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498
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ShareScore release 0.7.1
Dataset results
498 results for “liver fibrosis”
Relationship Between the Development of Impaired Glucose Tolerance, the Phenotype of CFLD, and the Risk of Liver Fibrosis
ClinicalTrials.gov study NCT05229640. IPD Sharing: NO. Countries: 1. Publications: 5.
Liver Fibrosis and Steatosis in dm Non Invasive Evaluation
ClinicalTrials.gov study NCT05605717. IPD Sharing: UNDECIDED. Countries: 1. Publications: 11.
Noninvasive Staging of Liver Fibrosis: MR vs Ultrasound
ClinicalTrials.gov study NCT02044523. IPD Sharing: Not stated. Countries: 1. Publications: 1.
The EUS ShearWave Elastography Liver Fibrosis Study
ClinicalTrials.gov study NCT04115046. IPD Sharing: YES. Countries: 1. Publications: 1.
The Impact of Everolimus Based Immunosuppression in the Evolution of Hepatitis C Fibrosis After Liver Transplantation
ClinicalTrials.gov study NCT01707849. IPD Sharing: NO. Countries: 1. Publications: 23.
Clinical Application of Non-invasive Assessment for Staging Liver Steatosis and Liver Fibrosis
ClinicalTrials.gov study NCT03386890. IPD Sharing: Not stated. Countries: 1. Publications: 2.
The Sonic Incytes Liver Incyte System, Assessment of Liver Fibrosis and Steatosis
ClinicalTrials.gov study NCT03957070. IPD Sharing: NO. Countries: 2. Publications: 1.
Hepatocyte-specific Prominin-1 protects against liver injury-induced fibrosis by stabilizing SMAD7
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Data from: Nrf2 ameliorates DDC-induced sclerosing cholangitis and biliary fibrosis and improves the regenerative capacity of the liver.
The Nrf2 pathway protects against oxidative stress and induces regeneration of various tissues. Here, we investigated whether Nrf2 protects from sclerosing cholangitis and biliary fibrosis and simultaneously induces liver regeneration. Diet containing 3,5-diethoxycarbonyl-1,4-dihydrocollidine (DDC) was fed to Nrf2-KO mice (Nrf2-/-), mice with liver-specific hyper-activated Nrf2 (HKeap1-/-) and wild type (WT) littermates to induce cholangitis, liver fibrosis, and oval cell expansion. HKeap1-/--mice were protected from almost all DDC-induced injury compared to WT and Nrf2-/-. Liver injury in Nrf2-/- and WT mice was mostly similar, albeit Nrf2-/- suffered more from DDC diet as seen for several parameters. Nrf2 activity was especially important for the expression of the hepatic efflux transporters Abcg2 and Abcc2-4, which are involved in hepatic toxin elimination. Surprisingly, cell proliferation was more enhanced in Nrf2-/-- but also HKeap1-/--mice compared to WT. Interestingly, Nrf2-/--mice failed to sufficiently activate oval cell expansion after DDC-treatment and showed almost no resident oval cell population under control conditions. The resident oval cell population of untreated HKeap1-/--mice was increased and DDC-treatment resulted in a stronger oval cell expansion compared to WT. We provide evidence that Nrf2 activation protects from DDC-induced sclerosing cholangitis and biliary fibrosis. Moreover, our data establish a possible role of Nrf2 in oval cell expansion.
THE SIGNIFICANCE OF CYTOKINES IN THE DEVELOPMENT OF LIVER FIBROSIS
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Human iPSC-derived liver co-culture spheroids to model liver fibrosis
<div> <p><span>The lack of adequate human <em>in vitro</em> models that recapitulate the cellular composition and response of the human liver to injury hampers the development of anti-fibrotic drugs. The goal of this study was to develop a human spheroid culture model to study liver fibrosis by using induced pluripotent stem cell (iPSC)-derived liver cells. iPSCs were independently differentiated towards hepatoblasts (iHepatoblasts), hepatic stellate cells (iHSCs), endothelial cells (iECs) and macrophages (iMΦ), before assembly into free floating spheroids by culturing cells in 96-well U-bottom plates and orbital shaking for up to 21 days to allow further maturation. Through transcriptome analysis, we show further maturation of iECs and iMΦ, the differentiation of the iHepatoblasts towards hepatocyte-like cells <span> </span>(iHeps) and the inactivation of the iHSCs by the end of the 3D culture. Moreover, these cultures display a similar expression of cell-specific marker genes (<em>CYP3A4</em>, <em>PDGFRβ</em>, <em>CD31</em> and <em>CD68</em>) and sensitivity to hepatotoxicity as spheroids made using freshly isolated primary human liver cells. Furthermore, we show the functionality of the iHeps and the iHSCs by mimicking liver fibrosis through iHep-induced iHSC activation, using acetaminophen.<span> </span><br>In conclusion, we have established a reproducible human iPSC-derived liver culture model that can be used to mimic fibrosis <em>in vitro</em> as a replacement of primary human liver derived 3D models. The model can be used to investigate pathways involved in fibrosis development and to identify new targets for chronic liver disease therapy.</span></p> </div>
Liver Fibrosis Evaluation Using Ultrasound Shear Wave Imaging
ClinicalTrials.gov study NCT03637959. IPD Sharing: Not stated. Countries: 1. Publications: 0.
FibroTouch Non-invasive Evaluation of Liver Fibrosis and Cirrhosis
ClinicalTrials.gov study NCT02476695. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Clinical Trial to Evaluate Efficacy of GR-MD-02 for Treatment of Liver Fibrosis in Patients With NASH With Advanced Fibrosis
ClinicalTrials.gov study NCT02421094. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Study to Learn About the Safety of Fazirsiran and if it Can Help People With Alpha-1 Antitrypsin Liver Disease With Mild Liver Scarring (Fibrosis)
ClinicalTrials.gov study NCT06165341. IPD Sharing: YES. Countries: 13. Publications: 0.
Rollover Study of Cenicriviroc for the Treatment of Liver Fibrosis in Participants With Nonalcoholic Steatohepatitis
ClinicalTrials.gov study NCT03059446. IPD Sharing: Not stated. Countries: 11. Publications: 0.
Studying Non Alcoholic Fatty Liver Disease and Liver Fibrosis Among Systemic Lupus Erythematosus Patients At Assiut University Hospital
ClinicalTrials.gov study NCT06601361. IPD Sharing: Not stated. Countries: 0. Publications: 1.
Real Time Elastography in Liver Fibrosis
ClinicalTrials.gov study NCT01948687. IPD Sharing: Not stated. Countries: 1. Publications: 0.
The Effect of GLP-1 Analogues on Liver Steatosis and Fibrosis in Diabetic and Obese Patients in a Clinical Setting
ClinicalTrials.gov study NCT07021443. IPD Sharing: NO. Countries: 1. Publications: 0.
Evaluation of Liver Fibrosis in HIV-infected Patients With Metabolic Syndrome
ClinicalTrials.gov study NCT02353767. IPD Sharing: Not stated. Countries: 0. Publications: 4.
ScienceDex guides
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These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.