Find research datasets worth reusing
Search datasets from major research repositories and use ShareScore to quickly assess how well each record supports discovery, access, and reuse.
192
datasets available to search
ShareScore release 0.9.0
Dataset results
192 results for “arylation”
Genome-wide ChIP-chip analysis of the binding targets of the naïve and activated aryl hydrocarbon receptor
GEO Series GSE11850. Mus musculus. 16 samples. Type: Genome binding/occupancy profiling by genome tiling array.
Loss of aryl hydrocarbon receptor and long-term, but not short-term treatment with BAY2416964 alters gene expression profiles and reduces proliferation and migration of PyMT mammary cancer cells
GEO Series GSE272215. Mus musculus. 16 samples. Type: Expression profiling by high throughput sequencing.
An angiogenic role for the aryl hydrocarbon receptor in choroidal neovascularization
GEO Series GSE56983. Mus musculus. 2 samples. Type: Expression profiling by high throughput sequencing.
The environment-sensing aryl-hydrocarbon receptor inhibits the chondrogenic fate of modulated smooth muscle cells in atherosclerotic lesions
GEO Series GSE150768. Mus musculus; Homo sapiens. 34 samples. Type: Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing.
The aryl hydrocarbon receptor regulates nucleolar activity and protein synthesis in MYC-expressing cells
GEO Series GSE135061. Rattus norvegicus. 18 samples. Type: Expression profiling by high throughput sequencing.
Endogenous aryl hydrocarbon receptor ligands-dysregulated transcriptomic profiles and vascular function in rat placentas
GEO Series GSE250269. Rattus norvegicus. 50 samples. Type: Expression profiling by high throughput sequencing.
The Aryl Hydrocarbon Receptor Regulates Th17/Th22 Effector Functions and HIV Replication/Outgrowth in Human CD4+ T-cells
GEO Series GSE198078. Homo sapiens. 12 samples. Type: Expression profiling by high throughput sequencing.
Mast cell expression data from murine aryl hydrocarbon receptor (AhR) null, AhR_d and normal control mice
GEO Series GSE44715. Mus musculus. 9 samples. Type: Expression profiling by array.
Chronic Aryl Hydrocarbon Receptor Activity Causes Adverse Muscle Affect: Implications for Smoking-induced Muscle Impairment
GEO Series GSE151099. Mus musculus. 24 samples. Type: Expression profiling by high throughput sequencing.
Using fish models to understand the role of aryl hydrocarbon receptor (AHR)-interacting protein (AIP) in controlling sensitivity and resistance to dioxin-like compounds in vivo 5dpf
GEO Series GSE295203. Danio rerio. 24 samples. Type: Expression profiling by high throughput sequencing.
Aryl hydrocarbon receptor senses bacterial pigmented virulence factors and orchestrates anti-bacterial defenses (part 1)
GEO Series GSE48130. Mus musculus. 8 samples. Type: Expression profiling by array.
Figure 2 from: Demchenko SА, Fedchenkova YА, Yeromina HО, Herashenko IV, Berdnyk OH, Demchenko AM (2021) The synthesis of N-(4-aryl-thiazol-2-yl)-N1-(4,5,6,7-tetrahydro-3H-azepin-2-yl)-hydrazine hydrobromides and the cardioprotective activity of (41-methoxyphenyl-thiazol-2-yl) derivative. Pharmacia 68(1): 141-146. https://doi.org/10.3897/pharmacia.68.e58788
Figure 2 Mildronate (meldonium).
