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990 results for “coronary artery disease”
ABCA1-eRNA as a novel Epigenetic Regulator, promotes cholesterol efflux, Attenuates Macrophage Inflammation and Severity of Coronary Artery Disease [CUT&TAG]
GEO Series GSE192937. Homo sapiens. 14 samples. Type: Genome binding/occupancy profiling by high throughput sequencing.
Dataset related to the article "Diagnostic accuracy of subendocardial vs. transmural myocardial perfusion defect for the detection of in-stent restenosis or progression of coronary artery disease after percutaneous coronary intervention
<p>This record contains raw datarelated to the article"Diagnostic accuracy of subendocardial vs. transmural myocardial perfusion defect for the detection of in-stent restenosis or progression of coronary artery disease after percutaneous coronary intervention</p> <p> </p> <p>Background. The ADVANTAGE study demonstrated in a cohort of stented patients a diagnostic accuracy of stress myocardial CT perfusion (CTP) significantly higher than that of coronary CT angiography (CCTA) for the detection of in-stent restenosis (ISR) or CAD progression vs. quantitative coronary angiography (QCA). This is a pre-defined subanalysis of the ADVANTAGE aimed at assessing the difference in terms of diagnostic accuracy vs. QCA of a subendocardial vs. a transmural perfusion defect using static stress CTP.<br> Methods. We enrolled consecutive patients who previously underwent coronary stenting and were referred for QCA. All patients underwent stress CTP and rest CTP+CCTA. The diagnostic accuracy of CCTA and CTP were evaluated in territory-based and patient-based analyses. We compared the diagnostic accuracy of “subendocardial” perfusion defect, defined as hypo-enhancement encompassing >25% but <50% of the transmural myocardial thickness within a specific coronary territory vs. “transmural” perfusion defect, defined as hypo-enhancement encompassing >50% of the transmural thickness.<br> Results. In 150 patients (132 men, mean age 65.1±9.1 years), the diagnostic accuracy of subendocardial vs. transmural perfusion defect in a vessel-based analysis was 93.5% vs. 87.7%, respectively (p<0.0001). The sensitivity and specificity of subendocardial vs. transmural defect were 87.9% vs. 46.9% (p<0.001) and 94.9% vs. 97.9% (p=0.004), respectively. In a patient-based analysis, the diagnostic accuracy of the subendocardial vs. transmural approach was 86.6% vs. 68% (p<0.0001).<br> Conclusions. This study shows that detection of a subendocardial perfusion defect as compared to a transmural defect is significantly more accurate to identify coronary territories with ISR or CAD progression.</p> <p> </p>
Comprehensive analysis of RNA expression profiling in patients with multi- vs single-vessel coronary artery disease
GEO Series GSE190627. Homo sapiens. 19 samples. Type: Expression profiling by high throughput sequencing; Non-coding RNA profiling by high throughput sequencing.
Microarray analysis to identify differential molecular signatures in subjects with stable coronary artery disease on standard dosage regimens versus healthy controls
GEO Series GSE56885. Homo sapiens. 6 samples. Type: Expression profiling by array.
Global gene expression studies for coronary artery disease and its severity in North Indian population
GEO Series GSE98583. Homo sapiens. 18 samples. Type: Expression profiling by array.
Data set from the article Petrini M, Alì M, Cannaò PM, Zambelli D, Cozzi A, Codari M, Malavazos AE, Secchi F, Sardanelli F. Epicardial adipose tissue volume in patients with coronary artery disease or non-ischaemic dilated cardiomyopathy: evaluation with cardiac magnetic resonance imaging. Clin Radiol. 2019 Jan;74(1):81.e1-81.e7. doi: 10.1016/j.crad.2018.09.006. Epub 2018 Oct 15. PMID: 30336943.
