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633 results for “TCR”
Molecular structures of the antibody-TCR complexes described in the paper by Pitaro et al. in Frontiers in Immunology
Open the record for dataset details and reuse information.
Phosphoproteomics analysis of antibody-based stimulation of TCR in CD4+ T cells
<p>Code associated with the paper "LymphoAtlas: a dynamic and integrated phosphoproteomic resource of TCR signaling in primary T cells reveals ITSN2 as a regulator of effector functions" published in Molecular Systems Biology in 2020.</p> <p>abstract: <br> T-cell receptor (TCR) ligation-mediated protein phosphorylation regulates the activation, cellular responses, and fates of T cells. Here, we used time-resolved high-resolution phosphoproteomics to identify, quantify, and characterize the phosphorylation dynamics of thousands of phosphorylation sites in primary T cells during the first 10 min after TCR stimulation. Bioinformatic analysis of the data revealed a coherent orchestration of biological processes underlying T-cell activation. In particular, functional modules associated with cytoskeletal remodeling, transcription, translation, and metabolic processes were mobilized within seconds after TCR engagement. Among proteins whose phosphorylation was regulated by TCR stimulation, we demonstrated, using a fast-track gene inactivation approach in primary lymphocytes, that the ITSN2 adaptor protein regulated T-cell effector functions. This resource, called LymphoAtlas, represents an integrated pipeline to further decipher the organization of the signaling network encoding T-cell activation. LymphoAtlas is accessible to the community at: <a href="https://bmm-lab.github.io/LymphoAtlas">https://bmm-lab.github.io/LymphoAtlas</a>.</p>
TCR repertoire sequencing related to "Unique roles of coreceptor-bound LCK in helper and cytotoxic T cells"
<p>This archive contains datasets needed for recapitulating the analysis of TCR repertoires for the manuscript <em>“Unique roles of coreceptor-bound LCK in helper and cytotoxic T cells”</em> by Horkova et al., 2022. The code for the analysis can be found on GitHub: https://github.com/Lab-of-Adaptive-Immunity/lck-tcrseq. Raw data are deposited in the SRA (https://www.ncbi.nlm.nih.gov/bioproject/PRJNA872031).</p> <p>The Zenodo archive contains the following files, which are needed to run the analysis script:</p> <ul> <li>merged outputs from MiXCR <code>merged_TCR_repertoires.csv</code></li> <li>metadata file <code>metadata_Lck.csv</code></li> <li>TRA and TRB repertoires prepared for processing with the Immunarch package <code>immdata_tra.rds</code>, <code>immdata_trb.rds</code></li> </ul>
Supplemental Data: Discrete LAT condensates encode antigen information from single pMHC:TCR binding events
<p>Microscopy data and associated code for analysis. For more information refer to https://doi.org/10.1038/s41467-022-35093-9</p>
TCR-α/β and CD19 Depleted Stem Cell Grafts From Haplo Donors for HSCT in Relapsed Lymphoma
ClinicalTrials.gov study NCT02652468. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Safety & Activity of Controllable PRAME-TCR Therapy in Previously Treated AML/MDS or Metastatic Uveal Melanoma
ClinicalTrials.gov study NCT02743611. IPD Sharing: NO. Countries: 1. Publications: 0.
Exploratory Study of EBV-TCR-T Cell Injection for EBV DNAemia After Allogeneic Hematopoietic Stem Cell Transplantation
ClinicalTrials.gov study NCT07368634. IPD Sharing: NO. Countries: 1. Publications: 0.
CT Antigen TCR-Engineered T Cells for Myeloma
ClinicalTrials.gov study NCT01892293. IPD Sharing: Not stated. Countries: 1. Publications: 0.
E7 TCR T Cell Induction Immunotherapy for Stage IIB-IVA Cervical Cancer
ClinicalTrials.gov study NCT04476251. IPD Sharing: NO. Countries: 1. Publications: 0.
Haploidentical Hematopoietic Cell Transplantation Using TCR Alpha/Beta and CD19 Depletion
ClinicalTrials.gov study NCT05236764. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Phase I/II Study to Assess the Safety and Activity of Enhanced TCR Transduced Autologous T Cells in Metastatic Melanoma
ClinicalTrials.gov study NCT01350401. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Ex Vivo TCR αβ T Cell Depletion for Graft-Versus-Host Disease Prophylaxis in Mismatched Donor Peripheral Blood Stem Cell Transplantation for Hematologic Malignancies
ClinicalTrials.gov study NCT03717480. IPD Sharing: NO. Countries: 1. Publications: 0.
TCR Alpha Beta T-cell and CD19 B-cell Depleted Peripheral Blood Stem Cell Transplantation Using the CliniMACS System for Patients With Non-Malignant Hematologic Disorders From Matched or Mismatched, R
ClinicalTrials.gov study NCT03615144. IPD Sharing: Not stated. Countries: 1. Publications: 0.
CT Antigen TCR-redirected T Cells for Ovarian Cancer.
ClinicalTrials.gov study NCT01567891. IPD Sharing: Not stated. Countries: 1. Publications: 0.
E7 TCR Cell Induction Immunotherapy for Stage II and Stage III HPV-Associated Oropharyngeal Cancer
ClinicalTrials.gov study NCT04015336. IPD Sharing: YES. Countries: 1. Publications: 0.
T Cell Receptor (TCR) Sequencing and Transcriptional Profiling in Adult Celiac Disease Patients Undergoing Gluten Challenge
ClinicalTrials.gov study NCT04614571. IPD Sharing: YES. Countries: 1. Publications: 0.
Immunotherapy With E6 T Cell Receptor (TCR) T Cells for Vulvar High-Grade Squamous Intraepithelial Lesions
ClinicalTrials.gov study NCT03197025. IPD Sharing: NO. Countries: 1. Publications: 0.
Murine TCR-beta repertoire sequencing
The purpose of this project was to determine the effects of chronic exposure to unpredictable mild socio-environmental stressors during gestation on the TCR-beta repertoire of newborn mice.
RELB Reprograms Exhausted Tumor-Infiltrating Lymphocytes for Improved Adoptive Cell Therapy [TCR-Seq]
GEO Series GSE303438. Homo sapiens. 38 samples. Type: Other.
Human CCR6+ Th cells show both an extended stable gradient of Th17 activity and imprinted plasticity [Spsingh-10x-TCR-plus-transcriptome-kit]
GEO Series GSE227656. Homo sapiens. 16 samples. Type: Expression profiling by high throughput sequencing; Other.
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International Brain Laboratory public data
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OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.