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Dataset results
512 results for “Antidepressant”
Efficacy and Safety Study of SPD489 in Combination With an Antidepressant in the Treatment of Adults With Major Depressive Disorder
ClinicalTrials.gov study NCT01436149. IPD Sharing: Not stated. Countries: 6. Publications: 1.
The Combination of Aripiprazole and Antidepressants in Psychotic Major Depression
ClinicalTrials.gov study NCT00556140. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Data from: Field-realistic antidepressant exposure disrupts group foraging dynamics in mosquitofish
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Data for: Warmer temperatures limit the effects of antidepressant pollution on life history traits
<p>Pharmaceutical pollutants pose a threat to aquatic ecosystems worldwide. Yet, few studies have considered the interaction between pharmaceuticals and other chronic stressors contemporaneously, even though the environmental challenges confronting animals in the wild seldom, if ever, occur in isolation. Thermal stress is one such environmental challenge that may modify the threat of pharmaceutical pollutants. Accordingly, we investigated how fluoxetine (Prozac), a common psychotherapeutic and widespread pollutant, interacts with temperature to affect life-history traits in the water flea, <i>Daphnia magna</i>. We chronically exposed two genotypes of <i>Daphnia</i> to two ecological relevant concentrations of fluoxetine (30ng/L and 300ng/L) and a concentration representing levels used in acute toxicity tests (3000ng/L), and quantified the change in phenotypic trajectories at two temperatures (20°C and 25°C). Across multiple life-history traits, we found that fluoxetine exposure impacted the fecundity, body size and intrinsic growth rate of <i>Daphnia</i> in a non-monotonic manner at 20°C, and often in genotypic-specific ways. At 25°C, however, the life-history phenotypes of individuals converged under the widely varying levels of fluoxetine, irrespective of genotype. Our study underscores the importance of considering the complexity of interactions that can occur in the wild when assessing the effects of chemical pollutants on life-history traits.</p>
Field-realistic antidepressant exposure disrupts group foraging dynamics in mosquitofish
<p></p><p> Psychoactive pollutants, such as antidepressants, are increasingly detected in the environment. Mounting evidence suggests that such pollutants can disrupt the behaviour of non-target species. Despite this, few studies have considered how the response of exposed organisms might be mediated by social context. To redress this, we investigated the impacts of two environmentally realistic concentrations of a pervasive antidepressant pollutant, fluoxetine, on foraging behaviour in fish (Gambusia holbrooki), tested individually or in a group. Fluoxetine did not alter behaviour of solitary fish. However, in a group setting, fluoxetine exposure disrupted the frequency of aggressive interactions and food consumption, with observed effects being contingent on both the mean weight of group members and the level of within-group variation in weight. Our results suggest that behavioural tests in social isolation may not accurately predict the environmental risk of chemical pollutants for group-living species and highlight the potential for social context to mediate the effects of psychoactive pollutants in exposed wildlife. </p><p></p>
Glutamate and Opioid Mechanisms of Antidepressant Response to Ketamine
ClinicalTrials.gov study NCT04977674. IPD Sharing: NO. Countries: 1. Publications: 1.
Patient Decision Aid for Antidepressant Use in Pregnancy
ClinicalTrials.gov study NCT02308592. IPD Sharing: UNDECIDED. Countries: 1. Publications: 2.
Rapid Antidepressant Improvement Secondary to Excitatory Brain Responses
ClinicalTrials.gov study NCT04276259. IPD Sharing: YES. Countries: 1. Publications: 1.
Improving Retention of Hispanics Receiving Antidepressant Therapy
ClinicalTrials.gov study NCT00057642. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Antidepressants Trial in Parkinson's Disease
ClinicalTrials.gov study NCT03652870. IPD Sharing: NO. Countries: 1. Publications: 2.
Ethnic Variations in Antidepressant Response
ClinicalTrials.gov study NCT00047671. IPD Sharing: Not stated. Countries: 1. Publications: 2.
Cognitive Behavioral Therapy Combined With Antidepressants to Reduce HIV Risk and Drug Relapse Among Depressed Intravenous Drug Users
ClinicalTrials.gov study NCT00183768. IPD Sharing: Not stated. Countries: 1. Publications: 3.
Antidepressant Treatment in Older Adults With Schizophrenia
ClinicalTrials.gov study NCT00047450. IPD Sharing: Not stated. Countries: 1. Publications: 2.
Rapid Antidepressant Effects of ATP and Phosphocreatine
ClinicalTrials.gov study NCT03138681. IPD Sharing: NO. Countries: 1. Publications: 1.
A Study of the Effects of a New Antidepressant Treatment (GSK561679) in Females With Major Depressive Disorder
ClinicalTrials.gov study NCT00733980. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Sedating Antidepressant Improves Driving Safety in Patients With Major Depressive Disorder
ClinicalTrials.gov study NCT00385437. IPD Sharing: Not stated. Countries: 1. Publications: 3.
Mindfulness Based Cognitive Therapy and Antidepressant Medication in Recurrent Depression
ClinicalTrials.gov study NCT00928980. IPD Sharing: Not stated. Countries: 1. Publications: 7.
Intranasal Esketamine to Maintain the Antidepressant Response to IV Racemic Ketamine
ClinicalTrials.gov study NCT04856124. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Excessive Sweating Caused by Antidepressants: Measurement and Treatment With Terazosin
ClinicalTrials.gov study NCT00449683. IPD Sharing: UNDECIDED. Countries: 1. Publications: 1.
The Outcome of Treatment of Traumatised Refugees With Psychotherapy and/or Antidepressants
ClinicalTrials.gov study NCT00917397. IPD Sharing: Not stated. Countries: 1. Publications: 2.
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Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.