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1,295 results for “exosome”
The Effect of Stem Cells and Stem Cell Exosomes on Visual Functions in Patients With Retinitis Pigmentosa
ClinicalTrials.gov study NCT05413148. IPD Sharing: NO. Countries: 1. Publications: 24.
Effect of Dietary Protein on the Regulation of Exosome microRNA Expression in Patients With Insulin Resistance.
ClinicalTrials.gov study NCT05318898. IPD Sharing: NO. Countries: 1. Publications: 7.
ExosoMe as Integrative Tool for pRognostic Stratification of Adverse Cardiac remodeLing in stEmi Patients: the MIRACLE Study
ClinicalTrials.gov study NCT06070974. IPD Sharing: Not stated. Countries: 1. Publications: 4.
Effects of Exosome Adminstration in Preventing Early Leakage in Rectal Cancer Patients Undergoing Low Anterior Resection
ClinicalTrials.gov study NCT06536712. IPD Sharing: UNDECIDED. Countries: 1. Publications: 5.
Exosomal microRNAs as a Biomarker in Panic Disorder and in Response to CBT
ClinicalTrials.gov study NCT04029740. IPD Sharing: YES. Countries: 1. Publications: 10.
ncRNAs in Exosomes of Cholangiocarcinoma
ClinicalTrials.gov study NCT03102268. IPD Sharing: NO. Countries: 1. Publications: 1.
Clinical Efficacy of Exosome in Degenerative Meniscal Injury
ClinicalTrials.gov study NCT05261360. IPD Sharing: NO. Countries: 1. Publications: 3.
Use of Autologous Exosomes vs Platelet Growth Factors to Regenerate the Ovary in Women With Infertility (Exosomas2024-1)
ClinicalTrials.gov study NCT06773572. IPD Sharing: YES. Countries: 1. Publications: 3.
A Clinical Study on Safety and Effectiveness of Mesenchymal Stem Cell Exosomes for the Treatment of COVID-19.
ClinicalTrials.gov study NCT05787288. IPD Sharing: Not stated. Countries: 1. Publications: 22.
The Influence of High and Low Salt on Exosomes in the Urine
ClinicalTrials.gov study NCT02823613. IPD Sharing: NO. Countries: 1. Publications: 2.
Study Investigating the Ability of Plant Exosomes to Deliver Curcumin to Normal and Colon Cancer Tissue
ClinicalTrials.gov study NCT01294072. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Evaluation of Urinary Exosomes Presence From Clear Cell Renal Cell Carcinoma
ClinicalTrials.gov study NCT04053855. IPD Sharing: NO. Countries: 1. Publications: 1.
Effects on Facial Skin Aging After Topical Application of Exosomes With a Microneedling Device
ClinicalTrials.gov study NCT07372001. IPD Sharing: YES. Countries: 1. Publications: 13.
Exosome Cargo From Preeclampsia Patients
ClinicalTrials.gov study NCT04154332. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Pilot Study of Human Adipose Tissue Derived Exosomes Promoting Wound Healing
ClinicalTrials.gov study NCT05475418. IPD Sharing: NO. Countries: 1. Publications: 1.
Multicenter Clinical Research for Early Diagnosis of Lung Cancer Using Blood Plasma Derived Exosome
ClinicalTrials.gov study NCT04529915. IPD Sharing: UNDECIDED. Countries: 1. Publications: 5.
Adiponectin stimulates exosome release to enhance mesenchymal stem cell driven therapy of heart failure in mice
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Data from: Exosomes in mammals with greater habitat variability contain more proteins and RNAs
Factors determining habitat variability are poorly understood despite possible explanations based on genome and physiology. This is because previous studies only focused on primary measures such as genome size and body size. In this study, we hypothesize that specific gene functions determine habitat variability in order to explore new factors beyond primary measures. We comprehensively evaluate the relationship between gene functions and the climate envelope while statistically controlling for potentially confounding effects by using data on the habitat range, genome, body size and metabolism of various mammals. Our analyses show that the number of proteins and RNAs contained in exosomes is predominantly associated with the climate envelope. This finding indicates the importance of exosomes to habitat range expansion of mammals and provides a new hypothesis for the relationship between the genome and habitat variability.
Raw data for the article: 3D Culture and Interferon-? Priming Modulates Characteristics of Mesenchymal Stromal/Stem Cells by Modifying the Expression of Both Intracellular and Exosomal microRNAs
<p>Mesenchymal stromal/stem cells (MSCs) have emerged as a therapeutic tool in regenerative medicine. Recent studies have shown that exosome (EXO)-derived microRNAs (miRNAs) play a crucial role in mediating MSC functions. Additionally, intracellular miRNAs have been found to regulate MSC therapeutic capacities. However, the molecular mechanisms underlying miRNA-mediated MSC effects are not fully understood. We used 3D culture and IFN-γ to prime/enhance the MSC therapeutic effects in terms of functional miRNAs. After priming, our analysis revealed stable variations in intracellular miRNA among the MSC biological replicates. Conversely, a significant variability of miRNA was observed among EXOs released from biological replicates of the priming treatment. For each priming, we observed distinct miRNA expression profiles between the MSCs and their EXOs. Moreover, in both types of priming, gene ontology (GO) analysis of deregulated miRNAs highlighted their involvement in tissue repair/regeneration pathways. In particular, the 3D culture enhanced angiogenic properties in both MSCs and EXOs, while IFN-γ treatment enriched miRNAs associated with immunomodulatory pathways. These findings suggest that 3D culture and IFN-γ treatment are promising strategies for enhancing the therapeutic potential of MSCs by modulating miRNA expression. Additionally, the identified miRNAs may contribute to understanding the molecular mechanisms underlying the miRNA-mediated therapeutic effects of MSCs.</p>
Exosomal proteome at birth predicts insulin resistance and liver fat in childhood
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Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.