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91 results for “mitral valve repair”
Research on the Development and Application of a Preoperative Assessment Model for Transcatheter Mitral Valve Edge-to-Edge Repair Based on Visual Foundation Models
ClinicalTrials.gov study NCT07247890. IPD Sharing: NO. Countries: 0. Publications: 0.
The Effect of Posterior Annulus Elevation Technique in Reducing Residual Regurgitation During Mitral Valve Repair in Children
ClinicalTrials.gov study NCT04518709. IPD Sharing: Not stated. Countries: 0. Publications: 0.
Atrial Fibrillation Risk After Miniinvasive Mitral Valve Repair
ClinicalTrials.gov study NCT06707506. IPD Sharing: Not stated. Countries: 0. Publications: 0.
Safety and Efficacy Study of a New Device for Making Neochordae in Mitral Valve Repair
ClinicalTrials.gov study NCT01811537. IPD Sharing: Not stated. Countries: 0. Publications: 0.
Dataset related to the article "Predictive Value of Pre‐Operative 2D and 3D Transthoracic Echocardiography in Patients Undergoing Mitral Valve Repair: Long Term Follow Up of Mitral Valve Regurgitation Recurrence and Heart Chamber Remodeling"
<p>This record contains raw data related to the article "Predictive Value of Pre‐Operative 2D and 3D Transthoracic Echocardiography in Patients Undergoing Mitral Valve Repair: Long Term Follow Up of Mitral Valve Regurgitation Recurrence and Heart Chamber Remodeling"</p> <p><strong>Abstract</strong>: The “ideal” management of asymptomatic severe mitral regurgitation (MR) in valve<br> prolapse (MVP) is still debated. The aims of this study were to identify pre‐operatory parameters<br> predictive of residual MR and of early and long‐term favorable remodeling after MVP repair. We<br> included 295 patients who underwent MV repair for MVP with pre‐operatory two‐ and threedimensional<br> transthoracic echocardiography (2DTTE and 3DTTE) and 6‐months (6M) and 3‐years<br> (3Y) follow‐up 2DTTE. MVP was classified by 3DTTE as simple or complex and surgical procedures<br> as simple or complex. Pre‐operative echo parameters were compared to post‐operative values at 6M<br> and 3Y. Patients were divided into Group 1 (6M‐MR < 2) and Group 2 (6M‐MR ≥ 2), and predictors<br> of MR 2 were investigated. MVP was simple in 178/295 pts, and 94% underwent simple<br> procedures, while in only 42/117 (36%) of complex MVP a simple procedure was performed. A<br> significant relation among prolapse anatomy, surgical procedures and residual MR was found. Postoperative<br> MR ≥ 2 was present in 9.8%: complex MVP undergoing complex procedures had twice the<br> percentage of MR ≥ 2 vs. simple MVP and simple procedures. MVP complexity resulted<br> independent predictor of 6M‐MR ≥ 2. Favorable cardiac remodeling, initially found in all cases, was<br> maintained only in MR < 2 at 3Y. Pre‐operative 3DTTE MVP morphology identifies pts undergoing<br> simple or complex procedures predicting MR recurrence and favorable cardiac remodeling.</p>
Machine Learning Prediction Models for Mitral Valve Repairability and Mitral Regurgitation Recurrence in Patients Undergoing Surgical Mitral Valve Repair
<p>This record contains raw data related to the article "Machine Learning Prediction Models for Mitral Valve Repairability and Mitral Regurgitation Recurrence in Patients Undergoing Surgical Mitral Valve Repair"</p> <p>Abstract: Background: Mitral valve regurgitation (MR) is the most common valvular heart disease and current variables associated with MR recurrence are still controversial. We aim to develop a machine learning-based prognostic model to predict causes of mitral valve (MV) repair failure and MR recurrence. Methods: 1000 patients who underwent MV repair at our institution between 2008 and 2018 were