Find research datasets worth reusing

Safety and Pharmacokinetic Characteristics of DP-R206(Vitamin D3) in Healthy Adult Volunteers

ClinicalTrials.gov study NCT01577849. IPD Sharing: Not stated. Countries: 1. Publications: 1.

A Pharmacokinetic Study to Compare CBD-NE to Epidyolex in Healthy Adult Volunteers Under Both Fed and Fasted Conditions

ClinicalTrials.gov study NCT06578455. IPD Sharing: Not stated. Countries: 1. Publications: 9.

A Study to Investigate the Pharmacokinetics of Prolonged-release Melatonin Compared to Standard, Immediate-release Melatonin in Healthy Adults

ClinicalTrials.gov study NCT04067791. IPD Sharing: NO. Countries: 1. Publications: 1.

Safety of and Immune Response to a DNA Vaccine and a Recombinant HIV-1-MVA Vaccine, Separately and in Combination, in Healthy Adults

ClinicalTrials.gov study NCT00428337. IPD Sharing: Not stated. Countries: 1. Publications: 4.

A Study to Evaluate the Safety, Reactogenicity and Immunogenicity of GSK Biologicals' Staphylococcal Investigational Vaccine in Healthy Adults

ClinicalTrials.gov study NCT01160172. IPD Sharing: Not stated. Countries: 1. Publications: 1.

A Bridging Study of the SYN023 on Healthy Adult Subjects

ClinicalTrials.gov study NCT04495569. IPD Sharing: NO. Countries: 1. Publications: 3.

Safety, Tolerability, and Immunogenicity of Zoster Vaccine Live (ZOSTAVAX™) in Healthy Adults in India (V211-025)

ClinicalTrials.gov study NCT01527370. IPD Sharing: YES. Countries: 0. Publications: 1.

Effects of a Healthy Lifestyle Program on Health Outcomes in Older Adults

ClinicalTrials.gov study NCT03576209. IPD Sharing: YES. Countries: 1. Publications: 2.

Cholesterol and Statin in Healthy Adults

ClinicalTrials.gov study NCT02908425. IPD Sharing: NO. Countries: 1. Publications: 20.

A Drug-Drug Interaction Study of N91115 +/- Rifampin in Healthy Adult Subjects

ClinicalTrials.gov study NCT02500667. IPD Sharing: Not stated. Countries: 1. Publications: 1.

Efficacy of Ramelteon on Insomnia Symptoms Associated With Jet Lag in Healthy Adult Volunteers

ClinicalTrials.gov study NCT00492011. IPD Sharing: Not stated. Countries: 1. Publications: 1.

publicFeb 2019View details →

dryad32/100

Data from: Performance of glomerular filtration rate estimation equations in Congolese healthy adults: inopportunity of ethnic correction

Open the record for dataset details and reuse information.

dryad32/100

Data from: Complete blood count reference intervals from a healthy adult urban population in Kenya

Open the record for dataset details and reuse information.

publicMay 2019View details →

dryad28/100

Data from: Increased CAIDE dementia risk, cognition, CSF biomarkers and vascular burden in healthy adults

Objective: To investigate the cognitive profile of healthy individuals with increased CAIDE dementia risk score, and to explore whether this association is related to vascular burden and CSF biomarkers of amyloidosis and neurodegeneration. Method: Cognitively normal participants (mean age = 57.6 years) from the Gipuzkoa Alzheimer Project study were classified as having high risk (HR, n = 82) or low risk (LR, n = 293) for dementia according to a CAIDE score cut off of 9. Cognitive composites were compared between groups. We explored the role of APOE genotype, MRI white matter hyperintensities (WMH) and CSF (n = 218) levels of amyloid-β1-42 (Aβ1-42), total tau (t-tau) and phosphorylated tau (p-tau) in the association between CAIDE and cognition conducting generalized linear models. Results: HR participants obtained lower scores on executive function (EF) (p = .001) and visual perception and construction (VPC) (p < .001) composites. EFc was associated with CAIDEp-tau (p = .001), CAIDEt-tau (p = .001) and WMH (p = .003). VPCc was associated with APOE (p = .001), Aβ1-42 (p = .004), the interaction APOEAβ1-42 (p = .003), and WMH (p = .004). Performance on global memory was associated with Aβ1-42 (p = .006), APOE (p = .008), and their interaction (p = .006). Analyses were adjusted for age, education, sex, premorbid intelligence and stress. Conclusion: Healthy participants at increased dementia risk, based on CAIDE scores, show lower performance in executive function and visual perception and construction. This difference is related to APOE, WMH and Alzheimer's biomarkers.

