Find research datasets worth reusing

opennotspecifiedOct 2022View details →

Fig. 1 in Non-volatile constituents from Monimiaceae, Siparunaceae and Atherospermataceae plant species and their bioactivities: An up-date covering 2000-2021

Fig. 1. Previously undescribed γ-lactone compounds and ring opened derivative 10 isolated from the Monimiaceae family.

opennotspecifiedJul 2022View details →

Fig. 1 in Neritriterpenols A-G, euphane and tirucallane triterpenes from Euphorbia neriifolia L. and their bioactivity

Fig. 1. Structures of the isolated triterpenes 1–11 isolated from the stems extract of Euphorbia neriifolia.

opennotspecifiedOct 2022View details →

Fig. 7 in Non-volatile constituents from Monimiaceae, Siparunaceae and Atherospermataceae plant species and their bioactivities: An up-date covering 2000-2021

Fig. 7. Previously undescribed and known flavonoids isolated from the Siparunaceae family (The substituents of flavonoids are denoted in blue font). (For interpretation of the references to colour in this figure legend, the reader is referred to the Web version of this article.)

opennotspecifiedOct 2022View details →

Fig. 10. Previously undescribed homogentisic acid derivatives isolated from G in Non-volatile constituents from Monimiaceae, Siparunaceae and Atherospermataceae plant species and their bioactivities: An up-date covering 2000-2021

Fig. 10. Previously undescribed homogentisic acid derivatives isolated from G. Brevipes in the Siparunaceae family.

Fig. 5 in Biotransformation of artemisinic acid to bioactive derivatives by endophytic Penicillium oxalicum B4 from Artemisia annua L.

Fig. 5. Time course for the biotransformation of artemisinic acid (AA) by Penicillium oxalicum B4. AA (3.50 mg/50 mL) was added to 2-day-old culture for the biotransformation.

Fig. 4 in Biotransformation of artemisinic acid to bioactive derivatives by endophytic Penicillium oxalicum B4 from Artemisia annua L.

Fig. 4. Time course of mycelial biomass (A) and the biotransformation of artemisinic acid (AA) by Penicillium oxalicum B4. AA (3.50 mg/50 mL) was added to 2-day-old culture for the biotransformation. Data presented are the means ± SD of results from three independent experiments.

Fig. 7 in Biotransformation of artemisinic acid to bioactive derivatives by endophytic Penicillium oxalicum B4 from Artemisia annua L.

Fig. 7. Inhibitory effects of metabolite 4 (A) and 7 (B) on cell viability and LPSinduced nitrite production in RAW 264.7 cells. Normal cells were incubated for 24 h with metabolite 4 and 7 at indicated concentrations. Cells were pretreated with the indicated concentrations of metabolite 4 and 7 for 1 h followed by treatment with LPS (1.0 μg/mL). After 24 h of incubation, the amount of nitrite in the culture supernatants and cell viability were measured. Data presented are the means ± SD of results from three independent experiments (###p <0.001 versus untreated group; *p <0.05, **p <0.01 versus LPS treated group. The small letters indicate the significant difference (p <0.05) between groups).

Fig. 2 in Asporychalasin, a bioactive cytochalasan with an unprecedented 6/6/11 skeleton from the Red Sea sediment Aspergillus oryzae

Fig. 2. Left: 2D NMR COSY (red bold) and HMBC (blue arrows) correlations detected for asporychalasin. Right: Key NOESY correlations (red arrows) for asporychalasin. (For interpretation of the references to colour in this figure legend, the reader is referred to the Web version of this article.)

Fig. 4 in Asporychalasin, a bioactive cytochalasan with an unprecedented 6/6/11 skeleton from the Red Sea sediment Aspergillus oryzae

Fig. 4. Experimental ECD curve of asporychalasin (red) and calculated ECD curves for 1a (black) and its enantiomer (green). (For interpretation of the references to colour in this figure legend, the reader is referred to the Web version of this article.)

Fig. 3. The four possible diastereomers 1a-1d in Asporychalasin, a bioactive cytochalasan with an unprecedented 6/6/11 skeleton from the Red Sea sediment Aspergillus oryzae

Fig. 3. The four possible diastereomers 1a-1d and the most populated conformer for each diastereomer.

Fig. 2 in Conoidecyclics A-C from marine macroalga Turbinaria conoides: Newly described natural macrolides with prospective bioactive properties

Fig. 2. (A1-C1) 1H–1H COSY (bold-face bonds), selected HMBCs (double-barbed arrows), (A2-C2) NOE (colored arrows) correlations of conoidecyclics A-C isolated from T. conoides and (A3-C3) computer-generated models using MM2 force field calculations were displayed.