enrolled. Patients were followed longitudinally for up to three years. Clinical and echocardiographic data were included in the analysis. Endpoints were MV repair surgical failure with consequent MV replacement or moderate/severe MR (>2+) recurrence at one-month and moderate/severe MR recurrence after three years. Results: 817 patients (DS1) had an echocardiographic examination at one-month while 295 (DS2) also had one at three years. Data were randomly divided into training (DS1: n = 654; DS2: n = 206) and validation (DS1: n = 164; DS2 n = 89) cohorts. For intra-operative or early MV repair failure assessment, the best area under the curve (AUC) was 0.75 and the complexity of mitral valve prolapse was the main predictor. In predicting moderate/severe recurrent MR at three years, the best AUC was 0.92 and residual MR at six months was the most<br> important predictor. Conclusions: Machine learning algorithms may improve prognosis after MV repair procedure, thus improving indications for correct candidate selection for MV surgical repair.</p>
Dataset related to the article "Head to Head Comparison between Different 3-Dimensional Echocardiographic Rendering Tools in the Imaging of Percutaneous Edge-to-Edge Mitral Valve Repair"
<p>This record contains raw data related to the article "Head to Head Comparison between Different 3-Dimensional Echocardiographic Rendering Tools in the Imaging of Percutaneous Edge-to-Edge Mitral Valve Repair"</p> <p>MitraClip (MC) is the most common percutaneous treatment for severe mitral regurgitation<br> (MR). An accurate two-dimensional and three-dimensional echocardiographic (3DTEE) imaging is<br> mandatory for the optimal procedural result. Recently transillumination 3DTEE rendering (3DTr) has<br> been introduced integrating a virtual light source into the dataset and with the addition of glass effect<br> (3DGl) allows to adjust tissue transparency improving depth perception and anatomical structure<br> delineation in comparison with the standard 3DTEE (3DSt). The aim of this retrospective study in<br> 30 patients undergoing MC, was to compare 3DSt, 3DTr, and 3DGl in mitral valve (MV) evaluation<br> and procedural result assessment. 3DTEE acquisitions obtained before and after MC were processed<br> with 3DSt, 3DTr, and 3DGl rendering. Each reconstruction was scored for quality and for ability<br> to recognize MV anatomy, MR origin, clip position, dimension and grasping. Imaging quality was<br> judged good or optimal in 52%, 76%, and 96% in 3DSt, 3DTr, and 3DGl reconstructions respectively.<br> In 26/30 patients a diagnostic incremental value was found with 3DTr vs. 3DSt and in 15/26 with<br> 3DGl vs. 3DTr and 3DSt. Only 3DGl with perpendicular cropping of the clip allowed to visualize and<br> measure the grasped portion of each mitral leaflets. 3DTEE imaging during MC may be improved<br> by 3DTr and 3DGl providing a better evaluation of MV, of leaflet grasping and of residual MR jets<br> after MC.</p>
Dataset related to the article "Rest and exercise oxygen uptake and cardiac output changes 6 months after successful transcatheter mitral valve repair"
<p><strong>Aims: </strong>Changes in peak exercise oxygen uptake (VO<sub>2</sub> ) and cardiac output (CO) 6 months after successful percutaneous edge-to-edge mitral valve repair (pMVR) in severe primary (PMR) and functional mitral regurgitation (FMR) patients are unknown. The aim of the study was to assess the efficacy of pMVR at rest by echocardiography, VO<sub>2</sub> and CO (inert gas rebreathing) measurement and during cardiopulmonary exercise test with CO measurement.