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147 results for “Telomere Length”
Data from: Telomere length and dynamics predict mortality in a wild longitudinal study
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Data from: Brood size, telomere length, and parent-offspring color signaling in barn swallows
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Telomere length in relation to colour polymorphism across life stages in the tawny owl
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Data for: When does early-life telomere length predict survival? A case study and meta-analysis
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Wing: A suitable non-lethal tissue type for repeatable and rapid telomere length estimates in bats
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Data from: Telomere length is highly heritable and independent of growth rate manipulated by temperature in field crickets
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Data from: Extent and variability of interstitial telomeric sequences and their effects on estimates of telomere length
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Early life growth and telomere length in wild boar piglets 2018
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Data from: High heritability of telomere length and low heritability of telomere shortening in wild birds
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Data from: Telomere length is repeatable, shortens with age and reproductive success, and predicts remaining lifespan in a long-lived seabird
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Data from: Is telomere length associated with mate choice in a songbird with a high rate of extra-pair paternity?
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Telomere length correlates with physiological and behavioural responses of a long-lived seabird to an ecologically-relevant challenge
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Data from: Primers to highly conserved elements optimized for qPCR-based telomere length measurements in vertebrates
<p>Telomere length dynamics are an established biomarker of health and aging in animals. The study of telomeres in numerous species has been facilitated by methods to measure telomere length by real-time quantitative PCR (qPCR). In this method, telomere length is determined by quantifying the amount of telomeric DNA repeats in a sample and normalizing this to the total amount of genomic DNA. This normalization requires the development of genomic reference primers suitable for qPCR, which remains challenging in non-model organism with genomes that have not been sequenced. Here we report reference primers that can be used in qPCR to measure telomere lengths in any vertebrate species. We designed primer pairs to amplify genetic elements that are highly conserved between evolutionarily distant taxa and tested them in species that span the vertebrate tree of life. We report five primer pairs that meet the specificity and reproducibility standards of qPCR. In addition, we demonstrate an approach to choose the best primers for a given species by testing the primers on multiple individuals within a species and then applying an established computational tool. These reference primers can facilitate qPCR-based telomere length measurements in any vertebrate species of ecological or economic interest.</p>
Data and code for 'Telomere length measurement for longitudinal analysis: the role of assay precision'
<p>Data and code for<strong> </strong>'Telomere length measurement for longitudinal analysis: implications of assay precision' by Nettle, Gadalla, Susser, Bateson and Aviv'</p> <p>The R script will run both the numerical simulations and the analysis of the empirical data. The exact results of the simulations will vary slightly from run to run.</p>
Data from: Telomere length reflects phenotypic quality and costs of reproduction in a long-lived seabird
Telomere length is associated with cellular senescence, lifestyle and ageing. Short telomeres indicate poor health in humans and reduced life expectancy in several bird species, but little is known about telomeres in relation to phenotypic quality in wild animals. We investigated telomere lengths in erythrocytes of known-age common terns (Sterna hirundo), a migratory seabird, in relation to arrival date and reproductive performance. Cross-sectional data revealed that, independent of age, individuals with short telomeres performed better: they arrived and reproduced earlier in the season and had more chicks in the nest. The latter effect was stronger the older the brood and stronger in males, which do most of the chick provisioning. Longitudinal data confirmed this pattern: compared with birds that lost their brood, birds that raised chicks beyond the 10th nestling day experienced higher telomere attrition from one year to the next. However, more detailed analysis revealed that the least and most successful individuals lost the fewest base pairs compared with birds with intermediate success. Our results suggest that reproductive success is achieved at the expense of telomeres, but that individual heterogeneity in susceptibility to such detrimental effects is important, as indicated by low telomere loss in the most successful birds.
Data from: Reduced telomere length in offspring of old fathers in a long-lived seabird
Evidence for transgenerational effects of senescence, whereby offspring from older parents have a reduced lifetime reproductive success, is increasing. Such effects could arise from compromised germline maintenance in old parents, potentially reflected in reduced telomere length in their offspring. We test the relationship between parental age and offspring early-life telomere length in a natural population of common terns and find a significant negative correlation between paternal age and offspring telomere length. Offspring telomere length is reduced by 35 base pairs for each additional year of paternal age. We find no correlation with maternal age. These results fit with the idea of compromised germline maintenance in males, whose germline stem cells require continued division.