<p>Data set from the article Petrini M, Alì M, Cannaò PM, Zambelli D, Cozzi A, Codari M, Malavazos AE, Secchi F, Sardanelli F. Epicardial adipose tissue volume in patients with coronary artery disease or non-ischaemic dilated cardiomyopathy: evaluation with cardiac magnetic resonance imaging. Clin Radiol. 2019 Jan;74(1):81.e1-81.e7. doi: 10.1016/j.crad.2018.09.006. Epub 2018 Oct 15. PMID: 30336943.</p> <p> </p> <p>This is the abstract:</p> <p><strong>Aim: </strong> To compare the amount of epicardial adipose tissue (EAT) in patients with coronary artery disease (CAD) or non-ischaemic dilated cardiomyopathy (NIDCM) with that in patients with negative cardiac magnetic resonance imaging (CMR).</p> <p><strong>Materials and methods: </strong> One hundred and fifty patients (median age 57 years, interquartile range [IQR] 46-66 years) who underwent CMR were evaluated retrospectively: 50 with CAD, 50 with NIDCM, and 50 with negative CMR. For each patient, the EAT mass index (EATMI) to body surface area, end-diastolic volume index (EDVI), end-systolic volume index (ESVI), stroke volume (SV), ejection fraction (EF) for both ventricles, and left ventricle (LV) mass index were estimated. Intra and inter-reader reproducibility was tested in a random subset of 30 patients, 10 for each group. Mann-Whitney U test, Kruskal-Wallis test, Spearman's correlation, and Bland-Altman statistics were used.</p> <p><strong>Results: </strong> The EATMI in CAD patients (median 15.7 g/m<sup>2</sup>, IQR 8.3-25.7) or in NIDCM patients (15.9 g/m<sup>2</sup>, 11.5-18.1) was significantly higher than that in negative CMR patients (9.1 g/m<sup>2</sup>, 6-12; p<0.001 both). No significant difference was found between CAD and NIDCM patients (p=1.000). A correlation between EATMI and LV mass index was found in NIDCM patients (r=0.455, p=0.002). Intra- and inter-reader reproducibility were up to 80% and 72%, respectively.</p> <p><strong>Conclusion: </strong> Patients with NIDCM or CAD exhibited an increased EATMI in comparison to negative CMR patients. CMR can be used to estimate EAT with good reproducibility.</p>
Aortic Valve Sclerosis in High-Risk Coronary Artery Disease Patients
<p>This record contains raw data related to the article “Aortic Valve Sclerosis in High-Risk Coronary Artery Disease Patients”<strong>Background:</strong> Current knowledge regarding the relationship between aortic valve sclerosis (AVSc), cardiovascular risk factors, and mortality in patients with known coronary artery disease (CAD) is still unclear. The present study aimed at investigating the prevalence of AVSc as well as its association with long-term all-cause mortality in high-risk CAD patients that has never been explored in large cohorts thus far. <strong>Methods and Results:</strong> In this retrospective and observational cohort study we enrolled high-risk CAD patients, hospitalized at Centro Cardiologico Monzino (CCM), Milan, Italy, between January 2006 and December 2016. The morphology and function of the aortic valve were assessed from the recorded echocardiographic images to evaluate the presence of AVSc, defined as a non-uniform thickening of the aortic leaflets with no consequences on hemodynamics. Data on 5-year all-cause mortality was retrieved from a Regional database. Of the 5,489 patients initially screened, 4,938 (mean age 67 ± 11 years, 3,954 [80%] men) were enrolled in the study. In the overall population, AVSc was detected in 2,138 (43%) patients. Multivariable LASSO regression revealed that age, female gender, diabetes mellitus, previous MI, and left ventricular ejection fraction were independently associated with AVSc. All-cause mortality (adjusted hazard ratio: 1.29, 95%CI: 1.05-1.58) was significantly higher in AVSc than in non-AVSc patients. <strong>Conclusions:</strong> AVSc is frequently detected in high-risk CAD patients and is associated with long-term mortality. Our findings corroborate the hypothesis that AVSc is an underestimated marker of systemic cardiovascular risk. Thus, AVSc detection may be used to improve long-term risk stratification of high-risk CAD patients.</p>
Does chest shape influence exercise stress echocardiographic results in patients with suspected coronary artery disease?
