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ShareScore release 0.9.0
Dataset results
110 results for “Hydroxylase”
Genome-wide Regulation of 5hmC, 5mC and Gene Expression by Tet1 Hydroxylase in Mouse Embryonic Stem Cells (expression data)
GEO Series GSE28530. Mus musculus. 5 samples. Type: Expression profiling by array.
Fig. 6. The V19H four-point mutant retained V19H activity and gained T3O-like activity. Recombinant yeast expressing different V19H in Site directed mutagenesis of Catharanthus roseus (+)-vincadifformine 19-hydroxylase (CYP71BY3) results in two distinct enzymatic functions
Fig. 6. The V19H four-point mutant retained V19H activity and gained T3O-like activity. Recombinant yeast expressing different V19H mutants were incubated with (+)-vincadifformine (15) (A) or with ()-tabersonine (1) (B) and reaction products were submitted to UPLV-MS analysis. Traces from yeast expressing the V19H single mutants (orange), from top to bottom, are V19H-L106R, V19H–S312T, V19H-A376P, and V19H–F377L. Traces from yeast expressing the V19H double mutant (pink) is V19H- A376P–F377L, and the 4-point mutant (red) is V19HL106R–S312T-A376P–F377L. Yeast expressing wildtype V19H (green) and wild-type T3O (blue) were used as positive controls for (+)-minovincinine (15) (A) and tabersonine-2,3-epoxide (5) (B) biosynthesis. All V19H mutants retain V19H activity, producing (+)-minovincinine (16) from (+)-vincadifformine (15) (A: orange, pink, and red), but the V19H 4-point mutant gained T3O-like activity, producing tabersonine-2,3-epoxide (5) from ()-tabersonine (1) (B: red). V19H: (+)-vincadifformine 19-hydroxylase; T3O: tabersonine 3-oxygenase. (For interpretation of the references to colour in this figure legend, the reader is referred to the Web version of this article.)
Tyrosine Hydroxylase Antibody Levels in Autoimmune Polyglandular Syndrome Type 1 Associated Keratitis
ClinicalTrials.gov study NCT04375852. IPD Sharing: NO. Countries: 0. Publications: 0.
Effects of gene-by-environment interaction on the transcriptome and methylome of mice deficient for tryptophan hydroxylase 2
GEO Series GSE110330. Mus musculus. 96 samples. Type: Expression profiling by high throughput sequencing; Methylation profiling by high throughput sequencing.
Interleukin-33 induces the enzyme tryptophan hydroxylase 1 to promote inflammatory group 2 innate lymphoid cell-mediated immunity
GEO Series GSE145289. Mus musculus. 26 samples. Type: Expression profiling by high throughput sequencing.
Cholesterol 25-hydroxylase mediates neuroinflammation and neurodegeneration in a mouse model of tauopathy
GEO Series GSE250277. Mus musculus. 16 samples. Type: Expression profiling by high throughput sequencing.
Gene expression profiling in mice with the depletion of prolyl hydroxylase domain proteins in endothelial cells
GEO Series GSE118082. Mus musculus. 8 samples. Type: Expression profiling by high throughput sequencing.
Inhibition of prolyl hydroxylase promotes the reprogramming of Sox9+ renal progenitor cells and renal regeneration
GEO Series GSE247560. Mus musculus. 6 samples. Type: Expression profiling by high throughput sequencing.
Prolyl Hydroxylase Substrate Adenylosuccinate Lyase Is An Oncogenic Driver In Triple Negative Breast Cancer
GEO Series GSE136414. Homo sapiens. 9 samples. Type: Expression profiling by high throughput sequencing.
Prolyl-4-hydroxylase domain 3 (PHD3) is a critical terminator for cell survival of macrophages under stress conditions
GEO Series GSE55693. Mus musculus. 18 samples. Type: Expression profiling by array.
