Find research datasets worth reusing
Search datasets from major research repositories and use ShareScore to quickly assess how well each record supports discovery, access, and reuse.
448
datasets available to search
ShareScore release 0.9.0
Dataset results
448 results for “Infection risk”
Data from: Recolonizing grey wolves increase parasite infection risk in their prey
The recent recolonization of Central Europe by the European grey wolf (Canis lupus) provides an opportunity to study the dynamics of parasite transmission for cases when a definitive host returns after a phase of local extinction. We investigated whether a newly established wolf population increased the prevalence of those parasites in ungulate intermediate hosts representing wolf prey, whether some parasite species are particularly well adapted to wolves, and the potential basis for such adaptations. We recorded Sarcocystis species richness in wolves and Sarcocystis prevalence in ungulates harvested in study sites with and without permanent wolf presence in Germany using microscopy and DNA metabarcoding. Sarcocystis prevalence in red deer (Cervus elaphus) was significantly higher in wolf areas (79.7%) than in control areas (26.3%) but not in roe deer (Capreolus capreolus) (97.2% vs. 90.4%) or wild boar (Sus scrofa) (82.8% vs. 64.9%). Of 11 Sarcocystis species, S. taeniata and S. grueneri occurred more often in wolves than expected from the Sarcocystis infection patterns of ungulate prey. Both Sarcocystis species showed a higher increase in prevalence in ungulates in wolf areas than other Sarcocystis species, suggesting that they are particularly well adapted to wolves, and are examples of 'wolf specialists'. Sarcocystis species richness in wolves was significantly higher in pups than in adults. 'Wolf specialists' persisted during wolf maturation. The results of this study demonstrate that (1) predator–prey interactions influence parasite prevalence, if both predator and prey are part of the parasite life cycle, (2) mesopredators do not necessarily replace the apex predator in parasite transmission dynamics for particular parasites of which the apex predator is the definitive host, even if meso– and apex predators were from the same taxonomic family (here: Canidae, e.g. red foxes Vulpes vulpes), and (3) age–dependent immune maturation contributes to the control of protozoan infection in wolves.
Data from: Small-scale spatial variation in infection risk shapes the evolution of a Borrelia resistance gene in wild rodents
Spatial variation in pathogen-mediated selection is predicted to influence the evolutionary trajectory of host populations and lead to spatial variation in their immunogenetic composition. However, to date few studies have been able to directly link small-scale spatial variation in infection risk to host immune gene evolution in natural, non-human populations. Here we use a natural rodent-Borrelia system to test for associations between landscape-level spatial variation in Borrelia infection risk along replicated elevational gradients in the Swiss Alps and Toll-like receptor 2 (TLR2) evolution, a candidate gene for Borrelia resistance, across bank vole (Myodes glareolus) populations. We found that Borrelia infection risk (i.e. the product of Borrelia prevalence in questing ticks and the average tick load of voles at a sampling site) was spatially variable and significantly negatively associated with elevation. Across sampling sites, Borrelia prevalence in bank voles was significantly positively associated with Borrelia infection risk along the elevational clines. We observed a significant association between naturally occurring TLR2 polymorphisms in hosts and their Borrelia infection status. The TLR2 variant associated with a reduced likelihood of Borrelia infection was most common in rodent populations at lower elevations that face a high Borrelia infection risk, and its frequency changed in accordance with the change in Borrelia infection risk along the elevational clines. These results suggest that small-scale spatial variation in parasite-mediated selection affects the immunogenetic composition of natural host populations, providing a striking example that the microbial environment shapes the evolution of the host's immune system in the wild.
Data from: Parasitized mates increase infection risk for partners
Individuals can gain fitness benefits and costs through their mates. However, studies on sexual selection have tended to focus on genetic benefits. A potentially widespread cost of pairing with a parasitized mate is that it will increase an individual's parasite abundance. Such a cost has been overlooked in systems where parasites are indirectly transmitted. We manipulated the abundance of the nematode parasite Trichostrongylus tenuis, an indirectly transmitted parasite, within pairs of wild red grouse Lagopus lagopus scoticus in spring. Parasite levels were correlated within pairs before the experiment. We removed parasites from either males, females, or both members of the pair, and evaluated individual parasite uptake over the subsequent breeding period. At the end of the breeding season, an individual's parasite abundance was greater when its mate had not been initially purged of parasites. This cost appeared greater for males. We discuss the implications of our results in relation to the costs that parasites may have on sexual selection processes.
