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1,260
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1,260 results for “Pharmacology”
Clinical Pharmacology Study of Oral Edaravone in Healthy Adult Subjects (Food Effect Study)
ClinicalTrials.gov study NCT05342597. IPD Sharing: NO. Countries: 1. Publications: 1.
Pharmacological Effects of Crushing Prasugrel in STEMI Patients
ClinicalTrials.gov study NCT02212028. IPD Sharing: NO. Countries: 1. Publications: 1.
A Pilot Project of Virologic, Pharmacologic and Immunologic Correlates of Gastrointestinal-Associated Lymphoid Tissue Immune Reconstitution Following Maraviroc Therapy
ClinicalTrials.gov study NCT00870363. IPD Sharing: Not stated. Countries: 1. Publications: 4.
A network pharmacology approach to predict potential targets and mechanisms of Gui Zhi-Shao Yao herb pair in treating chronic pain with comorbid anxiety and depression
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Data from: Pharmacologic hyperstabilisation of the HIV-1 capsid lattice induces capsid failure
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Pleiotropic effects of trisomy and pharmacologic modulation on structural, functional, molecular, and genetic systems in a Down syndrome mouse model
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Data from: Pharmacological HIF-1 activation upregulates extracellular vesicle production synergistically with adiponectin through transcriptional induction and protein stabilization of T-cadherin
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Molecular dynamics dataset for pharmacological repositioning in the treatment of non-small-cell lung cancer
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Data from: Effectiveness of physically ablative and pharmacological treatments for anal condyloma in HIV-infected men
There is limited information on the effectiveness of available treatments for anal condyloma acuminata in HIV-1-infected men. AIM: To provide data on the effectiveness of electrosurgical excision, infrared coagulation and pharmacological (imiquimod) treatments for anal condyloma acuminata (peri-anal and/or intra-anal) in HIV-1-infected men based on authors' practice. METHODS: Single-center, retrospective descriptive analysis of HIV-1-infected men, 18 years or older treated for anal condyloma acuminata. Standard treatments were offered: electrosurgery excision, infrared coagulation and topical imiquimod. Effectiveness was evaluated by the recurrence rate at 1 year after treatment. Recurrence was defined as any anal condyloma acuminata diagnosed after 3 months of condyloma-free survival post-treatment. Anal cytology and human-papillomavirus-infection (HPV) was assessed. RESULTS: Between January 2005 and May 2009, 101 men were treated for anal condyloma acuminata: 65 (64%) with electrosurgery, 27 (27%) with infrared coagulation and 9 (9%) with imiquimod. At 1 year after treatment, the cumulative recurrence rate was 8% (4/65, 95%CI: 2-15%) with electrosurgery excision, 11% (3/27, 95%CI: 4-28%) with infrared coagulation and 11% (1/9, 95%CI: 2-44%) with imiquimod treatment. No predictive factors were associated with recurrence. Anal HPV-6 or HPV-11 was detectable in 98 (97%) patients and all had high-risk HPV genotypes, and 89 (88%) patients had abnormal anal canal cytology. Limitations: this was a retrospective descriptive analysis; limited to a single center; it cannot know if the recurrence is related to new infection. CONCLUSION. Recurrence of anal condyloma after any treatment was common. Abnormal anal cytology and high-risk HPV-infection were highly prevalent in this population, therefore at high-risk of anal cancer, and warrants careful follow-up.
A pharmacological chaperone stabilizer rescues the expression of the vast majority of pathogenic variants in a G protein-coupled receptor
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Network Pharmacology-based Approach combined with Bioinformatic Analytics to Elucidate the Potential of Curcumol Against Hepatocellular Carcinoma
<p>File S1: Expression distribution of common targets; File S2: GSEA result of common targets, File S3: Rare data for top 10 most enriched GO terms in biological process, cellular component, and molecular function of common targets, File S4: Rare data for KEGG enrichment result of common targets, File S5: Rare data for cluster classification performed by MCODE, File S6: Rare data for GO terms and KEGG pathways enrichment analyses of cluster 1 and cluster 2, File S7: Prognosis-related genes, Table S1: Putative targets of curcumol.</p>
video presentations about COVID mortality and pharmacological and non pharmacological interventions
<p>I am uploading some videos published in youtube discussing COVID from the point of view of the impact of pharmacological and non pharmacological interventions on the mortality as reported in ourworldindata.org and other sources of public data.</p>
Kroll et al., 2024. Behavioural pharmacology predicts disrupted signalling pathways and candidate therapeutics from zebrafish mutants of Alzheimer's disease risk genes
<p>Data repository for</p> <p>François Kroll, Joshua Donnelly, Joshua Donnelly, Güliz Gürel Özcan, Eirinn Mackay, Jason Rihel</p> <div> <div><strong>Behavioural pharmacology predicts disrupted signalling pathways and candidate therapeutics from zebrafish mutants of Alzheimer’s disease risk genes</strong></div> <br> <div>eLife, 2024.</div> <br> <div><a href="https://doi.org/10.7554/eLife.96839.1">https://doi.org/10.7554/eLife.96839.1</a></div> <div> </div> <div>Code is found in the <a href="https://github.com/francoiskroll/ZFAD">GitHub repository</a>. Please see notes there.</div> </div> <p>___</p> <p>Contact:</p> <p>Twitter: @francois_kroll</p> <p>Email: francois@kroll.be</p>
Exploring the potential effects of Periplaneta americana (L.) extract on Alzheimer's disease based on network pharmacology combined with cellular experiments
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Fig. 7 in Hyperforin: A natural lead compound with multiple pharmacological activities
Fig. 7. The mechanisms of anti-ischemic stroke activity, anti-diabetes activity, effect on cutaneous wound healing and treating hypertrophic scars and anti-obesity activity of hyperforin.
