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1,242 results for “Cell proliferation”
Data from: Cell proliferation and migration during early development of a symbiotic scleractinian coral
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A Tasquinomod-loaded dopamine-modified pH sensitive hydrogel is effective at inhibiting the proliferation of KRAS mutant lung cancer cells
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Data: Size-dependent patterns of cell proliferation and migration in freely-expanding epithelia
<p>Raw images ('*.tif" file extensions) and core measurement files ('*.mat file extension). For small and large circles, we include images of phase, GFP, RFP, and nuclei. We also include two ellipses in phase. '<a href="https://zenodo.org/api/files/f94dc36b-aa3a-40f5-800a-035282fdfad7/t0SummaryStats.mat">t0SummaryStats.mat</a>' gives information for the starting conditions of tissues represented by the '<a href="https://zenodo.org/api/files/f94dc36b-aa3a-40f5-800a-035282fdfad7/PIVunsmoothed.mat">PIVunsmoothed.mat</a>' and '<a href="https://zenodo.org/api/files/f94dc36b-aa3a-40f5-800a-035282fdfad7/Kymographs.mat">Kymographs.mat</a>' datasets. '<a href="https://zenodo.org/api/files/f94dc36b-aa3a-40f5-800a-035282fdfad7/ContinuityEqn_FVM.m">ContinuityEqn_FVM.m</a>' includes the solution to the continuity equation via the finite volume method as detailed in the materials and methods, and relies on data in '<a href="https://zenodo.org/api/files/f94dc36b-aa3a-40f5-800a-035282fdfad7/Kymographs.mat">Kymographs.mat</a>' and '<a href="https://zenodo.org/api/files/f94dc36b-aa3a-40f5-800a-035282fdfad7/t0SummaryStats_continuityEqn.mat">t0SummaryStats_continuityEqn.mat</a>'.</p>
Genome sequencing of P. tricornutum mother and daughter cultures derived from single cell and separated by 30 days of proliferation - processed datasets
<p><strong>Genome sequencing of <em>P. tricornutum</em> mother and daughter cultures derived from single cell and separated by 30 days of proliferation - processed datasets.</strong></p> <p>Raw data for this experiment are available at https://www.ncbi.nlm.nih.gov/bioproject/PRJNA658224.</p> <p> </p> <p><strong>Please note that the naming of files differs from the general description on /www.ncbi.nlm.nih.gov/bioproject website and in related publication:</strong></p> <p>Instead of MC1-3, the processed datasets are labelled Sc1-3</p> <p>Instead of DC1.1; DC1.2 and DC1.3, the processed datasets are labelled Sc11, Sc12 and Sc14 respectively</p> <p>Instead of DC2.1; DC2.2 and DC2.3, the processed datasets are labelled Sc21, Sc22 and Sc24 respectively</p> <p>Instead of DC3.1; DC3.2 and DC3.3, the processed datasets are labelled Sc31, Sc32 and Sc33 respectively</p> <p><strong>Available datasets: </strong></p> <p><em>.bam</em> files with ILLUMINA reads aligned to the reference P. tricornutum v2 genome used for SNP calling </p> <p><em>.vcf</em> files for individual samples with SNPs called using GATK3.7.0</p> <p><em>joint_genotyping_cohort.vcf</em> file with SNPs called jointly for all samples using GATK4.2.1 </p> <p> </p> <p><strong>Description of the experiment:</strong> </p> <p>Whole-genome Illumina sequencing of mother and daughter cultures derived from single cell to reveal genomic changes occurring within 30 day time frame. Three independent single cells were isolated from CCAP 1055/1 culture (sample label: Pt1) to start mother cultures (MC1; MC2; MC3 . On day 30 after mother culture isolation (T1 time point), three daughter cells were isolated from each mother culture forming cultures DC11-DC33. Part of mother cultures and CCAP 1055/1 culture were harvested at T1 (Samples: Pt1T1; MC1T1; MC2T1; MC3T1) . After another 30 days (T2 time point), all cultures were harvested (Samples: Pt1T2; mother culture MC1T2 and respective daughter cultures DC11, DC12 and DC13 ; mother culture MC2T2 and respective daughter cultures DC21, DC22 and DC23; mother culture MC3T1 and respective daughter cultures DC31, DC32, DC33).</p>
Data from: Effect of Ghost pepper on cell proliferation, apoptosis, senescence and global proteomic profile in human renal adenocarcinoma cells
Chili peppers are an important constituent of many foods and contain medicinally valuable compounds, such as capsaicin and dihydrocapsaicin. As various dietary botanicals have anticancer properties, this study was aimed to examine the effect of Ghost pepper (Bhut Jolokia), one of the hottest chili peppers in the world, on cell proliferation, apoptosis, senescence and the global proteomic profile in human renal cell adenocarcinoma in vitro. 