opencc-zeroDec 2017View details →

dryad28/100

Raw data of body-specific attention to the hands and feet in healthy adults

To execute the intended movement, the brain directs attention, called body-specific attention, to the body to obtain information useful for movement. Body-specific attention to the hands has been examined but not to the feet. We aimed to confirm the existence of body-specific attention to the hands and feet, and examine its relation to motor and sensory functions from a behavioral perspective. The study included two groups of 27 right-handed and right-footed healthy adults, respectively. Visual detection tasks were used to measure body-specific attention. We measured reaction times to visual stimuli on or off the self-body and calculated the index of body-specific attention score to subtract the reaction time on self-body from that off one. Participants were classified into low and high attention groups based on each left and right body-specific attention index. For motor functions, Experiment 1 comprised handgrip strength and ball-rotation tasks for the hands, and Experiment 2 comprised toe grip strength involved in postural control for the feet. For sensory functions, the tactile thresholds of the hands and feet were measured. The results showed that, in both hands, the reaction time to visual stimuli on the hand was significantly lesser than that offhand. In the foot, this facilitation effect was observed in the right foot but not the left, which showed the correlation between body-specific attention and the normalized toe gripping force, suggesting that body-specific attention affected postural control. In the hand, the number of rotations of the ball was higher in the high than in the low attention group, regardless of the elaboration exercise difficulty or the left or right hand. However, this relation was not observed in the handgripping task. Thus, body-specific attention to the hand is an important component of elaborate movements. The tactile threshold was higher in the high than in the low attention group, regardless of the side in hand and foot. The results suggested that more body-specific attention is directed to the limbs with lower tactile abilities, supporting the sensory information reaching the brain. Therefore, we suggested that body-specific attention regulates the sensory information to help motor control.

