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1,052
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Dataset results
1,052 results for “cardiomyocytes”
Cardiomyocyte-specific Nitric Oxide Synthase 3 Overexpression in Pressure-Overloaded Left Ventricle.
GEO Series GSE37597. Mus musculus. 16 samples. Type: Expression profiling by array.
Pathogenic variants in PRDM16 impair cardiomyocytes maturation and cause cardiomyopathy phenotypes in humans
GEO Series GSE193877. Homo sapiens. 6 samples. Type: Expression profiling by high throughput sequencing.
Mechanosensitive Gene Regulation by Myocardin-Related Transcription Factors is Required for Cardiomyocyte Integrity in Load-Induced Ventricular Hypertrophy
GEO Series GSE102792. Mus musculus. 12 samples. Type: Expression profiling by high throughput sequencing.
RNA-sequence analysis of WT mice hearts and cardiomyocyte-specific deletion of STAT3 mice hearts
GEO Series GSE160248. Mus musculus. 6 samples. Type: Expression profiling by high throughput sequencing.
Amniotic fluid cardiomyocytes
GEO Series GSE76965. Homo sapiens. 12 samples. Type: Expression profiling by RT-PCR.
Effect of doxorubicin and SPEDOX-6 on human iPSC-derived cardiac spheroids comprised of cardiomyocytes, endothelial cells, and fibroblasts.
GEO Series GSE235470. Homo sapiens. 8 samples. Type: Expression profiling by high throughput sequencing.
Direct regulation of myocardial triglyceride metabolism by the cardiomyocyte circadian clock
GEO Series GSE21028. Mus musculus. 19 samples. Type: Expression profiling by array.
Deubiquitinase JOSD2 improves calcium handling and attenuates cardiac hypertrophy and dysfunction through stabilizing SERCA2a in cardiomyocytes
GEO Series GSE236431. Mus musculus. 9 samples. Type: Expression profiling by high throughput sequencing.
PLK inhibitors identified by high content phenotypic screening promote maturation of human iPSC-derived cardiomyocytes
GEO Series GSE197835. Homo sapiens. 9 samples. Type: Expression profiling by high throughput sequencing.
Activation of Hydroxy-carboxylic Acid Receptor 1 effect on cardiomyocytes
GEO Series GSE224822. Rattus norvegicus. 6 samples. Type: Expression profiling by high throughput sequencing.
Activation of endogenous protein phosphatase 1 enhances the calcium sensitivity of the ryanodine receptor type 2 in murine ventricular cardiomyocytes
<p>Each ZIP file contains the confocal or Western blot images (.tif, .oib, .oif) as well as voltage-clamp recordings (.pxp files - Igor, Wavemetrics). It also contains the analyses of the data used in that figure. Data are organised by dates (cell isolations) and by measured cells.</p>
Dataset related to the article "Pro-oxidant and pro-inflammatory effects of glycated albumin on cardiomyocytes"
<p>This record contains raw data related to the article "Pro-oxidant and pro-inflammatory effects of glycated albumin on cardiomyocytes"</p> <p>A B S T R A C T<br> Human serum albumin (HSA) is the most abundant circulating protein in the body and presents an extensive range of biological functions. As such, it is prone to undergo post-translational modifications (PTMs). The nonenzymatic early glycation of HSA, one of the several PTMs undergone by HSA, arises from the addition of reducing sugars to amine group residues, thus modifying the structure of HSA. These changes may affect HSA functions impairing its biological activity, finally leading to cell damage.<br> The aim of this study was to quantitate glycated-HSA (GA) levels in the plasma of heart failure (HF) patients and to evaluate the biological effects of GA on HL-1 cardiomyocytes.<br> Plasma GA content from HF patients and healthy subjects was measured by direct infusion electrospray ionization mass spectrometry (ESI-MS). Results pointed out a significant increase of GA in HF patients with respect to the control group (p < 0.05). Additionally, after stimulation with GA, proteomic analysis of HL-1 secreted proteins showed the modulation of several proteins involved, among other processes, in the response to stress. Further, stimulated cells showed a rapid increase in ROS generation, higher mRNA levels of the inflammatory cytokine interleukin-6 (IL-6) and tumor necrosis factor alpha (TNF-α), and higher levels of the oxidative 4-HNE-protein adducts and carbonylated proteins.<br> Our findings show that plasma GA is increased in HF patients. Further, GA exerts pro-inflammatory and prooxidant effects on cardiomyocytes, which suggest a causal role in the etiopathogenesis of HF.</p>
Partial dataset related to the article: "Fibrosis Rescue Improves Cardiac Function in Dystrophin-Deficient Mice and Duchenne Patient-Specific Cardiomyocytes by Immunoproteasome Modulation".
