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1,036
datasets available to search
ShareScore release 0.9.0
Dataset results
1,036 results for “Cell mechanics”
Mechanical forces direct the cell fate of inner ear organoids in a stage-dependent manner
GEO Series GSE202640. Mus musculus. 6 samples. Type: Expression profiling by high throughput sequencing.
Compensatory induction of MYC expression by sustained CDK9 inhibition via a BRD4-dependent mechanism: Pol II occupancy profiling by ChIP-Seq in HeLa cell line in the presence or absence of CDK9 inhibi
GEO Series GSE60953. Homo sapiens. 5 samples. Type: Genome binding/occupancy profiling by high throughput sequencing.
Neuronal mimicry mechanisms promote the growth small-cell lung cancer in the brain
GEO Series GSE179032. Mus musculus. 8 samples. Type: Expression profiling by high throughput sequencing.
A comprehensive analysis of metabolomics and transcriptomics reveals a novel crizotinib resistance mechanism in non-small cell lung cancer
GEO Series GSE186767. Homo sapiens. 6 samples. Type: Expression profiling by high throughput sequencing.
Molecular Mechanisms of Bortezomib Resistant Adenocarcinoma cells
GEO Series GSE29713. Homo sapiens. 10 samples. Type: Genome variation profiling by genome tiling array; Expression profiling by array.
Tumor-induced double positive T cells display distinct lineage commitment mechanisms and functions (4)
GEO Series GSE203186. Mus musculus. 18 samples. Type: Expression profiling by high throughput sequencing.
Single cell atlas of enthesitis reveals a mechanical strain responsing and SOX5 programmed SDC1+ sheath fibroblast in ankylosing spondylitis [scRNA-seq]
GEO Series GSE271475. Mus musculus. 2 samples. Type: Expression profiling by high throughput sequencing.
Osr2 functions as a mechanical checkpoint to augment CD8+ T cell exhaustion [Osr2KO_vs_WT_RNA_CD8]
GEO Series GSE223159. Mus musculus. 6 samples. Type: Expression profiling by high throughput sequencing.
Comprehensive transcriptome characterization deciphers mechanisms underpinning the positive selection of B cells in germinal centers. [mouse; short-read]
GEO Series GSE278742. Mus musculus. 20 samples. Type: Expression profiling by high throughput sequencing.
Tumor-Infiltrating Myeloid Cells Confer de novo Resistance to PD-L1 Blockade through EMT-stromal and Tgf-beta Dependent Mechanisms
GEO Series GSE211388. Homo sapiens. 14 samples. Type: Expression profiling by high throughput sequencing.
Perfluorooctanoic acid toxicity on zebrafish embryonic development and mechanism exploration with single-cell RNA sequencing
GEO Series GSE176853. Danio rerio. 2 samples. Type: Expression profiling by high throughput sequencing.
Integrated Analysis of T-cell Repertoire and Transcriptome Shed Light into the Mechanisms of Regulatory T cell (Treg) Suppression of Acute Graft-versus-Host-Disease
GEO Series GSE205375. Mus musculus. 32 samples. Type: Expression profiling by high throughput sequencing; Other.
Loss-of-Function of the Hippo Transducer TAZ Reduces Mammary Tumor Growth through a Myeloid-Derived Suppressor Cell-Dependent Mechanism
GEO Series GSE205160. Mus musculus. 10 samples. Type: Expression profiling by high throughput sequencing.
Molecular mechanisms implicated in myogenic differentiation of human alveolar mucosa derived cells
GEO Series GSE134207. Homo sapiens. 36 samples. Type: Expression profiling by array.
Next generation seuquencing of 3D breast cancer cell culture in synthetic hydrogels presenting either a collagen mimic or laminin mimic with low and high mechanical properties
GEO Series GSE145696. Homo sapiens. 26 samples. Type: Expression profiling by high throughput sequencing.
