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213
datasets available to search
ShareScore release 0.9.0
Dataset results
213 results for “drug screening”
Medium-throughput drug screening of patient-derived organoids from colorectal peritoneal metastases can be used to guide therapy
GEO Series GSE147971. Homo sapiens. 17 samples. Type: Expression profiling by high throughput sequencing.
Drug sensitivity screening and genomic characterization of 45 HPV-negative head and neck carcinoma cell lines for novel biomarkers of drug efficacy [gene expression]
GEO Series GSE108061. Homo sapiens. 45 samples. Type: Expression profiling by array.
Drug screen combining RNA landscape analysis reveals targetable pathways in HIV-1 reactivation
GEO Series GSE149353. Homo sapiens. 45 samples. Type: Expression profiling by high throughput sequencing; Other.
High-content, targeted RNA-seq screening in organoids for drug discovery in colorectal cancer
GEO Series GSE157167. Mus musculus. 1249 samples. Type: Expression profiling by high throughput sequencing.
High-throughput Drug Screening Identifies Fluoxetine as a Potential Therapeutic Agent for Neuroendocrine Prostate Cancer
GEO Series GSE224715. Homo sapiens. 4 samples. Type: Expression profiling by high throughput sequencing.
High-throughput 3D screening reveals differences in drug sensitivities between culture models of JIMT1 breast cancer cells.
GEO Series GSE42529. Homo sapiens. 12 samples. Type: Expression profiling by array.
Drug screening identifies tazarotene and bexarotene as therapeutic agents in Multiple Sulfatase Deficiency II
GEO Series GSE205556. Homo sapiens. 22 samples. Type: Expression profiling by high throughput sequencing.
A human organoid drug screen identifies α2-adrenergic receptor signaling as a therapeutic target for cartilage regeneration
GEO Series GSE271815. Homo sapiens. 22 samples. Type: Expression profiling by high throughput sequencing.
Transcriptomic RNAseq drug screen in cerebrocortical cultures; towards novel neurogenetic disease therapies.
GEO Series GSE110256. Mus musculus. 227 samples. Type: Expression profiling by high throughput sequencing.
ERK signaling mediates resistance to immunomodulatory drugs in the bone marrow microenvironment (CRISPR Screen)
GEO Series GSE171339. Homo sapiens. 14 samples. Type: Other.
A human organoid drug screen identifies α2-adrenergic receptor signaling as a therapeutic target for cartilage regeneration [bulk RNA-seq]
GEO Series GSE249229. Homo sapiens. 18 samples. Type: Expression profiling by high throughput sequencing.
High-throughput Drug Screening Identifies Ketotifen as a Potential Therapeutic Agent for Neuroendocrine Prostate Cancer
GEO Series GSE225007. Homo sapiens. 4 samples. Type: Expression profiling by high throughput sequencing.
Domain-invariant features for mechanism of action prediction in a multi-cell-line drug screen
<p><strong>Motivation: </strong>As a proxy for diseased cells, a cell line cannot be thought of as a perfect model. Many diseases feature an important molecular heterogeneity. Consequently, a drug may be effective against one molecular subtype of a disease, but less so against another. To characterise drugs with respect to their effect not only on one cell line but on a consensus of several is therefore a promising strategy to streamline the drug discovery process.</p> <p><strong>Results: </strong>The contribution of this paper is twofold. First, we investigate whether we can predict MOA at the molecular level without optimisation of the MOA classes to the screen specificities. To this end, we benchmark a set of algorithms within a conventional pipeline, and evaluate their MOA prediction performance according to a statistically rigorous framework. Second, we extend this conventional pipeline to the simultaneous analysis of multiple cell lines, each with potentially different morphological baselines. For this, we propose multitask autoencoders, including a domain-adaptive model used to construct domain-invariant feature representations across cell lines. We apply these methods to a pilot screen of two triple negative breast cancer cell lines as models for two different molecular subtypes of the disease.</p>
Optimizing Toxicological Screening in Drug Endangered Children
ClinicalTrials.gov study NCT01037569. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Efficacy of Organoid-Based Chemotherapy Drug Precision Screening to Guide Treatment for Thyroid Cancer
ClinicalTrials.gov study NCT06713057. IPD Sharing: NO. Countries: 1. Publications: 0.
DETERMINE (Determining Extended Therapeutic Indications for Existing Drugs in Rare Molecularly Defined Indications Using a National Evaluation Platform Trial) - Master Screening Protocol
ClinicalTrials.gov study NCT05722886. IPD Sharing: YES. Countries: 1. Publications: 0.
Clinical Studies by Using Alphacait to Screen Drugs for Advanced Solid Tumor
ClinicalTrials.gov study NCT03299452. IPD Sharing: YES. Countries: 1. Publications: 0.
CYP2D6 Screening for Adverse Drug Reactions to Codeine in Breast Milk
ClinicalTrials.gov study NCT01050400. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Drug Screening of Pancreatic Cancer Organoids Developed From EUS-FNA Guided Biopsy Tissues
ClinicalTrials.gov study NCT03544255. IPD Sharing: UNDECIDED. Countries: 1. Publications: 0.
The Consistency of Drug Screening in Vitro and Neoadjuvant Chemotherapy Results in Breast Cancer Patients
ClinicalTrials.gov study NCT04131881. IPD Sharing: NO. Countries: 1. Publications: 0.
ScienceDex guides
Understand access before you commit
These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.