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1,286 results for “Spinal cord injury”
AXER-204 in Participants With Chronic Spinal Cord Injury
ClinicalTrials.gov study NCT03989440. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Transcutaneous Tibial Nerve Stimulation in Acute Spinal Cord Injury
ClinicalTrials.gov study NCT03965299. IPD Sharing: YES. Countries: 1. Publications: 8.
Reclaiming Independence: Daily Activities and Rehabilitation Goals in Spinal Cord Injury
ClinicalTrials.gov study NCT07237035. IPD Sharing: YES. Countries: 1. Publications: 3.
Long Duration Activity and Metabolic Control After Spinal Cord Injury
ClinicalTrials.gov study NCT03139344. IPD Sharing: NO. Countries: 1. Publications: 28.
Botox-A Injection to Improve Bladder Function in Early Spinal Cord Injury (#H-20344)
ClinicalTrials.gov study NCT00711087. IPD Sharing: Not stated. Countries: 1. Publications: 2.
Contours of the caregiver experience: Social resources and health behaviors in caregiving partners of persons with a spinal cord injury
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Feasibility of using remotely delivered Spring Forest Qigong to reduce neuropathic pain in adults with spinal cord injury: A pilot study
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Effects of ACTH4-10Pro8-Gly9-Pro10 on anti-inflammatory cytokine (IL-4, IL-10, IL-13) expression in acute spinal cord injury model (Sprague Dawley rats)
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Data from: Mental health in individuals with spinal cord injury: the role of socioeconomic conditions and social relationships
Objectives: To evaluate socioeconomic inequalities in social relationships, and to assess whether socioeconomic conditions and social relationships are independently related to mental health problems in individuals with a physical disability due to spinal cord injury (SCI). Methods: We analyzed cross-sectional data from 511 individuals with SCI aged over 16 years who participated in the community survey of the Swiss SCI Cohort Study. Indicators for socioeconomic conditions included years of formal education, household income, and financial strain. Social relationships were operationalized by three structural (partner status, social contact frequency, number of supportive relationships) and four functional aspects (satisfaction with: overall social support, family relationships, contacts to friends, partner relationship). General mental health was assessed by the Mental Health Inventory (MHI-5) of SF-36 and depressive symptoms were measured by the Hospital Anxiety and Depression Scale (depression subscale, HADS-D). Established cut-offs for general mental health problems (MHI-5 ≤56) and depressive symptomatology (HADS-D ≥8) were used to dichotomize outcomes. Associations were assessed using logistic regressions. Results: Lower household income was predominately associated with poor structural social relationships, whereas financial strain was robustly linked to poor functional social relationships. Financial strain was associated with general mental health problems and depressive symptomatology, even after controlling for social relationships. Education and household income were not linked to mental health. Poor structural and functional social relationships were related to general mental health problems and depressive symptomatology. Notably, trends remained stable after accounting for socioeconomic conditions. Conclusion: This study provides evidence for socioeconomic inequalities in social relationships as well as for independent associations of financial strain and poor social relationships with mental health problems in individuals with SCI. Further research may develop strategies to improve mental health in SCI by strengthening social relationships. Such interventions may be especially beneficial for individuals in unfavorable socioeconomic conditions.
