling by high throughput sequencing.
Genome-Wide Analysis of cell-free DNA Methylation Profiling for the Early Diagnosis of Pancreatic Cancer
<p>This dataset mainly contains analysis pipeline and R codes used in the corresponding paper。</p>
Genomic Biomarkers of CDK 4/6 Inhibitor Resistance in Hormone Receptor Positive Metastatic Breast Cancer
<p>Supplementary figures and tables</p>
Cancer Genome Study Using Samples From Patients With Stage I or Stage II Non-Small Cell Lung Cancer Treated on Clinical Trial ACOSOG-Z0030
ClinicalTrials.gov study NCT00899535. IPD Sharing: Not stated. Countries: 0. Publications: 0.
Rociletinib Genomic Landscape in Non-small Cell Lung Cancer (NSCLC)
ClinicalTrials.gov study NCT02705339. IPD Sharing: NO. Countries: 0. Publications: 0.
Prospective Study Assessing EndoPredict® Genomic Test Impact on Shared Decision of Adjuvant Chemotherapy in Patients With ER-positive, Her2-negative Early Breast Cancer
ClinicalTrials.gov study NCT02773004. IPD Sharing: YES. Countries: 0. Publications: 0.
The Establishment and Clinical Application of a Prediction Model of Lung Cancer Distant Metastasis Based on the Genomic Characteristics of Circulating Tumor Cells
ClinicalTrials.gov study NCT04568720. IPD Sharing: UNDECIDED. Countries: 0. Publications: 0.
ScienceDex guides
Understand access before you commit
These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.