</p> <p><strong>Methods and results: </strong>We evaluated 145 and 115 patients at rest and 98 and 66 during exercise before and after pMVR, respectively. After successful pMVR, significant reductions in MR and NYHA class were observed in FMR and PMR patients. Cardiac ultrasound showed reverse remodelling (left ventricular end-diastolic volume from 158 ± 63 mL to 147 ± 64, P < 0.001; ejection fraction from 51 ± 15 to 48 ± 14, P < 0.001; pulmonary artery systolic pressure (PASP) from 43 ± 13 to 38 ± 8 mmHg, P < 0.001) in the entire population. These changes were significant in PMR (n = 62) and a trend in FMR (n = 53), except for PASP, which decreased in both groups. At rest, CO and stroke volume (SV) increased in FMR with a concomitant reduction in arteriovenous O<sub>2</sub> content difference [ΔC(a-v)O<sub>2</sub> ]. Peak exercise, CO and SV increased significantly in both groups (CO from 5.5 ± 1.4 L/min to 6.3 ± 1.5 and from 6.2 ± 2.4 to 6.7 ± 2.0, SV from 57 ± 19 mL to 66 ± 20 and from 62 ± 20 to 69 ± 20, in FMR and PMR, respectively), whereas peak VO<sub>2</sub> was unchanged and ΔC(a-v)O<sub>2</sub> decreased.</p> <p><strong>Conclusions: </strong>These data confirm pMVR-induced clinical improvement and reverse ventricular remodelling at a 6-month analysis and show, in spite of an increase in CO, an unchanged exercise performance, which is achieved through a 'more physiological' blood flow distribution and O<sub>2</sub> extraction behaviour. Direct rest and exercise CO should be measured to assess pMVR efficacy.</p> <p><strong>Keywords: </strong>Cardiac output; Exercise; Oxygen uptake; Percutaneous edge-to-edge mitral valve repair; Transcatheter mitral valve repair.</p>
Mitral Valve Surgery After Transcatheter Edge-to-Edge Repair: Mid-Term Outcomes From the CUTTING-EDGE International Registry
<p>Dataset from Kaneko T, Hirji S, Zaid S, Lange R, Kempfert J, Conradi L, Hagl C, Borger MA, Taramasso M, Nguyen TC, Ailawadi G, Shah AS, Smith RL, Anselmi A, Romano MA, Ben Ali W, Ramlawi B, Grubb KJ, Robinson NB, Pirelli L, Chu MWA, Andreas M, Obadia JF, Gennari M, Garatti A, Tchetche D, Nazif TM, Bapat VN, Modine T, Denti P, Tang GHL; CUTTING-EDGE Investigators. Mitral Valve Surgery After Transcatheter Edge-to-Edge Repair: Mid-Term Outcomes From the CUTTING-EDGE International Registry. JACC Cardiovasc Interv. 2021 Sep 27;14(18):2010-2021. doi: 10.1016/j.jcin.2021.07.029. PMID: 34556275.</p> <p>Abstract</p> <p><strong>Objectives: </strong>The aim of this study was to determine clinical and echocardiographic characteristics, mechanisms of failure, and outcomes of mitral valve (MV) surgery after transcatheter edge-to-edge repair (TEER).</p> <p><strong>Background: </strong>Although >100,000 mitral TEER procedures have been performed worldwide, longitudinal data on MV surgery after TEER are lacking.</p> <p><strong>Methods: </strong>Data from the multicenter, international CUTTING-EDGE registry were retrospectively analyzed. Clinical and echocardiographic outcomes were evaluated. Median follow-up duration was 9.0 months (interquartile range [IQR]: 1.2-25.7 months) after MV surgery, and follow-up was 96.1% complete at 30 days and 81.1% complete at 1 year.</p> <p><strong>Results: </strong>From July 2009 to July 2020, 332 patients across 34 centers underwent MV surgery after TEER. The mean age was 73.8 ± 10.1 years, median Society of Thoracic Surgeons risk for MV repair at initial TEER was 4.0 (IQR: 2.3-7.3), and primary/mixed and secondary mitral regurgitation were present in 59.0% and 38.5%, respectively. The median interval from TEER to surgery was 3.5 months (IQR: 0.5-11.9 months), with overall median Society of Thoracic Surgeons risk of 4.8% for MV replacement (IQR: 2.8%-8.4%). The primary indication for surgery was recurrent mitral regurgitation (33.5%), and MV replacement and concomitant tricuspid surgery were performed in 92.5% and 42.2% of patients, respectively. The 30-day and 1-year mortality rates were 16.6% and 31.3%, respectively. On Kaplan-Meier analysis, the actuarial estimates of mortality were 24.1% at 1 year and 31.7% at 3 years after MV surgery.</p> <p><strong>Conclusions: </strong>In this first report of the CUTTING-EDGE registry, the mortality and morbidity risks of MV surgery after TEER were not negligible, and only <10% of patients underwent MV repair. These registry data provide valuable insights for further research to improve these outcomes.</p>
