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ShareScore release 0.9.0
Dataset results
97 results for “Neurofibroma”
Feasibility and Tolerability of IMLYGIC for the Treatment of Cutaneous Neurofibromas in Adults With NF1
ClinicalTrials.gov study NCT07102394. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Atypical Neurofibromas reveal distinct epigenetic features with proximity to benign peripheral nerve sheath tumor entities
GEO Series GSE216262. Homo sapiens. 40 samples. Type: Methylation profiling by array; Methylation profiling by genome tiling array.
Cxcr3 expressing leukocytes are necessary for neurofibroma formation in mice
GEO Series GSE122730. Mus musculus. 1 samples. Type: Expression profiling by high throughput sequencing.
Unraveling the Development of Cutaneous Neurofibromas in Neurofibromatosis Type 1
GEO Series GSE289794. Mus musculus. 25 samples. Type: Expression profiling by high throughput sequencing.
Genome-wide gene expression analysis of neurofibroma-derived NF1+/- and NF1-/- Schwann cells
GEO Series GSE32029. Homo sapiens. 36 samples. Type: Expression profiling by array.
Differential expression in wild-type and mutant neurofibroma and MPNST cell lines
GEO Series GSE118185. Homo sapiens. 16 samples. Type: Expression profiling by high throughput sequencing.
Gene expression profiling of malignant peripheral nerve sheath tumors (MPNSTs) and benign neurofibroma tissue samples.
GEO Series GSE241224. Homo sapiens. 79 samples. Type: Expression profiling by array.
Combined CDK4/6 and ERK1/2 inhibition enhances anti-tumor activity in NF1-associated plexiform neurofibroma
GEO Series GSE213789. Mus musculus. 36 samples. Type: Expression profiling by high throughput sequencing.
MicroRNA expression profiles in plexiform neurofibromas and malignant peripheral nerve sheath tumors derived from the same neurofibromatosis type 1 patient
GEO Series GSE140913. Homo sapiens. 18 samples. Type: Expression profiling by RT-PCR.
Cxcr3 expressing leukocytes are necessary for neurofibroma formation in mice
GEO Series GSE122999. Mus musculus. 23 samples. Type: Expression profiling by array.
Expression data of three sets of cells: (1) Schwann cells and macrophages from 1m-old WT DRG, (2) Schwann cells (Nf1-/-) and macrophages (Nf1+/+) from 1m-old neurofibroma, (3) Schwann cells (Nf1-/-) a
GEO Series GSE78901. Mus musculus. 23 samples. Type: Expression profiling by array.
Cdkn2a loss in a model of neurofibroma demonstrates stepwise tumor progression to atypical neurofibroma and MPNST
GEO Series GSE148249. Mus musculus. 20 samples. Type: Expression profiling by high throughput sequencing.
Neurofibroma
GEO Series GSE118186. Homo sapiens. 18 samples. Type: Genome binding/occupancy profiling by high throughput sequencing; Expression profiling by high throughput sequencing.
Efficacy and Safety of Tunlametinib in Adults with Inoperable Neurofibromatosis Type 1-Associated Plexiform Neurofibromas: A Single Arm, Open-label Phase IIa Trial and Biomarker Research
GEO Series GSE317549. Homo sapiens. 6 samples. Type: Expression profiling by high throughput sequencing.
Selumetinib in adults with NF1 and inoperable plexiform neurofibroma
GEO Series GSE277520. Homo sapiens. 47 samples. Type: Expression profiling by high throughput sequencing.
Combined CDK inhibition overcomes MEK inhibitor resistance in plexiform neurofibroma of neurofibromatosis type I
GEO Series GSE173577. Homo sapiens. 12 samples. Type: Expression profiling by high throughput sequencing.
Low mutation burden and frequent loss of CDKN2A/B and SMARCA2, but not PRC2, define pre-malignant neurofibromatosis type 1-associated atypical neurofibromas
Neurofibromatosis type 1 (NF1) is a tumor-predisposition disorder caused by germline mutations in NF1. NF1 patients have an 8-16% lifetime risk of developing a malignant peripheral nerve sheath tumor (MPNST), a highly aggressive soft-tissue sarcoma, often arising from pre-existing benign plexiform neurofibromas (PN) and atypical neurofibromas (ANF). ANF are distinct from both PN and MPNST, representing an intermediate step in malignant transformation. In the first comprehensive genomic analysis of ANF, we performed tumor/normal exome sequencing (ES) of 16 ANFs. In addition, we conducted ES of three MPNSTs, copy-number meta-analysis of 26 ANF and 28 MPNST, and whole transcriptome RNA-seq analysis of five ANF and five MPNST. We identified low mutation burden (median 1, range 0-5) in the exomes of ANF (only NF1 somatic mutations were recurrent), and frequent deletions of CDKN2A/CDKN2B (69%) and SMARCA2(42%) loci. We determined that polycomb repressor complex 2 (PRC2) genes EED or SUZ12 were frequently mutated, deleted or downregulated in MPNST but not in ANF. Our gene expression study revealed upregulated NRAS, MDM2, CCND1/CCND2/CCND3 and CDK4/CDK6 in both ANF and MPNST, and overexpression of EZH2 in MPNST only. We conclude that the PN-ANF transition is primarily driven by the deletion of CDKN2A/CDKN2B in addition to already present inactivated NF1. Further progression from ANF to MPNST likely involves broad chromosomal rearrangements and frequent inactivation of the PRC2 genes, loss of the DNA repair genes, and copy-number increase of signal transduction, cell cycle and pluripotency self-renewal genes.
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Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.