opencc-zeroJan 2022View details →

zenodo28/100

Structural and functional connectome from 70 young healthy adults

Data Acquisition Informed written consent in accordance with institutional guidelines (protocol approved by the Ethics Committee of Clinical Research of the Faculty of Biology and Medicine, University of Lausanne, Switzerland, #82/14, #382/11, #26.4.2005) was obtained for all subjects. Data provided are fully anonymized. A total of 70 healthy participants (age 28.8 +- 9.1 years, 27 females) were scanned in a 3-Tesla MRI scanner (Trio, Siemens Medical, Germany) using a 32-channel head-coil. The session protocol was comprised of (1) a magnetization-prepared rapid acquisition gradient echo (MPRAGE) sequence sensitive to white/gray matter contrast (1-mm in-plane resolution, 1.2-mm slice thickness), (2) a DSI sequence (128 diffusion-weighted volumes and a single b0 volume, maximum b-value 8,000 s/mm2, 2.2x2.2x3.0 mm voxel size), and (3) a gradient echo EPI sequence sensitive to BOLD contrast (3.3-mm in-plane resolution and slice thickness with a 0.3-mm gap, TR 1,920 ms, resulting in 280 images per participant). During the fMRI scan, participants were not engaged in any overt task, and the scan was treated as eyes-open resting-state fMRI (rs-fMRI). Data Pre-processing  Initial signal processing of all MPRAGE, DSI, and rs-fMRI data was performed using the Connectome Mapper pipeline (Daducci et al., 2012). Gray and white matter were segmented from the MPRAGE volume using freesurfer (Desikan et al., 2006) and parcellated into 83 cortical and subcortical areas. The parcels were then further subdivided into 129, 234, 463 and 1015 approximately equally sized parcels according to the Lausanne anatomical atlas following the method proposed by (Cammoun et al., 2012). DSI data were reconstructed following the protocol described by (Wedeen et al., 2005), allowing us to estimate multiple diffusion directions per voxel. The diffusion probability density function was reconstructed as the discrete 3D Fourier transform of the signal modulus. The orientation distribution function (ODF) was calculated as the radial summation of the normalized 3D probability distribution function. Thus, the ODF is defined on a discrete sphere and captures the diffusion intensity in every direction. Structural Connectivity Structural connectivity matrices were estimated for individual participants using deterministic streamline tractography on reconstructed DSI data, initiating 32 streamline propagations per diffusion direction, per white matter voxel (Wedeen et al., 2008). Within each voxel, the starting points were spatially random. For each starting point, a fiber streamline was grown in two opposite directions with a fixed step of 1 mm. Once the fiber entered a new voxel, the fiber growth continued along the ODF maximum direction that produces the least curvature for the fiber (i.e., was most similar to the trajectory of the fiber to that point). Fibers were stopped if the change in direction was greater than 60 degrees/mm. The process was complete when both ends of the fiber left the white matter mask. Structural connectivity between pairs of regions was measured in terms of fiber density, defined as the number of streamlines between the two regions, normalized by the average length of the streamlines and average surface area of the two regions (Hagmann et al., 2008). The goal of this normalization was to compensate for the bias toward longer fibers inherent in the tractography procedure, as well as differences in region size. Functional Connectivity Functional data were pre-processed using routines designed to facilitate subsequent network exploration (Murphy et al., 2009; Power et al., 2012). fMRI volumes were corrected for physiological variables, including regression of white matter, cerebrospinal fluid, as well as motion (three translations and three rotations, estimated by rigid body co-registration). BOLD time series were then subjected to a lowpass filter (temporal Gaussian filter with full width half maximum equal to 1.92 s). The first four time points were excluded from subsequent analysis to allow the time series to stabilize. Motion ‘‘scrubbing’’ was performed as described by (Power et al., 2012). A group-average functional connectivity matrix was constructed from the fMRI BOLD time series by concatenating the regional time series from all participants and estimating a single correlation matrix. To threshold this matrix, we sampled at random 276 points from the concatenated times series and calculated a full correlation matrix from these points. We repeated this analysis 1,000 times. From these bootstrapped samples, we estimated confidence intervals for the correlation magnitude between every pair of brain regions. Pairs whose correlation was consistently positive or negative across the 1,000 samples were retained (along with the sign and weight of the correlation) as putative functional connections.

opencc-by-4.0May 2019View details →

A Study to Learn About the Study Medicine PF-07853578 and How it Acts in the Bodies of Healthy Adults

ClinicalTrials.gov study NCT05890105. IPD Sharing: NO. Countries: 1. Publications: 0.

A First-in-human Single and Repeated Dose Escalation Study of SAR442501 in Healthy Adults Subjects

ClinicalTrials.gov study NCT05846009. IPD Sharing: YES. Countries: 1. Publications: 0.

Crossover Study to Evaluate the Relative Bioavailability and Palatability of a Lenvatinib Suspension Compared to the Capsule Formulation in Adult Healthy Volunteers

ClinicalTrials.gov study NCT02792829. IPD Sharing: Not stated. Countries: 1. Publications: 0.

Safety and Efficacy of GSK Neisseria Gonorrhoeae GMMA (NgG) Investigational Vaccine When Administered to Healthy Adults 18 to 50 Years of Age.

ClinicalTrials.gov study NCT05630859. IPD Sharing: YES. Countries: 8. Publications: 0.