<p>This record contains raw data related to the article: "Fibrosis Rescue Improves Cardiac Function in Dystrophin-Deficient Mice and Duchenne Patient-Specific Cardiomyocytes by Immunoproteasome Modulation".</p> <p>Abstract</p> <p>Patients affected by Duchenne muscular dystrophy (DMD) develop a progressive dilated cardiomyopathy<br> characterized by inflammatory cell infiltration, necrosis, and cardiac fibrosis. Standard<br> treatments consider the use of b-blockers and angiotensin-converting enzyme inhibitors that are<br> symptomatic and unspecific toward DMD disease. Medications that target DMD cardiac fibrosis are<br> in the early stages of development. We found immunoproteasome dysregulation in affected hearts<br> of mdx mice (murine animal model of DMD) and cardiomyocytes derived from induced pluripotent<br> stem cells of patients with DMD. Interestingly, immunoproteasome inhibition ameliorated cardiomyopathy<br> in mdx mice and reduced the development of cardiac fibrosis. Establishing the<br> immunoproteasome inhibitionedependent cardioprotective role suggests the possibility of modulating<br> the immunoproteasome as new and clinically relevant treatment to rescue dilated cardiomyopathy<br> in patients with DMD.</p>
Use of hiPSC-Derived Cardiomyocytes to Rule Out Proarrhythmic Effects of Drugs: The Case of Hydroxychloroquine in COVID-19
<p>Raw and unfiltered datasets used for the publication.</p>
Transcriptional Variabilities in Human hiPSC-derived Cardiomyocytes: All Genes Are Not Equal and Their Robustness May Foretell Donor's Disease Susceptibility
<p>We characterized transcriptional variability from a hiPSC-derived cardiomyocyte (hiPSC-CM) study of left ventricular hypertrophy (LVH) using donor samples from the HyperGEN study. Multiple hiPSC-CM cell lines were used to assess variabilities from reprogramming, differentiation, and donors. Variability arising from pathological alterations was assessed using a cardiac stimulant applied to the hiPSC-CMs to trigger hypertrophic responses. We found that for most genes (73.3%~85.5%), technical variability was smaller than biological variability. Further, we identified and characterized lists of "noise" genes showing greater technical variability and "signal" genes showing greater biological variability. Together, they support a "genetic robustness" hypothesis of disease-modeling whereby cellular response to relevant stimuli in hiPSC-derived somatic cells from diseased donors tends to show more transcriptional variability. Our findings suggest that hiPSC-CMs can provide a valid model for cardiac hypertrophy and distinguish between technical and disease-relevant transcriptional changes.</p>
Excessive Antioxidant Activity Impedes Neonatal Cardiomyocyte Regeneration
GEO Series GSE275297. Mus musculus. 12 samples. Type: Expression profiling by high throughput sequencing.
Effect of lincRNA-p21 knockdown on neonatal mouse cardiomyocytes (CMs) treated with phenylephrine (PE)
GEO Series GSE262892. Mus musculus. 12 samples. Type: Expression profiling by high throughput sequencing.
Gene expression profile at single cell level of cardiomyocyte and non cardiomyocyte from the heart of pressure-overload model mice.
GEO Series GSE221744. Homo sapiens; Mus musculus. 1141 samples. Type: Expression profiling by high throughput sequencing.
Cardiomyocyte peroxisome proliferator-activated receptor α prevents septic cardiomyopathy via improving mitochondrial function
GEO Series GSE229298. Mus musculus. 16 samples. Type: Expression profiling by high throughput sequencing.
RNA-seq of human induced pluripotent stem cell differentiation into cardiomyocytes using Wnt inhibition
GEO Series GSE158578. Homo sapiens. 12 samples. Type: Expression profiling by high throughput sequencing.
ScienceDex guides
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These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.