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361 results for “hedgehog”
Figure 2 in Brandt's Hedgehog, Paraechinus hypomelas (Brandt, 1836), new to the mammal fauna of Iraq
Figure 2: Brandt's Hedgehog, Paraechinus hypomelas, form the Bamo-Khoshk Mountains, Sulaymaniyah Province, Kurdistan region, northeastern Iraq. (A) Adult individual from the Town of Bamo; (B) juveniles from the Kanizhalla Village; (C) Dorsal head with necked scalp just behind the front; (D) anterior dentition; (E) general landscape of the site. Photos © Soran H. Ahmed.
Hedgehog induced oxidative phosphorylation rescues the neuronal differentiation defect of human enteric neural crest cells underlying Hirschsprung disease
<p>Hedgehog induced oxidative phosphorylation rescues the neuronal differentiation defect of human enteric neural crest cells underlying Hirschsprung disease</p>
Study of Vismodegib in Combination With Temozolomide Versus Temozolomide Alone in Patients With Medulloblastomas With an Activation of the Sonic Hedgehog Pathway
ClinicalTrials.gov study NCT01601184. IPD Sharing: Not stated. Countries: 4. Publications: 33.
Oral Hedgehog Inhibitors in the Treatment of Basal Cell Carcinoma in the Netherlands: a Prospective Registration Study
ClinicalTrials.gov study NCT05463757. IPD Sharing: UNDECIDED. Countries: 1. Publications: 12.
Itraconazole as a Targeted Therapy for Inhibiting Hedgehog Pathway Signaling in Esophageal Cancer Patients
ClinicalTrials.gov study NCT02749513. IPD Sharing: UNDECIDED. Countries: 1. Publications: 3.
Ribavirin and Hedgehog Inhibitor With or Without Decitabine in AML
ClinicalTrials.gov study NCT02073838. IPD Sharing: Not stated. Countries: 1. Publications: 2.
A Study of Hedgehog Pathway Inhibitor GDC-0449 in Patients With Locally Advanced or Metastatic Solid Tumors That Are Refractory to Standard Therapy or for Whom No Standard Therapy Exists
ClinicalTrials.gov study NCT00968981. IPD Sharing: Not stated. Countries: 0. Publications: 1.
Data from: Population biology of establishment in New Zealand hedgehogs inferred from genetic and historical data: conflict or compromise?
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Pathogenic LRRK2 control of primary cilia and Hedgehog signaling in neurons and astrocytes of mouse brain
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Plasticity and genetic basis of cichlid gill arch anatomy reveal novel roles for Hedgehog signaling
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Host-driven subspeciation in hedgehog fungus, Trichophyton erinacei, an emerging cause of human dermatophytosis
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The novel ciliogenesis regulator DYRK2 governs Hedgehog signaling during mouse embryogenesis
<p>Mammalian Hedgehog (Hh) signaling plays key roles in embryogenesis and uniquely requires primary cilia. Functional analyses of several ciliogenesis-related genes led to the discovery of the developmental diseases known as ciliopathies. Hence, identification of mammalian factors that regulate ciliogenesis can provide insight into the molecular mechanisms of embryogenesis and ciliopathy. Here, we demonstrate that DYRK2 acts as a novel mammalian ciliogenesis-related protein kinase. Loss of <i>Dyrk2</i> in mice causes suppression of Hh signaling and results in skeletal abnormalities during <i>in vivo</i> embryogenesis<i>.</i> Deletion of <i>Dyrk2</i> induces abnormal ciliary morphology and trafficking of Hh pathway components. Mechanistically, transcriptome analyses demonstrate down-regulation of <i>AurkA</i> and other disassembly genes following <i>Dyrk2</i> deletion. Taken together, the present study demonstrates for the first time that DYRK2 controls ciliogenesis and is necessary for Hh signaling during mammalian development.</p>
Data from: Proteolytic processing of palmitoylated Hedgehog peptides specifies the 3-4 intervein region of the Drosophila wing
Cell fate determination during development often requires morphogen transport from producing to distant responding cells. Hedgehog (Hh) morphogens present a challenge to this concept, as all Hhs are synthesized as terminally lipidated molecules that form insoluble clusters at the surface of producing cells. While several proposed Hh transport modes tie directly into these unusual properties, the crucial step of Hh relay from producing cells to receptors on remote responding cells remains unresolved. Using wing development in Drosophila melanogaster as a model, we show that Hh relay and direct patterning of the 3-4 intervein region strictly depend on proteolytic removal of lipidated N-terminal membrane anchors. Site-directed modification of the N-terminal Hh processing site selectively eliminated the entire 3-4 intervein region, and additional targeted removal of N-palmitate restored its formation. Hence, palmitoylated membrane anchors restrict morphogen spread until site-specific processing switches membrane-bound Hh into bioactive forms with specific patterning functions.