769-P human renal adenocarcinoma cells were cultured on RPMI-1640 media supplemented with fetal bovine serum (10%) and antibiotic-antimycotic solution (1%). Treatment stock solutions were prepared in ethanol. Cell proliferation was tested with phenol red-free media with capsaicin (0–400 μM), dihydrocapsaicin (0–400 μM), capsaicin + dihydrocapsaicin (5:1), and dry Ghost peppers (0–3 g L-1) for 24, 48 and 72 h. Polycaspase and senescence associated-beta-galactosidase (SA-beta-gal) activities were tested with capsaicin (400 μM), dihydrocapsaicin (400 μM), capsaicin (400 μM) + dihydrocapsaicin (80 μM), and ghost pepper (3 g L-1) treatments. Global proteomic profile of cells in control and ghost pepper treatment (3 g L-1) was analyzed after 6 h by a shotgun proteomic approach using tandem mass spectrometry. At 24 h after treatment (24 HAT), relative to control, cell proportion with capsaicin (400 μM), dihydrocapsaicin (400 μM), capsaicin (400 μM) + dihydrocapsaicin (80 μM), and ghost pepper (3 g L-1) treatments was reduced to 36%, 18%, 33% and 20%, respectively, and further reduced at 48 and 72 HAT. All treatments triggered an early polycaspase response. SA-beta-gal activity was normal or suppressed with all treatments. About 68,220 protein isoforms were identified by shotgun proteomic approach. Among these, about 8.2% were significantly affected by ghost pepper. Ghost pepper regulated various proteins involved in intrinsic and extrinsic apoptotic pathways, Ras, Rb/E2F, p53, TGF-beta, WNT-beta catenin, and calcium induced cell death pathways. Ghost pepper also induced changes in proteins related to methylation, acetylation, genome stability, cell cycle check points, carbohydrate, protein and other metabolism and cellular mechanisms. Ghost pepper exhibited antiproliferation activity by inducing apoptosis through a complex network of proteins in human renal cell adenocarcinoma in vitro.
Data from: Collective cell migration without proliferation: density determines cell velocity and wave velocity
Collective cell migration contributes to embryogenesis, wound healing and tumor metastasis. Cell monolayer migration experiments help understanding what determines the movement of cells far from the leading edge. Inhibiting cell proliferation limits cell density increase and prevents jamming; we observe long-duration migration and quantify space-time characteristics of the velocity profile over large length- and time-scales. Velocity waves propagate backwards and their frequency depends only on cell density at the moving front. Both cell average velocity and wave velocity increase linearly with the cell effective radius regardless of the distance to the front. Inhibiting lamellipodia decreases cell velocity while waves either disappear or have a lower frequency. Our model combines conservation laws, monolayer mechanical properties and a phenomenological coupling between strain and polarity: advancing cells pull on their followers which then become polarized. With reasonable values of parameters, this model agrees with several of our experimental observations. Together, our experiments and model disantangle the respective contributions of active velocity and of proliferation in monolayer migration, explain how cells maintain their polarity far from the moving front, and highlight the importance of strain-polarity coupling and density in long-range information propagation.
Data from: Contribution of cell proliferation to axial elongation in the red flour beetle Tribolium castaneum
Most arthropods generate their posterior bodies by adding segments periodically, as the embryo grows, from a posteriorly located region called the segment addition zone. This mode of segmentation is shared with vertebrates and relies on oscillatory mechanisms, where the temporal periodicity of a clock is translated into repetitive spatial patterns. This ordered anterior-to-posterior pattern is achieved at the same time as the tissue elongates, opening the question of the functional coordination between the mechanisms of segmental patterning and posterior growth. The study of these processes in different arthropods has played an important role in unravelling some of the molecular mechanisms of segment formation. However, the behavior of cells during elongation and how cellular processes affect this segmental patterning has been poorly studied. Cell proliferation together with cell rearrangements are presumed to be the major forces driving axis elongation in the red flour beetle Tribolium castaneum. However, there still no strong evidence about the role and distribution of cell proliferation within the embryo. In this study, we propose to address these questions by using whole embryo cultures and pharmacological manipulation. We show that considerable cell proliferation occurs during germband elongation, measured by incorporation of the nucleoside analog of thymidine 5-Ethynyl-2'-deoxyuridine, EdU. Moreover, proliferating cells appeared to be spread along the elongating embryo with a posterior bias at early segmentation. In addition, when we blocked cell division, treated germbands were always shorter than controls and in some cases not able to fully elongate, even when control embryos already started to retract and leg buds are evident. Finally, we found that the absence of cell proliferation has no apparent effect on segmental patterning, as evidenced by Tc-engrailed (Tc-en) gene expression.
