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939 results for “Validation studies”
Interventional Validation Study (WeTakeCare-Project)
ClinicalTrials.gov study NCT02899975. IPD Sharing: NO. Countries: 0. Publications: 0.
A Study to Prospectively Validate Blood Markers Associated With Differences in Efficacy of Neoadjuvant Therapy for NSCLC
ClinicalTrials.gov study NCT06503042. IPD Sharing: NO. Countries: 0. Publications: 0.
Validation of Osmolarity System: Clinical Usability Study
ClinicalTrials.gov study NCT03769324. IPD Sharing: NO. Countries: 0. Publications: 0.
The VALIDATE Study of Valsartan for Patients With Early Stage Heart Failure
ClinicalTrials.gov study NCT00241098. IPD Sharing: Not stated. Countries: 0. Publications: 0.
A Validation Study on a Prognostic Prediction Model for Respiratory Tract Infections
ClinicalTrials.gov study NCT07109310. IPD Sharing: NO. Countries: 0. Publications: 0.
caArray_jacob-00182: Gene expression-based survival prediction in lung adenocarcinoma: a multi-site, blinded validation study
GEO Series GSE68465. Homo sapiens. 462 samples. Type: Expression profiling by array.
The validation case study of read-across based on IATA for hepatotoxicity of Naphthalene and its structurally similar analogs
GEO Series GSE156442. Rattus norvegicus. 15 samples. Type: Expression profiling by array.
DNA methylation analysis validates organoids as a viable model for studying human intestinal aging (expression)
GEO Series GSE141255. Homo sapiens. 22 samples. Type: Expression profiling by array.
Validation studies and multi-omics analysis of Zhx2 as a candidate quantitative trait gene underlying brain oxycodone metabolite (oxymorphone) levels and behavior
GEO Series GSE275965. Mus musculus. 16 samples. Type: Expression profiling by high throughput sequencing.
Validation of a clinicopathological classification for predicting outcomes of pituitary tumours: retrospective cohort study in a pituitary tumour centre of excellence, 2013–2023
<p><strong>Simple Summary:</strong> This retrospective study aims to classify a series of pituitary neuroendocrine tumours (PitNETs), typified according to the WHO 2017 recommendations, using Trouillas et al.’s clinicopathological classification from 2013. We analysed 166 patients who underwent PitNET surgery from 2013 to 2023. The tumours were identified according to the gene and immunohistochemistry expression of pituitary transcription factors and adenohypophyseal hormones. The PitNETs were graded based on the invasion observed in MRI and the Ki-67 index. The study found that grade 2a and 2b tumours, T2 signal intensity ratio (SIR), and silent corticotroph tumours were associated with lower progression-free survival rates. Tumour volume and T2 SIR were independent predictors of recurrence/progression, with a T2 SIR of 2 or more showing a significantly higher risk. These findings emphasise the prognostic value of the five-grade classification and underscore the importance of radiological evaluation for managing PitNETs.</p> <p> </p> <p><strong>Abstract: </strong>Immunostaining of transcription factors allows a more exact classification of pituitary neuroendocrine tumours (PitNETs), but not a better prediction of their clinical behaviour. This retrospective, single-centre study aims to classify a series of PitNETs using Trouillas et al.’s clinicopathological classification from 2013. We analysed 166 patients undergoing PitNET surgery in 2013–2023. Tumours were identified according to the gene and immunohistochemical expression of PitNET transcription factors plus adenohypophyseal hormones. Tumours were classified according to a grading system based on MRI invasion and Ki-67 index. Eighty-one (48.8%) patients had grade 2a tumours; 71 (42.8%), grade 1a; 8 (4.8%), 2b; and 6 (3.6%), 1b. At a mean follow-up of 57.8 (standard deviation 30) months, 13.9% (n=23) showed recurrence/progression; independent predictors of recurrence were tumour volume (p=0.031) and T2 signal intensity ratio (SIR) (p<0.001). This risk was 18.6-fold higher for a T2 SIR of 2 or more. Grade 2a and 2b tumours, T2 SIR, and silent corticotroph adenomas (SCAs) were associated with lower progression-free survival. Our results add more evidence to the prognostic value of the five-grade PitNET classification and suggest higher clinical surveillance of patients with SCAs is warranted. The MRI findings highlight the increasing value of radiological evaluation for managing PitNETs.</p>
A Study to Validate a New Oral Fluid/Saliva Antibody Test for Novel H1N1v Influenza
ClinicalTrials.gov study NCT01192958. IPD Sharing: Not stated. Countries: 0. Publications: 0.
Electrocardiogram (ECG) Validation Study
ClinicalTrials.gov study NCT06414447. IPD Sharing: Not stated. Countries: 0. Publications: 0.
