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Figure 4 from: Abdullah AH, Alarareh AK, Al-Sha'er MA, Habashneh AY, Awwadi FF, Bardaweel SK (2024) Docking, synthesis, and anticancer assessment of novel quinoline-amidrazone hybrids. Pharmacia 71: 1-12. https://doi.org/10.3897/pharmacia.71.e117192
Figure 4 A. The co-crystallized pyrimidine ligand (1IEP); B. The co-crystallized pose and the docked pose of the co-crystallized ligand with RMSD = 2.10 Å; C. The binding site of the c-Abl-kinase protein (PDB code: 1IEP, resolution: 2.10 Å). Blue is for the co-crystal compounds, and red is for the highest Libdock score compound (Libdock score = 169.76).
Figure 1 from: Talib WH, Atawneh S, Shakhatreh AN, Shakhatreh GN, Rasheed aljarrah IS, Hamed RA, Adel banyyounes D, Al-Yasari IH (2024) Anticancer potential of garlic bioactive constituents: Allicin, Z-ajoene, and organosulfur compounds. Pharmacia 71: 1-23. https://doi.org/10.3897/pharmacia.71.e114556
Figure 1 Enhancement of DNA repair mechanisms by garlic compounds (created by BioRender.com). This diagram illustrates how garlic compounds enhance DNA repair mechanisms: DNA Damage: The process begins with DNA damage, represented as breaks and mutations in the DNA strands. Recognition: The damaged DNA is recognized by cellular repair machinery, signaling the need for repair. Garlic Compounds: Garlic compounds, highlighted in the diagram, play a crucial role at this stage. They are known for their Genoprotective properties. DNA Repair Mechanism: The diagram illustrates the sequential steps of DNA repair, including excision, polymerization, and ligation. Enhanced Repair: Garlic compounds facilitate and enhance the DNA repair process, as indicated by connecting lines and arrows.
Figure 2 from: Talib WH, Atawneh S, Shakhatreh AN, Shakhatreh GN, Rasheed aljarrah IS, Hamed RA, Adel banyyounes D, Al-Yasari IH (2024) Anticancer potential of garlic bioactive constituents: Allicin, Z-ajoene, and organosulfur compounds. Pharmacia 71: 1-23. https://doi.org/10.3897/pharmacia.71.e114556
Figure 2 Angiogenesis processes and garlic compound interference (created by: BioRender.com). Fig. 2 provides an overview of the intricate process of angiogenesis within the tumor microenvironment and demonstrates how garlic compounds interfere with this critical pathway. Tumor Microenvironment: On the left, the tumor microenvironment is depicted as the origin of angiogenesis.
Figure 3 from: AlNaimat S, Abu-Odeh A, Talib WH (2024) Anticancer and antioxidant activities of essential oils of Chiliadenus iphionoides from Jordan: in vitro and in vivo study. Pharmacia 71: 1-7. https://doi.org/10.3897/pharmacia.71.e116195
Figure 3 A plot of change in average tumor size (mm3) vs. time in (days) of treatment iEMT6/P (p < 0.05) compared to the control group
Figure 5 from: AlNaimat S, Abu-Odeh A, Talib WH (2024) Anticancer and antioxidant activities of essential oils of Chiliadenus iphionoides from Jordan: in vitro and in vivo study. Pharmacia 71: 1-7. https://doi.org/10.3897/pharmacia.71.e116195
Figure 5 Effect of C. iphionoides treatment on serum levels of (A) Creatinine and (B) ALT, AST. Serum creatinine level is expressed in mg/dL, and concentrations of ALT and AST are expressed by IU/L. Mice were treated with (60 mg/kg/ day) of essential oil. Results are expressed as means (bars) ± SEM (lines). ALT, alanine transaminase; AST, aspartate transaminase.
Figure 2 from: AlNaimat S, Abu-Odeh A, Talib WH (2024) Anticancer and antioxidant activities of essential oils of Chiliadenus iphionoides from Jordan: in vitro and in vivo study. Pharmacia 71: 1-7. https://doi.org/10.3897/pharmacia.71.e116195
Figure 2 Antiproliferative activity of essential oil of C. iphionoides on MDA-MB- 231, T47, A549, EMT6, Vero cell lines
Figure 4 from: AlNaimat S, Abu-Odeh A, Talib WH (2024) Anticancer and antioxidant activities of essential oils of Chiliadenus iphionoides from Jordan: in vitro and in vivo study. Pharmacia 71: 1-7. https://doi.org/10.3897/pharmacia.71.e116195
Figure 4 Effect of C. iphionoides essential oil on tumor size and cure percentage. Treatment with C. iphionoides essential oil reduced tumor size and increased cure percentage compared to the negative control. (N = 9 mice) in each group.