Pharmacokinetics, Safety, and Tolerability of Intravenous Posaconazole Solution Followed by Oral Posaconazole Suspension in Subjects at High Risk for Invasive Fungal Infections (P05520)
ClinicalTrials.gov study NCT01075984. IPD Sharing: YES. Countries: 0. Publications: 2.
Transfer of Infection Fighting Immune Cells Generated in the Laboratory to High Risk Patients With COVID-19 Infection
ClinicalTrials.gov study NCT04765449. IPD Sharing: NO. Countries: 1. Publications: 1.
Evaluation of Multisite Sampling to Detect C. Trachomatis or N. Gonorrheae Compared With Vaginal Sampling in Women at Risk for Sexually Transmitted Infections
ClinicalTrials.gov study NCT05872438. IPD Sharing: Not stated. Countries: 1. Publications: 5.
Pre-hospital Risk Factors for Invasive Fungal Infection
ClinicalTrials.gov study NCT01315925. IPD Sharing: Not stated. Countries: 1. Publications: 6.
Mobile Outreach Screening of High-Risk Human Papillomavirus Infection in Women with Limited Access to Health Services in Seine-Saint-Denis (greater Paris Area, France)
ClinicalTrials.gov study NCT06656611. IPD Sharing: UNDECIDED. Countries: 1. Publications: 2.
When Closing Midline Incisions, do Small Stitches Reduce the Risk for Incisional Hernia, Wound Infection or Dehiscence?
ClinicalTrials.gov study NCT00508053. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Reducing Visitors- and Personnel-associated Infection Risk on Perinatal Care Station
ClinicalTrials.gov study NCT03032887. IPD Sharing: UNDECIDED. Countries: 1. Publications: 4.
Comparison of 5-ALA Photodynamic Therapy and CO2 Laser for Treating Persistent Low-Grade Cervical Lesions With High-Risk HPV Infection
ClinicalTrials.gov study NCT06052033. IPD Sharing: NO. Countries: 1. Publications: 10.
Incidence and Risk Factors for Surgical Site Infection After Intramedullary Nailing of Femoral and Tibial Fractures
ClinicalTrials.gov study NCT03148067. IPD Sharing: NO. Countries: 0. Publications: 23.
Risk of Aspergillus Infection in Patients With Chronic Lung Disease
ClinicalTrials.gov study NCT06379568. IPD Sharing: UNDECIDED. Countries: 1. Publications: 1.
HIV Infection and Risk Related Coinfections/Comorbidities in Indonesia
ClinicalTrials.gov study NCT03663920. IPD Sharing: NO. Countries: 1. Publications: 1.
Cardiovascular Risk Factor Management in HIV Infection
ClinicalTrials.gov study NCT00264394. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Management Practices and the Risk of Infection Following Cardiac Surgery
ClinicalTrials.gov study NCT01089712. IPD Sharing: Not stated. Countries: 2. Publications: 2.
DEFLAGYN® Vaginal Gel and Spontaneous Remission and Regression of Unclear Cervical Smears and HPV High-risk Infections
ClinicalTrials.gov study NCT05509413. IPD Sharing: YES. Countries: 1. Publications: 12.
PancRea: Risk Factors and Outcomes of Infected Pancreatic Necrosis
ClinicalTrials.gov study NCT03253861. IPD Sharing: Not stated. Countries: 0. Publications: 1.
A Phase I Study of Modified Vaccinia Virus Ankara (MVA-B) in Healthy Volunteers at Low Risk of HIV Infection
ClinicalTrials.gov study NCT00679497. IPD Sharing: Not stated. Countries: 1. Publications: 1.
no Antibiotics for Elective Cesarean With Low Risk of Infection
ClinicalTrials.gov study NCT02126228. IPD Sharing: Not stated. Countries: 1. Publications: 1.
ScienceDex guides
Understand access before you commit
These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.