Data from: Labor market integration of people with disabilities: results from the Swiss Spinal Cord Injury Cohort Study
Objectives: We aimed to describe labor market participation (LMP) of persons with spinal cord injury (SCI) in Switzerland, to examine potential determinants of LMP, and to compare LMP between SCI and the general population. Methods: We analyzed data from 1458 participants of employable age from the cross-sectional community survey of the Swiss Spinal Cord Injury Cohort Study. Data on LMP of the Swiss general population were obtained from the Swiss Federal Statistics Office. Factors associated with employment status as well as the amount of work performed in terms of full-time equivalent (FTE) were examined with regression techniques. Results: 53.4% of the participants were employed at the time of the study. Adjusted odds of being employed were increased for males (OR=1.73, 95% CI 1.33 - 2.25) and participants with paraplegia (OR=1.78, 95% CI 1.40 - 2.27). The likelihood of being employed showed a significant concave relationship with age, peaking at age 40. The relation of LMP with education was s-shaped, while LMP was linearly related to time since injury. On average, employment rates were 30% lower than in the general population. Males with tetraplegia aged between 40 and 54 showed the greatest difference. From the 771 employed persons, the majority (81.7%) worked part-time with a median of 50% FTE (IRQ: 40%-80%). Men, those with younger age, higher education, incomplete lesions, and non-traumatic etiology showed significantly increased odds of working more hours a week. Significantly more people worked part-time than in the general population with the greatest difference found for males with tetraplegia aged between 40 and 54. Conclusions: LMP of persons with SCI is comparatively high in Switzerland. LMP after SCI is, however, considerably lower than in the general population. Future research needs to show whether the reduced LMP in SCI reflects individual capacity adjustment, contextual constraints or both on higher LMP.
Data from: Empirical targets for acute hemodynamic management of individuals with spinal cord injury
Objective: To determine the hemodynamic conditions associated with optimal neurological improvement in acute traumatic spinal cord injury (SCI) individuals who had lumbar intrathecal catheters placed to measure cerebrospinal fluid pressure (CSFP). Methods: Ninety-two acute SCI individuals were enrolled in this multi-center prospective observational clinical trial. We monitored mean arterial pressure (MAP) and CSFP during the first week post-injury, and assessed neurologic function at baseline and six-months post-injury. We used relative risk iterations to determine transition points at which the likelihood of either improving neurologically or remaining unchanged neurologically was equivalent. These transition points guided our analyses where we examined the linear relationships between time spent within target hemodynamic ranges (i.e., clinical adherence) and neurological recovery. Results: Relative risk transition points for CSFP, MAP, and spinal cord perfusion pressure (SCPP) were linearly associated with neurological improvement and directed the identification of key hemodynamic target ranges. Clinical adherence to the target ranges was positively and linearly related to improved neurological outcomes. Adherence to SCPP targets, not MAP targets, was the best indicator of improved neurological recovery, which occurred with SCPP targets of 60-65 mmHg. Failing to maintain the SCPP within the target ranges was an important detrimental factor in neurologic recovery, particularly if the target range is set lower. Conclusion: We provide an empirical, data-driven approach to aid institutions in setting hemodynamic management targets that accept the real-life challenges of adherence to specific targets. Our results provide a framework to guide the development of widespread institutional management guidelines for acute traumatic SCI.
Usability, Acceptability, User Experience, Human-Device Interaction, and Ergonomics in Two Mobile FES-Cycling Systems for Individuals with Spinal Cord Injury