Maternal sterol 27-hydroxylase is crucial for securing fetal development
GEO Series GSE247494. Mus musculus. 4 samples. Type: Expression profiling by high throughput sequencing.
DNA methylation of a novel regulatory element within the tyrosine hydroxylase gene (TH) is dysregulated by chronic cocaine dependence in the human striatum
GEO Series GSE182585. Homo sapiens. 58 samples. Type: Methylation profiling by high throughput sequencing.
Biosynthesis of oxyresveratrol in mulberry (Morus alba L.) is mediated by a group of p-coumaroyl-CoA 2'-hydroxylases acting upstream of stilbene synthases
GEO Series GSE261571. Morus alba. 35 samples. Type: Expression profiling by high throughput sequencing.
HIF Prolyl Hydroxylase Inhibition Protects Skeletal Muscle from Contraction-Induced Injury
GEO Series GSE95244. Mus musculus. 72 samples. Type: Expression profiling by array.
Microarray data from ferulate/coniferaldehyde 5-hydroxylase F5H Arabidopsis mutant lines
GEO Series GSE106691. Arabidopsis thaliana. 8 samples. Type: Expression profiling by array.
Molecular dynamics simulation data of regulatory ACT domain dimer mutation (A47V) of human phenylalanine hydroxylase (PAH)
<p>Raw data of molecular dynamics simulations of regulatory ACT domain dimer mutation (A47V).</p> <p><strong>binding.zip</strong>: simulation of dimer with 19 Phe ligand </p> <p><strong>bound.zip</strong>: simulation of dimer with bound Phe ligand</p> <p><strong>dimer.zip</strong>: simulation of dimer only</p> <p>Simulation setup files are also included in each folder.</p>
Molecular dynamics simulation data of regulatory ACT domain dimer mutation (G46S) of human phenylalanine hydroxylase (PAH)
<p>Raw data of molecular dynamics simulations of regulatory ACT domain dimer mutation (G46S).</p> <p><strong>binding.zip</strong>: simulation of dimer with 19 Phe ligand </p> <p><strong>bound.zip</strong>: simulation of dimer with bound Phe ligand</p> <p><strong>dimer.zip</strong>: simulation of dimer only</p> <p>Simulation setup files are also included in each folder.</p>
Molecular dynamics simulation data of regulatory ACT domain dimer mutation (F55L) of human phenylalanine hydroxylase (PAH)
<p>Raw data of molecular dynamics simulations of regulatory ACT domain dimer mutation (F55L).</p> <p><strong>binding.zip</strong>: simulation of dimer with 19 Phe ligand </p> <p><strong>bound.zip</strong>: simulation of dimer with bound Phe ligand</p> <p><strong>dimer.zip</strong>: simulation of dimer only</p> <p>Simulation setup files are also included in each folder.</p>
Molecular dynamics simulation data of regulatory ACT domain dimer mutation (F39L) of human phenylalanine hydroxylase (PAH)
<p>Raw data of molecular dynamics simulations of regulatory ACT domain dimer mutation (F39L).</p> <p><strong>binding.zip</strong>: simulation of dimer with 19 Phe ligand </p> <p><strong>bound.zip</strong>: simulation of dimer with bound Phe ligand</p> <p><strong>dimer.zip</strong>: simulation of dimer only</p> <p>Simulation setup files are also included in each folder.</p>
Molecular dynamics simulation data of regulatory ACT domain dimer mutation (D59Y) of human phenylalanine hydroxylase (PAH)
<p>Raw data of molecular dynamics simulations of regulatory ACT domain dimer mutation (D59Y).</p> <p><strong>binding.zip</strong>: simulation of dimer with 19 Phe ligand </p> <p><strong>bound.zip</strong>: simulation of dimer with bound Phe ligand</p> <p><strong>dimer.zip</strong>: simulation of dimer only</p> <p>Simulation setup files are also included in each folder.</p>
ScienceDex guides
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These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.