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2,292
datasets available to search
ShareScore release 0.9.0
Dataset results
2,292 results for “glioma”
Vorasidenib and ivosidenib in IDH1-mutant low-grade glioma: a randomized, perioperative phase 1 trial
GEO Series GSE232312. Homo sapiens. 41 samples. Type: Expression profiling by high throughput sequencing.
H2A.Z histone variants facilitate HDACi-dependent removal of H3.3K27M mutant protein in paediatric high-grade glioma cells
GEO Series GSE232283. Homo sapiens. 47 samples. Type: Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing.
Diffuse glioma cells with perineural satellitosis invade by mediating metabolic reprogramming
GEO Series GSE126725. Mus musculus. 6 samples. Type: Expression profiling by array.
Spatial immune profiling defines a subset of human gliomas with functional tertiary lymphoid structures [GEOMX]
GEO Series GSE271255. Homo sapiens. 81 samples. Type: Other.
Gene expression profiling of Glioma Stem Cells (GSCs) and their differentiated cell counterparts after MG132 treatment
GEO Series GSE62356. Homo sapiens. 4 samples. Type: Expression profiling by array.
Genome wide maps of H3K4me3 and H3ac histone modifications in C6 rat glioma cells [Illumina]
GEO Series GSE46820. Rattus norvegicus. 3 samples. Type: Genome binding/occupancy profiling by high throughput sequencing.
The histone H3.3K27M mutation in pediatric glioma reprograms H3K27 methylation and gene expression
GEO Series GSE61586. Homo sapiens. 16 samples. Type: Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing.
The oncolytic adenovirus Delta-24-RGD in combination with ONC201 displays a potent antitumor effect in pediatric high-grade glioma models [RNA-seqI]
GEO Series GSE243223. Homo sapiens. 52 samples. Type: Expression profiling by high throughput sequencing.
PRMT5 promotes growth of pediatric high grade glioma [bulk RNA-seq]
GEO Series GSE261512. Homo sapiens. 20 samples. Type: Expression profiling by high throughput sequencing.
Hypoxic stress dysregulates functions of glioma-associated myeloid cells through epigenomic and transcriptional programs [RNA-seq]
GEO Series GSE279536. Mus musculus. 38 samples. Type: Expression profiling by high throughput sequencing.
Neuronal activity promotes glioma growth
GEO Series GSE62563. Homo sapiens. 2 samples. Type: Expression profiling by high throughput sequencing.
EZH2 inhibition as a targeted therapy for H3K27M mutant pediatric gliomas [ChIP-seq]
GEO Series GSE71225. Mus musculus; Homo sapiens. 13 samples. Type: Genome binding/occupancy profiling by high throughput sequencing.
miRNA expression profile of Idh1 wild-type and mutant glioma initiating cells
GEO Series GSE119740. Mus musculus. 5 samples. Type: Non-coding RNA profiling by high throughput sequencing.
Combined epigenetic therapy with FACT and BET inhibitors remodels chromatin and disrupts oncogenic transcription in Diffuse Midline Glioma [Nascent RNA-Seq]
GEO Series GSE299509. Homo sapiens. 30 samples. Type: Expression profiling by high throughput sequencing.
BRAF V600E in Pediatric Low-Grade Gliomas: Exploring the Tumor Microenvironment and Immune Cell Infiltration dynamics in vivo.
GEO Series GSE252367. Mus musculus. 6 samples. Type: Expression profiling by high throughput sequencing.
Expression data from Glioma-Initiating Cells (GICs) cultured under hypoxia and normoxia
GEO Series GSE73556. Homo sapiens. 6 samples. Type: Expression profiling by array.
