Find research datasets worth reusing
Search datasets from major research repositories and use ShareScore to quickly assess how well each record supports discovery, access, and reuse.
2,709
datasets available to search
ShareScore release 0.9.0
Dataset results
2,709 results for “mouse models”
TGF-β3 increases the severity of radiation-induced oral mucositis and salivary gland fibrosis in a mouse model
<p>This is a collection of results from a preclinical trial investigating the effects of TGF-B3 treatment on healthy tissue radiotoxicity in C57BL/6 mice after fractionated head and neck radiotherapy. Survival, body weight, oral mucositis, lip dermatitis, saliva volume, and salivary gland collagen deposition were monitored. This data set is used in the manuscript "TGF-β3 increases the severity of radiation-induced oral mucositis and salivary gland fibrosis in a mouse model". </p> <p> </p>
Millions of lung tumors harboring KRAS, BRAF, EGFR, and tumor suppressor alterations from genetically engineered mouse models
<p><span>Tumors acquire alterations in oncogenes and tumor suppressor genes in an adaptive walk through the fitness landscape of tumorigenesis. However, the <a>interactions </a></span><span>between oncogenes and tumor suppressor genes that shape this landscape remain poorly resolved and cannot be revealed by human cancer genomics alone. Here, we use a multiplexed, autochthonous mouse platform to model and quantify the initiation and growth of more than one hundred genotypes of lung tumors across four oncogenic contexts: KRAS G12D, KRAS G12C, BRAF V600E, and EGFR L858R. We show that the fitness landscape is rugged—the effect of tumor suppressor inactivation often switches between beneficial and deleterious depending on the oncogenic context—and shows no evidence of diminishing-returns epistasis within variants of the same oncogene. These findings argue against a simple linear signaling relationship amongst these three oncogenes and imply a critical role for off-axis signaling in determining the fitness effects of inactivating tumor suppressors.</span></p>
Dataset: Disease-associated KCNMA1 variants decrease circadian clock robustness in channelopathy mouse models
<p><em>KCNMA1</em> encodes the voltage- and calcium-activated K<sup>+</sup> (BK) channel, which regulates suprachiasmatic nucleus (SCN) neuronal firing and circadian behavioral rhythms. Gain-of-function (GOF) and loss-of-function (LOF) alterations in BK channel activity disrupt circadian behavior, but the effect of human disease-associated <em>KCNMA1</em> channelopathy variants has not been studied on clock function. Here, we assess circadian behavior in two GOF and one LOF mouse lines. Heterozygous <em>Kcnma1</em><sup>N999S/WT</sup> and homozygous <em>Kcnma1</em><sup>D434G/D434G</sup> mice are validated as GOF models of paroxysmal dyskinesia (PNKD3), but whether circadian rhythm is affected in this hypokinetic locomotor disorder is unknown. Conversely, homozygous LOF <em>Kcnma1</em><sup>H444Q/H444Q </sup>mice do not demonstrate PNKD3. We assessed circadian behavior by locomotor wheel running activity. All three mouse models were rhythmic, but <em>Kcnma1</em><sup>N999S/WT</sup> and <em>Kcnma1</em><sup>D434G/D434G</sup> showed reduced circadian amplitude and decreased wheel activity, corroborating prior studies focused on acute motor coordination. In addition, <em>Kcnma1</em><sup>D434G/D434G</sup> mice had a small decrease in period. However, the phase-shifting sensitivity for both GOF mouse lines was abnormal. Both <em>Kcnma1</em><sup>N999S/WT</sup> and <em>Kcnma1</em><sup>D434G/D434G</sup> mice displayed increased responses to light pulses and took fewer days to re-entrain to a new light:dark cycle. In contrast, the LOF <em>Kcnma1</em><sup>H444Q/H444Q </sup>mice showed no difference in any of the circadian parameters tested. The enhanced sensitivity to phase-shifting stimuli in <em>Kcnma1</em><sup>N999S/WT</sup> and <em>Kcnma1</em><sup>D434G/D434G</sup> mice was similar to other <em>Kcnma1</em> GOF mice. Together with previous studies, these results suggest that increasing BK channel activity decreases circadian clock robustness, without rhythm ablation.</p>
Parenting_mouse_demo_model
<p>Please see https://www.nature.com/articles/s41592-022-01443-0 for full details on this data and model. Here, as a demo we provide a DLCRNet-50_ms4 trained for 60K iterations, batch size 4. It was trained on 70% of the dataset as presented at: https://benchmark.deeplabcut.org/datasets.html</p>
Novel DMD mouse model carrying a multi-exonic Dmd deletion exhibit progressive muscular dystrophy and early-onset cardiomyopathy
Open the record for dataset details and reuse information.
Data from: Therapeutic treatment with OLX-07010 inhibited tau aggregation and ameliorated motor deficits in an aged mouse model of tauopathy
Open the record for dataset details and reuse information.
Systemic application of the TRPV4 antagonist GSK2193874 induces tail vasodilation in a mouse model of thermoregulation
Open the record for dataset details and reuse information.
Pleiotropic effects of trisomy and pharmacologic modulation on structural, functional, molecular, and genetic systems in a Down syndrome mouse model
Open the record for dataset details and reuse information.
Ectopic expression of BBS1 rescues male infertility, but not retinal degeneration, in a BBS1 mouse model
Open the record for dataset details and reuse information.
Dataset: Disease-associated KCNMA1 variants decrease circadian clock robustness in channelopathy mouse models
Open the record for dataset details and reuse information.
Microglial replacement in a Sandhoff disease mouse model reveals myeloid-derived β- hexosaminidase is necessary for neuronal health
Open the record for dataset details and reuse information.
Data from: Sex specific emergence of trisomic Dyrk1a-related skeletal phenotypes in the development of a Down syndrome mouse model
Open the record for dataset details and reuse information.
Lung microbiota analyses in asthma mouse model
Open the record for dataset details and reuse information.
Modelling the genetic aetiology of complex disease: human-mouse conservation of noncoding features and disease-associated loci
Open the record for dataset details and reuse information.
Machine learning on syngeneic mouse tumor profiles to model clinical immunotherapy response
Open the record for dataset details and reuse information.
Gene augmentation prevents retinal degeneration in a CRISPR/Cas9-based mouse model of PRPF31 retinitis pigmentosa
Open the record for dataset details and reuse information.
Data from: Compromised femoral and lumbovertebral bone in the Dp(16)1Yey Down syndrome mouse model
Open the record for dataset details and reuse information.
Data from: Effect of stretching on inflammation in a subcutaneous carrageenan mouse model analyzed at single-cell resolution
Open the record for dataset details and reuse information.
Ex vivo 100 μm isotropic diffusion MRI‐based tractography of connectivity changes in the end‐stage R6/2 mouse model of Huntington's disease
Open the record for dataset details and reuse information.
Cerebrovascular alterations in a mouse model of late-onset Alzheimer's disease
Open the record for dataset details and reuse information.
ScienceDex guides
Understand access before you commit
These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.