Figure 1 in Investigation the effects of vitreous humor on proliferation and dedifferentiation of differentiated NTERA2 cells
Figure 1. Cell count analysis of NT2, NT2-RA and NT2 RA-VH cells at 3 and 9 days after culturing at 6 well plates. NT2 RA-VH cell numbers were increased in comparison to those of the NT2-RA cells. Data represent the mean ± SEM. (a) P <0.05; (b) P <0.01 vs control group, compared with NT2-RA cells.
Figure 3 in Investigation the effects of vitreous humor on proliferation and dedifferentiation of differentiated NTERA2 cells
Figure 3. Flow cytometry analysis to assess the level of TRA-81, SSEA1, and SSEA3 cell surface antigens on NT2, NT2-RA, and NT2-RA cells treated with different concentrations of VH for 6 days. (A) NT2-RA cells treated with 2.5% and 7.5% VH; (B) NT2-RA cells treated with 15% VH.
AEG-1 inhibits proliferation and invasion of colorectal cancer HCT116 cells via the PI3K/AKT/mTOR pathway
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Eupatorin modulates BCPAP in thyroid cancer cell proliferation via suppressing the NF-κB/P13K/AKT signaling pathways
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Figure 1. H&E in Resveratrol-Tempeh reduce micronucleus frequencies bone marrow cells and stimulate osteocyte proliferation in aluminum chloride-induced mice
Figure 1. H&E staining of the femur bone mice. (A) untreated-group, 10X20; (B) Al-treated group 10X10; (C) Al+Res5-treated group, 10X10 and (D) Al+Res10-treated group, 10X10. Green star: Bone trabecular, Blue arrow: osteocytes, Red arrow: empety lacunae.
AEG-1 inhibits proliferation and invasion of colorectal cancer HCT116 cells via the PI3K/AKT/mTOR pathway
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Retroviral transduction, cell proliferation assay and myeloid colony formation assay
<p><strong>Retroviral </strong><strong>t</strong><strong>ransduction</strong><strong>, cell proliferation assay </strong><strong>and </strong><strong>m</strong><strong>yeloid </strong><strong>c</strong><strong>olony </strong><strong>f</strong><strong>ormation </strong><strong>a</strong><strong>ssay</strong></p>
Fig. 1 in Effects of Roscovitine on Schedule of Divisional Morphogenesis, Basal Bodies Proliferation and Cell Divisions in Tetrahymena thermophila
Fig. 1. Divisional morphogenesis and cytokinesis in untreated (control) T. thermophila. Cells were immunostained with the anti-centrin 20H5 antibody. A–F' stomatogenesis, stages I–VI; G–H cytokinesis. AF – an anarchic field, ARF – parental apical ring of filaments, mARF material for new ARF localised on in the proximal ends (couplets of BBs) of cortical rows in opisthe cell, FZ – fission zone, OA1 and OA2 – parental and new oral apparatuses, OC – parental oral crescent, nOC – new oral crescents in both daughter cells. Bar: 10 µm for A–H.
Fig. 11 in Effects of Roscovitine on Schedule of Divisional Morphogenesis, Basal Bodies Proliferation and Cell Divisions in Tetrahymena thermophila
Fig. 11. Cortical structures of T. thermophila immunogoldlabelled with anti-cdc14A antibody. A – longitudinal section of the ciliated basal body; B – transversal section of the fragment of the cortical row; C – section at the level of basal bodies of oral membranelle. Kt – kinetodesmal fiber, pc – postciliary microtubules, arrowhead – filamentous material. Bar: 1 μm.
Fig. 3 in Effects of Roscovitine on Schedule of Divisional Morphogenesis, Basal Bodies Proliferation and Cell Divisions in Tetrahymena thermophila
Fig. 3. Divisional morphogenesis and cytokinesis in T. thermophila after 5.5 h treatment with roscovitine. Cells were immunostained with the anti-centrin 20H5 antibody. A–C – stage VI of divisional morphogenesis; D–F' – cytokinesis; A and A' – ventral and dorsal views of the same cell. Other explanations as in Fig. 1. Bar in F': 10 µm for A–F'.
CircRPPH1 promotes cell proliferation, migration and invasion of non-small cell lung cancer (NSCLC) via the PI3K/AKT and JAK2/STAT3 signaling axes
<p>original numerical data before creating graphs</p>
Ascorbic acid ameliorates corneal endothelial dysfunction and enhances cell proliferation via the noncanonical GLUT1-ERK axis
<p>The datasets supporting the conclusions of the article submitting.</p>
Figure 1 in The study of exposure times and dose-escalation of tick saliva on mouse embryonic stem cell proliferation
Figure 1. Effect of H. marginatum SGE (0-160 µg/ml) on mouse embryonic stem cell proliferation and viability. Values represent relative fold change of cell viability normalized to untreated negative control. The Geisser –Greenhouse correction and Dunnett´s test on multiple comparison were used. The results are mean ± standard deviation (SD) from a representative experiment carried out in triplicate and were seeded in equal amount in 3 different 96 -well cultured plates.
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Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.