SNSynergy: similarity network-based machine learning framework for synergy prediction towards new cell lines and new anticancer drug combinations
Open the record for dataset details and reuse information.
Figure 3 from: Mahmod AI, Talib WH (2021) Anticancer activity of Mandragora autumnalis: an in vitro and in vivo study. Pharmacia 68(4): 827-835. https://doi.org/10.3897/pharmacia.68.e71695
Figure 3 A plot of change in average tumor size (mm³) vs. time in (days) of treatment in EMT6/P cell line. (P < 0.001) compared to the control group.
Figure 4 from: Mahmod AI, Talib WH (2021) Anticancer activity of Mandragora autumnalis: an in vitro and in vivo study. Pharmacia 68(4): 827-835. https://doi.org/10.3897/pharmacia.68.e71695
Figure 4 Effect of M. autumnalis ethanol extract on tumor size and cure percentage. Treatment with M. autumnalis ethanol extract resulted in reducing tumors size and increasing cure percentage compared to the negative control. (N = 10 mice) in each group.
Figure 5 from: Mahmod AI, Talib WH (2021) Anticancer activity of Mandragora autumnalis: an in vitro and in vivo study. Pharmacia 68(4): 827-835. https://doi.org/10.3897/pharmacia.68.e71695
Figure 5 Effect of M. autumnalis treatment on serum levels of: (A) AST, ALT and (B) Creatinine. Concentrations of AST and ALT are expressed by IU/L and serum creatinine level by mg/dl. Mice were treated with (137.4 mg/kg) of ethanol extract. Creatinine, ALT, and AST levels in normal healthy mouse were 0.8 mg/dl, 47.7 IU/L, 159 IU/L, respectively. Results are expressed as means (bars) ± SEM (lines). ALT, alanine transaminase; AST, aspartate transaminase.
Figure 2 from: Mahmod AI, Talib WH (2021) Anticancer activity of Mandragora autumnalis: an in vitro and in vivo study. Pharmacia 68(4): 827-835. https://doi.org/10.3897/pharmacia.68.e71695
Figure 2 The effect of IC₅₀ concentration of M. autumnalis ethanol crude extract (0.5 mg/ml), n-hexane fraction (0.6 mg/ml) and vincristine (0.02 mg/ml) on VEGF expression in MCF-7 cell line. (* P < 0.01) compared to the control.
Figure 1 from: Mahmod AI, Talib WH (2021) Anticancer activity of Mandragora autumnalis: an in vitro and in vivo study. Pharmacia 68(4): 827-835. https://doi.org/10.3897/pharmacia.68.e71695
Figure 1 (A) Antiproliferative activity of ethanol crude extract of M. autumnalis on MCF-7, MDA-MB-231, EMT6, HCT 116, A549 and VERO cell lines. (B) Antiproliferative activity of n-hexane fraction of M. autumnalis on MCF-7, MDA-MB-231, EMT6, HCT 116, A549 and VERO cell lines. (C) Antiproliferative activity of aqueous/methanol fraction of M. autumnalis on MCF-7, MDA-MB-231, EMT6, HCT 116, A549 and VERO cell lines. (D) Antiproliferative activity of aqueous fraction of M. autumnalis on MCF-7, MDA-MB-231, EMT6/P, HCT 116, A549 and VERO cell lines. Results expressed as means (bars)± SEM (lines).
Assessing the anticancer effects of Metformin
<p>Metformin is an anti-hyperglycemic biguanide drug that is widely used as the first-line prescription for managing type 2 Diabetes Mellitus (T2DM). Research suggests metformin use helps control T2DM which is one of the many risk factors for cancer and is proposed to have multiple antagonistic actions against cancer cells. Suggested biological means that metformin utilizes include AMPK-driven cascades involving two pathways, a direct and an indirect one. This leads to a decrease in the mechanistic activity of rapamycin (mTOR), folate level, c-MYC, NF-B, and also increases P53 phosphorylation. These cascades will also decrease cyclin D1, reactive oxygen species (ROS), and increase mTOR Complex1 (mTORC1) concentrations, apoptosis, and autophagy. Some researchers suggest metformin also exerts anti-inflammatory effects through reducing Interleukins-6 (IL6) and 8 (IL8), inhibition of protein translation via LKB1, increasing expression of GPD1 which suppresses cancer by inhibiting mitochondria and inducing cell apoptosis, and inhibiting leptin while increasing adiponectin production. There is also evidence of possible suppressive effects on overexpressed signals in some cancers, such as Notch1/Hes1, STAT3, and HER2+ which ultimately could increase survival rates in cancer patients.<br> <br> Our goal is to explore the mechanisms in which metformin can act as an anticancer drug and assess the effect of metformin on various types of malignancies.<br> <br> We retrospectively studied 266 cancer patients diagnosed in 2018 – 2019 in King Fahd Hospital of the University (KFHU). This population was furtherly divided into non-diabetic and diabetic cancer patients and the latter group into those who received metformin and those who did not.<br> <br> The results showed the statistical significance of metformin use on the cancer grade at diagnosis that favourably influences the morbidity/mortality.<br> <br> Metformin might have an anti-cancer effect on the grade of cancer at the time of diagnosis regardless of its dosage, and this might improve the prognosis of malignancy.</p>
Supplementary material 1 from: Yaseen Y, Kubba A, Shihab W, Tahtamouni L (2022) Synthesis, docking study, and structure-activity relationship of novel niflumic acid derivatives acting as anticancer agents by inhibiting VEGFR or EGFR tyrosine kinase activities. Pharmacia 69(3): 595-614. https://doi.org/10.3897/pharmacia.69.e86504
Figures S1, S2, Tables S1, S2
Figure 5 in The inhibitory and anticancer properties of Annona squamosa L. seed extracts
Figure 5. (A) XRD spectra of A. squamosa presentation projecting extract image. (B) ESE of A. squamosa powder measured by energy dispersive X-ray spectroscopy (C) ESE of A. squamosa powder as seen using scanning electron microscopy.