Fig. 5 in Conoidecyclics A-C from marine macroalga Turbinaria conoides: Newly described natural macrolides with prospective bioactive properties

Fig. 5. (A1-A2) Representative hydrogen binding interactions between conoidecyclic C and the amino acyl residues in the catalytic sites of COX-2; (A3-A4) Representative hydrogen binding interactions between conoidecyclic C and the amino acyl residues in the catalytic sites of 5-LOX; (A5-A6) Representative hydrogen binding interactions between conoidecyclic C and the amino acyl residues in the catalytic sites of PTP-1B; (A7-A8) Representative hydrogen binding interactions between conoidecyclic C and the amino acyl residues in the catalytic sites of ACE as obtained from in silico molecular docking analysis.

Fig. 3 in Conoidecyclics A-C from marine macroalga Turbinaria conoides: Newly described natural macrolides with prospective bioactive properties

Fig. 3. (A1-A2) Representative hydrogen binding interactions between conoidecyclic A and the amino acyl residues in the catalytic sites of COX-2; (A3-A4) Representative hydrogen binding interactions between conoidecyclic A and the amino acyl residues in the catalytic sites of 5-LOX; (A5-A6) Representative hydrogen binding interactions between conoidecyclic A and the amino acyl residues in the catalytic sites of PTP-1B; (A7-A8) Representative hydrogen binding interactions between conoidecyclic A and the amino acyl residues in the catalytic sites of ACE as obtained from in silico molecular docking analysis.

Fig. 1 in Conoidecyclics A-C from marine macroalga Turbinaria conoides: Newly described natural macrolides with prospective bioactive properties

Fig. 1. Structural representations of conoidecyclics A-C purified from the solvent extract of T. conoides. The thallus structure (leaf-like) of T. conoides was illustrated.

Fig. 4 in Conoidecyclics A-C from marine macroalga Turbinaria conoides: Newly described natural macrolides with prospective bioactive properties

Fig. 4. (A1-A2) Representative hydrogen binding interactions between conoidecyclic B and the amino acyl residues in the catalytic sites of COX-2; (A3-A4) Representative hydrogen binding interactions between conoidecyclic B and the amino acyl residues in the catalytic sites of 5-LOX; (A5-A6) Representative hydrogen binding interactions between conoidecyclic B and the amino acyl residues in the catalytic sites of PTP-1B; (A7-A8) Representative hydrogen binding interactions between conoidecyclic B and the amino acyl residues in the catalytic sites of ACE as obtained from in silico molecular docking analysis.

Fig. 6 in Conoidecyclics A-C from marine macroalga Turbinaria conoides: Newly described natural macrolides with prospective bioactive properties

Fig. 6. Kinetic studies of the pharmacologic response with regard to inhibition mode of ACE-I (A–C), PTP-1B (D–F) and 5-LOX (G–I), respectively to the studied conoidecyclics A-C. Representation of Dixon plots for conoidecyclics A-C, for the determination of the inhibition constant Ki. The Ki value was determined from the negative X-axis value at the point of the intersection of the four lines. The data were expressed as the mean reciprocal of initial velocity for triplicates (n = 3) at each substrate concentration. Different concentrations of isolated compounds were used, and the inhibitory potentials were expressed in mM.

Fig. 1 in Plant-cyanobacteria interactions: Beneficial and harmful effects of cyanobacterial bioactive compounds on soil-plant systems and subsequent risk to animal and human health

Fig. 1. Cyanobacterial active compounds induce negative, (A) ROS and enzyme activities such as superoxide dismutase (SOD), glutathione peroxidase (GPx), peroxidase (POD); and positive effects (B) expression of stress responsive genes (Ssglc and slr1562) that can have a positive effect on increasing plants' stress tolerance.

Fig. 3 in Bioactive metabolites from the desert plant-associated endophytic fungus Chaetomium globosum (Chaetomiaceae)

Fig. 3. Comparison of the 13C NMR chemical shift values of the left part of structure 1 with those of spiciferone A (3) in the same solvent (DMSO d).

opennotspecifiedNov 2020View details →

Fig. 5 in Bioactive diterpenoid metabolism and cytotoxic activities of genetically transformed Euphorbia lathyris roots

Fig. 5. Cytotoxic activities of transformed E. lathyris root extract in human carcinoma and embryonic cell lines. a) DU-145 (prostate) b) HeLa (cervix) c) MCF-7 (breast) d) MDA-MB-231 (breast) e) and H2347 (lung) were treated with DMSO (carrier), or increasing concentrations of transformed root MeOH extracts (31.3 μg/ml, 52.5 μg/ml, 125 μg/ml, 250 μg/ml). Titer-Glo® (Promega) was used to count cell lines 48 h post-treatment. Each dose and timepoint was performed in triplicate. Asterisks indicate statistical significance in comparison to carrier (DMSO) control assessed by one-way ANOVA (**,P <0.01; *,P <0.05).