Data set from Caruso R, Grugnetti AM, Pastore U, Dellafiore F, Pittella F, Ausili D, Stievano A, Arrigoni C. Modified Research Utilization Questionnaire: Development and Validation Study among Italian Nurses. Asian Nurs Res (Korean Soc Nurs Sci). 2019 Feb;13(1):61-68. doi: 10.1016/j.anr.2019.01.006. Epub 2019 Jan 18. PMID: 30660835.
<p>Data set from Caruso R, Grugnetti AM, Pastore U, Dellafiore F, Pittella F, Ausili D, Stievano A, Arrigoni C. Modified Research Utilization Questionnaire: Development and Validation Study among Italian Nurses. Asian Nurs Res (Korean Soc Nurs Sci). 2019 Feb;13(1):61-68. doi: 10.1016/j.anr.2019.01.006. Epub 2019 Jan 18. PMID: 30660835.</p> <p> </p> <p>This is the abstract:</p> <p><strong>Purpose: </strong>The purpose of this study was to develop the modified research utilization questionnaire (M-RUQ) and to establish its content and face validity, construct validity, and reliability.</p> <p><strong>Methods: </strong>This study has a multiphase (three phases), methodological, and cross-sectional design. First, research utilization questionnaire (RUQ) was translated into Italian, which is the target language to develop the M-RUQ. Second, the RUQ psychometric proprieties were assessed using exploratory factorial analysis to identify ambiguous or problematic items (e.g., cross-loadings) (cross-sectional sampling A). The RUQ modification (i.e., item deleting, wording modification, and scoring procedure) represented the development of the M-RUQ among Italian nurses. The third phase was aimed to confirm the construct validity of the M-RUQ and to test its stability and internal consistency (cross-sectional sampling B).</p> <p><strong>Results: </strong>This study's findings show that M-RUQ has a three-dimensional structure and a total of 22 items. The M-RUQ shows evidence of validity and reliability. Precisely, the factorial structure coming from an exploratory factorial analysis on the first sample (n = 504) was confirmed by a final model of confirmatory factorial analysis (CFA) on a second sample (n = 362). The final CFA model showed adequate goodness of fit, where all the factor loadings showed values higher than .40. Cronbach's α was satisfactory for each domain and for the overall scale. Furthermore, the M-RUQ showed good stability described by the test-retest.</p> <p><strong>Conclusion: </strong>The M-RUQ should be used to assess research utilization among nurses for educational or research purposes to address the practice. Further research about its validity and reliability is suggested.</p> <p> </p>
The Italian midwifery core outcome set (M-COS) for healthy childbearing women and newborns: Development and initial validation study
<p>Maga G, Brigante L, Del Bo E, Cappadona R, Daniele MAS, Arrigoni C, Caruso R, Magon A. The Italian midwifery core outcome set (M-COS) for healthy childbearing women and newborns: Development and initial validation study. Midwifery. 2022 May;108:103292. doi: 10.1016/j.midw.2022.103292. Epub 2022 Feb 23. PMID: 35235891.</p> <p><strong>Abstract</strong></p> <p><strong>Objective: </strong>This study aimed to develop and validate a midwifery core outcome set (M-COS) for Italian settings based on a salutogenic framework of maternity care.</p> <p><strong>Design: </strong>A multi-phase and multi-method study was performed. In phase one, we conducted a literature review to identify a preliminary set of outcomes sensitive to midwifery care. In phase two, the qualitative and quantitative content validity of the M-COS was tested. Finally, in the third phase, construct validity was explored through a cross-sectional study to assess the psychometric properties of the M-COS through exploratory and confirmative factor analysis. This study was conducted from December 2019 to April 2020 in Italy.</p> <p><strong>Participants: </strong>Three main groups of experts/midwives were involved. Group One (n = 10) was involved in the content validity phase, while the other two groups (Group Two and Group Three) were involved in the construct validity phase (n = 300).</p> <p><strong>Results: </strong>The M-COS includes six outcome domains and thirty-one core outcomes perceived as sensitive to midwifery care, namely: mortality and morbidity (n = 6 outcomes), childbirth (n = 3), postnatal period (n = 6), maternal health (n = 11), maternal-infant bonding (n = 3), and maternal self-care (n = 2). All domains showed good evidence of internal consistency.</p> <p><strong>Conclusion: </strong>The Italian M-COS is a novel tool that will facilitate the consistent measurement of core outcomes sensitive to midwifery care from the antenatal to the postnatal period in Italian settings. This initial work will be followed by further studies, including validation by service users.</p> <p><strong>Implications for practice: </strong>The use of the M-COS in clinical practice would facilitate evidence-based data collection and thus contribute to promoting high-quality maternity care.</p>
Development and Psychometric Validation of the Nursing Self-Efficacy Scale for Managing Cancer Treatment-Induced Cardiotoxicity: An Exploratory Mixed-Method Study.
