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473 results for “role of humans”
THE ROLE OF INTERNATIONAL NGOS IN ADVANCING HUMAN RIGHTS
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Data from: On the relative roles of background selection and genetic hitchhiking in shaping human cytomegalovirus genetic diversity
A central focus of population genetics has been examining the contribution of selective and neutral processes in shaping patterns of intraspecies diversity. In terms of selection specifically, surveys of higher organisms have shown considerable variation in the relative contributions of background selection and genetic hitchhiking in shaping the distribution of polymorphisms, though these analyses have rarely been extended to bacteria and viruses. Here, we study the evolution of a ubiquitous, viral pathogen, human cytomegalovirus (HCMV), by analyzing the relationship among intraspecies diversity, interspecies divergence, and rates of recombination. We show that there is a strong correlation between diversity and divergence, consistent with expectations of neutral evolution. However, after correcting for divergence, there remains a significant correlation between intraspecies diversity and recombination rates, with additional analyses suggesting that this correlation is largely due to the effects of background selection. In addition, a small number of loci, centered on long non-coding RNAs, also show evidence of selective sweeps. These data suggest that HCMV evolution is dominated by neutral mechanisms as well as background selection, expanding our understanding of linked selection to a novel class of organisms.
Dying to cooperate: the role of environmental harshness in human collaboration
<p class="MsoNoSpacing">It has been proposed that environmental stress acted as a selection pressure on the evolution of human cooperation. Through agent-based evolutionary modelling, mathematical analysis and human experimental data we illuminate the mechanisms by which the environment influences cooperative success and decision making in a Stag Hunt game. The modelling and mathematical results show that only cooperative foraging phenotypes survive the harshest of environments but pay a penalty for mis-coordination in favourable environments. When agents are allowed to coordinate their hunting intentions by communicating, cooperative phenotypes outcompete those who pursue individual strategies in almost all environmental and payoff scenarios examined. Data from human participants show flexible decision-making in face of cooperative uncertainty, favouring high-risk, high-reward strategy when environments are harsher and starvation is imminent. Converging lines of evidence from the three approaches indicate a significant role for environmental variability in human cooperative dynamics and the species-unique cognition designed to support it.</p>
Datasets - Role of Secondary Organic Matter on Soot Particle Toxicity in Reconstituted Human Bronchial Epithelia Exposed at the Air–Liquid Interface
<p>Vuesz files corresponding to Figure2 and 3 of the following article: <a href="https://doi.org/10.1021/acs.est.2c03692">https://doi.org/10.1021/acs.est.2c03692</a>. Veusz is an open-source software which can be downloaded here: <a href="https://veusz.github.io/">Veusz – a scientific plotting package</a>.</p>
Supplementary material 1 from: Nunes P, Robinet C, Branco M, Franco JC (2023) Modelling the invasion dynamics of the African citrus psyllid: The role of human-mediated dispersal and urban and peri-urban citrus trees. In: Jactel H, Orazio C, Robinet C, Douma JC, Santini A, Battisti A, Branco M, Seehausen L, Kenis M (Eds) Conceptual and technical innovations to better manage invasions of alien pests and pathogens in forests. NeoBiota 84: 369-396. https://doi.org/10.3897/neobiota.84.91540
Supplementary tables
The Role of Acute Combined PPAR Alpha and Gamma Stimulation on Insulin Action in Humans
ClinicalTrials.gov study NCT00179400. IPD Sharing: NO. Countries: 1. Publications: 0.
Assessing the Potential Role of the Gut Microbiome in Modulating Physical Abilities in Humans
ClinicalTrials.gov study NCT05024188. IPD Sharing: NO. Countries: 0. Publications: 2.
Ischemia/Reperfusion Injury of Human Endothelium: Role of Glucose and Statins
ClinicalTrials.gov study NCT00995670. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Role of Copper-Albumin Complex in Treatment of Knee Osteoarthritis in Human
ClinicalTrials.gov study NCT03736109. IPD Sharing: Not stated. Countries: 0. Publications: 5.
Millennial-scale change in Caribbean coral reef ecosystem structure and the role of human and natural disturbance
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The role of common ancestry and gene flow in the evolution of human-directed play behavior in dogs
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Data from: On the relative roles of background selection and genetic hitchhiking in shaping human cytomegalovirus genetic diversity
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Data from: Potential role of Cyr61 induced degeneration of human Müller cells in diabetic retinopathy
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Data from: The role of human outdoor recreation in shaping patterns of grizzly bear-black bear co-occurrence
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Data from: Drosophila studies support a role for a presynaptic synaptotagmin mutation in a human congenital myasthenic syndrome
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Dying to cooperate: the role of environmental harshness in human collaboration
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A critical role of microRNAs in human pulmonary arterial hypertension. miR-204: a novel therapeutic target
GEO Series GSE21284. Homo sapiens. 8 samples. Type: Expression profiling by array; Expression profiling by RT-PCR.
Unraveling the role of human TSC-specific TFs [ChIP-Seq]
GEO Series GSE208361. Homo sapiens. 15 samples. Type: Genome binding/occupancy profiling by high throughput sequencing.
Essential role of JAB1 in human chondrosarcoma pathogenesis
GEO Series GSE137683. Homo sapiens. 6 samples. Type: Expression profiling by high throughput sequencing.
Role of STARD10 in human pancreatic β-cells
GEO Series GSE153466. Homo sapiens. 18 samples. Type: Expression profiling by high throughput sequencing.
ScienceDex guides
Understand access before you commit
These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.