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496
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ShareScore release 0.9.0
Dataset results
496 results for “metabolic activity”
Brown Fat Activation and Browning Efficiency Augmented by Chronic Cold and Nutraceuticals for Brown Adipose Tissue-mediated Effect Against Metabolic Syndrome (BEACON BEAMS Study)
ClinicalTrials.gov study NCT04595006. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Correlation Between Cardiopulmonary Metabolic Cost and Lower Limb Muscle Activity
ClinicalTrials.gov study NCT04614857. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Pharmacological Activation of Brown Adipose Tissue Metabolism
ClinicalTrials.gov study NCT02811289. IPD Sharing: Not stated. Countries: 1. Publications: 1.
SEMA4D Blockade Safety and Brain Metabolic Activity in Alzheimer's Disease (AD)
ClinicalTrials.gov study NCT04381468. IPD Sharing: Not stated. Countries: 1. Publications: 31.
WorkWell: Work-based Activity and Metabolic Health
ClinicalTrials.gov study NCT04269070. IPD Sharing: UNDECIDED. Countries: 1. Publications: 1.
Reducing Metabolic Dysregulation in Obese Latina Breast Cancer Survivors Using Physical Activity
ClinicalTrials.gov study NCT04717050. IPD Sharing: YES. Countries: 1. Publications: 0.
Physical Activity Targeting Metabolic Syndrome for Prevention of Breast Cancer in SAI Women
ClinicalTrials.gov study NCT06827704. IPD Sharing: NO. Countries: 1. Publications: 7.
Remote Physical Activity Monitoring in Individuals With Metabolic Syndrome
ClinicalTrials.gov study NCT05592704. IPD Sharing: NO. Countries: 1. Publications: 1.
Effect of Physical Activity and Diet on the Treatment of Metabolic Syndrome
ClinicalTrials.gov study NCT00917917. IPD Sharing: Not stated. Countries: 1. Publications: 9.
Data from: Allometric scaling of metabolism, growth, and activity in whole colonies of the seed harvester ant, Pogonomyrmex californicus
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Data from: Convergence in organ size but not energy metabolism enzyme activities among wild Lake Whitefish (Coregonus clupeaformis) species pairs
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An emerging fungal pathogen is associated with increased resting metabolic rate and total evaporative water loss rate in a winter‐active snake
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Unaltered soil microbial community composition, but decreased metabolic activity in a semi-arid grassland after two years of passive experimental warming
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Sex-specific genetic (co)variances of standard metabolic rate, body mass and locomotor activity in Drosophila melanogaster
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Common Blackbird weights, activity, fatty acid oxidation rates, and metabolic rates
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Data from: Curcumin improves glycolipid metabolism through regulating peroxisome proliferator activated receptor γ signalling pathway in high-fat diet-induced obese mice and 3T3-L1 adipocytes
Curcumin, an active component derived from the Curcuma longa L. which is a traditional Chinese medicine that is widely used for treating metabolic diseases through regulating different molecular pathway. Here, in this study, we aimed to comprehensively investigate the effects of curcumin on glycolipid metabolism in vivo and in vitro and then determine the underlying mechanism. Male C57BL/6J obese mice and 3T3-L1 adipocytes were used in vivo and in vitro study, respectively. Our results demonstrated that treatment with curcumin for 8 weeks decreased body weight, fat mass and serum lipid profiles. Meanwhile, it lowered fasting blood glucose and increased the insulin sensitivity in high-fat diet induced obese mice. In addition, curcumin stimulated lipolysis and improve glycolipid through upregulating the expressions of ATGL, HSL, PPARγ, C/EBPα and PPARα in adipose tissue of the mice. In differentiated 3T3-L1 cells, curcumin reduced glycerol release and increased glucose uptake via upregulating PPARγ and C/EBPα. We concluded that curcumin has potential to improve glycolipid metabolism disorders caused by obesity through regulating PPARγ signaling pathway.
Data from: Endocrine and metabolic disorders in survivors of childhood cancers and health-related quality of life and physical activity
Context: Childhood cancer survivors experience chronic health conditions that impact health related quality of life (HRQOL) and participation in optimal physical activity. Objective: The study aimed to determine independent effects of endocrine and metabolic disorders on HRQOL and physical activity. Design, Setting, and Patients: Retrospective cohort with longitudinal follow-up of survivors of childhood cancer enrolled in the North American Childhood Cancer Survivor Study. Main Outcome Measures: Medical Outcomes Short Form-36 estimated HRQOL while participation in physical activity was dichotomized as meeting or not meeting recommendations from the Center for Disease Control and Prevention. Log binomial regression evaluated the association of each endocrine/metabolic disorder with HRQOL scales and physical activity. Results: Of 7,287 survivors, median age 32 years (18-54) at their last follow-up survey, 4,884 (67%) reported one or more endocrine/metabolic disorders. Survivors with either disorder were significantly more likely to be male, older, received radiation treatment, and experience other chronic health conditions. After controlling for covariates, survivors with any endocrine/metabolic disorder were more likely to report poor physical function risk ratio ([RR] 1.25; 95% confidence interval [CI] 1.05-1.48), increased bodily pain (RR 1.27; CI 1.12-1.44), poor general health (RR 1.49; CI 1.32-1.68) and lower vitality (RR 1.21; CI 1.09-1.34) compared to survivors without. The likelihood of meeting recommended physical activity was lower among survivors with growth disorders (RR 0.90; CI=0.83-0.97), osteoporosis (RR 0.87; CI=0.76-0.99), and overweight/obesity (RR 0.92; CI 0.88-0.96). Conclusion: Endocrine and metabolic disorders are independently associated with poor HRQOL and sub-optimal physical activity among childhood cancer survivors.
Figure 2 from: Mateeva A, Peikova L, Kondeva-Burdina M, Georgieva M (2022) Development of new HPLC method for identification of metabolic degradation of N-pyrrolylhydrazide hydrazones with determined MAO- B activity in cellular cultures. Pharmacia 69(1): 15-20. https://doi.org/10.3897/pharmacia.69.e78417
Figure 2 Chromatograms demonstrating the hepatocytic metabolism of analyte at 30th min (A) and at 60th min (B).
Data from: Akt-mTORC1 signaling regulates Acly to integrate metabolic input to control of macrophage activation
Macrophage activation/polarization to distinct functional states is critically supported by metabolic shifts. How polarizing signals coordinate metabolic and functional reprogramming, and the potential implications for control of macrophage activation, remains poorly understood. Here we show that IL-4 signaling co-opts the Akt-mTORC1 pathway to regulate Acly, a key enzyme in Ac-CoA synthesis, leading to increased histone acetylation and M2 gene induction. Only a subset of M2 genes is controlled in this way, including those regulating cellular proliferation and chemokine production. Moreover, metabolic signals impinge on the Akt-mTORC1 axis for such control of M2 activation. We propose that Akt-mTORC1 signaling calibrates metabolic state to energetically demanding aspects of M2 activation, which may define a new role for metabolism in supporting macrophage activation.
Fig. 3 in Metabolic fingerprinting of banana passion fruits and its correlation with quorum quenching activity
Fig. 3. Barcoding of primary metabolites for banana passion fruit species.
ScienceDex guides
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These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.