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103 results for “DUX4”
CIC-DUX4 chromatin prolfiling reveals new epigenetic dependencies and actionable therpaeutic targets in CIC-rearranged sarcomas
<p>CIC-DUX4-rearranged sarcoma (CDS) is a rare and aggressive soft tissue tumor that occurs most frequently in young adults. The key oncogenic driver of this disease is the expression of the CIC-DUX4 fusion protein as a result of chromosomal rearrangements. CIC-DUX4 displays chromatin binding properties, and is therefore believed to function as an aberrant transcription factor. However, the chromatin remodeling events induced by CIC-DUX4 are not well understood, limiting our ability to identify new mechanism-based therapeutic strategies for these patients. Here we generated a genome wide profile of CIC-DUX4 DNA occupancy and associated chromatin states in human CDS cell models and primary tumors. Combining chromatin profiling, proximity ligation assays, as well as genetic and pharmacological perturbations, we show that CIC-DUX4 operates as a potent transcriptional activator at its binding sites. This property is in contrast with the repressive function of the wild type CIC protein, and is mainly mediated through the direct interaction of CIC-DUX4 with the acetyltransferase p300. In keeping with this, we show p300 to be essential for CDS tumor cell proliferation, and its pharmacological inhibition to significantly impact tumor growth in vitro and in vivo. Taken together, our study elucidates the mechanisms underpinning CIC-DUX4-mediated transcriptional regulation and suggests a potential therapeutic approach for the clinical management of CDS patients. </p>
Allelic specificity of IGH-DUX4 translocation in acute lymphoblastic leukemia (ALL) [H3K27Ac HiChIP]
GEO Series GSE115492. Homo sapiens. 1 samples. Type: Genome binding/occupancy profiling by high throughput sequencing.
Conserved roles for murine mDUX and human DUX4 in activating cleavage stage genes and MERVL/HERVL retrotransposons [RNA-Seq Mouse]
GEO Series GSE85627. Mus musculus. 12 samples. Type: Expression profiling by high throughput sequencing.
P38α Regulates Expression of DUX4 in Facioscapulohumeral Muscular Dystrophy
GEO Series GSE153301. Homo sapiens. 12 samples. Type: Expression profiling by high throughput sequencing.
DNA virus infections shape transposable element activity in vitro and in vivo (DUX4 knockout)
GEO Series GSE287622. Homo sapiens. 32 samples. Type: Expression profiling by high throughput sequencing.
DUX4 induces a homogeneous sequence of molecular changes, culminating in cellular apoptosis
GEO Series GSE156154. Homo sapiens. 10 samples. Type: Expression profiling by high throughput sequencing.
DUX4 orchestrates translational reprograming by broadly suppressing translation efficiency [Ribo-seq]
GEO Series GSE206437. Homo sapiens. 12 samples. Type: Other.
Next generation sequencing to reveal the transcriptome of a DUX4 inducible FSHD model
GEO Series GSE154649. Homo sapiens. 20 samples. Type: Expression profiling by high throughput sequencing.
DNA virus infections shape transposable element activity in vitro and in vivo (HCMV,KSHV,DUX4)
GEO Series GSE280380. Homo sapiens. 54 samples. Type: Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing.
A genome-wide CRISPR/Cas phenotypic screen for modulators of DUX4 cytotoxicity reveals screen complications
GEO Series GSE155034. synthetic construct; Homo sapiens. 6 samples. Type: Other.
Cup-like nuclei is a hallmark of IGH:DUX4 acute lymphoblastic leukemia and reveals cytoplasmic mitochondria accumulation
GEO Series GSE288566. Homo sapiens. 57 samples. Type: Expression profiling by high throughput sequencing.
Chronic rare DUX4 expression in mouse drives transcriptional similarities to human FSHD in whole muscle and fibroadiopgenic progenitors
GEO Series GSE141562. Mus musculus. 32 samples. Type: Expression profiling by high throughput sequencing.
Herpesviral induction of germline transcription factor DUX4 is critical for viral gene expression
GEO Series GSE174759. Homo sapiens. 30 samples. Type: Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing.
Hit-and-run silencing of endogenous DUX4 by targeting DNA hypomethylation on D4Z4 repeats in facioscapulohumeral muscular dystrophy [RNA-seq]
GEO Series GSE201178. Homo sapiens. 4 samples. Type: Expression profiling by high throughput sequencing.
DUX4 promotes mitochondrial impairment in skeletal muscle
GEO Series GSE138768. Homo sapiens. 8 samples. Type: Expression profiling by high throughput sequencing.
DUX4 orchestrates translational reprograming by broadly suppressing translation efficiency [RNA-seq]
GEO Series GSE206438. Homo sapiens. 12 samples. Type: Expression profiling by high throughput sequencing.
H4K20me3 erasure facilitates reprogramming to totipotent-like state by promoting DUX4 mediated transcription [ChIP-Seq]
GEO Series GSE287565. Homo sapiens. 3 samples. Type: Genome binding/occupancy profiling by high throughput sequencing.
The transcription factor DUX4 orchestrates translational reprogramming by broadly suppressing translation efficiency and promoting expression of DUX4-induced mRNAs
GEO Series GSE206439. Homo sapiens. 48 samples. Type: Other; Expression profiling by high throughput sequencing.
H4K20me3 erasure facilitates reprogramming to totipotent-like state by promoting DUX4 mediated transcription [RNA-Seq]
GEO Series GSE287564. Homo sapiens. 12 samples. Type: Expression profiling by high throughput sequencing.
Hit-and-run silencing of endogenous DUX4 by targeting DNA hypomethylation on D4Z4 repeats in facioscapulohumeral muscular dystrophy
GEO Series GSE201185. Homo sapiens. 11 samples. Type: Methylation profiling by genome tiling array; Expression profiling by high throughput sequencing.
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