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803
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ShareScore release 0.9.0
Dataset results
803 results for “hippocampal”
Patch clamp recording from rat hippocampal neuron culture using bulk and NEA chip
<p>Patch-clamp, in current-clamp mode, recordings from rat hippocampal neuron culture using stimulated nano electrode array chip in bulk and low-density NEA chip. All the uncompressed data are in easy-to-use .mat files divided for type of chip (Bulk and NEA); type of coating material and type of stimulation (only for Bulk).</p>
Data from: Cannabinoids disrupt memory encoding by functionally isolating hippocampal CA1 from CA3
Much of the research on cannabinoids (CBs) has focused on their effects at the molecular and synaptic level. However, the effects of CBs on the dynamics of neural circuits remains poorly understood. This study aims to disentangle the effects of CBs on the functional dynamics of the hippocampal Schaffer collateral synapse by using data-driven nonparametric modeling. Multi-unit activity was recorded from rats doing an working memory task in control sessions and under the influence of exogenously administered tetrahydrocannabinol (THC), the primary CB found in marijuana. It was found that THC left firing rate unaltered and only slightly reduced theta oscillations. Multivariate autoregressive models, estimated from spontaneous spiking activity, were then used to describe the dynamical transformation from CA3 to CA1. They revealed that THC served to functionally isolate CA1 from CA3 by reducing feedforward excitation and theta information flow. The functional isolation was compensated by increased feedback excitation within CA1, thus leading to unaltered firing rates. Finally, both of these effects were shown to be correlated with memory impairments in the working memory task. By elucidating the circuit mechanisms of CBs, these results help close the gap in knowledge between the cellular and behavioral effects of CBs.
Joshi et al 2023: Dynamic synchronization between hippocampal representations and stepping
<p>Data and code accompanying Joshi et al 2023, 'Dynamic synchronization between hippocampal representations and stepping'. Please contact Abhilasha Joshi (abhilasha.joshi@ucsf.edu) with any questions.</p>
Sample datasets for review of "Sub-cellular population imaging tools reveal stable apical dendrites in hippocampal area CA3"
<p>2 sample .tiff stacks and desired output files for use in evaluating the algorithm described in "Sub-cellular population imaging tools reveal stable apical dendrites in hippocampal area CA3"</p>
Memory related processing is the primary driver of human hippocampal theta oscillations
<p>This dataset contains intra-cranial EEG (iEEG) recordings related to the paper: "Memory-related processing is the primary driver of human hippocampal theta oscillations" by Seger et al.</p> <p>The study investigates the role of hippocampal theta oscillations in the human brain during navigation (during which externally oriented sensorimotor processing occurs) and during mental simulation of navigation (when no externally oriented sensorimotor processing is present).</p> <p>The iEEG recordings underwent the initial preprocessing steps as described in the paper and were subsequently downsampled to 250Hz for the purpose of this dataset. The files in this dataset were saved as .MAT files. </p> <p>The dataset includes the following zip files:<br> “Seger_et_al_2023_iEEG_data.zip" </p> <p> </p> <p>Description of data structure:</p> <p>"electrode.info" contains information about subject and electrode contact<br> - electrode.info.subject_ID : participant ID<br> - electrode.info.elec_ID : channel ID <br> - electrode.info.anat_loc : anatomical localization (see paper for methods)<br> - electrode.info.hemi : hemisphere of electrode <br> - electrode.info.env_version : paradigm version </p> <p>"electrode.data" contains all trial level data for this electrode (** Please note that all trial level iEEG data contains a 2 second (500 sample) buffer flanking both ends.)