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305 results for “characterization model”
Characterizing and Understanding the Behavior of Quantized Models for Reliable Deployment
<p>Benchmark for quantization study</p>
Dataset related to: Characterization of a Rat Model of Myeloperoxidase-Anti-Neutrophil Cytoplasmic Antibody-Associated Crescentic Glomerulonephritis
<p><strong>Background/aim: </strong> Necrotizing crescentic glomerulonephritis (GN) associated with anti-neutrophil cytoplasmic antibodies (ANCA) against myeloperoxidase (MPO) is a devastating disease that quickly progresses to kidney failure. Current therapies are broadly immunosuppressive and associated with adverse effects. We wanted to set up a model that could be suitable for testing narrowly targeted therapies.</p> <p><strong>Methods: </strong> The model was constructed in male Wistar Kyoto rats through injections of human MPO (hMPO) and pertussis toxin, followed by a sub-nephritogenic dose of sheep anti-rat glomerular basement membrane (GBM) serum to boost the disease. Rats were monitored for 35 days. Rats given hMPO alone, saline, or human serum albumin with or without anti-GBM serum were also studied.</p> <p><strong>Results: </strong> Rats receiving hMPO developed circulating anti-hMPO and anti-rat MPO antibodies. Challenging hMPO-immunized rats with the anti-GBM serum led to more glomerular neutrophil infiltration and MPO release, and severe haematuria, heavy proteinuria, and higher blood urea nitrogen than hMPO alone. Pauci-immune GN developed with crescents, affecting 25% of glomeruli. The majority of crescents were fibrocellular. Necrotizing lesions and Bowman capsule ruptures were detected. Cells double positive for claudin-1 (a marker of parietal epithelial cells [PECs]) and neural cell adhesion molecule (NCAM; progenitor PECs) were present in crescents. Double staining for NCAM and Ki-67 established proliferative status of progenitor PECs. Podocyte damage was associated with endothelial and GBM changes by electron microscopy. Monocyte/macrophages and CD4+ and CD8+ T cells accumulated in glomeruli and the surrounding area and in the tubulointerstitium. Lung haemorrhage also manifested.</p> <p><strong>Conclusion: </strong> This model reflects histological lesions of human ANCA-associated rapidly progressive GN and may be useful for investigating new therapies.</p>
Electrochemical Characterization and Modelling of Anode and Electrolyte Supported Solid Oxide Fuel Cells
<p>Datasets from the paper: "Electrochemical Characterization and Modelling of Anode and Electrolyte Supported Solid Oxide Fuel Cells", Front. Energy Res., 27 September 2021.</p> <p>The work was carried out within the framework of the European Project AD ASTRA. This project has received funding from the Fuel Cells and Hydrogen 2 Joint Undertaking under <strong>Grant Agreement No 825027</strong>. This Joint Undertaking receives support from the European Union's Horizon 2020 research and innovation programme and Hydrogen Europe.</p>
Models from "Applying Machine Learning to Characterize and Extrapolate the Relationship Between Seismic Structure and Surface Heat Flow"
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Characterization of Neutrophil Functional Responses to SARS-CoV-2 Infection in a Translational Feline Model for COVID-19
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Genomic and single-cell characterization of patient-derived tumor organoid models of head and neck squamous cell carcinoma
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Data from: Computational and experimental characterization of dVHL establish a Drosophila model of VHL syndrome
The von Hippel-Lindau (VHL) cancer syndrome is associated with mutations in the VHL gene. The pVHL protein is involved in response to changes in oxygen availability as part of an E3-ligase that targets the Hypoxia-Inducible Factor for degradation. pVHL has a molten globule configuration with marginal thermodynamic stability. The cancer-associated mutations further destabilize it. The Drosophila homolog, dVHL, has relatively low sequence similarity to pVHL, and is also involved in regulating HIF1-α. Using in silico, in vitro and in vivo approaches we demonstrate high similarity between the structure and function of dVHL and pVHL. These proteins have a similar fold, secondary and tertiary structures, as well as thermodynamic stability. Key functional residues in dVHL are evolutionary conserved. This structural homology underlies functional similarity of both proteins, evident by their ability to bind their reciprocal partner proteins, and by the observation that transgenic pVHL can fully maintain normal dVHL-HIF1-α downstream pathways in flies. This novel transgenic Drosophila model is thus useful for studying the VHL syndrome, and for testing drug candidates to treat it.
Datasets and models about the geophysical characterization of the Mt. Melbourne Volcanic Field (Northern Victoria Land, Antarctica)
<p>Supplementary materials about the geophysical characterization of the Mt. Melbourne Volcanic Field</p>
Characterization, modelling, and optimization of high-performance nano-columnar micro–Solid Oxide Cell oxygen electrodes
<p>Dataset containing all the data used in the article entitled "Characterization, modelling, and optimization of high-performance nano-columnar micro–Solid Oxide Cell oxygen electrodes".</p>
Data from: Computational and experimental characterization of dVHL establish a Drosophila model of VHL syndrome
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Data from: Characterization of leukemia-inducing genes using a proto-oncogene/homeobox gene retroviral human cDNA library in a mouse in vivo model
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Data from: Synthesis, characterization and modelling of zinc and silicate co-substituted hydroxyapatite
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Raw in vitro screening data and R scripts for: A Bayesian method for population-wide cardiotoxicity hazard and risk characterization using an in vitro human model
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Data from: Characterization of a transgenic mouse model exhibiting spontaneous lung adenocarcinomas with a metastatic phenotype
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Data from: Characterization of advanced glycation end products and their receptor (RAGE) in an animal model of myocardial infarction
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Data from: Antagonistic versus non-antagonistic models of balancing selection: characterizing the relative timescales and hitchhiking effects of partial selective sweeps
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Characterizing the clinical features and atrophy patterns of MAPT-related frontotemporal dementia with disease progression modelling (Supplementary Data)
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Characterizing the Tumor Immune Microenvironment of Syngeneic Mouse Models of Ovarian Cancer to Predict Response to PD-L1 blockade
GEO Series GSE183368. Mus musculus. 2 samples. Type: Expression profiling by high throughput sequencing.
Microarray analysis of xenograft model to characterize the CNS leukemia
GEO Series GSE81517. Homo sapiens. 10 samples. Type: Expression profiling by array.
Generation and Characterization of an immortalized human mesenchymal stromal cell line model [Illumina adipocyte differentiation]
GEO Series GSE47647. Homo sapiens. 12 samples. Type: Expression profiling by array.
ScienceDex guides
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These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.