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226 results for “Active compounds”
Fig. 5. Compounds 1–9 in (þ/¡)-Dievodialetins A¡G: Seven pairs of enantiomeric coumarin dimers with anti-acetylcholinesterase activity from the roots of Evodia lepta Merr.
Fig. 5. Compounds 1–9 ameliorate oxidative stress and neuroinflammation in scopolamine-treated SH-SY5Y cells.
Fig. 5 in Catecholic alkaloid sulfonates and aromatic nitro compounds from Portulaca oleracea and screening of their anti-inflammatory and anti-microbial activities
Fig. 5. Possible biosynthetic pathway for the nitro derivatives, catecholic alkaloids and their sulfonates from P. oleracea (DDC: dopa decarboxylase; RNS: reactive nitrogen species; TH: tyrosine hydroxylase).
Fig. 4. Compound 1 in Diverse alkaloids from the aerial parts of Aconitum carmichaelii and antiproliferative activity of costemline via inhibiting SIRT1/ROCK1/ P-STAT3 pathways
Fig. 4. Compound 1 inhibited invasion of HCT116 colon cancer cells in a transwell assay, which showed by representative images (A) and attached data (B). Cells were incubated with compound 1 (a) 0 μM, (b) 5 μM, (c) 10 μM for 24 h (original magnification, × 200). Quantitative data are presented as the mean ± standard deviation of 3 replicates, relative to the 0 μM control group. **p <0.01 vs. the 0 μM control group.
Fig. 6 in Catecholic alkaloid sulfonates and aromatic nitro compounds from Portulaca oleracea and screening of their anti-inflammatory and anti-microbial activities
Fig. 6. Dose-dependent inhibition of nitro derivative 12 against LPS-induced NO production in RAW 264.7 macrophage cells (n = 3) (****p <0.0001, versus vehicle control, ####p <0.0001, versus LPS-treated model, 3,4-dihydroxy-benzohydroxamic acid (Didox) was used as the positive control with IC value of 70 μM).
Fig. 4 in Catecholic alkaloid sulfonates and aromatic nitro compounds from Portulaca oleracea and screening of their anti-inflammatory and anti-microbial activities
Fig. 4. Calculated and experiment ECD of compounds 4, 10–11, 15–17 and their possible stereostructures
Fig. 4. Compound 7 in Bufadienolide glycosides and bufadienolides from the whole plants of Helleborus lividus, and their cytotoxic activity
Fig. 4. Compound 7 induced apoptosis in HL- 60 cells. A, Morphology of HL-60 cells treated with 7. HL- 60 cells were stained with DAPI after treatment with either 0.21 μM of 7 or 15 μM of etoposide for 15 h and then observed under a fluorescence microscope. B, Electrophoretic profile of the DNA of HL-60 cells treated with 7. HL-60 cells were incubated with either 0.21 μM of 7 or 15 μM of etoposide for 15 h. DNA was then extracted and analyzed by agarose gel electrophoresis. C, Caspase-3 activity in the lysates of HL-60 cells treated with 7. HL-60 cells were incubated with either 0.21 μM of 7 or 15 μM of etoposide for 12 h, and the caspase-3 activity in the lysates was measured using a caspase-3 colorimetric kit. The data are presented as the mean ± S.E.M. of three experiments. Results significantly different from that of the control group are indicated by * (p <0.001).
Fig. 5. Compound 7 induced apoptosis through a mitochondria-dependent pathway. A in Bufadienolide glycosides and bufadienolides from the whole plants of Helleborus lividus, and their cytotoxic activity
Fig. 5. Compound 7 induced apoptosis through a mitochondria-dependent pathway. A, Mitochondrial membrane morphology of HL- 60 cells treated with 7. HL-60 cells were stained with MitoCapture™ reagent after treatment with either 0.21 μM of 7 or 33 μM of cisplatin for 6 h and observed under a fluorescence microscope. B, Release of cytochrome c from mitochondria of HL-60 cells treated with 7. HL-60 cells were treated with either 0.21 μM of 7 or 33 μM of cisplatin for 8 h, and the release of cytochrome c into the cytoplasm was evaluated by Western blot analysis.
Natural Fruit Extract Versus the Assumed Key Active Compound in Reducing the Post-prandial Blood Glucose Level
ClinicalTrials.gov study NCT02599740. IPD Sharing: Not stated. Countries: 1. Publications: 1.
The Effect of Prior Muscle Activation on the Compound Muscle Action Potential (CMAP)
ClinicalTrials.gov study NCT01182558. IPD Sharing: Not stated. Countries: 1. Publications: 1.
A Clinical Trial Evaluating IL-22BP/LNP Compound in Refractory Malignant Solid Tumors for Safety, Tolerability and Activity
ClinicalTrials.gov study NCT07100210. IPD Sharing: NO. Countries: 1. Publications: 9.
Procaspase Activating Compound-1 (PAC-1) in the Treatment of Advanced Malignancies - Component 1
ClinicalTrials.gov study NCT02355535. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Active Myeloid Target Compound Combinations in MDS/MPN Overlap Syndromes Overlap Syndromes (ABNL-MARRO)
ClinicalTrials.gov study NCT04061421. IPD Sharing: NO. Countries: 1. Publications: 1.
Active Hexose Correlated Compound in Tuberculosis-HIV (Human Immunodeficiency Virus) Infection
ClinicalTrials.gov study NCT05100758. IPD Sharing: NO. Countries: 1. Publications: 3.
Data from: Comparative chemical analysis of volatile compounds of Echinops ilicifolius using hydrodistillation and headspace solid-phase microextraction and the antibacterial activities of its essential oil
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Data from: Design of cinnamaldehyde amino acid Schiff base compounds based on the quantitative structure–activity relationship
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A phenotypic screening platform utilising human spermatozoa identifies compounds with contraceptive activity
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Data from: Molecular docking and dynamics studies to identify novel active compounds targeting potential breast cancer receptor proteins from an indigenous herb Euphorbia thymifolia Linn
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Screening of 6000 compounds for uncoupling activity: input parameters, the predicted uncoupling activity, as well as the results in respect to structural alerts
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Peptidomimetics-based identification of FDA approved compounds inhibiting IRE1 activity: Simulation Data
<p>Protocols and data sets for docking and MD simulations of Methotrexate, Cefoperazone, Folinic acd and Folic acid interaction with IRE1. All docking data based on Glide (Schrödinger), and all MD simulations are based on the Gromacs software. 2D interaction maps from the initial docking of the four molecules to the four Lysine sites, and from snapshots every 100 ns of the 500 ns MD simulations of the molecules interacting with Lys599 (kinase site) and Lys907 (RNase site). 2D interaction maps produced using Schrödinger. </p>
Figure 5 from: Okechukwu P, Sharma M, Tan WH, Chan HK, Chirara K, Gaurav A, Al-Nema M (2020) In-vitro antidiabetic activity and in-silico studies of the binding energies of palmatine and the standard compounds with the three receptors of alpha amylase, alpha glucosidase, and DPP-IV enzyme. Pharmacia 67(4): 363-371. https://doi.org/10.3897/pharmacia.67.e58392
Figure 5 Docking interaction and binding mode of palmatine and alpha-amylase enzyme. The π-π staked interactions are presented in magenta dotted lines.
ScienceDex guides
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These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.