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94
datasets available to search
ShareScore release 0.9.0
Dataset results
94 results for “diastolic dysfunction”
Angiotensin-Neprilysin Inhibition in Diastolic Dysfunction After AMI
ClinicalTrials.gov study NCT04149990. IPD Sharing: NO. Countries: 1. Publications: 0.
Mitochondrial NNT promotes diastolic dysfunction in cardiometabolic Heart Failure with Reduced Ejection Fraction (HFpEF)
GEO Series GSE225557. Mus musculus. 8 samples. Type: Expression profiling by high throughput sequencing.
Clinical symptoms of right ventricular failure in experimental chronic pressure load are associated with progressive diastolic dysfunction
GEO Series GSE46863. Rattus norvegicus. 16 samples. Type: Expression profiling by array.
Cardiac reprogramming and Gata4 overexpression reduce fibrosis and improve diastolic dysfunction in heart failure with preserved ejection fraction [RNA-seq]
GEO Series GSE218733. Mus musculus. 9 samples. Type: Expression profiling by high throughput sequencing.
Impact of HMGB1 on Diastolic Dysfunction in Hypertensive Patients
ClinicalTrials.gov study NCT03177408. IPD Sharing: NO. Countries: 0. Publications: 0.
Efficacy and Safety of TRC041266 in Patients With Heart Failure, LVEF ≥40%, Diastolic Dysfunction and Type 2 Diabetes Mellitus
ClinicalTrials.gov study NCT04507347. IPD Sharing: NO. Countries: 0. Publications: 0.
LV Diastolic Dysfunction Among the Patients With Systolic Heart Failure-clinical Significance and Prognostic Importance.
ClinicalTrials.gov study NCT01115764. IPD Sharing: Not stated. Countries: 0. Publications: 0.
Assessment of the Possible Association Between Left Ventricular Diastolic Dysfunction and Carotid Atherosclerosis and Brain White Matter Damage
ClinicalTrials.gov study NCT04549298. IPD Sharing: NO. Countries: 0. Publications: 0.
Frequency of Asymptomatic Left Ventricular Diastolic Dysfunction in Diabetes Mellitus Type 2
ClinicalTrials.gov study NCT03196687. IPD Sharing: UNDECIDED. Countries: 0. Publications: 0.
A Cross-sectional Study on the Impact of Shift Work on Diastolic Dysfunction in Healthcare Workers
ClinicalTrials.gov study NCT07331233. IPD Sharing: YES. Countries: 0. Publications: 0.
Genomic editing of pathogenic TNNI3 mutation in restrictive cardiomyopathy rescues diastolic dysfunction of human induced pluripotent stem cell-derived cardiomyocytes
GEO Series GSE240775. Homo sapiens. 6 samples. Type: Expression profiling by high throughput sequencing.
Single-Cell RNA Sequencing Reveals Metabolic Stress-Dependent Activation of Cardiac Macrophages in a Model of Dyslipidemia-Induced Diastolic Dysfunction
GEO Series GSE209549. Mus musculus. 36 samples. Type: Expression profiling by high throughput sequencing.
The Relation Between Serum Level of Amioterminal Propeptide of Type I Procollagen and Diastolic Dysfunction in Hypertensive Patients Without Diabetes Mellitus
ClinicalTrials.gov study NCT00172406. IPD Sharing: Not stated. Countries: 0. Publications: 0.
Nocturnal hypoxia indexes are associated with left ventricular remodeling and diastolic dysfunction in obstructive sleep apnea patients
<p><strong>Background and objective: </strong>Obstructive sleep apnea (OSA) is associated with heart derangements detected at echocardiography as higher left ventricular mass index (LVMI), higher left ventricular end-diastolic diameter, lower left ventricular ejection fraction (LVEF), and impaired diastolic function. However, the currently used parameter to define OSA diagnosis and severity, the apnea/hypopnea index (AHI), poorly predicts cardiovascular damage, cardiovascular events, and mortality. Our study aimed to assess if other polygraphic indices of OSA presence and severity, in addition to AHI, might better predict echocardiographic cardiac remodeling.</p> <p><strong>Methods and results: </strong>We enrolled two cohorts of individuals referred for suspected OSA to the outpatient facilities of the IRCCS Istituto Auxologico Italiano, Milano, and of the Clinica Medica 3, Padova. All patients underwent home sleep apnea testing and echocardiography. Based on the AHI the cohort was divided into no-OSA (AHI<15 events/hour) and moderate-severe OSA (AHI≥15 events/hour). We recruited 162 patients and found that compared to patients with no-OSA, those with moderate-severe OSA showed higher LV remodeling [left ventricular end-diastolic volume (LVEDV) 48.4 ± 11.5 ml/m2 vs. 54.1 ± 14.0 ml/m2, respectively, p = 0.005] and lower LVEF (65.3 ± 5.8% vs. 61.6 ± 7.8%, respectively, p = 0.002), whereas we could not find any difference in LVMI and early and late ventricular filling velocity ratio (E/A). At multivariate linear regression analysis two polygraphic hypoxic burden-related markers were independent predictors of LVEDV and E/A, i.e., the percentage of time with O2 saturation below 90% (β = 0.222) and ODI (β = -0.422), respectively.</p> <p><strong>Conclusions: </strong>Our study shows that nocturnal hypoxia-related indexes were associated with left ventricular remodeling and diastolic dysfunction in OSA patients.</p> <p><strong>Keywords: </strong>Apnea/hypopnea index; Echocardiography; Hypoxia index; Hypoxic burden; Obstructive sleep apnea.</p>
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Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.