1H HRMAS NMR dataset of glioma and control samples
<p>This repository contains the raw and processed 1H HRMAS NMR data to reproduce the results reported in the following preprint: Machine Learning Assisted Intraoperative Assessment of Brain Tumor Margins Using HRMAS NMR Spectroscopy (https://doi.org/10.1101/2020.02.24.20026955).</p>
Temporal changes in treatment and late mortality and morbidity in adult survivors of childhood glioma: a report from the Childhood Cancer Survivor Study
<p><strong>Abstract:</strong></p> <p>Pediatric glioma therapy has evolved to delay or eliminate radiation for low-grade tumors. This study examined these temporal changes in therapy with long-term outcomes in adult survivors of childhood glioma. Among 2,501 5-year survivors of glioma in the Childhood Cancer Survivor Study diagnosed 1970–1999, exposure to radiation decreased over time. Survivors from more recent eras were at lower risk of late mortality (≥5 years from diagnosis), severe/disabling/life-threatening chronic health conditions (CHCs) and subsequent neoplasms (SNs). Adjusting for treatment exposure (surgery only, chemotherapy, or any cranial radiation) attenuated this risk (for example, CHCs (1990s versus 1970s), relative risk (95% confidence interval), 0.63 (0.49–0.80) without adjustment versus 0.93 (0.72–1.20) with adjustment). Compared to surgery alone, radiation was associated with greater than four times the risk of late mortality, CHCs and SNs. Evolving therapy, particularly avoidance of cranial radiation, has improved late outcomes for childhood glioma survivors without increased risk for late recurrence.</p>
Unveiling Therapeutic Targets and Immunological Insights in Glioblastoma Through Analysis of Glioma-Associated Mesenchymal Stem Cells
<p>To analyze the binding affinities and interaction modes between the drug candidates and their targets, we employed the Autodock Vina software [21]. Molecular structures of the candidate drugs and targets of hub genes were retrieved from Pubchem (https://pubchem.ncbi.nlm.nih.gov/) and Protein Data Bank database (http://www.rcsb.org/), respectively. <span>In the analysis of docking, the files for all proteins and molecules were converted to PDBQT format. Water molecules were removed and polar hydrogen atoms were added. The grid box was positioned at the center to encompass the protein domain, allowing for unrestricted movement of molecules.</span></p>
EDEN2020 Human Brain MRI Datasets for Brain Glioma Patients
<p>The datasets available in this folder regard the acquisition of high-resolution MRI images of a cohort of 30 brain glioma adult patients acquired on a 3 Tesla Philips scanner at the Neuroradiology Unit and CERMAC <em>(Center of Excellence for High Field Magnetic Resonance)</em>, Vita-Salute San Raffaele University and IRCCS Ospedale San Raffaele, Milano, Italy. The acquisition is carried out in the context of the EU’s Horizon EDEN2020 project as part of the work for <em>Deliverable D2.2 Human Brain Imaging Database</em>. Histopathological and molecular details of this cohort of patients are reported in the Patients' Table included in the <em>Readme.md</em> file. </p> <p>The data includes:</p> <ul> <li>3D_FLAIR_Tra: Fluid‑Attenuated Inversion Recovery volumetric sequence acquired on the axial plane for morphological characterization of the lesion. </li> <li>raw_data_DTI_32: Diffusion Tensor Imaging raw data. This is a diffusion-weighted Spin Echo EPI single-shot pulse sequence acquired on the axial plane along 32 gradient directions at a b-value of 1000 s/mm<sup>2</sup> and one volume without diffusion-weighting (b0 image).</li> <li>Axial (AD), Radial (RD), Mean Diffusivity (MD) and Fractional Anisotropy maps derived from 'raw_data_DTI_32' sequence using the Philips IntelliSpace Portal software platform, version 8.0 (Philips Healthcare, Best, The Netherlands) and saved using the ‘_map_DTI_32_gray' suffix.</li> <li>raw_data_NODDI: multi-compartmental dMRI sequence for advanced tractography and NODDI analyses, including an axial high angular resolution diffusion-weighted imaging (HARDI) acquisition along 60 gradient directions at a b-value of 3000 s/mm<sup>2 </sup>a DTI acquisition along 35 directions at a b-value of 711 s/mm<sup>2</sup> and 11 volumes without diffusion-weighting (b0 images). Phase-encoding direction was anterior-to-posterior for all these acquisitions.</li> <li>B0_reverse: a sequence without diffusion-weighting having the same geometrical parameters of the ‘raw_data_NODDI’ images,but acquired using a reversed phase-encoding direction (posterior-to-anterior). This volume allowed estimation and correction for susceptibility-induced distortions.</li> <li>SWI_axial: Susceptibility‑Weighted Imaging sequence acquired on the axial plane for detection of Intratumoral Susceptibility Signals (ITSS), microhemorrages and calcifications. Phase map and magnitude image are separated in two distinguished files, using the ‘_ph’ suffix for phase maps.</li> <li>s3DI_MC_HR: three-dimensional high-resolution time of flight (TOF) MR angiography acquisition to visualize flow within the arterial vessel. </li> <li>Post-gadolinium T1_3D_PROSET_Sag: T1-weighted volumetric sequence acquired on the sagittal plane for morphological characterization of the lesions and detection of areas of contrast enhancement.</li> </ul> <p>Note that all MRI data files were converted from DICOM series using Chris Rorden's dcm2niiX version v1.0.20200331.</p>
ScienceDex guides
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These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.