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99 results for “lipid membrane”
Data from: Energy landscape for the insertion of amphiphilic nanoparticles into lipid membranes: a computational study
Amphiphilic, monolayer-protected gold nanoparticles (NPs) have been shown to enter cells via a non-endocytic, non-disruptive pathway that could be valuable for biomedical applications. The same NPs were also found to insert into a series of model cell membranes as a precursor to cellular uptake, but the insertion mechanism remains unclear. Previous simulations have demonstrated that an amphiphilic NP can insert into a single leaflet of a planar lipid bilayer, but in this configuration all charged end groups are localized to one side of the bilayer and it is unknown if further insertion is thermodynamically favorable. Here, we use atomistic molecular dynamics simulations to show that an amphiphilic NP can reach the bilayer midplane non-disruptively if charged ligands iteratively ``flip'' across the bilayer. Ligand flipping is a favorable process that relaxes bilayer curvature, decreases the nonpolar solvent-accessible surface area of the NP monolayer, and increases attractive ligand-lipid electrostatic interactions. Analysis of end group hydration further indicates that iterative ligand flipping can occur on experimentally relevant timescales. Supported by these results, we present a complete energy landscape for the non-disruptive insertion of amphiphilic NPs into lipid bilayers. These findings will help guide the design of NPs to enhance bilayer insertion and non-endocytic cellular uptake, and also provide physical insight into a possible pathway for the translocation of charged biomacromolecules.
Effect of EPA-DHA Supplement, Life Style Modification Standard Treatment on Clinical Outcome Lipid Membrane Composition in Type 2 Diabetes
ClinicalTrials.gov study NCT02705430. IPD Sharing: NO. Countries: 1. Publications: 0.
Diet and Physical Activity on NAFLD and Erytrocyte Membrane Lipid Profile.
ClinicalTrials.gov study NCT02347696. IPD Sharing: YES. Countries: 1. Publications: 0.
Data from: Energy landscape for the insertion of amphiphilic nanoparticles into lipid membranes: a computational study
Open the record for dataset details and reuse information.
Lipidomic profiling of clinical prostate cancer reveals targetable alterations in membrane lipid composition
GEO Series GSE180628. Homo sapiens. 24 samples. Type: Expression profiling by high throughput sequencing.
Lipid engineering reveals regulatory roles for membrane fluidity in yeast flocculation and oxygen-limited growth
GEO Series GSE94345. Saccharomyces cerevisiae. 27 samples. Type: Expression profiling by high throughput sequencing.
Commensal-derived short-chain fatty acids disrupt lipid membrane homeostasis in Staphylococcus aureus
GEO Series GSE309823. Staphylococcus aureus. 12 samples. Type: Expression profiling by array.
Reprogrammed lipid metabolism protects inner nuclear membrane against unsaturated fat
GEO Series GSE156951. Saccharomyces cerevisiae. 21 samples. Type: Expression profiling by high throughput sequencing.
Fatty acid oxidation protects cancer cells from apoptosis through increasing mitochondrial membrane lipids
GEO Series GSE201053. Homo sapiens. 12 samples. Type: Expression profiling by RT-PCR.
Mycoplasma gallisepticum Lipid Associated Membrane Proteins Up-regulate Inflammatory Genes in Chicken Tracheal Epithelial Cells via TLR-2 Ligation Through an NF-κB Dependent Pathway
GEO Series GSE61520. Gallus gallus. 64 samples. Type: Expression profiling by array.
Dysregulated Expression of Lipid Storage and Membrane Dynamics Factors in Tia1 Knock-Out Mouse Nervous Tissue
GEO Series GSE54418. Mus musculus. 48 samples. Type: Expression profiling by array.
Estrogen inhibits lipid content in liver exclusively from membrane receptor signaling
GEO Series GSE45346. Mus musculus. 12 samples. Type: Expression profiling by array.
High fat diet-induced modifications in membrane lipid and mitochondrial-membrane protein signatures precede the development of hepatic insulin resistance in mice
GEO Series GSE48615. Mus musculus. 42 samples. Type: Expression profiling by array.
Lipid metabolism dysregulation in solar lentigo: a multi-system-level analysis reveals membrane instability and energy homeostasis disruption
GEO Series GSE318414. Homo sapiens. 14 samples. Type: Expression profiling by high throughput sequencing.
A Membrane Lipid Signature Unravels the Dynamic Landscape of Group 1 ILCs across the Health-Disease Continuum
GEO Series GSE269280. Mus musculus. 6 samples. Type: Expression profiling by high throughput sequencing.
Lipid-anchored Proteasomes Control Membrane Protein Homeostasis
GEO Series GSE232308. Mus musculus. 12 samples. Type: Expression profiling by high throughput sequencing.
Long-chain lipids facilitate insertion of large nanoparticles into membranes of small unilamellar vesicles
<p>DLS data and Cryo Images of SUVs-QDs</p>
Long-chain lipids facilitate insertion of large nanoparticles into membranes of small unilamellar vesicles
<p>DLS data and Cryo Images of SUVs-QDs</p>
Dynamic Second Harmonic Imaging of Proton Translocation Through Water Needles in Lipid Membranes
<p>This dataset includes image/excel files for the data included in the manuscript "Dynamic Second Harmonic Imaging of Proton Translocation Through Water Needles in Lipid Membranes ". (https://pubs.acs.org/doi/full/10.1021/jacs.4c02810) </p>
ScienceDex guides
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These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.