<p>Raw data related to the article</p> <p>Abstract<br> Despite the good specificity of exercise stress echocardiography (ESE) for the detection of coronary artery disease (CAD),<br> false positive (FP) results may occur. We have previously reported that chest abnormalities may affect parameters of cardiac<br> contractility. The influence of chest shape on ESE results has never been previously investigated. We retrospectively analyzed<br> 160 consecutive patients (64.4 ± 13.0-year old, 91 women) who had undergone coronary angiography at our Institution<br> because of positive ESE, between June 2014 and May 2020. Modified Haller index (MHI; chest transverse diameter over<br> the distance between sternum and spine) was assessed in all patients. Obstructive CAD was diagnosed by ≥ 70% stenosis<br> in any epicardial coronary artery. Outcome was false-positivity at ESE. 80.6% of patients were diagnosed with obstructive<br> CAD, while 19.4% had no CAD (FP). We separately analyzed patients with normal chest shape (MHI ≤ 2.5) and those with<br> concave-shaped chest wall (MHI > 2.5). These latter were mostly women with small cardiac chambers, mitral valve prolapse<br> (MVP) and exercise-induced ST-segment changes. Likelihood of false-positivity was significantly higher in subjects with<br> MHI > 2.5 than those with MHI ≤ 2.5 (30.7% vs 9.4%, p = 0.001). By multivariate logistic regression analysis, MHI > 2.5<br> (OR 4.04, 95%CI 1.45–11.2, p = 0.007), MVP (OR 3.47, 95%CI 1.32–9–12, p = 0.01) and dyssynergy in the left circumflex<br> territory (OR = 3.35, 95%CI 1.26–8.93, p = 0.01) were independently associated with false-positivity. Concave-shaped chest<br> wall (MHI > 2.5) may be associated with false-positive stress echocardiographic result. Mechanisms underpinning this finding<br> need to be further explored.</p>
Appropriate use criteria implementation with modified Haller index for predicting stress echocardiographic results and outcome in a population of patients with suspected coronary artery disease
<p>Raw data related to the article</p> <p>Abstract<br> The hypothesis that modified Haller index (MHI) integration with the existing appropriate use criteria (AUC) categories may<br> predict exercise stress echocardiography (ESE) results and outcome of patients with suspected coronary artery disease (CAD)<br> has never been previously investigated. We retrospectively analyzed 1230 consecutive patients (64.8 ± 13.1 years, 58.9%<br> men) who underwent ESE for suspected CAD between February 2011 and September 2019 at our institution. MHI (chest<br> transverse diameter over the distance between sternum and spine) was assessed in all patients. A true positive (TP) ESE was<br> a positive ESE with obstructive CAD according to subsequent coronary angiography. During follow-up time, we evaluated<br> the occurrence of any of the following: (1) cardiovascular (CV) hospitalizations; (2) Cardiac death or sudden death. Overall,<br> 734 (59.7%), 357 (29.0%) and 139 (11.3%) indications for ESE were classified as appropriate (Group 1), rarely appropriate<br> (Group 2) and which may be appropriate (Group 3), respectively. A funnel chest (defined by an MHI > 2.5) was detected<br> in 30.3%, 82.1% and 49.6% of Groups 1, 2 and 3 subjects, respectively (p < 0.0001). On multivariate logistic regression<br> analysis, male sex (OR 1.41, 95%CI 1.02–2.03, p = 0.01) and type-2 diabetes (OR 3.63, 95%CI 2.49–5.55, p = 0.001) were<br> directly correlated to a TP ESE, while “rarely appropriate” indication for ESE with MHI > 2.5 (OR 0.16, 95%CI 0.11–0.22,<br> p < 0.0001) showed a significant inverse correlation with the outcome. During a mean follow-up of 2.5 ± 1.9 years, 299 CV<br> events occurred: 76.4%, 3.5% and 20.1% in Groups 1, 2 and 3, respectively. On multivariate Cox regression analysis, smoking<br> (HR 1.33, 95%CI 1.19–1.48), type 2 diabetes (HR 2.28, 95%CI 1.74–2.97), dyslipidemia (HR 3.51, 95%CI 2.33–5.15), betablockers<br> (HR 0.55, 95%CI 0.41–0.75), statins (HR 0.60, 95%CI 0.45–0.80), peak exercise average E/e′ ratio (HR 1.08, 95%CI<br> 1.06–1.09), positive ESE (HR 3.12, 95%CI 2.43–4.01) and finally “rarely appropriate” indication for ESE with MHI > 2.5<br> (HR 0.15, 95%CI 0.08–0.23) were independently associated with CV events. The implementation of AUC categories with<br> MHI assessment may select a group of patients with extremely low probability of both TP ESE and adverse CV events over<br> a medium-term follow-up. A simple noninvasive chest shape assessment could reduce unnecessary exams.</p>
Raw data_Evaluation of the prognostic role of NLR, CAR, and PLR in patients with the co-presentation of coronary artery disease and COVID-19
<p>Raw data </p>
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