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626 results for “Testosterone”
CYP19A1 (Cytochrome P450 Family 19 Subfamily A Member 1) Gene and Pharmacogenetics of Response to Testosterone Therapy
ClinicalTrials.gov study NCT01378299. IPD Sharing: YES. Countries: 1. Publications: 2.
Testopel ® vs. Generic Testosterone Pellets.
ClinicalTrials.gov study NCT04523480. IPD Sharing: NO. Countries: 1. Publications: 10.
A Study Called ARAMON to Learn to What Extent Does Study Treatment With Darolutamide Affects Testosterone Levels in Men With Prostate Cancer That Had Not Been Treated With Hormonal Therapy Compared to
ClinicalTrials.gov study NCT05526248. IPD Sharing: NO. Countries: 1. Publications: 0.
Effects of Testosterone Replacement on Pain Sensitivity and Pain Perception
ClinicalTrials.gov study NCT00351819. IPD Sharing: NO. Countries: 1. Publications: 3.
Testosterone Administration and ACL Reconstruction in Men
ClinicalTrials.gov study NCT01595581. IPD Sharing: NO. Countries: 1. Publications: 2.
Beyond sex and aggression: Testosterone rapidly matches behavioral responses to social context and tries to predict the future
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Social environment and masculinization level interact to explain male testosterone levels in a social rodent: Part 1: The male side
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Data from: Testosterone eliminates strategic prosocial behavior in healthy males
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Data from: Exogenous testosterone increases the audience effect in healthy males: evidence for the social status hypothesis
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Social environment and masculinization level interact to explain testosterone levels in a communally rearing rodent: part 2: the female side
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Data from: Androgen-armoured amazons – reversed sex roles in coucals are associated with testosterone in females but not males
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Data from: Testosterone modulates status-specific patterns of cooperation in a social network
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Reduced cooperative courtship behavior as a cost of high testosterone in a lekking passerine bird
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Data from: Testosterone activates sexual dimorphism including male-typical carotenoid but not melanin plumage pigmentation in a female bird
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Activational and organizational effects of testosterone on the number of mating partners and reproductive success in males of a social rodent
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Data from: Female ornamentation is associated with elevated aggression and testosterone in a tropical songbird
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Inter-annual repeatability and age-dependent changes in plasma testosterone levels in a longitudinally monitored free-living passerine bird
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Data from: Testosterone regulates CYP2J19-linked carotenoid signal expression in male red-backed fairywrens (Malurus melanocephalus)
<p>Carotenoid pigments produce most red, orange, and yellow colours in vertebrates. This coloration can serve as an honest signal of quality that mediates social and mating interactions, but our understanding of the underlying mechanisms that control carotenoid signal production, including how different physiological pathways interact to shape and maintain these signals, remains incomplete. We investigated the role of testosterone in mediating gene expression associated with a red plumage sexual signal in red-backed fairywrens (<i>Malurus melanocephalus</i>). In this species, males within a single population can flexibly produce either red/black nuptial plumage or female-like brown plumage. Combining correlational analyses with a field-based testosterone implant experiment and qPCR, we show that testosterone mediates expression of carotenoid-based plumage in part by regulating expression of CYP2J19, a ketolase gene associated with ketocarotenoid metabolism and pigmentation in birds. This is the first time that hormonal regulation of a specific genetic locus has been linked to carotenoid production in a natural context, revealing how endocrine mechanisms produce sexual signals that shape reproductive success.</p>
Data from: Sexually opposite effects of testosterone on mating success in wild rock hyrax
Although males and females share traits, their motivations and needs may be different, due to life-history disparities that lead to divergent selection pressures. Proximate mechanisms underlying differences between the sexes include hormones that mediate the development and activation of suites of traits. Testosterone is associated with morphological features, physiological processes and social behaviours in both sexes. The goal of this study is to test whether testosterone affects males and females differently in a species where it is present in similar concentrations in the circulation. We combined behavioural mating observations of the wild polygynandrous rock hyrax (Procavia capensis) with hair testosterone that represents long-term integrated levels. We found that whereas copulation success increases with the rise in testosterone in males it decreases in females. We did not find an association between testosterone and choosiness in either sex. However, we found that males with higher testosterone mate-guarded females with lower testosterone. Our findings show disassortative mating and mate-guarding in respect to testosterone and provide clues to the cost of testosterone for females, in terms of copulation success. These results open up intriguing questions relating to the role of testosterone in mediating a similar trade-off in male and female reproductive success.
Data from: Measuring fecal testosterone in females and fecal estrogens in males: comparison of RIA and LC/MS/MS methods for wild baboons (Papio cynocephalus).
The development of non-invasive methods, particularly fecal determination, has made possible the assessment of hormone concentrations in wild animal populations. However, measuring fecal metabolites needs careful validation for each species and for each sex. We investigated whether radioimmunoassays (RIAs) previously used to measure fecal testosterone (fT) in male baboons and fecal estrogens (fE) in female baboons were well suited to measure these hormones in the opposite sex. We compared fE and fT concentrations determined by RIA to those measured by liquid chromatography combined with triple quadropole mass spectrometry (LC/MS/MS), a highly specific method. Additionally, we conducted a biological validation to assure that the measurements of fecal concentrations reflected physiological levels of the hormone of interest. Several tests produced expected results that led us to conclude that our RIAs can reliably measure fT and fE in both sexes, and that within-sex comparisons of these measures are valid: (i) fTRIA were significantly correlated to fTLC/MS/MS for both sexes; (ii) fTRIA were higher in adult than in immature males; (iii) fTRIA were higher in pregnant than non-pregnant females; (iv) fERIA were correlated with 17β-estradiol (fE2) and with estrone (fE1) determined by LC/MS/MS in pregnant females; (v) fERIA were significantly correlated with fE2 in non-pregnant females and nearly significantly correlated in males; (vi) fERIA were higher in adult males than in immature males. fERIA were higher in females than in males, as predicted, but unexpectedly, fTRIA were higher in females than in males, suggesting a difference in steroid metabolism in the two sexes; consequently, we conclude that while within-sex comparisons are valid, fTRIA should not be used for intersexual comparisons. Our results should open the field to important additional studies, as to date the roles of testosterone in females and estrogens in males have been little investigated.
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Allen Brain Atlas
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International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.