<p>Magon A, Conte G, Arrigoni C, Dellafiore F, de Maria M, Pittella F, Rocco G, Stievano A, Ghizzardi G, Caruso R. Development and Psychometric Validation of the Nursing Self-Efficacy Scale for Managing Cancer Treatment-Induced Cardiotoxicity: An Exploratory Mixed-Method Study. Semin Oncol Nurs. 2022 Nov 18:151367. doi: 10.1016/j.soncn.2022.151367. Epub ahead of print. PMID: 36411124.</p> <p>Abstract</p> <p><strong>Objective: </strong>Assessing nursing self-efficacy could be strategic to sustain nursing competence. This study aimed to develop and validate the nursing self-efficacy scale for managing cancer treatment-induced cardiotoxicity (NSS-CTC).</p> <p><strong>Data sources: </strong>An exploratory mixed-method study was performed by including two main phases. The first comprised the developmental tasks to generate the initial pool of items, including a literature review and a consensus meeting based on a nominal group technique. The second phase initially involved an external panel of experts in assessing the content validity of the novel scale, followed by a cross-sectional data collection to perform exploratory factor analysis by employing a multicenter and convenience sampling approach. The most plausible psychometric structure derived from the exploratory factor analysis was tested with a confirmatory factor analysis using a second data collection round on another sample enrolled with a multicenter and convenience sampling approach. Internal consistency was assessed using Cronbach's alfa.</p> <p><strong>Conclusion: </strong>The NSS-CTS is a novel 15-item self-report measure for assessing nurse self-efficacy in dealing with cancer treatment-related cardiotoxicity. Its two plausible domains were labeled knowledge-related self-efficacy (Cronbach's α = 0.924) and practice-related self-efficacy (Cronbach's α = 0.937); the factor analyses in both samples showed adequate fit to sample statistics. Future studies are necessary to corroborate its construct validity and assess its measurement invariance across various country contexts.</p> <p><strong>Implications for nursing practice: </strong>Assessing nursing self-efficacy for managing cancer treatment-induced cardiotoxicity is a promising approach for identifying educational gaps and promoting nursing competency in this particular area of cancer care.</p>
Affymetrix CytoScan 750K data for validation of the BoBs/CNV-seq comparison study
GEO Series GSE152288. Homo sapiens. 10 samples. Type: Genome variation profiling by SNP array.
Is SF-12 a valid and reliable measurement of health-related quality of life among adults with Marfan syndrome? A confirmatory study
<p>Dataset from Udugampolage N, Caruso R, Panetta M, Callus E, Dellafiore F, Magon A, Marelli S, Pini A. Is SF-12 a valid and reliable measurement of health-related quality of life among adults with Marfan syndrome? A confirmatory study. PLoS One. 2021 Jun 9;16(6):e0252864. doi: 10.1371/journal.pone.0252864. PMID: 34106976; PMCID: PMC8189474.</p> <p>Abstract</p> <p><strong>Introduction: </strong>The structural validity and reliability of the Short-Form Health Survey 12 (SF-12) has not yet been tested in adults with the Marfan syndrome (MFS). This gap could undermine an evidence-grounded practice and research, especially considering that the need to assess health-related quality of life in patients with MFS has increased due to the improved life expectancy of these patients and the need to identify their determinants of quality of life. For this reason, this study aimed to confirm the dimensionality (structural validity) of the SF-12, its concurrent validity, and its reliability (internal consistency).</p> <p><strong>Methods: </strong>We performed a cross-sectional study in a convenience sample of 111 Italian adults with MFS, collecting anamnestic and socio-demographic information, the SF-12, and short-form Health Survey 36 (SF-36). A confirmatory factor analysis was performed to verify whether the items of SF-12 related to physical restrictions, physical functioning, and bodily pain were retained by the physical summary component of the SF-12. The items referred to the role limitations due to emotional issues, social functioning, and mental health were retained by the mental summary component (MCS12). SF-36 was used to assess the concurrent validity of SF-12, hypothesizing positive correlations among the equivalent summary scores.</p> <p><strong>Results: </strong>The two-factor structural solution resulted in fitting the sample statistics adequately. The internal consistency was adequate for the two factors. Furthermore, the physical and mental summary scores of the SF-36 were positively correlated with their equivalent summary scores derived from the SF-12.</p> <p><strong>Conclusions: </strong>This study confirmed the factor structure of the SF-12. Therefore, the use of SF-12 in clinical practice and research for assessing the health-related quality of life among adults with MFS is evidence-grounded. Future research is recommended to determine whether the SF-12 shows measurement invariance in different national contexts and determine eventual demographic variation in the SF-12 scores among patients with MFS.</p>
Development and validation of a prediction model using sella magnetic resonance imaging-based radiomics and clinical parameters for diagnosis of growth hormone deficiency and idiopathic short stature: A multicenter, cross-sectional study
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Pay attention: you can fall! The Mini-BESTest scale and the turning duration of the TUG test provide valid balance measures in neurological patients: a prospective study with falls as the balance criterion
<p>The Excel file contains the database used for the LASSO logistic regression, i.e. the study's primary analysis (Figure 3 in the main text).</p>
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These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.