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349 results for “anti-inflammatory activity”
Fig. 7. Compounds 5a, 8b in Meroterpenoids with diverse structures and anti-inflammatory activities from Rhododendron anthopogonoides
Fig. 7. Compounds 5a, 8b, and 9 suppress the LPS-induced inflammatory responses in RAW 264.7 macrophages. A. Effects on the mRNA level of IL-1β. B. Effects on the mRNA level of IL-6. BAY 11–7082 (10 μM) was set as the positive control. Results are presented as mean ± SD (n = 3). *p <0.05, **p <0.01, ***p <0.001, ****p <0.001 vs the LPS group using one-way ANOVA.
Fig. 5 in Polyketides from the endolichenic fungus Eupenicillium javanicum and their anti-inflammatory activities
Fig. 5. Inhibitory activity of compounds 5, 9 and 10 against NO production in RAW 264.7 cells. Cells were treated with various concentrations of compounds along with LPS (1 μg/mL) for 24 h, and the accumulation of nitrite was evaluated by Griess reagent. Values were presented as mean ± SD from three independent experiments. **P <0.01, ***P <0.001. Column: relative NO level; Dot: cell viability. C: control.
Fig. 5 in Abietane diterpenoids from Dracocephalum moldavica L. and their anti-inflammatory activities in vitro
Fig. 5. Inhibition rates of compounds 1–11 on TNF-α, IL-1β and NO production in LPS–stimulated RAW 264.7 cells at the concentration of 10 μM * The concentration of the compound was 30 μM.
Fig. 7 in HRESIMS-guided isolation of aspidosperma-scandine type bisindole alkaloids from Melodinus cochinchinensis and their anti-inflammatory and cytotoxic activities
Fig. 7. Effect of BIAs 1 and 6 on LPS-stimulated NO (A), IL-6 (B) and TNF-α (C) production in RAW 264.7 macrophages. DXM was used as a positive control at 30 μM concentration. The values are presented as mean SD of triplicate replicates. Statically significant difference was determined by ANOVA and Tukey test (#p <0.05, ± compared with control group, *p<0.05, compared with model group).
Fig. 1 in HRESIMS-guided isolation of aspidosperma-scandine type bisindole alkaloids from Melodinus cochinchinensis and their anti-inflammatory and cytotoxic activities
Fig. 1. (A) Total ion chromatogram of the extract of M. cochinchinensis. (B) UV absorption bands of compounds 1–3. (C) HRESIMS data of melokhanines KM (1–3).
Fig. 6 in HRESIMS-guided isolation of aspidosperma-scandine type bisindole alkaloids from Melodinus cochinchinensis and their anti-inflammatory and cytotoxic activities
Fig. 6. Key HMBC (single arrows in red), 1 H– 1 H COSY (bold in blue) and ROESY (double-headed arrows in red) correlations of BIA 3. (For interpretation of the references to color in this figure legend, the reader is referred to the Web version of this article.)
Fig. 6 in Glycoglycerolipids from the leaves of Perilla frutescens (L.) Britton (Labiatae) and their anti-inflammatory activities in lipopolysaccharide-stimulated RAW264.7 cells
Fig. 6. Inhibitory effects of three glycoglycerolipids on pro-inflammatory cytokines (IL-6, TNF-α, and IL-1β) secretion in 200 ng/ml LPS-stimulated murine macrophages RAW 264.7 cells after 24 h incubation. Different lowercase letters above the bars represented the significant difference (P <0.05) (+: presence; -: absence).
Fig. 5 in Glycoglycerolipids from the leaves of Perilla frutescens (L.) Britton (Labiatae) and their anti-inflammatory activities in lipopolysaccharide-stimulated RAW264.7 cells
Fig. 5. Inhibitory effects of three glycoglycerolipids from Perilla frutescens leaves on the production of NO in 200 ng/ml LPS-stimulated murine macrophages RAW 264.7 cells. Different lowercase letters above the bars represented the significant difference (P <0.05) (+: presence; -: absence).
Fig. 3 in HRESIMS-guided isolation of aspidosperma-scandine type bisindole alkaloids from Melodinus cochinchinensis and their anti-inflammatory and cytotoxic activities
Fig. 3. Key HMBC (single arrows in red), 1H–1H COSY (bold in blue) and ROESY (double-headed arrows in red) correlations of BIA 1. (For interpretation of the references to color in this figure legend, the reader is referred to the Web version of this article.)
Fig. 5 in HRESIMS-guided isolation of aspidosperma-scandine type bisindole alkaloids from Melodinus cochinchinensis and their anti-inflammatory and cytotoxic activities
Fig. 5. Key HMBC (single arrows in red), 1H–1H COSY (bold in blue) and ROESY (double-headed arrows in red) correlations of BIA 2. (For interpretation of the references to color in this figure legend, the reader is referred to the Web version of this article.)