Data set related to the article "Predictors of Prognosis in Patients With Secondary Mitral Regurgitation Undergoing Mitral Valve Transcatheter Edge-to-Edge Repair"
<p>This record contains raw data related to the article <em>Predictors of Prognosis in Patients With Secondary Mitral Regurgitation Undergoing Mitral Valve Transcatheter Edge-to-Edge Repair</em></p>
Data set from Adamo M, Grasso C, Capodanno D, Rubbio AP, Scandura S, Giannini C, Fiorelli F, Fiorina C, Branca L, Brambilla N, Bedogni F, Petronio AS, Curello S, Tamburino C. Five-year clinical outcomes after percutaneous edge-to-edge mitral valve repair: Insights from the multicenter GRASP-IT registry. Am Heart J. 2019 Nov;217:32-41. doi: 10.1016/j.ahj.2019.06.015. Epub 2019 Jul 3. PMID: 31473325.
<p>Data set from Adamo M, Grasso C, Capodanno D, Rubbio AP, Scandura S, Giannini C, Fiorelli F, Fiorina C, Branca L, Brambilla N, Bedogni F, Petronio AS, Curello S, Tamburino C. Five-year clinical outcomes after percutaneous edge-to-edge mitral valve repair: Insights from the multicenter GRASP-IT registry. Am Heart J. 2019 Nov;217:32-41. doi: 10.1016/j.ahj.2019.06.015. Epub 2019 Jul 3. PMID: 31473325.</p> <p> </p> <p>This is the abstract:</p> <p>Limited evidence is available on 5-year clinical outcomes after percutaneous edge-to-edge mitral valve repair.</p> <p><strong>Methods: </strong>The Getting Reduction of mitrAl inSufficiency by Percutaneous clip implantation in ITaly (GRASP-IT) is a multicenter registry including 304 consecutive patients undergoing Mitraclip between October 2008 and October 2013 at 4 Italian centers. Primary end point (all-cause mortality) and secondary end point (all-cause mortality or heart failure [HF] hospitalization) were evaluated up to 5 years and between 1 and 5 years.</p> <p><strong>Results: </strong>Cumulative incidence of the primary and secondary end points at 1, 2, 3, 4, and 5 years were 15.1%, 26.4%, 35.5%, 42.1%, and 47.3% and 29.1%, 41.7%, 49.8%, 56%, and 62.3%, respectively. Landmark analysis between 1 and 5 years showed an incidence of primary and secondary end point of 37.9% and 46.8%, respectively. Five-year event rates were significantly higher in patients with functional ischemic mitral regurgitation (MR) compared to other etiologies. MR recurrence and left ventricular ejection fraction <30% were associated with an increased risk of both primary and secondary end points. EuroSCORE II >5% was associated with an increased risk of 5-year mortality. Ischemic etiology of MR, baseline serum creatinine >1.5 mg/dL, chronic obstructive pulmonary disease, and previous HF hospitalizations were independent predictors of 5-year secondary end point.</p> <p><strong>Conclusions: </strong>At 5-year follow-up after Mitraclip, nearly half of patients died and almost two thirds died or were admitted for HF. MR recurrence, ischemic etiology, high comorbidity burden (ie, EuroSCORE II >5%, chronic obstructive pulmonary disease), and advanced cardiomyopathy (ie, left ventricular ejection fraction <30%, prior HF admission, creatinine >1.5 mg/dL) significantly increase the relative risk of 5-year clinical events.</p>
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