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694 results for “Stiffness”
The Effect of Extracellular Matrix Stiffness on Inducing Adipogenic Differentiation of ADSCs
<p>Extracellular matrix (ECM) is a critical biophysical factor in adipose-derived stem cells differentiation. However, the specific regulatory mechanisms and signaling pathways of Yes-associated protein (YAP) are unknown, though it plays a critically important role in ECM-induced differentiation. Here, we embedded ADSCs in collagen hydrogels with varying stiffness, elastic moduli, to be exact, of 61Pa, 217Pa, and 321Pa. The expression of adipogenic-specific genes was highly correlated with stiffness of ECM<span>,</span> in addition, our study has found that the levels of YAP phosphorylation were significantly altered on the 9th day after stimulation with ECM stiffness. Staining of lipid droplets with BODIPY indicates that accumulation of lipid droplets depended on hydrogel stiffness; the most pronounced accumulation was registered in 321Pa hydrogels. By inhibiting the YAP signaling pathway, we found that lipid droplet accumulation increased; thus, inhibition of YAP signaling increased YAP phosphorylation in the cytoplasm, thereby promoting accumulation of lipid droplets. In conclusion, YAP played a crucial role in regulating ECM stiffness-induced adipogenic differentiation. Adipose stem cells are differentiated in a microenvironment that offers new insights into their differentiation process. </p>
Additional material for the Wind Energy manuscript "An engineering approach for the estimation of slewing bearing stiffness in Wind Turbine Generators"
<p>This documment compiles the additional material for the manuscript “An engineering approach for the estimation of slewing bearing stiffness in Wind Turbine Generators”. The document shows the results for all the considered design points, comparing the the proposed approach with the Finite Element model.</p>
Assessing instantaneous stiffness of cracked reinforced concrete beams based on crack depths
<p>The crack presence changes the shape or size of sections in reinforced concrete beams, and greatly affects the section inertias and the beam stiffness. To assess the instantaneous stiffness of the cracked beams, a method is proposed based on the exact crack depth. The region affected by cracks is determined firstly, and different nonlinear strain distributions are modeled in the effect region to describe the change of concrete strains caused by cracks. The internal force equilibria are adopted to find a solution to the top strain and neutral axis, and according to the solution, the inertias of key sections are calculated to assess the beam stiffness. The proposed method has been validated using experimental results obtained from two-stage tests on five reinforced concrete beams. The dataset stores valuable results calculated by the proposed method.</p>
Data from: "Glycerol-blended chitosan membranes with directional micro-grooves and reduced stiffness improve Schwann cell wound healing"
<h3>ABSTRACT</h3> <p>Regenerative medicine is continuously looking for new natural biocompatible and possibly biodegradable materials, but also mechanically compliant. Chitosan is emerging as a promising FDA-approved biopolymer for tissue engineering, however, its exploitation in regenerative devices is limited by its brittleness and can be further improved, for example, by blending it with other materials or by tuning its superficial microstructure. Here, we developed membranes made of chitosan and glycerol, by solvent casting and micropatterned them with directional geometries with different levels of axial symmetry. These membranes were characterized by light microscopy and atomic force microscopy (AFM), thermal, mechanical, and degradation assays, and also tested in vitro as scaffolds with Schwann cells. The glycerol-blended chitosan membranes are optimized in terms of mechanical properties, and present a physiological-grade Young's modulus (≈ 0.7 MPa). The directional topographies are effective in directing cell polarization and migration and in particular are highly performant substrates for collective cell migration. Here, we demonstrate that a combination of a soft compliant biomaterial and topographical micropatterning can improve the integration of these scaffolds with Schwann cells, which is a fundamental step in the peripheral nerve regeneration process.</p>
Genomic variation within the maize Stiff Stalk heterotic germplasm pool
