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2,012 results for “kinase”
Protein kinase inhibitors
<p>The deposition contains data sets of human and mouse protein kinase inhibitors with reliable activity measurements and corresponding compounds classified as inactive that were assembled from public repositories. The human protein kinase inhibitors have recently been analyzed in detail [Xerxa et al., Data-Driven Global Assessment of Protein Kinase Inhibitors with Emphasis on Covalent Compounds. <em>J Med Chem</em>, 2023, in press, <a href="https://doi.org/10.1021/acs.jmedchem.3c00621">https://doi.org/10.1021/acs.jmedchem.3c00621</a>].</p>
Supplementary information for the manuscript 'Mutation in SHAGGY-like kinase AsGSK2.1 causes a short kernel phenotype in oat (Avena sativa)'
<p>This is the supplementary information of the manuscript 'Mutation in SHAGGY-like kinase AsGSK2.1 causes a short kernel phenotype in oat (<em>Avena sativa</em>)' published as a part of the thesis 'Annotating and making use of the <em>Avena sativa</em> cv. Sang reference genome' by Nikos Tsardakas Renhuldt.</p> <p>SI.pdf contains supplementary figures 1-3.</p> <p>Supplementary figure 4.html contains supplementary figure 4.</p> <p>Supplementary tables.xlsx contains supplementary tables 1-5.</p>
Phase I Study of LDK378 in Pediatric, Malignancies With a Genetic Alteration in Anaplastic Lymphoma Kinase (ALK)
ClinicalTrials.gov study NCT01742286. IPD Sharing: NO. Countries: 10. Publications: 2.
Safety And Efficacy Study Of Bosutinib In Patients With Philadelphia Chromosome Positive Chronic Myeloid Leukemia Previously Treated With One Or More Tyrosine Kinase Inhibitors
ClinicalTrials.gov study NCT02228382. IPD Sharing: YES. Countries: 8. Publications: 5.
A Study Comparing Alectinib With Crizotinib in Treatment-Naive Anaplastic Lymphoma Kinase-Positive Advanced Non-Small Cell Lung Cancer Participants
ClinicalTrials.gov study NCT02075840. IPD Sharing: Not stated. Countries: 29. Publications: 7.
Clinical Pharmacology of p38 MAP Kinase Inhibitor, VX-745, in Mild Cognitive Impairment Due to Alzheimer's Disease (AD) or Mild AD
ClinicalTrials.gov study NCT02423200. IPD Sharing: Not stated. Countries: 1. Publications: 1.
A Phase 1, First Time in Human (FTIH) Study to Evaluate GSK3352589, a REarranged During Transfection (RET) Growth Factor Receptor Tyrosine Kinase Inhibitor, in Healthy Volunteers
ClinicalTrials.gov study NCT03154086. IPD Sharing: NO. Countries: 1. Publications: 1.
Phase II Trial of the Cyclin-Dependent Kinase Inhibitor PD 0332991 in Patients With Cancer
ClinicalTrials.gov study NCT01037790. IPD Sharing: Not stated. Countries: 1. Publications: 2.
A Study Of Oral Palbociclib (PD-0332991), A Cyclin-Dependent Kinase Inhibitor, In Patients With Advanced Cancer
ClinicalTrials.gov study NCT00141297. IPD Sharing: Not stated. Countries: 1. Publications: 2.
A Dose Escalation/Expansion Study of LDK378 in Patients With Tumors Characterized by Genetic Abnormalities in Anaplastic Lymphoma Kinase
ClinicalTrials.gov study NCT01283516. IPD Sharing: UNDECIDED. Countries: 11. Publications: 4.
Study of Pemetrexed + Platinum Chemotherapy With or Without Pembrolizumab (MK-3475) in Adults With Tyrosine Kinase Inhibitor- (TKI)-Resistant Epidermal Growth Factor Receptor- (EGFR)-Mutated Metastati
ClinicalTrials.gov study NCT03515837. IPD Sharing: YES. Countries: 17. Publications: 1.
Response to the SHINGRIX Varicella Zoster Virus (VZV) Vaccine in Chronic Lymphocytic Leukemia (CLL) and CLL Treated With Bruton's Tyrosine Kinase Inhibitor (BTK-I)
ClinicalTrials.gov study NCT03702231. IPD Sharing: Not stated. Countries: 1. Publications: 2.
A Trial of the FMS-like Tyrosine Kinase 3 (FLT3) Inhibitor Gilteritinib Administered as Maintenance Therapy Following Allogeneic Transplant for Patients With FLT3/Internal Tandem Duplication (ITD) Acu
ClinicalTrials.gov study NCT02997202. IPD Sharing: YES. Countries: 16. Publications: 5.
A Broad Multi-histology Phase II Study of the Multi-Kinase Inhibitor R935788 (Fostamatinib Disodium) in Advanced Colorectal, Non-small Cell Lung, Head and Neck Hepatocellular and Renal Cell Carcinomas
ClinicalTrials.gov study NCT00923481. IPD Sharing: Not stated. Countries: 1. Publications: 3.
The Life After Stopping Tyrosine Kinase Inhibitors Study (The LAST Study)
ClinicalTrials.gov study NCT02269267. IPD Sharing: NO. Countries: 1. Publications: 2.
Zanubrutinib (BGB-3111) in Participants With Previously Treated B-Cell Lymphoma Intolerant of Prior Bruton Tyrosine Kinase Inhibitor (BTKi) Treatment
ClinicalTrials.gov study NCT04116437. IPD Sharing: YES. Countries: 1. Publications: 2.
TACE Combined With Tyrosine Kinase Inhibitors and Tislelizumab in Unresectable Hepatocellular Carcinoma
ClinicalTrials.gov study NCT06232759. IPD Sharing: YES. Countries: 1. Publications: 4.
Avastin and Temsirolimus Following Tyrosine Kinase Inhibitor Failure in Patients With Advanced Renal Cell Carcinoma
ClinicalTrials.gov study NCT00782275. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Trial of Topotecan With VX-970 (M6620), an ATR Kinase Inhibitor, in Small Cell Cancers and Extrapulmonary Small Cell Cancers
ClinicalTrials.gov study NCT02487095. IPD Sharing: NO. Countries: 1. Publications: 4.
Tyrosine Kinase Inhibitor (TKI) + Anti-PD-1 Antibody in TKI-responded Microsatellite Stability/Proficient Mismatch Repair (MSS/pMMR) Metastatic Colorectal Adenocarcinoma.
ClinicalTrials.gov study NCT04483219. IPD Sharing: YES. Countries: 1. Publications: 1.
ScienceDex guides
Understand access before you commit
These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.