Figure 2 in Studies on the recombinant production and anticancer activity of thermostable L- asparaginase I from Pyrococcus abyssi
Figure 2. Effect of temperature on the stability and activity of enzyme. The optimum activity of purified enzyme was calculated at 80°C. The enzyme was considerably stable at temperatures up to 100°C.
Supplementary material 1 from: Yusuf H, Kamarlis RK, Yusni Y, Fahriani M (2021) The anticancer activity of ethanol extract of Chromolaena odorata leaves in 7,12-Dimethylbenz[a]anthracene in (DMBA) induced breast cancer Wistar rats (Rattus novergicus). Pharmacia 68(2): 493-499. https://doi.org/10.3897/pharmacia.68.e63956
Table S1
Figure 5 from: Abbas AH, Mahmood AAR, Tahtamouni LH, Al-Mazaydeh ZA, Rammaha MS, Alsoubani F, Al-bayati RI (2021) A novel derivative of picolinic acid induces endoplasmic reticulum stress-mediated apoptosis in human non-small cell lung cancer cells: synthesis, docking study, and anticancer activity. Pharmacia 68(3): 679-692. https://doi.org/10.3897/pharmacia.68.e70654
Figure 5 Compound 5 induces the ER-mediated apoptosis. A) Representative Western blot showing the enhanced release of Smac/DIABLO but not cytochrome c from the mitochondria (MF) into the cytosol (CF) of compound 5-treated A549 lung cancer cells (GI50). Equal protein loading was controlled by staining membranes with Ponceau S (a representative section of the stained membrane is shown). The experiment was repeated three times and the corresponding quantification is shown in (B), B) Quantification of smac/DIABLO and cytochrome C levels in vehicle-treated control A549 cells and cells treated with GI50 amount of compound 5 or 5% DMSO as a negative control. M: mitochondria fraction; C: cytosol fraction. Scale bars: mean ± SEM of three independent experiments. ** p < 0.01 compared to vehicle-treated control cells, C) Representative Western blot showing the induction of phosphorylation of eukaryotic initiation factor-2 (eIF-2) in A549 cells treated with GI50 amounts of compound 5. For comparison purposes, thapsigargin (TG), an ER stress-causing drug was used (3 μM, 2 h) as a positive control. The experiment was repeated three times.
Figure 4 from: Abbas AH, Mahmood AAR, Tahtamouni LH, Al-Mazaydeh ZA, Rammaha MS, Alsoubani F, Al-bayati RI (2021) A novel derivative of picolinic acid induces endoplasmic reticulum stress-mediated apoptosis in human non-small cell lung cancer cells: synthesis, docking study, and anticancer activity. Pharmacia 68(3): 679-692. https://doi.org/10.3897/pharmacia.68.e70654
Figure 4 Compound 5 causes caspase activation. A) qRT-PCR analysis of caspase 3, 4, 8 and 9 mRNA in compound 5-treated cells (GI50) as compared to vehicle-treated control cells [set as 1 arbitrary unit (a.u.)]. Values were normalized to β-actin. Scale bars: mean ± SEM of three independent experiments performed in triplicates. *p < 0.05, **p < 0.01 compared to vehicle-treated control cells, B) Representative Western blots showing cleavage "activation' of procaspase 3 to the active form p17, procaspase 4 to the active form p20, and procaspase 9 to the active forms p35/p37. C: vehicle-treated control cells; 0.5%: 0.5% DMSO-treated cells; 1%: 1% DMSO-treated cells; 5%: 5% DMSO-treated cells; C.5: Compound 5-treated cells. The experiment was repeated three times.
ScienceDex guides
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These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.