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15,247 results for “Breast cancer;”
Data from: Pilot study demonstrating potential association between breast cancer image-based risk phenotypes and genomic biomarkers.
<p>Genotype data from</p> <p>Li H, Giger ML, Sun C, Ponsukcharoen U, Huo D, Lan L, Olopade OI, Jamieson AR, Brown JB, Di Rienzo A. (2014) Pilot study demonstrating potential association between breast cancer image-based risk phenotypes and genomic biomarkers. Med Phys. 41(3)</p>
Case report for Assessment and impact in quality-of-life post radiotherapy in breast cancer patients treated at Acharya Vinoba Bhave Rural Hospital (AVBRH), Sawangi, 2023 - 2024
<p>Case report for Assessment and impact in quality-of-life post radiotherapy in breast cancer patients treated at Acharya Vinoba Bhave Rural Hospital (AVBRH), Sawangi, 2023 - 2024</p>
QOL questionnaires for Assessment and impact in quality-of-life post radiotherapy in breast cancer patients treated at Acharya Vinoba Bhave Rural Hospital (AVBRH), Sawangi, 2023 - 2024
<p>QOL questionnaires for Assessment and impact in quality-of-life post radiotherapy in breast cancer patients treated at Acharya Vinoba Bhave Rural Hospital (AVBRH), Sawangi, 2023 - 2024</p>
Xenium Breast Cancer Gene Count
<p>Xenium Breast Cancer Gene Count (JSON format)</p>
Xenium Breast Cancer Factor Analysis
<p>Xenium Breast Cancer Factor Analysis (TSV format)</p>
Cytotoxic activity of betulinic acid and ursolic acid againts T47D breast cancer cells
<p><em><span>Uncaria nervosa</span></em><span> Elmer is an Indonesian herbal plant that is traditionally used for breast cancer. The results of phytochemical screening contained alkaloids, flavonoids, and terpenoids in the ethanol extract of this plant. Based on literature searches, reports regarding the bioactive compounds responsible for breast cancer have not been found. </span><span>This study aims to determine the metabolite profiling of ethanol extract, the isolation, characterization of bioactive compounds, and their bioactivity in T47D breast cancer cells. The ethanol extract of <em>Uncaria nervosa</em> Elmer leaves contains nine compounds consisting of alkaloids, terpenoids, and fatty acid. The bioactive compounds that were successfully isolated were betulinic acid, and ursolic acid, with IC50 values of ˃100 and 14,70±4,50 µg/ml, respectively.</span></p>
Distant metastases of breast cancer resemble primary tumors in tumor cell composition but differ in immune cell phenotypes
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Breast cancer risk markedly lower with serum 25-hydroxyvitamin D concentrations ≥60 vs <20 ng/ml (150 vs 50 nmol/L): Pooled analysis of two randomized trials and a prospective cohort
<p>Background: While numerous epidemiologic studies have found an association between higher serum 25-hydroxyvitamin D [25(OH)D] concentrations and lower breast cancer risk, few have assessed this association for concentrations >40 ng/ml.</p> <p> </p> <p>Objective: To investigate the relationship between 25(OH)D concentration and breast cancer risk across a broad range of 25(OH)D concentrations among women aged 55 years and older.</p> <p> </p> <p>Methods: Analyses used pooled data from two randomized clinical trials (N=1129, N=2196) and a prospective cohort (N=1713) to examine a broad range of 25(OH)D concentrations. The outcome was diagnosis of breast cancer during the observation periods (median: 4.0 years). Three analyses were conducted: 1) Incidence rates were compared according to 25(OH)D concentration from <20 to ≥60 ng/ml (<50 to ≥150 nmol/L), 2) Kaplan-Meier plots were developed and 3) multivariate Cox regression was used to examine the association between 25(OH)D and breast cancer risk using multiple 25(OH)D measurements.