<p>The Stiff Stalk heterotic group is an important source of inbreds used in U.S. commercial hybrid production. Founder inbreds B14, B37, B73, and to a lesser extent B84, are found in the pedigrees of a majority of commercial seed parent inbred lines. We created high-quality genome assemblies of B84 and four ex-Plant Variety Protection lines LH145 representing B14, NKH8431 of mixed descent, PHB47 representing B37, and PHJ40 which is a Pioneer Hi-Bred early Stiff Stalk type. Sequence was generated using long-read sequencing achieving highly contiguous assemblies of 2.13 to 2.18 Gbp with N50 scaffold lengths greater than 200 Mbp. Inbred-specific gene annotations were generated using a core five-tissue gene expression atlas and transposable element annotation was conducted using de novo and homology-directed methodologies. In comparison to the reference inbred B73, synteny analyses revealed extensive collinearity across the five Stiff Stalk genomes, although unique components of the maize pan-genome were detected. Comparison of this set of Stiff Stalk genome sequences with the original Stiff Stalk population revealed that these inbreds represent only a proportion of variation in the original Stiff Stalk pool and there are highly conserved haplotypes in released public and ex-Plant Variety Protection inbreds. Despite the reduction in variation from the original Stiff Stalk population, substantial genetic and genomic variation was identified supporting the potential for continued breeding success in this pool. The assemblies described here represent Stiff Stalk inbreds that have historical and commercial relevance and provide further insight into the emerging maize pan-genome.</p>
Reassessing variations in the small-strain stiffness of London Clay
<p>Supplementary dataset for "Reassessing variations in the small-strain stiffness of London Clay" Le, Standing and Potts (2023), Geotechnique.</p>
Additional data - Using a micro-device with a deformable ceiling to probe stiffness heterogeneities within 3D cell aggregates
<p>Additional data for the article <em>"Using a micro-device with a deformable ceiling to probe stiffness heterogeneities within 3D cell aggregates" </em>by Jain, Belkadi et al.</p> <p><strong>additionaldata_jain-belkadi_2023/data_fig_3/data_fig_3_bc:</strong> One .tif file per spheroid shown in Fig 3b,c. the air cavity pressure levels are the following (respectively for each frame): 0 (mbar), -50, -100, -150, -200, -250, -300, -450, -500, 0</p> <p><strong>additionaldata_jain-belkadi_2023/data_fig_3/data_fig_3_def: </strong>One .tif file for the cyclic compression of the spheroids.</p> <p><strong>additionaldata_jain-belkadi_2023/data_fig_4_d: </strong>One folder per spheroid. See readme.txt</p>
Magnetic Resonance Elastography as a Method to Estimate Stiffness of Soft Tissues
ClinicalTrials.gov study NCT01757730. IPD Sharing: Not stated. Countries: 1. Publications: 5.
Nifedipine GITS and Amlodipine Besylate on Recovery of Blood Pressure Rhythm and Arterial Stiffness
ClinicalTrials.gov study NCT02940548. IPD Sharing: UNDECIDED. Countries: 1. Publications: 2.
Comparison of GT With TF Technique in Patient With Post-Operative Knee Stiffness
ClinicalTrials.gov study NCT07204119. IPD Sharing: NO. Countries: 1. Publications: 13.
Postprandial Effects of Bean and Whole Grain Consumption on Arterial Stiffness
ClinicalTrials.gov study NCT05818358. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Effect of Dry-weight Probing Guided by Lung-Ultrasound on Ambulatory Blood Pressure and Arterial Stiffness in Hemodialysis Patients (LUST Sub-Study)
ClinicalTrials.gov study NCT03058874. IPD Sharing: NO. Countries: 2. Publications: 15.
Prediction of Functional Disability and Clinical Trial in Subjects With Stiff Shoulders
ClinicalTrials.gov study NCT01813396. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Relative Stiffness of Lumbar Spine and Hamstrings Muscle Stretching
ClinicalTrials.gov study NCT03787979. IPD Sharing: YES. Countries: 1. Publications: 4.
Extracorporeal Photopheresis (ECP) in the Treatment of Stiff Person Syndrome (OPTION Study)
ClinicalTrials.gov study NCT06703333. IPD Sharing: NO. Countries: 1. Publications: 1.
Rituximab to Treat Stiff Person Syndrome
ClinicalTrials.gov study NCT00091897. IPD Sharing: Not stated. Countries: 1. Publications: 3.
Tissue Flossing Technique on Post Traumatic Elbow Stiffness.
ClinicalTrials.gov study NCT05948423. IPD Sharing: NO. Countries: 1. Publications: 12.
Arterial Stiffness and General Anesthesia Induced Hypotension in Patients on Angiotensin-converting Enzyme Inhibitors
ClinicalTrials.gov study NCT02416024. IPD Sharing: Not stated. Countries: 1. Publications: 7.
A Prospective Randomized Controlled Trial of Effect of Enhanced External Counter Pulsation to Arterial Stiffness in Chronic Hemodialysis Patient
ClinicalTrials.gov study NCT06608953. IPD Sharing: UNDECIDED. Countries: 1. Publications: 1.
Ultrasonographic Assessment of Painful and Stiff Hemiplegic Shoulder in Terms of Adhesive Capsulitis
ClinicalTrials.gov study NCT04613648. IPD Sharing: NO. Countries: 1. Publications: 20.
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