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241 results for “polyphenols”
The Effects of Red Wine Polyphenols on Microvascular Dysfunction
ClinicalTrials.gov study NCT01518764. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Impact of the Combined Treatment of Liposomed Polyphenols With G04CB02 on the ALS Patients
ClinicalTrials.gov study NCT04654689. IPD Sharing: YES. Countries: 1. Publications: 47.
Dietary Polyphenols and Insulin Sensitivity in Overweight and Obese Humans
ClinicalTrials.gov study NCT02381145. IPD Sharing: Not stated. Countries: 1. Publications: 3.
Polyphenols and Insulin Resistance
ClinicalTrials.gov study NCT01478841. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Evaluation of a New Orange-Based Beverage Enriched With Polyphenols in Adult Humans
ClinicalTrials.gov study NCT01290250. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Effect of Cocoa Polyphenols Supplementation on Cardiovascular Risk of Postmenopausal Women
ClinicalTrials.gov study NCT05158673. IPD Sharing: NO. Countries: 1. Publications: 2.
Characterization of Wild Blueberry Polyphenols Bioavailability and Kinetic Profile Over 24-hour Period
ClinicalTrials.gov study NCT02167555. IPD Sharing: UNDECIDED. Countries: 1. Publications: 1.
Effectiveness of a Butyrate Formulation and Butyrate + Polyphenol Formulation on Gut Health, Permeability and Associated Symptoms
ClinicalTrials.gov study NCT06419231. IPD Sharing: NO. Countries: 1. Publications: 18.
Effects of Polyphenols Found in Pomegranate and Olives Food Supplements on Postprandial Blood Glucose in Vivo.
ClinicalTrials.gov study NCT02486978. IPD Sharing: Not stated. Countries: 1. Publications: 7.
Data from: Seed polyphenols in a diverse tropical plant community
Open the record for dataset details and reuse information.
Data from: Pattern of polyphenol intake and the long-term risk of dementia in older persons
Open the record for dataset details and reuse information.
Short-term exposure to the simple polyphenolic compound gallic acid induces neuronal hyperactivity in zebrafish larvae
<p>Zebrafish locomotor test</p> <p>Larval locomotion in zebrafish was investigated at 72 hpf using the automated analyzer DanioVision<sup>TM</sup> Observation Chamber (Noldus Information Technology). Larvae were individually exposed to 50 µg/ml GA dissolved in E3 medium. The activity was measured at three time points: 30, 60, and 180 min. The activity measured in treated and control larvae included: 1) total distance covered by each larva (total distance, in mm), 2) total time larvae spent moving (movement, in seconds), 3) mean velocity of each larva across movement measures (velocity, in mm/sec), 4) total number of rotations completed by each larva during the experiment (one rotation was counted every time larvae turned more than 180° left or right with respect to its own body axis, counted as the frequency of left and right rotations).</p> <p> </p> <p>Cadmium treatment of zebrafish larvae</p> <p>Two batches of wild-type larvae were exposed for 3 h (from 69 to 72 hpf) to 50 and 100 µM CdCl<sub>2</sub>·H<sub>2</sub>O in an E3 medium, respectively. Half of the 50 µM and half of the 100 µM treated larvae underwent the exposition to 50 µg/ml GA. The four obtained subgroups were: <em>i.</em> Cd 50 µM only treated larva; <em>ii.</em> <em>Cd 100</em> µM only treated; <em>iii</em>. Cd 50 µM exposed to GA larvae; and <em>iv</em>. 100 µM exposed to GA larvae. All the groups underwent the behavioral observations reported above. As control groups were used: one group (Control E3) consisting of larvae in E3 medium only, and a second control with larvae exposed to 50 µg/ml GA for 30 minutes only. Larval locomotion was evaluated in a 96-well plate using the automated analyzer DanioVision<sup>TM</sup> Observation Chamber (Noldus Information Technology). Each experiment was performed in triplicate.</p> <p> </p> <p>Neurotransmitter analyses</p> <p>Neur_data report the final concentration expressed as ng of neurotransmitter per larva.</p>
Data from: Genome-wide association studies in apple reveal loci of large effect controlling apple polyphenols
Apples are a nutritious food source with significant amounts of polyphenols that contribute to human health and wellbeing, primarily as dietary antioxidants. Although numerous pre- and post-harvest factors can affect the composition of polyphenols in apples, genetics is presumed to play a major role because polyphenol concentration varies dramatically among apple cultivars. Here we investigated the genetic architecture of apple polyphenols by combining high performance liquid chromatography (HPLC) data with ~100,000 single nucleotide polymorphisms (SNPs) from two diverse apple populations. We found that polyphenols can vary in concentration by up to two orders of magnitude across cultivars, and that this dramatic variation was often predictable using genetic markers and frequently controlled by a small number of large effect genetic loci. Using GWAS, we identified candidate genes for the production of quercitrin, epicatechin, catechin, chlorogenic acid, 4-O-caffeoylquinic acid and procyanidins B1, B2, and C1. Our observation that a relatively simple genetic architecture underlies the dramatic variation of key polyphenols in apples suggests that breeders may be able to improve the nutritional value of apples through marker-assisted breeding or gene editing.