</p> <p> </p> <p>Results: Within the pooled cohort (N=5038), 77 women were diagnosed with breast cancer (age-adjusted incidence: 512 cases per 100,000 person-years). Results were similar for the three analyses. First, comparing incidence rates, there was an 82% lower incidence rate of breast cancer for women with 25(OH)D concentrations ≥60 vs <20 ng/ml (Rate Ratio=0.18, <em>P</em>=0.006). Second, Kaplan-Meier curves for concentrations of <20, 20-39, 40-59 and ≥60 ng/ml were significantly different (<em>P</em>=0.02), with the highest proportion breast cancer-free in the ≥60 ng/ml group (99.3%) and the lowest proportion breast cancer-free in the <20 ng/ml group (96.8%). The proportion with breast cancer was 78% lower for ≥60 vs <20 ng/ml (<em>P</em>=0.02). Third, multivariate Cox regression revealed that women with 25(OH)D concentrations ≥60 ng/ml had an 80% lower risk of breast cancer than women with concentrations <20 ng/ml (HR=0.20, <em>P</em>=0.03), adjusting for age, BMI, smoking status, calcium supplement intake, and study of origin.</p> <p> </p> <p>Conclusions: Higher 25(OH)D concentrations were associated with a dose-response decrease in breast cancer risk with concentrations ≥60 ng/ml being most protective.</p>
Analysis of opposing histone modifications H3K4me3 and H3K27me3 reveals candidate diagnostic biomarkers for triple negative breast cancer and gene set prediction combinations
<p>Supplementary data of manuscript <strong>'Analysis of opposing histone modifications H3K4me3 and H3K27me3 reveals candidate diagnostic biomarkers for triple negative breast cancer and gene set prediction combinations </strong><strong>Analysis of opposing histone modifications H3K4me3 and H3K27me3 reveals candidate diagnostic biomarkers for triple negative breast cancer and gene set prediction combinations'</strong></p>
A multimodal and fully automated system for prediction of pathological complete response to neoadjuvant chemotherapy in breast cancer
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A stratification system for breast cancer based on basoluminal tumor cells and spatial tumor architecture (IF/mIF data)
<p>This repository contains all <strong>raw whole-slide immunofluorescence (IF) data</strong> for the breast cancer study from Meyer et al., 2025. The code that was used to process and analyze the data is available at <a href="https://github.com/BodenmillerGroup/TNBC_publication">https://github.com/BodenmillerGroup/TNBC_publication</a>. </p> <p><strong>Structure:</strong><br>BasoLum.zip - Contains whole-slide IF data for CK5, CK7, CK19 stainings of selected TNBC patients (related to Figure 4)</p> <p><strong>NOTE:</strong> Raw <strong>multiplexed whole-slide immunofluorescence (mIF) data</strong> (related to Figure 5) for this study is available from the corresponding author upon reasonable request and has not been uploaded to Zenodo due to the large data size (~ 50 GB per image). </p>
Single-cell RNA sequencing reveals immunosuppressive pathways associated with metastatic breast cancer
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Dataset for "Luminal breast epithelial cells from wildtype and BRCA mutation carriers harbor copy number alterations commonly associated with breast cancer"
<p>Processed single cell whole genome sequencing data from:</p> <p>Luminal breast epithelial cells from wildtype and BRCA mutation carriers harbor copy number alterations commonly associated with breast cancer Williams, Vinci Oliphant et al 2024</p> <p>Included are processed copy number profiles for all cells included in the study.</p>
Fig. 7 in Ethanolic extract of Mimosa caesalpiniifolia leaves: Chemical characterization and cytotoxic effect on human breast cancer MCF-7 cell line
Fig. 7. Agarose gel electrophoresis of MCF-7 cell genomic DNA. 1, ladder marker; 2, negative control; 3, cyclophosphamide (CP)-treated; 4–7, ethanolic extracts of Mimosa caesalpiniifolia leaves (EEM) in different concentrations (5.0; 20.0; 160.0 and 320.0 μg/mL). The results are representative of three independent experiments carried out in the same conditions. DNA ladder formation indicates apoptosis as seen in lanes 3–7.
