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1,337
datasets available to search
ShareScore release 0.9.0
Dataset results
1,337 results for “Neuropathy”
Duloxetine in Treating Peripheral Neuropathy Caused by Chemotherapy in Patients With Cancer
ClinicalTrials.gov study NCT00489411. IPD Sharing: Not stated. Countries: 1. Publications: 2.
Exercise-facilitated Neurorehabilitation in Diabetic Neuropathy
ClinicalTrials.gov study NCT00955201. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Study Evaluating Desvenlafaxine Succinate Sustained-release (DVS SR) in Adult Outpatients With Pain Associated With Diabetic Peripheral Neuropathy
ClinicalTrials.gov study NCT00283842. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Baclofen-Amitriptyline Hydrochloride-Ketamine Gel in Treating Peripheral Neuropathy Caused by Chemotherapy in Patients With Cancer
ClinicalTrials.gov study NCT00516503. IPD Sharing: Not stated. Countries: 1. Publications: 2.
Study of Metanx® in Subjects With Type 2 Diabetic Peripheral Neuropathy (DPN)
ClinicalTrials.gov study NCT00726713. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Acupuncture on Chemotherapy-induced Peripheral Neuropathy
ClinicalTrials.gov study NCT03626220. IPD Sharing: NO. Countries: 1. Publications: 4.
Electrical Stimulation in Diabetic Peripheral Neuropathy
ClinicalTrials.gov study NCT02082145. IPD Sharing: NO. Countries: 1. Publications: 2.
Proximal Versus Distal Superior Cluneal Nerve Block in Entrapment Neuropathy
ClinicalTrials.gov study NCT07372430. IPD Sharing: NO. Countries: 1. Publications: 0.
A Long-term Study for the Treatment of Painful Diabetic Neuropathy
ClinicalTrials.gov study NCT00641719. IPD Sharing: Not stated. Countries: 1. Publications: 1.
A Trial to Assess the Efficacy and Safety of 400mg/Day Lacosamide in Subjects With Painful Diabetic Neuropathy
ClinicalTrials.gov study NCT00350103. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Effect of Intravenous Methylprednisolone and Intravenous Erythropoietin in Toxic Optic Neuropathies: Randomized Clinical Trial.
ClinicalTrials.gov study NCT05748561. IPD Sharing: NO. Countries: 1. Publications: 15.
A New Method for Identifying Sensory Changes in Painful Chemotherapy-induced Peripheral Neuropathy (CIPN)
ClinicalTrials.gov study NCT03687970. IPD Sharing: YES. Countries: 1. Publications: 1.
Randomized, Double-Blind, Multicenter, Placebo-Controlled Study Of Pregabalin For Pain Associated With Diabetic Peripheral Neuropathy
ClinicalTrials.gov study NCT00553475. IPD Sharing: Not stated. Countries: 1. Publications: 5.
Chronic Neuropathy Following Chemotherapy
ClinicalTrials.gov study NCT02654691. IPD Sharing: NO. Countries: 1. Publications: 2.
SERENDEM : MD1003 in Patients Suffering From Demyelinating Neuropathies, an Open Label Pilot Study
ClinicalTrials.gov study NCT02967679. IPD Sharing: Not stated. Countries: 1. Publications: 1.
A Study of Purified Human Antibodies Administered Subcutaneously to Patients With Multifocal Motor Neuropathy (MMN)
ClinicalTrials.gov study NCT00701662. IPD Sharing: Not stated. Countries: 3. Publications: 1.
Data from: Schwann cell transcript biomarkers for hereditary neuropathy skin biopsies
Open the record for dataset details and reuse information.
A sensory and motor neuropathy caused by a genetic variant of NAMPT
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Data from: Differential clinicopathological features of EGPA-associated neuropathy with and without ANCA
Objective: To investigate the clinicopathological features of eosinophilic granulomatosis with polyangiitis (EGPA)-associated neuropathy with a focus on the presence or absence of anti-neutrophil cytoplasmic antibodies (ANCAs). Methods: We examined the clinical features and pathological findings of sural nerve biopsy specimens from 82 patients with EGPA-associated neuropathy. Of these patients, 32.9% were myeloperoxidase (MPO)-ANCA-positive, and 67.1% were MPO-ANCA-negative. PR3-ANCA was negative in all of 78 examined patients. Results: Upper-limb symptoms were more frequently reported as initial neuropathic manifestations in the MPO-ANCA-positive group than in the MPO-ANCA-negative group (44.4% vs. 14.6%, p < 0.01). The serum levels of C-reactive protein were significantly higher in the MPO-ANCA-positive group than in the MPO-ANCA-negative group (p < 0.05). Sural nerve biopsy specimens showed findings suggestive of vasculitis (i.e., destruction of vascular structures) in epineurial vessels; these results were more frequently seen in the MPO-ANCA-positive group than in the MPO-ANCA-negative group (p < 0.0001). Conversely, the numbers of eosinophils in the lumen of the epineurial vessels (p < 0.01) and epineurial vessels occluded by intraluminal eosinophils (p < 0.05) were higher in the MPO-ANCA-negative group than in the MPO-ANCA-positive group. Furthermore, the incidence of eosinophil infiltration in the endoneurium was higher in the MPO-ANCA-negative group than in the MPO-ANCA-positive group (p < 0.01). Conclusions: This study suggests that the pathogenesis of EGPA comprises at least two distinct mechanisms: ANCA-associated vasculitis resulting in ischemic effects and inflammation, which is prominent in MPO-ANCA-positive patients, and eosinophil-associated vascular occlusion leading to ischemia and eosinophil-associated tissue damage, which is conspicuous in MPO-ANCA-negative patients.
Data from: The genetic landscape of axonal neuropathies in the middle aged and elderly: focus on MME (supplementary information)
<p class="BarbaraStandard">OBJECTIVE: To test the hypothesis that monogenic neuropathies such as Charcot-Marie-Tooth disease (CMT) contribute to frequent but often unexplained neuropathies in the elderly, we performed genetic analysis of 230 patients with unexplained axonal neuropathies and disease onset <u>></u>35 years.</p> <p class="BarbaraStandard">METHODS: We recruited patients, collected clinical data and conducted whole-exome sequencing (WES, n=126) and <i>MME</i> single-gene sequencing (n=104). We further queried WES repositories for <i>MME</i> variants and measured blood levels of the <i>MME</i>-encoded protein neprilysin.</p> <p class="BarbaraStandard">RESULTS: In the WES cohort, the overall detection rate for assumed disease-causing variants in genes for CMT or other conditions associated with neuropathies was 18.3% (familial cases 26.4%, apparently sporadic cases 12.3%). <i>MME</i> was most frequently involved and accounted for 34.8% of genetically solved cases. The relevance of <i>MME</i> for late-onset neuropathies was further supported by detection of a comparable proportion of cases in an independent patient sample, preponderance of <i>MME</i> variants among patients compared to population frequencies, retrieval of additional late-onset neuropathy patients with <i>MME</i> variants from WES repositories, and low neprilysin levels in patients' blood samples. Transmission of <i>MME</i> variants was often consistent with an incompletely penetrant autosomal dominant trait and less frequently with autosomal recessive inheritance.</p> <p class="BarbaraStandard">CONCLUSIONS: A detectable fraction of unexplained late-onset axonal neuropathies is genetically determined, either by variants in CMT genes or genes involved in other conditions that affect the peripheral nerves and can mimic a CMT phenotype. <i>MME</i> variants can act as completely penetrant recessive alleles but also confer dominantly inherited susceptibility to axonal neuropathies in an aging population.</p> <p> </p>
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Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.