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568 results for “condensate”
Data for the manuscript "Ion-mediated condensation controls the mechanics of mitotic chromosomes"
<p>Data accompanying the manuscript "Ion-mediated condensation controls the mechanics of mitotic chromosomes". Each folder contians data to one set of experiments together with scripts to analyse the data and produce plots.</p>
Simulation data for: Poly(A)-binding protein is an ataxin-2 chaperone that regulates biomolecular condensates.
<p>Trajectory data and analysis scripts for the simulation component in: <strong>Poly(A)-binding protein is an ataxin-2 chaperone that regulates biomolecular condensates, </strong>by Steven Boeynaems et al.</p>
Extreme dynamics in a biomolecular condensate
<p>Simulation inputs, subsampled trajectory, and outputs of lifetime calculation from paper "Extreme dynamics in a biomolecular condensate". Lifetime outputs are provided because these cannot be correctly calculated from the subsampled trajectory made available here.</p>
Dataset: A new working fluid for condensation particle counters for use in sensitive working environments
<p>Dataset used for the puplication in Aerosol-Research: A new working fluid for condensation particle counters<br> for use in sensitive working environments</p>
Intrinsically Disordered Regions Promote Protein Refoldability and Facilitate Retrieval from Biomolecular Condensates–Peptide Quantifications
<p>Many eukaryotic proteins contain intrinsically disordered regions (IDRs) that intersperse globular folded domains, in contrast with bacterial proteins which are typically highly globular. Recent years have seen great progress in identifying biological functions associated with these elusive protein sequence: in specific cases, they mediate liquid- liquid phase separation, perform molecular recognition, or act as sensors to changes in the environment. Nevertheless, only a small number of IDRs have annotated functions despite their presence in 64% of yeast proteins, stimulating some to question what ‘general purpose’ they may serve. Here, by interrogating the refoldability of two fungal proteomes (Saccharomyces cerevisiae and Neurosporra crassa), we show that IDRs render their host proteins more refoldable from the denatured state, allowing them to cohere more closely to Anfinsen’s thermodynamic hypothesis. The data provide an exceptionally clear picture of which biophysical and topological characteristics enable refoldability. Moreover, we find that almost all yeast proteins that partition into stress granules during heat shock are refoldable, a finding that holds for other condensates such as P-bodies and the nucleolus. Finally, we find that the Hsp104 unfoldase is the principal actor in mediating disassembly of heat stress granules and that the efficiency with which condensed proteins are returned to the soluble phase is also well explained by refoldability. Hence, these studies establish spontaneous refoldability as an adaptive trait that endows proteins with the capacity to reform their native soluble structures following their extraction from condensates. Altogether, our results provide an intuitive model for the function of IDRs in many multidomain proteins and clarifies their relationship to the phenomenon of biomolecular condensation.</p> <p>This dataset provides peptide quantifications (and their respective P-values) from three separate types of experiments used to support the claims in this study.</p> <p>1. Peptide quantifications from global refolding reactions, assessed with limited-proteolysis mass spectrometry (LiP-MS), carried out on two fungal organisms (S. cerevisiae [yeast] & N. crassa), at three refolding times, repeated on three separate iterations (for yeast).</p> <p>2. Peptide quantifications from LiP-MS experiments conducted on yeast extracts during heat shock or recovery from heat shock</p> <p>3. Annotations for peptides in #1 that are associated with linker regions between folded domains.</p>
ATG9A regulates dissociation of recycling endosomes from microtubules leading to formation of influenza A virus liquid condensates - MAIN FIGURES
<p>Metadata for the manuscript entitled "ATG9A regulates dissociation of recycling endosomes from microtubules leading to formation of influenza A virus liquid inclusions" - MAIN FIGURES</p>
Ca2+ imaging data for: A rigidity transition of MEC-2/Stomatin condensates controls neuronal mechanotransduction during touch sensing
<p>Calcium imaging data from Sanfeliu et al, NCB, 2023.</p> <p>Project contains fluorescence data to characterize the activity of the touch receptor neurons (TRNs) - which are mechanically activated upon touch – in the model organism <em>Caenorhabditis elegans</em>. The set of data includes wild-type animals as a reference and two different mutants to understand their role during touch sensation: MEC-2(R385H) and UNC-89 knock-out.</p> <p> </p>
Condensed and Distributed Robotic Therapy in Spastic Stroke Post Botulinum Toxin Injection
ClinicalTrials.gov study NCT03321097. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Utilizing Exhaled Breathe Condensate Collection to Study Ion Regulation in Cystic Fibrosis
ClinicalTrials.gov study NCT01880723. IPD Sharing: Not stated. Countries: 1. Publications: 5.
Viscoelasticity of globular protein-based biomolecular condensates
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Data for: Phytochemical shift from condensed tannins to flavonoids in transgenic Betula pendula decreases consumption and growth but improves growth efficiency of Epirrita autumnata larvae
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Data from: In diverse conditions intrinsic chromatin condensate have liquid-like material properties
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Data from: Charge state-dependent ion condensation near conjugated polymer backbones
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Homotypic RNA clustering accompanies a liquid-to-solid transition inside the core of multi-component biomolecular condensates
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Data from: Supersaturation and critical size of cloud condensation nuclei in marine stratus clouds
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Concentrations of total phenolics and condensed tannins and the number of galls combined in each sample
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Small molecule properties define partitioning into biomolecular condensates
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Data for: Fabrication and characterization of antibacterial coatings using an amphoteric condensed tannin,Tanfloc
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Data from: Multi-scale structure of chromatin condensates explains phase separation and material properties
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Data from: Coactivator condensation drives cardiovascular cell lineage specification
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Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.