Figure 3 from: Nguyen N-VT, Nguyen CV, Duong NT, Dai X-TT, Nguyen KT, Le C-TT (2024) Optimization of ultrasound-assisted extraction using response surface methodology and quantification of polyphenol compounds in Avicennia officinalis L. from Vietnam. Pharmacia 71: 1-9. https://doi.org/10.3897/pharmacia.71.e115528
Figure 3 3D response surface curve showing the influences of independent variables on the TFC (A–F).
Figure 2 from: Nguyen N-VT, Nguyen CV, Duong NT, Dai X-TT, Nguyen KT, Le C-TT (2024) Optimization of ultrasound-assisted extraction using response surface methodology and quantification of polyphenol compounds in Avicennia officinalis L. from Vietnam. Pharmacia 71: 1-9. https://doi.org/10.3897/pharmacia.71.e115528
Figure 2 3D response surface curve showing the influences of independent variables on the TPC (A–F).
Figure 4 from: Nguyen N-VT, Nguyen CV, Duong NT, Dai X-TT, Nguyen KT, Le C-TT (2024) Optimization of ultrasound-assisted extraction using response surface methodology and quantification of polyphenol compounds in Avicennia officinalis L. from Vietnam. Pharmacia 71: 1-9. https://doi.org/10.3897/pharmacia.71.e115528
Figure 4 HPLC chromatogram of A. officinalis leaves extract. a Mobile phase solvent; b Solute sovent; c Extraction solvent; d Spiked sample; e Mixed standards solution; f Standard addition. (C1: Chlorogenic acid, C2: p-coumaric acid, C3: Sinapic acid, C4: Taxifolin, C5: Luteolin -7-O-glucoside, C6: Cinnamic acid).
Figure 1 from: Nguyen N-VT, Nguyen CV, Duong NT, Dai X-TT, Nguyen KT, Le C-TT (2024) Optimization of ultrasound-assisted extraction using response surface methodology and quantification of polyphenol compounds in Avicennia officinalis L. from Vietnam. Pharmacia 71: 1-9. https://doi.org/10.3897/pharmacia.71.e115528
Figure 1 Influence of methanol concentration, ratio of solid to liquid, temperature and time ultrasonic on the extration of TPC and TFC from A. officinalis leave extracts.
Figure 1 from: Koleva P, Tsanova-Savova S, Paneva S, Velikov S, Savova Z (2021) Polyphenols content of selected medical plants and food supplements present at Bulgarian market. Pharmacia 68(4): 819-826. https://doi.org/10.3897/pharmacia.68.e71460
Figure 1 Chromatogram of Standard mix of (+)-catechin, (-)-epicatechin and rutin at 275 nm (a) and 355 nm (b).
From Gut to Heart: Polyphenol-Mediated Microbiome in STEMI Patients
<p><span><span>This dataset is a part of "From Gut to Heart: Polyphenol-Mediated Microbiome Modulation in STEMI Patients" article. The study investigates the effects of polyphenol supplementation on gut microbiome composition and cardiovascular health in STEMI patients.</span></span> </p>
Data from: Dissolved iron elution from mangrove ecosystem associated with polyphenols and a herbivorous snail
Interest in the systems supplying dissolved forms of iron to the sea from upland-forests and wetlands has increased because iron is abundant on land but has low bioavailability in seawater. This can be a limiting factor for the growth of marine phytoplankton. Organic complex iron, a typical form of iron dissolved in seawater, is supplied to the ocean through rivers from forest and wetland soils. As a related study, we focus on mangrove ecosystems located at the boundary between the land and sea and on polyphenols present in leaves as ligands for the formation of iron complexes. When mangrove leaf litter falls on the wet forest floor, phenolic compounds leach out from the leaves and might solubilize insoluble iron in the sediments (i.e., iron complexation). However, the reaction mechanism is not simple in the field, and it might be made more complex by tidal currents and intervention by crabs and snails, which consume mangrove leaf litter. In the present study, we focused on a detritivorous snail, Terebralia palustris, as a facilitator of iron solubilization associated with phenolic compounds, and examined how the snail contribute to iron solubilization processes. Our results indicated that the amounts of phenolic compounds in mangrove sediments are strongly related to iron solubilization. Furthermore, the average dissolved iron and phenolic contents in sediments from areas inhabited by the snail were significantly higher than those of sediments where the snail was not present. We additionally report that the solubilization of iron was promoted when snail feces were added to mangrove sediments. In conclusion, we propose that iron solubilization in mangrove sediments is promoted by the interaction between i) iron in the sediment, ii) phenolic compounds derived from mangroves, and iii) the consumption of leaves and the deposition of feces by the snail.
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Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.