Supplementary material 1 from: Shi Z, Yao H, He K, Bai W, Zhou J, Fan J, Su W, Nie W, Yang S, Onditi KO, Jiang X, Chen Z (2023) A new species of forest hedgehog (Mesechinus, Erinaceidae, Eulipotyphla, Mammalia) from eastern China. ZooKeys 1185: 143-161. https://doi.org/10.3897/zookeys.1185.111615
Collection information of Mesechinus orientalis sp. nov.
Supplementary material 3 from: Shi Z, Yao H, He K, Bai W, Zhou J, Fan J, Su W, Nie W, Yang S, Onditi KO, Jiang X, Chen Z (2023) A new species of forest hedgehog (Mesechinus, Erinaceidae, Eulipotyphla, Mammalia) from eastern China. ZooKeys 1185: 143-161. https://doi.org/10.3897/zookeys.1185.111615
Morphological characteristic matrix
Supplementary material 4 from: Shi Z, Yao H, He K, Bai W, Zhou J, Fan J, Su W, Nie W, Yang S, Onditi KO, Jiang X, Chen Z (2023) A new species of forest hedgehog (Mesechinus, Erinaceidae, Eulipotyphla, Mammalia) from eastern China. ZooKeys 1185: 143-161. https://doi.org/10.3897/zookeys.1185.111615
Morphological transformation series
Supplementary material 2 from: Shi Z, Yao H, He K, Bai W, Zhou J, Fan J, Su W, Nie W, Yang S, Onditi KO, Jiang X, Chen Z (2023) A new species of forest hedgehog (Mesechinus, Erinaceidae, Eulipotyphla, Mammalia) from eastern China. ZooKeys 1185: 143-161. https://doi.org/10.3897/zookeys.1185.111615
Partitioning schemes used in mitogenome RAxML analyses
Fig. 9 in Morpholoical Study Of The Brandt'S Hedgehog, Paraechinus Hypomelas (Eulipotyphla, Erinaceidae), Tongue
Fig. 9. SEM micrograph of the dorsal surface of the fungiform papillae at higher magnification. Asterisk indicates a taste pore. Scale bar 5 µm.
Figure 1 in Changes in the feeding behavior and habitat use of the desert hedgehog Paraechinus aethiopicus (Ehrenberg 1832, Eulipotyphla: Erinaceidae), in Saudi Arabia
Figure 1. Comparison of food items in the stomach contents of males and females of the desert hedgehogs P. aethiopicus collected from the five study sites in Saudi Arabia.
FIGURE 7. Caparinia ictonyctis Lawrence, 1955, tritonymph. A in Validation of the status of a species with high CO1 and low nuclear genetic divergences: the scab mite Caparinia ictonyctis stat. res. (Acariformes: Psoroptidae) parasitizing the African hedgehog Atelerix albiventris
FIGURE 7. Caparinia ictonyctis Lawrence, 1955, tritonymph. A—dorsal view; B—ventral view.
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Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.