Data from: Shorter juvenile telomere length is associated with higher survival to spawning in migratory Atlantic salmon
The risk of mortality associated with a long-distance migration will depend on an animal's physiological state, as well as the prevailing ecological conditions. Here we assess whether juvenile telomere length, which in endotherms has been shown to be a biomarker of physiological state and expected lifespan, predicts whether wild Atlantic salmon Salmo salar successfully complete their marine migration. Over 1800 juvenile fish were trapped, measured, PIT-tagged and a tissue biopsy taken when migrating as juveniles down-river towards the sea. Survivors of the marine phase of the life cycle were then re-trapped and re-sampled when returning to the river to spawn as sexually mature adults, 1.5-2.5 years later. Most individuals experienced a reduction in telomere length during the marine migratory phase of their life cycle. While the relative rate of telomere loss was greater in males than females, telomere loss was unrelated to growth at sea. Contrary to expectations, salmon that had the shortest telomeres at the time of the outward migration had the greatest probability of surviving through to the return migration. This effect, independent of body size, may indicate a trade-off between investment in readiness for marine life (which favours high glucocorticoid levels, known to increase telomere attrition in other vertebrate species) and investment in telomere maintenance. Survival was also significantly influenced by the seasonal timing of outward migration, with the fish migrating downstream earliest in the spring having the highest probability of return. This study reveals that telomere length is associated with survival, although in ways that contrast with patterns seen in endotherms. This illustrates that while telomeres may be universally important for chromosome protection, the potential for telomere dynamics to predict performance may vary across taxa.
Data from: Is telomere length a molecular marker of individual quality? insights from a long-lived bird
1. In wild vertebrates, some individuals survive and reproduce better than others and this has led to the concept of individual quality. Despite its importance when studying ecological processes and life-history trade-offs, measuring individual quality is complex because individuals must be followed during a large part of their life. 2. Recently, telomere biology has been successfully brought into ecology and telomere length has been suggested to be a promising molecular tool to evaluate individual quality in wild vertebrates ('the telomere – individual quality hypothesis'). 3. In this study, we tested this hypothesis in a long-lived species, the Black-browed albatross (Thalassarche melanophrys) by simultaneously measuring telomere length and several potential complementary phenotypic proxies of individual quality in a single year. In addition, we followed the return rate and the reproductive performance of these same albatrosses for a decade. 4. We found that long telomeres were associated with several markers of high individual quality (foraging behaviour, body size, and stress hormone levels). Furthermore, we found that a single measure of telomere length could predict future offspring productivity, for at least several years following telomere measurement (better productivity being associated with longer telomeres). 5. Altogether, these results support the 'telomere – individual quality hypothesis' and suggest that telomere length can be useful to estimate individual quality in long-lived seabirds.
Data from: Sex differences in leucocyte telomere length in a free-living mammal
Mounting evidence suggests that average telomere length reflects previous stress and predicts subsequent survival across vertebrate species. In humans, leucocyte telomere length (LTL) is consistently shorter during adulthood in males than in females, although the causes of this sex difference and its generality to other mammals remain unknown. Here, we measured LTL in a cross-sectional sample of free-living Soay sheep and found shorter telomeres in males than in females in later adulthood (>3 years of age), but not in early life. This observation was not related to sex differences in growth or parasite burden, but we did find evidence for reduced LTL associated with increased horn growth in early life in males. Variation in LTL was independent of variation in the proportions of different leucocyte cell types, which are known to differ in telomere length. Our results provide the first evidence of sex differences in LTL from a wild mammal, but longitudinal studies are now required to determine whether telomere attrition rates or selective disappearance are responsible for these observed differences.
Early‐life seasonal, weather and social effects on telomere length in a wild mammal
<p class="MsoNoSpacing">Early-life environmental conditions can provide a source of individual variation in life-history strategies and senescence patterns. <a name="_Hlk65916590">Conditions experienced in early life can be quantified by measuring telomere length, which can act as a biomarker of survival probability in some species. </a>Here, we investigate whether seasonal changes, weather conditions, and group size are associated with early-life and/or early-adulthood telomere length in a wild population of European badgers (<i>Meles meles</i>). <a name="_Hlk68254810">We found substantial intra-annual changes in telomere length during the first three years of life (both between and within individuals), with shorter telomere lengths in the winter following the first spring and a trend for longer telomere lengths in the second spring compared to the first winter.</a> <a name="_Hlk65917227">In terms of weather conditions, cubs born in warmer, wetter springs with low rainfall variability had longer early-life (3–12 months old) telomere lengths</a>. Additionally, cubs born in groups with more cubs had marginally longer early-life telomeres, providing no evidence of resource constraint from cub competition. We also found that our previously documented positive association between early-life telomere length and cub survival probability remained when social and weather variables were included. Finally, after sexual maturity, in early adulthood (i.e. 12–36 months) we found no significant association between same-sex adult group size and telomere length (i.e. no effect of intra-sexual competition). Overall, we show that controlling for seasonal effects, which are linked to food availability and foraging success, is important in telomere length analyses, and that variation in telomere length in badgers reflects early-life conditions and also predicts first year cub survival.</p>
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