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129
datasets available to search
ShareScore release 0.9.0
Dataset results
129 results for “Gain-of-Function”
EZH2 gain-of-function mutations distort H3K27me3 landscapes and transform transcriptional responses to PRC2 inhibition.
GEO Series GSE218717. Homo sapiens; Mus musculus. 244 samples. Type: Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing; Other.
Heterozygous OAS1 Gain-of-Function Variants Cause a Polymorphic Autoinflammatory and Immunodeficiency Syndrome
GEO Series GSE173667. Homo sapiens. 31 samples. Type: Expression profiling by high throughput sequencing.
The Gain-of-Function TREM2-T96K Mutation Increases Risk for Alzheimer’s Disease by Impairing Microglial Function [scRNA-Seq]
GEO Series GSE307686. Mus musculus. 15 samples. Type: Expression profiling by high throughput sequencing.
bHLH transcription factor ATOH8 overexpression effect on endothelial cells: gain-of-function model [GOF]
GEO Series GSE104683. Homo sapiens. 2 samples. Type: Expression profiling by array.
The Tsk2/+ mouse fibrotic phenotype is due to a gain-of-function mutation in the PIIINP segment of the Col3a1 gene
GEO Series GSE61728. Mus musculus. 14 samples. Type: Expression profiling by array.
Genetic screen for suppressors of lncRNA-mediated transcription interference identifies a gain-of-function mutation in the essential Pol2 termination factor Seb1
GEO Series GSE168898. Schizosaccharomyces pombe. 6 samples. Type: Expression profiling by high throughput sequencing.
Phrenic neuron determinant gain-of-function screen in M. musculus ES cell-derived motor neurons
GEO Series GSE45808. Mus musculus. 72 samples. Type: Expression profiling by array.
The Gain-of-Function TREM2-T96K Mutation Increases Risk for Alzheimer’s Disease by Impairing Microglial Function
GEO Series GSE307564. Mus musculus. 44 samples. Type: Expression profiling by high throughput sequencing.
A gain-of-function single nucleotide variant creates a new promoter which acts as an orientation-dependent enhancer-blocker (ChIP-seq)
GEO Series GSE159872. Homo sapiens. 67 samples. Type: Genome binding/occupancy profiling by high throughput sequencing.
RNA-seq analysis of Arabidopsis ATAF2 loss- and gain-of-function mutants
GEO Series GSE172328. Arabidopsis thaliana. 9 samples. Type: Expression profiling by high throughput sequencing.
A gain-of-function single nucleotide variant creates a new promoter which acts as an orientation-dependent enhancer-blocker (ATAC-seq)
GEO Series GSE159871. Homo sapiens. 28 samples. Type: Genome binding/occupancy profiling by high throughput sequencing.
Exploiting orthologue diversity for systematic detection of gain-of-function phenotypes
GEO Series GSE11721. Canis lupus familiaris; Mus musculus. 7 samples. Type: Expression profiling by array.
A Stat1 gain-of-function mutant disrupts normal Stat4 innate lymphocyte programs during viral infection [CUT&Tag]
GEO Series GSE284322. Mus musculus. 14 samples. Type: Genome binding/occupancy profiling by high throughput sequencing.
A gain-of-function single nucleotide variant creates a new promoter which acts as an orientation-dependent enhancer-blocker (RNA-seq)
GEO Series GSE159873. Homo sapiens. 34 samples. Type: Expression profiling by high throughput sequencing.
Root hair specific transcriptome analysis of gain-of-function and loss-of-function of GTL1 and DF1
GEO Series GSE103917. Arabidopsis thaliana. 18 samples. Type: Expression profiling by array.
Sex and mutation specific p53 gain-of-function activity in gliomagenesis [ChIP-seq]
GEO Series GSE188708. Mus musculus. 30 samples. Type: Genome binding/occupancy profiling by high throughput sequencing.
STAT5 Gain-of-Function Mutations Promote Precursor T-Cell Receptor Activation to Drive Immature T-Lymphoblastic Leukemia or Lymphoma
GEO Series GSE219155. Homo sapiens. 12 samples. Type: Genome binding/occupancy profiling by high throughput sequencing.
Interferon signature in patients with STAT1 gain-of-function mutation is epigenetically determined
GEO Series GSE120580. Homo sapiens. 10 samples. Type: Genome binding/occupancy profiling by high throughput sequencing.
Gain-of-function MUC5B Promoter Variant, Strongly Linked to Idiopathic Pulmonary Fibrosis, Defines an Epigenetically Poised Enhancer (ATAC-seq)
GEO Series GSE157606. Homo sapiens. 10 samples. Type: Genome binding/occupancy profiling by high throughput sequencing.
Expression data from salivary tumor tissues derived from MMTV-ras transgenic mice with wild-type p53, no p53 or gain-of-function mutant p53
GEO Series GSE59452. Mus musculus. 12 samples. Type: Expression profiling by array.
ScienceDex guides
Understand access before you commit
These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.