Mechanism of Enhancing Chemotherapy Efficacy in Pancreatic Ductal Adenocarcinoma with Paricalcitol and Hydroxychloroquine: A Single Cell RNA Sequencing - PART2
<p><span>Pancreatic ductal adenocarcinoma (PDAC) boasts a dismal five-year survival rate of less than 15%, mainly due to therapy resistance. Recent studies have highlighted hydroxychloroquine (H) and paricalcitol (P), reducing stromal density and enhancing PDAC sensitivity to chemotherapy. This investigation aimed to elucidate the molecular impacts of combining H and P, focusing on their ability to sensitize PDAC to chemotherapy. <em>In vitro</em> and <em>in vivo</em> experiments demonstrated that the HP combination significantly (p<0.001) enhanced gemcitabine (G) effects, validated in orthotopic mouse models and patient-derived xenografts (PDX). Mechanistically, GPH induced cell death via the vitamin D receptor pathway upregulated autophagy and ER stress-related transcripts and suppressed mTOR signaling. Single-cell (sc) RNAseq analyses showed GPH increased quiescent cancer associated fibroblasts and reduced autophagy related transcripts. GPH treatment modulated T-cell populations favoring antitumor immunity. Findings from clinical trial patient biopsies underscored these effects, highlighting GPH's potential as a therapeutic adjunct in PDAC management (NCT04524702).</span></p>
Mechanism of Enhancing Chemotherapy Efficacy in Pancreatic Ductal Adenocarcinoma with Paricalcitol and Hydroxychloroquine: A Single Cell RNA Sequencing - Part3
<p><span>Pancreatic ductal adenocarcinoma (PDAC) boasts a dismal five-year survival rate of less than 15%, mainly due to therapy resistance. Recent studies have highlighted hydroxychloroquine (H) and paricalcitol (P), reducing stromal density and enhancing PDAC sensitivity to chemotherapy. This investigation aimed to elucidate the molecular impacts of combining H and P, focusing on their ability to sensitize PDAC to chemotherapy. <em>In vitro</em> and <em>in vivo</em> experiments demonstrated that the HP combination significantly (p<0.001) enhanced gemcitabine (G) effects, validated in orthotopic mouse models and patient-derived xenografts (PDX). Mechanistically, GPH induced cell death via the vitamin D receptor pathway upregulated autophagy and ER stress-related transcripts and suppressed mTOR signaling. Single-cell (sc) RNAseq analyses showed GPH increased quiescent cancer associated fibroblasts and reduced autophagy related transcripts. GPH treatment modulated T-cell populations favoring antitumor immunity. Findings from clinical trial patient biopsies underscored these effects, highlighting GPH's potential as a therapeutic adjunct in PDAC management (NCT04524702).</span></p>
Mechanism of Enhancing Chemotherapy Efficacy in Pancreatic Ductal Adenocarcinoma with Paricalcitol and Hydroxychloroquine: A Single Cell RNA Sequencing - Part4
<p><span>Pancreatic ductal adenocarcinoma (PDAC) boasts a dismal five-year survival rate of less than 15%, mainly due to therapy resistance. Recent studies have highlighted hydroxychloroquine (H) and paricalcitol (P), reducing stromal density and enhancing PDAC sensitivity to chemotherapy. This investigation aimed to elucidate the molecular impacts of combining H and P, focusing on their ability to sensitize PDAC to chemotherapy. <em>In vitro</em> and <em>in vivo</em> experiments demonstrated that the HP combination significantly (p<0.001) enhanced gemcitabine (G) effects, validated in orthotopic mouse models and patient-derived xenografts (PDX). Mechanistically, GPH induced cell death via the vitamin D receptor pathway upregulated autophagy and ER stress-related transcripts and suppressed mTOR signaling. Single-cell (sc) RNAseq analyses showed GPH increased quiescent cancer associated fibroblasts and reduced autophagy related transcripts. GPH treatment modulated T-cell populations favoring antitumor immunity. Findings from clinical trial patient biopsies underscored these effects, highlighting GPH's potential as a therapeutic adjunct in PDAC management (NCT04524702).</span></p>
Chip-chip from mechanical stretched interfollicular epidermal stem cells (IFESCs) with YAP
GEO Series GSE71314. Homo sapiens. 4 samples. Type: Genome binding/occupancy profiling by genome tiling array.
Molecular mechanisms of HIV-1 permissiveness in CCR4+CCR6+ Th17 cells
GEO Series GSE70396. Homo sapiens. 19 samples. Type: Expression profiling by array.
ScienceDex guides
Understand access before you commit
These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.