<p>This database originates from a study comparing two FES-cycling systems: the <strong>commercial BerkelBike Pro</strong> and a <strong>recumbent FES-bike prototype</strong> developed by the team at Politecnico di Milano. The aim of the study was to evaluate and compare the <strong>usability</strong>, <strong>acceptability</strong>, <strong>user experience</strong>, <strong>human-device interaction</strong>, and <strong>ergonomics</strong> of these two devices for individuals with spinal cord injury (SCI).</p> <p>The study involved 15 participants with SCI, covering a wide range of ages (18 to 65 years) and injury types (both complete and incomplete, at acute and chronic phases). Each participant underwent three sessions with both FES-cycling devices:</p> <ul> <li><strong>First session</strong>: Dedicated to setting up the system for each participant. For both the BerkelBike Pro and the FES-bike prototype, the system settings were tailored to meet individual needs, ensuring optimal comfort and function.</li> <li><strong>Second and third sessions</strong>: Focused on actual training, where participants used the devices to engage in cycling activities.</li> </ul> <p>At the end of the <strong>third session</strong>, participants completed a series of questionnaires to assess the usability, acceptability, user experience, and ergonomics of both devices. These questionnaires form the core of the study’s data collection and are central to understanding participants' interactions with the FES-cycling systems.</p> <p>The database is organized as follows:</p> <ol> <li><strong>Demographic data</strong>: The first page contains demographic information, including participants' age, gender, height, weight, time after injury, injury type (ASIA grade), and injury level.</li> <li><strong>PGWBI scores</strong>: The second page includes baseline data collected using the <strong>Psychological General Well-Being Index (PGWBI)</strong>, which assesses the participants' emotional and psychological state before engaging with the devices. The PGWBI consists of 22 questions grouped into 6 items: "anxiety", "depression", "positivity", "self-control", "health" and "vitality”. The responses are assessed on a 6-point scale ranging from 0 to 5. The score contributions for each question are then added together and transformed to achieve the final score that can range from 0 to 110.</li> <li><strong>SUS scores</strong>: The third page contains the results from the <strong>System Usability Scale (SUS)</strong>, a standard 10-item questionnaire that evaluates the usability of each FES-cycling system based on user ratings. The SUS is evaluated using a 5-point Likert scale, where 1 corresponds to strongly disagree, while 5 to strongly agree. The score contributions for each question are then added together and multiplied by 2.5 to achieve the final score that can range from 0 to 100, where higher scores indicate better usability.</li> <li><strong>TAM-3 scores</strong>: The fourth page presents data from the <strong>Technology Acceptance Model 3 (TAM-3)</strong>, which measures how participants perceive the ease of use and the usefulness of the devices. . The TAM-3 consists of 50 questions grouped into 14 items. These items include “perceived usefulness”, “perceived ease of use”, “self-efficacy”, “perception of external control”, “playfulness”, “anxiety”, “enjoyment”, “subjective norm”, “voluntariness”, “image”, “relevance”, “output quality”, “result demonstrability” and “behavioral intention”. The items are investigated using a 7-point Likert scale, where 1 corresponds to strongly disagree, while 7 to strongly agree.</li> <li><strong>UEQ scores</strong>: The fifth page includes responses from the <strong>User Experience Questionnaire (UEQ)</strong>, evaluating participants' experience with the devices. The UEQ consists of 26 questions grouped in six items: “attractiveness”, “perspicuity”, “efficiency”, “dependability”, “stimulation” and “novelty”. Questions are scored using a 7-point Likert scale, where 1 corresponds to strongly disagree, while 7 to strongly agree. Then scores per item are transformed using a scale ranging from -3 to +3, with +3 representing the most positive value (extremely good) and -3 the most negative one (horribly bad). Values between -0.8 and 0.8 represent a neutral evaluation of the corresponding scale, values > 0.8 represent a positive evaluation and values < -0.8 represent a negative one.</li> <li><strong>Custom questionnaire scores</strong>: The sixth page contains data from a <strong>custom-designed questionnaire</strong>, created specifically for this study to assess the ergonomics of the two FES-cycling systems, with particular attention to human-device interaction at both the physical and psychological levels. It consists of 12 questions covering four items: the transfer from/to the bikes and the initial tuning, bike comfort, its accessibility, and the ease of interaction. Questions are evaluated using a 5-point Likert scale, where 1 corresponds to strongly disagree/very uncomfortable, while 5 to strongly agree/very comfortable.