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Dataset results
172 results for “Engineering studies”
Transcripts for the "What is Token Engineering? A stakeholder study" publication
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Molecular basis for the increased affinity of an RNA recognition motif with re-engineered specificity: A molecular dynamics and enhanced sampling simulations study- PART 6
<p>Trajectories and input files of the simulations of the S151T Rbfox*·pre-miR20b* system.</p>
Molecular basis for the increased affinity of an RNA recognition motif with re-engineered specificity: A molecular dynamics and enhanced sampling simulations study- PART 1
<p>Simulations of the Rbfox protein.</p> <p> </p>
An Exploratory Empirical Study of Trust & Safety Engineering in Open-Source Social Media Platforms
<p>*</p>
SedLine Engineering Data Collection Study in Pediatric Patients Undergoing General Anesthesia or Sedation
ClinicalTrials.gov study NCT03128931. IPD Sharing: NO. Countries: 1. Publications: 0.
The Intrepid Clinical Engineering Study
ClinicalTrials.gov study NCT05636332. IPD Sharing: NO. Countries: 1. Publications: 0.
Safety Study of Adenovirus Vector Engineered to Express hIL-12 in Combination With Activator Ligand to Treat Melanoma
ClinicalTrials.gov study NCT01397708. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Efficacy Study on the Strategy of HSV-Tk Engineering Donor Lymphocytes to Treat Patients With High Risk Acute Leukemia
ClinicalTrials.gov study NCT00914628. IPD Sharing: NO. Countries: 10. Publications: 0.
Genetically Engineered HSV-1 Phase 1 Study for the Treatment of Recurrent Malignant Glioma
ClinicalTrials.gov study NCT02062827. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Data from: Interactive effects between physical forces and ecosystem engineers on seed burial: a case study using Spartina anglica
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Data from: Experimental study on diesel engine EGR performance and Optimum EGR Rate Determination Method
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Immune responses to the in vitro LPS assault engineered in the spaceflight multi-omics study
Microgravity alters the immune response to in vitro LPS assault engineered in spaceflight: A multi-omics study Microgravity can facilitate creation of a potent environment for opportunistic infection by augmenting virulence and suppressing the host defense. Presumably extraterrestrial infection may trigger potentially novel bionetworks different from the terrestrial equivalent which could only be probed by investigating the host-pathogen relationship with minimum terrestrial bias. Towards this objective we strategically engineered a cell culture module equipped with a feedback controlled semi-automated platform to expose human endothelial cells to lipopolysaccharide (LPS). The assay was carried out in the STS-135 space shuttle and a concurrent ground study constituted the baseline. Transcriptomic investigation revealed an immune blunting in microgravity; Lbp MyD88 and MD-2 failed to encode proteins responsible for early LPS uptake. Longer exposure results implied that there was a delayed response potentially ineffectual in preventing pathogens from opportunistically modulating the infection network. Lack of recruitment of growth factors and a debilitated apoptosome supported this potential explanation. Certain cytokines such as IL-6 and IL-8 surged in response to LPS insult in microgravity. Contrasting expressions of B2M TIMP-1 and VEGRs suggested impaired pro-survival adaptation and healing mechanisms. The susceptibility of oxidative stress and immune regulation to microgravity compelled further investigation of the respective microRNA modulators such as miR-200a and miR-146b. These miRNAs were expressed differently in response to LPS assaults in different gravitational limits. In conclusion despite a serious drawback attributed to the small sample size we delineated some of the important aspects of the extraterrestrial etiology; more comprehensive follow up studies are warranted. Present study though compromised by the small sample size was able to shade lights on several aspects of immunological responses to the endotoxic assault mediated by uG. Implementing the host-pathogen interactions in the spaceflight and subsequently lysing the cells onboard presented the critical distinguishing features of the present study from the past reports. We identified the CCM of Tissue Genesis Inc. HI as the suitable hardware system to carry out the experiment in the spaceflight. CCM is an automated feedback controlled module that can concurrently support 24 bioreactors following protocols exclusively programmed for individual bioreactor. For this experiment we use samples EA41 EA 47 EA45 and EA155 that were exposed to LPS for 4 hours. Samples EA123 EA165 EA127 EA126 were exposed to LPS for 8Hrs. Samples EA33 EA 125 EA79 and EA 39 were controls in this experiment.
Large-scale genomic study reveals robust activation of the immune system following advanced Inner Engineering meditation retreat
GEO Series GSE174083. Homo sapiens. 388 samples. Type: Expression profiling by high throughput sequencing.
The tissue-engineered human cornea as a model to study expression of matrix metalloproteinases during corneal wound healing
GEO Series GSE75336. Homo sapiens. 27 samples. Type: Expression profiling by array.
Tissue-engineered bone tumor as a reproducible human in vitro model for studies of anti-cancer drugs
GEO Series GSE135323. Homo sapiens. 132 samples. Type: Expression profiling by high throughput sequencing.
Endothelium muscle-specificity induction and fibroblast recruitment in engineered 3D human muscle environment for the study of fibrosis
GEO Series GSE122046. Homo sapiens. 5 samples. Type: Expression profiling by array.
Immune responses to the in vitro LPS assault engineered in the spaceflight multi-omics study
GEO Series GSE54213. Homo sapiens. 12 samples. Type: Expression profiling by array.
Endovascular Engineering ENGULF Study
ClinicalTrials.gov study NCT05597891. IPD Sharing: NO. Countries: 1. Publications: 0.
The Heidelberg Engineering ANTERION Imaging Agreement Study
ClinicalTrials.gov study NCT04068818. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Biovitals Analytics Engine - Altitude Study
ClinicalTrials.gov study NCT03661606. IPD Sharing: NO. Countries: 1. Publications: 0.
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Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.