Fig. 2. a in Hyperforin: A natural lead compound with multiple pharmacological activities
Fig. 2. a: Cross-section of leaf with translucent gland; b: Paradermal section of leaf with translucent gland; c: The translucent and dark glands on leaf under dissecting microscope. Scale bars = 1 cm.
Fig. 5. a in Alkaloids from Picrasma quassioides: An overview of their NMR data, biosynthetic pathways and pharmacological effects
Fig. 5. a The possible biosynthetic pathway of bis-β-carboline alkaloids. Fig. 5b The possible biosynthetic pathway of bis-β-carboline alkaloids.
Fig. 1 in Diterpenes of Scutellaria spp.: Phytochemistry and pharmacology
Fig. 1. The images of some Scutellaria species. A, B) S. baicalensis Georgi. (Photographer: Steffen Hauser, Berlin, Germany. https://www.picfair.com/pics/06495809- baikal-skullcap-scutellaria-baicalensis); C) S. altissima (https://www.plant-world-seeds.com/store/view_seed_item/1205); D) S. litwinowii (Photographer: Maryam Akaberi, location: Mount Binalud, Razavi Khorasan, Mashhad, Iran); E) S. incana (https://www.gardenia.net/plant/scutellaria-incana); F) S. suffrutescens (https://pl antlust.com/plants/17774/scutellaria-suffrutescens/); G) S. orientalis (https://www.ukwildflowers.com/Web_pages/scutellaria_orientalis_yellow_flowered_skullcap. htm); H) Roots of S. baicalensis (https://adaptogens.eu/zbozi/scutellaria-baicalensis-taiwantcm-wild-13708.aspx). (For interpretation of the references to color in this figure legend, the reader is referred to the Web version of this article.)
Fig. 8 in Polyacetylenes in herbal medicine: A comprehensive review of its occurrence, pharmacology, toxicology, and pharmacokinetics (2014-2021)
Fig. 8. Schematic representation of the possible mechanism of anti-obesity and anti-hyperglycemia activities of polyacetylenes. (Akt, protein kinase B; AMPK, adenosine 5′-monophosphate-activated protein kinase; GLUT4, glucose transporter 4; HMGR, 3-hydroxy-3-methyl-glutaryl-coenzyme A reductase; IRS, insulin receptor substrate; LKB1, liver kinase B1; MO25, mouse protein 25; PDK 1/2, pyruvate dehydrogenase kinase 1/2; PTP1B, protein tyrosine phosphatase 1B; PI3K, phosphatidylinositol 3-kinase; SREBP1c, sterol regulator elementing binding protein 1c; STRAD, STE-related adaptor protein).
Fig. 5 in Polyacetylenes in herbal medicine: A comprehensive review of its occurrence, pharmacology, toxicology, and pharmacokinetics (2014-2021)
Fig. 5. Schematic representation of the possible mechanism of antitumor activity of polyacetylenes. (AA, amino acid; Akt, protein kinase B; ASCT2, amino acid transporter alanine serine cysteine transporter 2; Bcl-2, B cell leukemia-2; CDK2, cyclin dependent kinase 2; Gln, glutamine; Glu, glutamate; HIF-1α, hypoxiainducible factor 1α; JAK, janus kinase; JNK, c-Jun N-terminal kinase; NF-κB, nuclear factor κB; PI3K, phosphatidylinositol 3-kinase; PTTG1, pituitary tumortransforming gene 1; STAT3, signal transducer and activator of transcription 3).
ScienceDex guides
Understand access before you commit
These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.