Fig. 6. MCF-7 in Ethanolic extract of Mimosa caesalpiniifolia leaves: Chemical characterization and cytotoxic effect on human breast cancer MCF-7 cell line
Fig. 6. MCF-7 cell death (%) after treatment with cyclophosphamide (CP, 550 μg/mL) and different concentrations (5.0–320.0 μg/mL) of the ethanolic extract of Mimosa caesalpiniifolia leaves (EEM) for 24 h, compared to the negative control cells (NC), estimated by the Fast green color dye exclusion. Results are expressed as mean ± SEM of three independent experiments. Different letters indicate significant differences (p <0.01) by the Tukey test. Inset: appearance of cells after fast green-hematoxylin–eosin staining; 1, living cell; 2, green dead cell. EEM treatment kills MCF-7 cells in a concentrationdependent manner.
Fig. 3 in Ethanolic extract of Mimosa caesalpiniifolia leaves: Chemical characterization and cytotoxic effect on human breast cancer MCF-7 cell line
Fig. 3. Morphology of MCF-7 cells stained with hematoxylin–eosin, after 24 and 48 h incubation. NC, negative control cells; CP, cells treated with 550 μg/mL cyclophosphamide; 5, 80 and 320, cells treated, respectively, with 5.0, 80.0 and 320.0 μg/mL ethanolic extract of Mimosa caenalpiniifolia leaves. All the pictures are typical of three independent experiments, each carried out under identical conditions. Bar = 5 μm. Arrow—nucleolus; R—rounding; CC—chromatin condensation.
Fig. 2. MCF-7 in Ethanolic extract of Mimosa caesalpiniifolia leaves: Chemical characterization and cytotoxic effect on human breast cancer MCF-7 cell line
Fig. 2. MCF-7 cell protein content decreasing (%), estimated by the sulforhodamine B assay, after treatment with cyclophosphamide (CP, 550 μg/mL) and different concentrations of the ethanolic extract of Mimosa caesalpiniifolia leaves (EEM 5.0 - 320.0 μg/mL) for 24 and 48 h. The results are expressed as mean ± SEM of three independent experiments. Different letters indicate significant differences (p <0.001) by the Tukey test. Protein content was calculated relative to the negative control and 320.0 μg/mL EEM produced the maximum effect.
Fig. 1 in Ethanolic extract of Mimosa caesalpiniifolia leaves: Chemical characterization and cytotoxic effect on human breast cancer MCF-7 cell line
Fig. 1. HPLC-DAD-ESI-MS analysis of the ethanolic extract of Mimosa caesalpiniifolia leaves. (A) UV 360 nm; (B) ESI-MS, base peak chromatogram, negative ion mode, m/z 100–1500. No additional peaks were detected when the UV trace was recorded at wavelengths down to 360 nm. Peaks assigned as m/z: 288.97, 318.00, and 576.77 were identified, respectively, as catechin, 2,3 dihydroquercetagetin, and procyanidin B2 [(epi)catechin–(epi)catechin)] (see structures).
Fig. 4. MCF-7 in Ethanolic extract of Mimosa caesalpiniifolia leaves: Chemical characterization and cytotoxic effect on human breast cancer MCF-7 cell line
Fig. 4. MCF-7 cell diameter (μm) after treatment with cyclophosphamide (CP, 550 μg/mL) and different concentrations (5.0–320.0 μg/mL) of the ethanolic extract of Mimosa caesalpiniifolia leaves (EEM) for 24 or 48 h, compared to the negative control cells (NC). Results are expressed as mean ± SEM of three independent experiments. Different letters indicate significant differences (p <0.01) by the Tukey test. Note cell-diameter reduction after treatment, in comparison to the negative control cells, thereby indicating EEM cytotoxicity.
Bone Scan Images Dataset for Study of Bone Metastases in Adult Breast Cancer Patients at IICS-UNA Paraguay
<p>This dataset contains 582 bone scan images from 291 adult patients who attended the Nuclear Medicine Service at the Instituto de Investigaciones en Ciencias de la Salud (IICS) of the Universidad Nacional de Asunción (UNA), Paraguay, between 2020 and 2024.</p> <p>The dataset is organized into two folders, each named according to the classification of the images: bone metastases and no bone metastases. Each of these is further subdivided into folders corresponding to the projections generated during the acquisition of the bone scan images, anterior and posterior.</p>
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Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.