</p> <p>"electrode.data.nav_and_sim_trials" contains all the trial level data for the navigation with mental simulation trials <br> -electrode.data.nav_and_sim_trials.trial_info : information about the navigated / mentally simulated routes (ex. Start and end store, catch trial condition)<br> -electrode.data.nav_and_sim_trials.nav_eeg : raw eeg for each navigation trial<br> -electrode.data.nav_and_sim_trials.nav_eeg_tVect : timeVector corresponding to raw eeg data in ms (t=0 is when the trial begins t(end) - 2000 ms is when trial ends). <br> -electrode.data.nav_and_sim_trials.nav_position : avatar XY position for all time points during navigation trials<br> -electrode.data.nav_and_sim_trials.sim_eeg : raw eeg for each mental simulation trial<br> -electrode.data.nav_and_sim_trials.sim_eeg_tVect : timeVector corresponding to raw eeg data in ms (t=0 is when the trial begins t(end) - 2000 ms is when trial ends). </p> <p>"electrode.data.nav_practice_trials" contains all the trial level data for the navigation practice trials<br> -electrode.data.nav_practice_trials.trial_info : information about the route navigated (ex. Start and end store)<br> -electrode.data.nav_practice_trials.nav_eeg : raw eeg for each practice navigation trial<br> -electrode.data.nav_practice_trials.nav_eeg_tVect : timeVector corresponding to raw eeg data in ms (t=0 is when the trial begins t(end) - 2000 ms is when trial ends). <br> -electrode.data.nav_practice_trials.nav_position : avatar XY position for all time points during practice navigation trials</p> <p><br> "electrode.data.storefront_pres_trials" contains all the trial level data for the storefront presentation trials<br> -electrode.data.storefront_pres_trials.eeg : raw eeg for each storefront presentation<br> -electrode.data.storefront_pres_trials.eeg_tVect : timeVector corresponding to raw eeg data in ms (t=0 is when the trial begins t(end) - 2000 ms is when trial ends). </p> <p>"electrode.data.crosshair_pres_trials" contains all the trial level data for the crosshair presentation trials<br> -electrode.data.crosshair_pres_trials.eeg : raw eeg for each crosshair presentation<br> -electrode.data.crosshair_pres_trials.eeg_tVect : timeVector corresponding to raw eeg data in ms (t=0 is when the trial begins t(end) - 2000 ms is when trial ends).</p>
Dataset for "A critical role for CaMKII in behavioral timescale synaptic plasticity in hippocampal CA1 pyramidal neurons"
<p>Dataset for "A critical role for CaMKII in behavioral timescale synaptic plasticity in hippocampal CA1 pyramidal neurons"</p>
Clinical Trial Evaluating the Efficacy of AGB101 for Reducing Hippocampal Overactivity in Older Adults
ClinicalTrials.gov study NCT06919926. IPD Sharing: NO. Countries: 1. Publications: 5.
Effects of Quetiapine on Ultrastructural Hippocampal and Neurochemical Changes in Patients With Bipolar Disorder: Searching for Antidepressant and Mood Stabilising Neurophysiology
ClinicalTrials.gov study NCT01552837. IPD Sharing: Not stated. Countries: 1. Publications: 3.
Memory Preservation of Prophylactic Cranial Irradiation With Hippocampal Avoidance (PREMER-TRIAL)
ClinicalTrials.gov study NCT02397733. IPD Sharing: Not stated. Countries: 1. Publications: 4.
Exercise, Age-Related Memory Decline, And Hippocampal Function
ClinicalTrials.gov study NCT01329653. IPD Sharing: YES. Countries: 1. Publications: 1.
Neurocognitive Impact and Dose-Effect Relationship of Hippocampal Avoidance During Whole Brain Radiotherapy Plus Simultaneous Integrated Boost - A Prospective Follow-up Study
ClinicalTrials.gov study NCT03223675. IPD Sharing: NO. Countries: 1. Publications: 1.
Representational Approach to Hippocampal Functions : a fMRI Study
ClinicalTrials.gov study NCT04562974. IPD Sharing: Not stated. Countries: 1. Publications: 1.
A Prospective Study of the Impact of Hippocampal Avoidance During Whole Brain Radiotherapy on Neurocognitive Function Decline
ClinicalTrials.gov study NCT02504788. IPD Sharing: NO. Countries: 1. Publications: 2.
Chronic Sleep Deprivation and Changes in Cortical and Hippocampal Volume
ClinicalTrials.gov study NCT06260280. IPD Sharing: UNDECIDED. Countries: 1. Publications: 6.
Hippocampal Volume and Memory Functions in Aneurysmal Subarachnoid Hemorrhage
ClinicalTrials.gov study NCT04449666. IPD Sharing: YES. Countries: 1. Publications: 1.
Intermittent Energy Restriction and Chewing on Neural Stem Cell Ageing and Adult Hippocampal Neurogenesis Associated Cognition
ClinicalTrials.gov study NCT03457870. IPD Sharing: UNDECIDED. Countries: 1. Publications: 3.
Hippocampal Sparing Whole Brain Radiation Versus Stereotactic Radiation in Patients With 5-20 Brain Metastases: A Phase III, Randomized Trial
ClinicalTrials.gov study NCT03075072. IPD Sharing: NO. Countries: 1. Publications: 0.
Memory Preservation of Hippocampal Avoidance Whole Brain Radiotherapy
ClinicalTrials.gov study NCT03247127. IPD Sharing: NO. Countries: 1. Publications: 8.
Effects of Parabolic Flight on Spatial Cognition and Hippocampal Plasticity
ClinicalTrials.gov study NCT02789007. IPD Sharing: NO. Countries: 1. Publications: 0.
Hippocampal Sparing Whole Brain Radiotherapy vs Conventional Whole Brain Radiotherapy in Patients With Brain Metastases
ClinicalTrials.gov study NCT02147028. IPD Sharing: Not stated. Countries: 1. Publications: 0.
ScienceDex guides
Understand access before you commit
These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.