</li> </ol> <p>This comprehensive data collection allows for a thorough comparison of the two FES-cycling systems in terms of user experience and overall acceptability in the SCI population.</p> <p>Please cite the following manuscript when using this database:<br>Nossa R, Biffi E, Sanna N, Diella E, Guanziroli E, Ferrari F, Ferrante S, Molteni F, Pedrocchi A, Tarabini M, Ambrosini E. Assessment of User Experience, Acceptability, Usability, Human-Device Interaction, and Ergonomics in Two Mobile FES-Cycling Systems for Individuals With Spinal Cord Injury. Artif Organs. 2025 Apr 16. doi: 10.1111/aor.15007. Epub ahead of print. PMID: 40237144.</p>
Transcutaneous spinal cord stimulation enhances motor score and gait recovery in incomplete spinal cord injury. A double-blind randomized controlled trial
<p><strong><span>Background: </span></strong><span>Although transcutaneous spinal cord stimulation (tSCS) has been suggested as a safe and feasible intervention for gait rehabilitation, no studies have determined its effectiveness compared to sham stimulation.</span></p> <p><strong><span>Objective: </span></strong><span>To determine the effectiveness of tSCS combined with robotic-assisted gait training (RAGT) on lower limb muscle strength and walking function in incomplete spinal cord injury (iSCI) participants.</span></p> <p><strong><span>Methods: </span></strong><span>A randomized, double-blind, sham-controlled clinical trial was designed. Twenty-seven subacute iSCI participants were randomly allocated to tSCS or sham-tSCS group. The intervention consisted of 20 sessions of standard Lokomat walking training enhanced with tSCS. Primary outcomes were the lower extremity motor score (LEMS) and dynamometry. Secondary outcomes included the 10-Meter Walk Test (10MWT), the Timed Up and Go test (TUG), the 6-Minute Walk test (6MWT), the Spinal Cord Independence Measure III (SCIM III) and the Walking Index for Spinal Cord Injury II (WISCI-II). Assessments were performed before and after the intervention and at 1-month follow-up.</span></p> <p><strong><span>Results: </span></strong><span>Although no significant differences between groups were detected after the intervention, the tSCS group showed greater effects than the sham-tSCS group for LEMS (3.4 points; p=0.033), 10MWT (37.5s; p=0.030), TUG (47.7s; p=0.009), and WISCI-II (3.4 points; p=0.023) at the 1-month follow-up. Furthermore, the percentage of subjects who were able to walk at the follow-up was greater in the tSCS group (85.7%) compared to the sham group (43.1%; p=0.029).</span></p> <p><strong><span>Conclusions:</span></strong><span> The combination of standard RAGT with tSCS for 20 sessions was effective for LEMS and gait recovery in subacute iSCI participants after one month of follow-up.</span></p> <p><strong><span>Key words: </span></strong><span>Spinal cord injury; Transcutaneous spinal cord stimulation; Lokomat; Robotic-assisted gait training; Motor function; </span><span>Gait rehabilitation.</span></p>
Figures for the publication ''The role of small extracellular vesicles and microRNA as their cargo in the spinal cord injury pathophysiology and therapy''
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The Aim of This Research is to Better Understand How Complete Spinal Cord Injury May Change Erogenous Zones in Adult Males
ClinicalTrials.gov study NCT06908850. IPD Sharing: UNDECIDED. Countries: 1. Publications: 5.
Study on Preliminary Safety and Efficacy of the ARC Therapy Using the ARC-IM Lumbar System to Support Mobility in People With Chronic Spinal Cord Injury (BoxSwitch)
ClinicalTrials.gov study NCT05942339. IPD Sharing: NO. Countries: 1. Publications: 26.
DiSCIoser: Improving Arm Sensorimotor Functions After Spinal Cord Injury Via Brain-Computer Interface Training
ClinicalTrials.gov study NCT05637775. IPD Sharing: NO. Countries: 1. Publications: 5.
Biofeedback Treatment of Anxiety Associated With Chronic Spinal Cord Injury
ClinicalTrials.gov study NCT03975075. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Minocycline in Acute Spinal Cord Injury (MASC)
ClinicalTrials.gov study NCT01828203. IPD Sharing: Not stated. Countries: 2. Publications: 1.
To Study the Safety and Efficacy of Autologous Bone Marrow Stem Cells in Patients With Spinal Cord Injury
ClinicalTrials.gov study NCT01730183. IPD Sharing: Not stated. Countries: 1. Publications: 1.
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Allen Brain Atlas
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DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.