Data from: Hepatocyte-specific deletion of TIPARP, a negative regulator of the aryl hydrocarbon receptor, is sufficient to increase sensitivity to dioxin-induced wasting syndrome
The aryl hydrocarbon receptor (AHR) mediates the toxic effects of dioxin (2,3,7,8-tetrachlorodibenzo-p-dioxin; TCDD), which include thymic atrophy, steatohepatitis, and a lethal wasting syndrome in laboratory rodents. Although the mechanisms of dioxin toxicity remain unknown, AHR signaling in hepatocytes is necessary for dioxin-induced liver toxicity. We previously reported that loss of TCDD-inducible poly(ADP-ribose) polymerase (TIPARP/PARP7/ARTD14), an AHR target gene and mono-ADP-ribosyltransferase, increases the sensitivity of mice to dioxin-induced toxicities. To test the hypothesis that TIPARP is a negative regulator of AHR signaling in hepatocytes, we generated Tiparpfl/fl mice in which exon 3 of Tiparp is flanked by loxP sites, followed by Cre-lox technology to create hepatocyte-specific (Tiparpfl/flCreAlb) and whole-body (Tiparpfl/flCreCMV; TiparpEx3-/-) Tiparp null mice. Tiparpfl/flCreAlb and TiparpEx3-/- mice given a single injection of 10 g/kg dioxin did not survive beyond day 7 and 9, respectively, while all Tiparp+/+ mice survived the 30-day treatment. Dioxin-exposed Tiparpfl/flCreAlb and TiparpEx3-/- mice had increased steatohepatitis and hepatotoxicity as indicated by greater staining of neutral lipids and serum alanine aminotransferase activity than similarly treated wild-type mice. Tiparpfl/flCreAlb and TiparpEx3-/- mice exhibited augmented AHR signalling, denoted by increased dioxin-induced gene expression. Metabolomic studies revealed alterations in lipid and amino acid metabolism in liver extracts from Tiparpfl/flCreAlb mice compared with wild-type mice. Taken together, these data illustrate that TIPARP is an important negative regulator of AHR activity, and that its specific loss in hepatocytes is sufficient to increase sensitivity to dioxin-induced steatohepatitis and lethality.
Carbene-Catalyzed Enantioselective Sulfonylation of Enone Aryl Al-dehydes: New Mode of Breslow Intermediate Oxidation
<p>This folder /final_xyz_structures/ contains the geometries (in .xyz format together with the gas-phase energy, E) accompanying the paper</p> <p>"Carbene-Catalyzed Enantioselective Sulfonylation of Enone Aryl Aldehydes: New Mode of Breslow Intermediate Oxidation and Remote Catalytic Control"</p> <p>Where conformers occur, they are always named from the lowest Gibbs energy to the highest in ascending order from c1 (sometimes omitted), c2, c3, ...</p>
A First-in-Humans Dose Finding Study for an Aryl Hydrocarbon Receptor Inhibitor (AhRi) in Patients With Advanced Cancer
ClinicalTrials.gov study NCT04069026. IPD Sharing: UNDECIDED. Countries: 5. Publications: 0.
Aryl Hydrocarbon Receptor Interacting Protein (AIP) Gene Mutations in Acromegaly
ClinicalTrials.gov study NCT01902420. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Transcriptomic signatures reveal a shift towards an antiinflammatory gene expression profile but also the induction of type-I and type-II interferon signaling networks through aryl hydrocarbon recepto
GEO Series GSE223122. Mus musculus. 64 samples. Type: Expression profiling by high throughput sequencing.
Disruption of the tumor suppressor-like activity of aryl hydrocarbon receptor by arsenic in epithelial cells and human lung cancer
GEO Series GSE214840. Homo sapiens. 9 samples. Type: Genome binding/occupancy profiling by high throughput sequencing; Expression profiling by high throughput sequencing.
Transcriptional Profiles Induced by the Aryl Hydrocarbon Receptor Agonists 2,3,7,8-Tetrachlorodibenzo-p-dioxin, 2,3,7,8-Tetrachlorodibenzofuran and 2,3,4,7,8-Pentachlorodibenzofuran in Primary Rat Hep
GEO Series GSE29095. Rattus norvegicus. 28 samples. Type: Expression profiling by array.
The aryl hydrocarbon receptor partially controls tissue adaptaion of intestinal eosinophils in mice
GEO Series GSE173831. Mus musculus. 18 samples. Type: Expression profiling by high throughput sequencing.
ScienceDex guides
Understand access before you commit
These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.