Fig. 3. 2D in Glycoglycerolipids from the leaves of Perilla frutescens (L.) Britton (Labiatae) and their anti-inflammatory activities in lipopolysaccharide-stimulated RAW264.7 cells
Fig. 3. 2D NMR spectra of compounds 1, 2 and 3 and structure of compounds 1. (A) Partial HMQC NMR spectrum of compound 1 (CDCl3, 600 MHz), see Supplementary Figs. 6 for the complete HMQC NMR spectrum of compound 1; (B) TCOSY NMR spectrum of compound 1 (CDCl3, 600 MHz); (C) HMBC NMR spectrum of compound 1 (CDCl, 600 MHz); (D) Structure of compound 1. (E) Key 1H–1H TCOSY (─) and HMBC (→) correlations in compound 2. (F) Key 1H–1H TCOSY (─) and 3 HMBC (→) correlations in compound 3.
Fig. 2 in Glycoglycerolipids from the leaves of Perilla frutescens (L.) Britton (Labiatae) and their anti-inflammatory activities in lipopolysaccharide-stimulated RAW264.7 cells
Fig. 2. Positive-ion MALDI-TOF/TOF-MS/MS spectrum of MGDG and DGDG from Perilla frutescens leaves. (A) Compound 1 (MGDG); (B) Compound 2 (DGDG); and (C) Compound 3 (DGDG).
Fig. 4 in Tirucallane triterpenoids from the mastic (Pistacia lentiscus) and their anti-inflammatory and cytotoxic activities
Fig. 4. (a) Key 1H–1H COSY (▬) and selected HMBC correlations (H→C) of 12; (b) Key NOESY correlations of 12.
Fig. 2 in Tirucallane triterpenoids from the mastic (Pistacia lentiscus) and their anti-inflammatory and cytotoxic activities
Fig. 2. (a) Key 1H–1H COSY (▬) and selected HMBC correlations (H→C) of 1; (b) Key NOESY correlations of 1.
Fig. 5 in Tirucallane triterpenoids from the mastic (Pistacia lentiscus) and their anti-inflammatory and cytotoxic activities
Fig. 5. Cytotoxic effects of compounds 1–16 on RAW 264.7 cell viability at concentration of 60 μM, Dexamethasone was used as a positive control. Cell viability was measured by the CKK-8 assay. Data are expressed as mean ± SD, n = 3, *p <0.05, **p <0.01, ***p <0.001 vs control group.
Fig. 5 in Catecholic alkaloid sulfonates and aromatic nitro compounds from Portulaca oleracea and screening of their anti-inflammatory and anti-microbial activities
Fig. 5. Possible biosynthetic pathway for the nitro derivatives, catecholic alkaloids and their sulfonates from P. oleracea (DDC: dopa decarboxylase; RNS: reactive nitrogen species; TH: tyrosine hydroxylase).
Fig. 6 in Catecholic alkaloid sulfonates and aromatic nitro compounds from Portulaca oleracea and screening of their anti-inflammatory and anti-microbial activities
Fig. 6. Dose-dependent inhibition of nitro derivative 12 against LPS-induced NO production in RAW 264.7 macrophage cells (n = 3) (****p <0.0001, versus vehicle control, ####p <0.0001, versus LPS-treated model, 3,4-dihydroxy-benzohydroxamic acid (Didox) was used as the positive control with IC value of 70 μM).
Fig. 4 in Catecholic alkaloid sulfonates and aromatic nitro compounds from Portulaca oleracea and screening of their anti-inflammatory and anti-microbial activities
Fig. 4. Calculated and experiment ECD of compounds 4, 10–11, 15–17 and their possible stereostructures
Fig. 7 in Sarcoelegans A-H, eight undescribed cembranes with anti-inflammatory and anti-thrombotic activities from the South China Sea soft coral Sarcophyton elegans
Fig. 7. Anti-thrombotic assays of compounds 2–3. (A) Images of staining intensity of erythrocytes in heart in arachidonic acid (AA)-induced thrombus in zebrafish, treated with sarcoelegans B–C (2–3), using aspirin as positive control. (B) Quantitative analysis of staining intensity of erythrocytes in heart in zebrafish treated with sarcoelegans B–C (2–3) in zebrafish. (C) Images of area of caudal vein thrombosis in arachidonic acid (AA)-induced thrombus in zebrafish, treated with sarcoelegans B–C (2–3), using aspirin as positive control. (D) Quantitative analysis of area of caudal vein thrombosis in zebrafish treated with sarcoelegans B–C (2–3) in zebrafish. #### Indicates that the arachidonic acid model group has a very significant difference compared with the control group (P <0.01). ** indicate that sample groups have significant differences compared with the arachidonic acid model group (P <0.01).
Fig. 4 in Sarcoelegans A-H, eight undescribed cembranes with anti-inflammatory and anti-thrombotic activities from the South China Sea soft coral Sarcophyton elegans
Fig. 4. ORTEP drawing of compounds 1, 4, 6, and 8. Displacement ellipsoids are drawn at the 50% probability.
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Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
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DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.